50
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2225 |
4-Hydroxyantipyrine
|
COX | Immunology/Inflammation; Neuroscience |
4-Hydroxyantipyrine 是在氨基比林的氧化脱氨过程中形成的。 | |||
T35337L |
Teduglutide acetate
|
Glucagon Receptor | GPCR/G Protein |
Teduglutide acetate 是一种 GLP-2 类似物,可使小肠黏膜肥大。它通过改变 claudin-10 的分布部分恢复小肠上皮功能,促进钠再循环以进行钠耦合葡萄糖转运和水吸收。 | |||
T9897 |
7-Methoxy-1-naphthaleneacetic acid
|
Others | Others |
7-Methoxy-1-naphthaleneacetic acid 是植物生长素作用的抑制剂。 7-Methoxy-1-naphthaleneacetic acid 抑制与拟南芥和玉米中生长素不对称分布相关的极性生长素转运和热带反应。 7-Methoxy-1-naphthaleneacetic acid 抑制由酵母中表达的 AUX1、PIN 和 ABCB 蛋白介导的生长素转运。 | |||
T14835 |
BTRX-335140
CYM-53093 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BTRX-335140 (CYM-53093) 是一种有效的选择性口服活性 κ 阿片受体 (KOR) 拮抗剂,对 κOR、μOR 和 δOR 具有拮抗活性,IC50 值分别为 0.8、110 和 6500 nM。它可以很好地分布到 CNS 中,在大鼠中具有良好的体外吸收、分布、代谢、排泄和毒性以及体内药代动力学特征。 | |||
T13247 |
UK-101
UK101,UK 101 |
Proteasome | Proteases/Proteasome; Ubiquitination |
UK-101 是一种强效且具有选择性的免疫蛋白酶体 LMP2 的抑制剂 ,对 β1i (LMP2) 、 β1c (LMP2) 和 β5 (LMP2) 具有抑制作用,IC50 为 104nM 、15 μM 和 1 μM 。UK-101 对 β1i 的亲和力比β1c 和 β5 亚基分布高的 144 倍和 10 倍。UK-101 可诱导细胞凋亡且可用于研究前列腺癌的相关疾病。 | |||
T1083L |
Theophylline monohydrate
Quibron,茶碱一水合物 |
HDAC; PDE; Adenosine Receptor | Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生,调节钙通量和细胞内钙分布,并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物,从植物山茶花和小粒咖啡中分离出来。在生理上,该药剂可放松支气管平滑肌,产生血管舒张(脑血管除外),刺激中枢神经系统,刺激心肌,利尿,增加胃酸分泌;它还可以抑制炎症并改善横膈膜的收缩性。 | |||
T32082 |
Histidyl-aspartyl-glutamyl-leucine
His-asp-glu-leu,Hdel sequence |
||
HDEL intracellular distribution is characteristic of plant endoplasmic reticulum (ER). | |||
T33392 |
MIP-1095 I-123
123-I-MIP-1095,(123I)MIP 1095 |
||
MIP-1095 I-123, as a radiotracer, is under investigation in clinical trial NCT00712829 (Evaluating the Safety, Pharmacokinetics, Tissue Distribution, Metabolism and Dosimetry of Two Prostate Cancer Imaging Agents). | |||
T16992 |
Taribavirin hydrochloride
|
Others | Others |
Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin hydrochloride is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells and | |||
T34166 | PROTAC_ERRalpha | ||
PROTAC_ERRalpha is a proteolysis targeting chimeras (PROTAC) which provides broad tissue distribution and knockdown of the targeted ERRalpha protein in tumor xenografts. | |||
T24924 |
Umibecestat HCl (1387560-01-1 free base)
CNP 520,Umibecestat HCl,Umibecestat hydrochloride,CNP520,CNP-520 |
||
Umibecestat is a beta-secretase inhibitor. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. | |||
T26230 |
Stilbamidine dihydrochloride
NSC 35605,NCI 174 |
||
Stilbamidine dihydrochloride is a blocker of neuromuscular transmission and axonal conduction used to study the distribution of the drug in the organs and tissues of rats following intravenous injection. | |||
T29154 |
WB403
WB-403,WB 403 |
||
WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores the normal distribution pattern of α- | |||
T14289 |
Anguizole
|
Others | Others |
Anguizole, a small molecule, effectively inhibits Hepatitis C Virus (HCV) replication by modifying the subcellular distribution of NS4B. It demonstrates its potency with an IC50 value, highlighting its specific target action against HCV. | |||
T30118 |
Arbaclofen placarbil
XP 19986,XP19986,XP-19986 |
||
Arbaclofen placarbil( XP19986) is a GABA(B) receptor agonist.Arbaclofen Placarbil is a novel R-baclofen prodrug with improved absorption, distribution, metabolism, and elimination properties compared to R-baclofen. And it can reduce postprandial reflux in | |||
T82238 |
HAPSBC
|
||
HAPSBC,一种S-苄基铁螯合剂,具有动员细胞内59Fe分布的能力。 | |||
T16993 |
Taribavirin
|
Others | Others |
Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of he | |||
TP1529 |
Galanin (1-19), human
|
||
Galanin (1-19), human, represents the fragment encompassing amino acids 1 to 19 of the human galanin neuropeptide. Galanin (GAL) is known for its extensive distribution and multifaceted biological roles, such as regulating hormone secretion, providing antinociceptive effects, and altering feeding behavior. | |||
T13862L |
Recilisib sodium
Brand name: Ex-RAD,ON 01210.Na,ON01210,ON-01210 |
||
Recilisib, also known as ON 01210.Na, is a radioprotectant, which modifys cell cycle distribution patterns in cancer cells subjected to radiation therapy, and it has been identified as a potential candidate for radiation protection studies. It appears tha | |||
T76369 |
CEDAEVFKDSMVPGEK
|
||
CEDAEVFKDSMVPGEK 为大鼠辣椒素受体亚型 1 (VR1) 的多肽序列片段,适用于探测 VR1 的存在、分布及分子形态。 | |||
T37290 |
Resolvin D3 methyl ester
|
||
Resolvin D3 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid. | |||
T75355 | LtIA-F | ||
LtIA-F 是一种新型的 LtIA 荧光类似物,为探索α3β2nAChR 亚型的构效关系、分布和配体结合域提供了丰富的药理学工具。 | |||
T75381 |
Bodipy TMR-X muscimol
|
||
Bodipy TMR-X muscimol为标记有Bodipy的Muscimol(Ex=543 nm, Em=572 nm),是GABAA受体的激动剂。该化合物适用于可视化可逆脑失活的扩散研究。 | |||
T37463 |
CAY10704
|
||
CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 μM). It displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without significant hepatotoxicity. CAY10704 is selective for HCV over dengue virus (EC50 = 4.62 μM). | |||
T79438 |
c-Myc inhibitor 11
|
c-Myc | Cell Cycle/Checkpoint |
c-Myc inhibitor11(Compound 67e),一种c-MYC抑制剂(pEC50: 6.4),在大鼠药代动力学评估中表现出高清除率、中等体积分布和短半衰期,适用于癌症研究领域。 | |||
T37169 |
Resolvin D2 methyl ester
|
||
Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase. It evokes diverse anti-inflammatory effects which may mediate the resolution of inflammation. RvD2 methyl ester is a methyl ester version of the free acid which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid. | |||
T37168 |
Resolvin D1 methyl ester
Resolvin D1 methyl ester |
||
Resolvin D1 is produced physiologically from the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase . It reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with an EC50 value of ~30 nM. RvD1 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracell... | |||
T69664 | Umibecestat HCl | ||
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP‐transgenic mice | |||
T35448 |
10-Thiastearic Acid
|
||
Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools. 10-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 μM. This activity is associated with a hypolipidemic effect, making this 10-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics. | |||
T81249 | Ru3 | PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Ru3是一种poly(ADP-ribose)polymerase 1抑制剂,能够通过诱导DNA损伤、抑制DNA修复机制、扰乱细胞周期、降低线粒体膜电位及增加reactive oxygen species水平来诱导MCF-7细胞的apoptosis。 | |||
T73610 | Lipoprotein lipase | ||
Lipoprotein lipase 是来自于脂肪组织、心肌和骨骼肌、胰岛和巨噬细胞的多功能酶。Lipoprotein lipase 促进正常脂蛋白代谢、组织特异性底物的输送和利用。Lipoprotein lipase 催化脂质在血液循环的限速步骤。 | |||
T72982 |
DPNB-ABT594
|
||
DPNB-ABT594 是一个硝基苄基 cage 修饰的 ABT594 ,对nAChR 的α4β2亚型的选择性比对 α7 亚型更加良好。DPNB-ABT594 可用于检查内侧缰核 (MHb) 神经元上nAChR 的分布,并有助于更深入地理解nAChR 介导的 Ca2+信号在 MHb 中的作用。 | |||
T76395 |
(Met(O)35)-Amyloid β-Protein (1-42)
|
||
'(Met(O)35)-Amyloid β-Protein (1-42),Aβ42的一种氧化形态,位于Met35。该化合物可形成与Aβ40具有相似大小和分布特征的寡聚体,适用于阿尔茨海默病(AD)研究。' | |||
T70914 |
GBR-12935 maleate
|
||
GBR-12935 is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application. GBR-12935 is now widely used in animal research into Parkin... | |||
T37586 |
DMHAPC-Chol
|
||
DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells when used at lipid concentrations greater than 20 μM. DMHAPC-Chol, as part of a lipoplex with DOPE , has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to delive... | |||
T37953 |
Sphingomyelins (buttermilk)
|
||
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling... | |||
T68356 | AM-3189 | ||
AM-3189 is a potent and selective GPR40 Agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. Similar to AMG 837, while highly potent on GPR40, AM-3189 was highly selective over the closely related GPCRs, GPR41 and GPR43. 13kdemonstrated low clearance, moderate volume of distribution, and good oral bioavai... | |||
T82937 |
ATV041
|
||
ATV041是一种结合了布洛芬和核苷酸类似物的口服活性化合物。该化合物优化了口服药物动力学(PK)特性和组织分布,显示出对抗小鼠肝炎病毒(MHV)的能力。ATV041能够剂量依赖性地降低病毒载量,减少组织损伤并减轻病毒引发的炎症。 | |||
T77254 | Maltodextrin, dextrose equivalent 16.5-19.5 | ||
Maltodextrin(麦芽糊精),dextrose equivalent(葡萄糖当量)为16.5-19.5,可作为药用辅料。药用辅料,亦称药用助剂,非药物成分的化学物质,用于辅助药物制剂过程。此类辅料提升药物制剂的稳定性、溶解性及加工性,同时影响药物的吸收、分布、代谢及排泄(ADME)过程。 | |||
T68765 |
Spirorenone
|
||
Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I clinical trials Spirorenone was absorbed with a half-life of 20-30 min, achieving maximum concentrations of about 100 ng/ml (10 mg) and 260 ng/ml (40 mg) after 1-2 h. Disposition of the parent drug was biphasic with half-lives of 50-60 min (distribution) and 5-6 h (elimination).... | |||
T75329 | Cellulose | ||
Cellulose 可用作药用辅料。药用辅料或药用助剂,是指制药过程中使用的除药物成分以外的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,能提高药物制剂的稳定性、溶解性和加工性。药用辅料还会影响合并用药的吸收、分布、代谢和消除 (ADME) 过程。 | |||
T77228 | Polyoxyethylene Sorbitan Monostearate | ||
Polyoxyethylene Sorbitan Monostearate 是一种由饱和脂肪酸硬脂酸 (C18:0) 构成的酯,广泛应用作药用辅料,包括表面活性剂、乳化剂、增溶剂和润湿剂。作为药用助剂,其主要作用是改善药物制剂的稳定性、溶解性和加工性,同时对药物的吸收、分布、代谢和消除 (ADME) 过程具有影响。 | |||
T71252 |
PC-046
|
||
PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with di... | |||
T76180 |
Urocortin III (human)
|
||
Urocortin III (human) 是一种促肾上腺皮质激素释放因子 (CRF) 相关肽。Urocortin III (human) 优先结合并激活CRF-R2,并且具有离散的中枢神经系统和外周分布。Urocortin III (human) 选择性结合 2 型 CRF 受体,mCRF2β、rCRF2α 和 hCRF1 的Ki 值分别为 13.5、21.7 和 >100 nM。Urocortin III (human) 介导Insulin(human) 分泌的生长抑素依赖性负反馈控制。 | |||
T73620 | Poly(acrylic acid) | ||
Poly(acrylic acid) 通过吸附作用在金属表面形成保护层,有效抑制纯铸铝在酸性介质中的腐蚀现象。此外,Poly(acrylic acid) 还可作为药物制剂中的包衣材料、释放阻断剂等药用辅料使用。药用辅料,亦称药用助剂,是指在制药过程中,除药物活性成分外使用的其他化学物质。这些辅料通常作为非活性成分加入药物制剂中,旨在提升制剂的稳定性、溶解性及加工性。同时,药用辅料对药物的吸收、分布、代谢与排泄(ADME)过程也具有一定影响。 | |||
T38844 |
MK-8245 Trifluoroacetate
|
||
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. IC50 value: 1 nM (hSCD1) Target: SCD1 in vitro: MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK... | |||
T64692 |
AMY-101 acetate
|
||
Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exerting direct effector functions, and helping to coordinate downstream immune responses[3]. In C3-/- mice alcohol-induced liver steatosis is absent or strongly reduced after chronic or acute alcohol exposure. This suggests that the complement system and its component C3 contribute... | |||
T35890 |
Pentosidine
|
||
Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.[1][2] Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of ... | |||
T37880 |
OPC-167832
|
||
OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-167832 exhibits very low MICs against laboratory strains of M. tuberculosis H37Rv (MIC: 0.0005 μg/ml) and Kurono (MIC: 0.0005 μg/ml) and strains with monoresistance to rifampin (RIF), isoniazid (INH), ethambutol (EMB), streptomycin (STR), and pyrazinamide (PZA) (MIC: 0.00024-0.001 ... | |||
T36308 |
PF-06843195
|
||
PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy[1]. PF-06843195 inhibits the breast cancer cell lines MCF7 and T47D proliferation with IC50s of 62 nM and 32 nM, respectively[1].PF-06843195 inhibits pAKT (T308) in MCF7 and T47D cells w... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3875 |
CLINODISIDE A
|
Others | Others |
Clinodiside A 是来自中草药Clinopodium chinensis 中。 | |||
T3S0057 |
Dihydrochelerythrine
12,13-Dihydrochelerythrine,二氢白屈菜红碱 |
Antifungal | Microbiology/Virology |
Dihydrochelerythrine (12,13-Dihydrochelerythrine) 是一种从榕树叶片分离出的天然化合物,具有抗真菌活性,有潜力治疗多丝蚴引起的严重感染。 | |||
T4685 |
INOSINIC ACID
Inosine 5′-monophosphate,IMP,5'-肌苷酸,I-5'-P |
Endogenous Metabolite | Metabolism |
Inosinic acid (IMP) 是内源性代谢产物。 | |||
T6S2227 |
Spinosin
斯皮诺素,Flavoayamenin |
Others | Others |
Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮,从 Zizyphus jujube 种子分离得到,能够激活 Nrf2/HO-1 通路,并抑制 Aβ1-42的产生和聚合。 | |||
TN2080 |
Pinoresinol
松脂酚,松脂素,(+)-Pinoresinol |
Apoptosis; NF-κB; CDK; p53 | Apoptosis; Cell Cycle/Checkpoint; NF-κB |
Pinoresinol ((+)-Pinoresinol) 是一种植物来源的木质素,具有抗炎、保肝和杀真菌活性。它导致 CDK 抑制剂 p21(WAF1/Cip1) 在 mRNA 和蛋白质水平上调,抑制 NF-kappaB 和激活蛋白 1 。 | |||
T82032 |
Isoglobotriaose
Gala-3Galb-4Glc |
||
Isoglobotriaose (Gala-3Galb-4Glc)是哺乳动物组织中的一种糖鞘脂,属于球状三脂糖的类似物。其神经节苷脂衍生物isoglobotriaosylceramide特定分布于小肠非上皮细胞的残基中,而globotriaosylceramide则在两种细胞隔室中都有分布。 |