|
T36596
|
Isoprothiolane
|
Antifungal |
Microbiology/Virology |
|
Isoprothiolane 是一种叶面喷雾杀菌剂，对由 Pyvioutavia oryzae Cav 引起的水稻真菌病害具有根除和保护作用。 |
|
T22708
|
Darglitazone
CP-86325
|
PPAR |
DNA Damage/DNA Repair;
Metabolism |
|
Darglitazone (CP-86325) 是一种噻唑烷二酮，是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢，在 II 型糖尿病中有研究价值。 |
|
T13612
|
Chromafenozide
2'-叔丁基-5-甲基-2'-(3,5-二甲基苯甲酰基)色满-6-甲酰肼,环虫酰肼,ANS118
|
Others |
Others |
|
Chromafenozide (ANS118) 是一种鳞翅目昆虫的杀虫剂，能高效地控制多种鳞翅目害虫。 |
|
T27460
|
GSK2324
GSK-2324,GSK 2324
|
FXR |
Metabolism |
|
GSK2324 是一种有效的 FXR 激动剂，通过减少脂肪酸合成的吸收和选择性减少来控制肝脂质，可用于治疗非酒精性脂肪肝。 |
|
T14527
|
Benfluralin
|
|
|
|
Benfluralin 是一种除草剂，是一种农用化学品，可用作芽前除草剂。 用于控制一系列粮食和非粮食作物中的草和其他杂草。 |
|
T40864
|
Magnesium sulfate
|
Others |
Others |
|
Magnesium sulfate 是目前预防和控制子痫发作的抗惊厥剂。Magnesium sulfate 也被广泛用作宫缩剂。 |
|
T24836
|
ß-pBrPh-Glc
Beta-pBrPh-Glc,ßpBrPhGlc,p-Bromophenyl-beta-D-glucopyranoside,p-Bromophenyl-ß-D-glucopyranoside
|
Antioxidant |
oxidation-reduction |
|
ß-pBrPh-Glc (ßpBrPhGlc) 是冰块再结晶的抑制剂，控制细胞外冰的生长，对细胞内冰的再结晶有抑制作用。ß-pBrPh-Glc 可被当作低温保存剂 ，可能具有抗氧化活性。 |
|
T22375
|
N-hexanoyl-L-Homoserine lactone
己酰-L-高丝氨酸内酯,C6-HSL
|
Others;
Antibacterial |
Microbiology/Virology;
Others |
|
N-hexanoyl-L-Homoserine lactone (C6-HSL) 是一种可扩散信号分子，参与控制基因表达、影响细胞代谢和群体感应。 |
|
T21142
|
Bupirimate
Nimrod
|
Antifungal |
Microbiology/Virology |
|
Bupirimate (Nimrod) 是植物保护产品中的一种活性成分，常用作全身杀菌剂，可用于控制玫瑰和苹果种植园中的白粉病。Bupirimate 属于嘧啶类。 |
|
T27794
|
λ-Cyhalothrin
lambda-Cyhalothrin,Karate,λ-氯氟氰菊酯,Icon
|
Sodium Channel;
Parasite |
Membrane transporter/Ion channel;
Microbiology/Virology |
|
λ-Cyhalothrin (Icon) 是广谱的 II 型合成除虫菊酯杀虫剂，含有 α-氰基，用于防治多种害虫。它是一种钠通道神经毒素，靶向中枢神经系统中神经元膜。 |
|
T1561
|
Clobetasol propionate
Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,丙酸氯倍他索,CCl 4725
|
Glucocorticoid Receptor;
P450 |
Endocrinology/Hormones;
Metabolism |
|
Clobetasol propionate (CGP9555) 是CYP3A5的选择性抑制剂(IC50:0.206 μM)，而对 CYP3A4 或其他主要 CYP 无抑制作用。它是皮质类固醇，对于牛皮癣和其他皮肤病具有潜在的研究价值。 |
|
T69443
|
Aminobutane bisphosphonate
|
|
|
|
Aminobutane bisphosphonate is a powerful inhibitor of bone resorption. It can potentially be a useful measure for controlling hypercalcemia in patients with carcinoma. |
|
T25126
|
Azaconazole
R 28644,Madurox,R-28644,R28644
|
|
|
|
Azaconazole, an agricultural fungicide, is used for controlling powdery mildew on crops and bean rust. |
|
T21154
|
Chlorfluazuron
IKI 7899,AI3-29785,CCRIS 2680,CGA 112913,Atabron
|
|
|
|
Chlorfluazuron, a chitin synthesis inhibitor, is commonly used as an insect growth regulator for controlling the major insect pests in crops. |
|
T40871
|
Diclobutrazol
|
|
|
|
Diclobutrazol is a potent systemic fungicide effective against rusts, powdery mildews, and other fungal phytopathogens. It exhibits high activity in controlling various crop diseases, making it a valuable pesticide option. |
|
T68720
|
Plomestane
|
|
|
|
Plomestane is a selective inhibitor of aromatization in human breast tissue and may provide a mechanism for controlling estrogen responsive processes. |
|
T70577
|
PEN-866
|
|
|
|
PEN-866 is a potential agent for controlling early stage tumor growth for non-small cell lung cancer (NSCLC). PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor, SN-38 |
|
T37339
|
N-3-oxo-tetradecanoyl-L-Homoserine lactone
3-oxo-C14-HSL,N-3-oxo-myristoyl-L-Homoserine lactone,N-3-oxo-tetradecanoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-3-oxo-tetradecanoyl-L-homoserine lactone (3-oxo-C14-HSL) is ... |
|
T37342
|
N-butyryl-L-Homocysteine thiolactone
|
|
|
|
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-... |
|
T69957
|
Quoromycin
|
|
|
|
Quoromycin is a novel antivirulence agent against Vibrio vulnificus, inhibiting the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviating the virulence of V. vulnificus in vitro and in vivo. |
|
T78576
|
Orysastrobin
|
|
|
|
Orysastrobin为一种QoI类杀菌剂，针对水稻叶瘟、穗瘟及纹枯病均展现出卓越防治效能。 |
|
T37747
|
N-tetradecanoyl-L-Homoserine lactone
C14-HSL,tDHL,N-tetradecanoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-tetradecanoyl-L-Homoserine lactone (C14-HSL) is a small diffu... |
|
T78900
|
Antibacterial agent 157
|
|
|
|
Antibacterialagent 157 (compound B12)，作为一种杀真菌剂，能够干扰Botrytis cinerea的蛋白质合成，主要应用于灰霉病防治的研究领域。 |
|
T40889
|
DMNB-caged-Serine
|
|
|
|
DMNB-caged-Serine is a photocaged amino acid . DMNB is a caging group which is sensitive to blue light. DMNB-caged-Serine can be incorporated into proteins in Saccharomyces cerevisiae in response to the amber nonsense codon TAG, which can be helpful for controlling the chemical composition of mammalian proteins.. |
|
T41034
|
Triclopyricarb
氯啶菌酯,SYP-7017
|
|
|
|
Triclopyricarb (SYP-7017) is a strobilurin fungicide that can be used in crops disease control. Triclopyricarb inhibits mycelial growth with EC 50 values ranged from 0.006 μg/mL to 0.047 μg/mL. |
|
T36469
|
Atrazine Mercapturate
|
|
|
|
Atrazine mercapturate is a major, glutathione-derived metabolite of atrazine , an herbicide that is effective in controlling a broad range of weeds. Atrazine has been reported to cause cancer in certain laboratory animals, have diverse effects on the reproductive system in animals and humans, and disrupt the normal function of the endocrine system. Atrazine mercapturate is readily measured in urine samples. |
|
T82025
|
Isotianil
|
|
|
|
Isotianil 是植物防御诱导剂，无直接抗菌效果，主要通过激活植物的典型防御反应来发挥作用。该化合物用于作为植物保护剂，防治稻瘟病。 |
|
T70896
|
PF05020182
|
|
|
|
PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in cont... |
|
T35839
|
3-Iodothyronamine (hydrochloride)
|
|
|
|
3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon it rapidly influences thyroid hormone actions including body temperature, heart rate, and cardiac output. It has also been reported to function in controlling lipid and glucose utilization, hormonal secretion, and neuronal function, and has been considered for use in chemically-... |
|
T26628
|
Andolast
CR2039,CR-2039,CR 2039
|
|
|
|
Andolast, also known as CR-2039, an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast acts at different cellular levels to inhibit immunoglobulin E synthesis. Andolast proved to be significan |
|
T38154
|
N-3-hydroxydecanoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Different quorum sensing molecules are produced at different times in bacterial population growth and have distinct cellular effects mediated through changes in gene expression. N-3-hydroxydecanoyl-L-Homoserine lactone is a small diffusible signaling molecule secreted by various bacteria. This lactone is produced via lactonolysis from 3-oxodecanoyl-homoserine lactone, al... |
|
T37963
|
Methylchloroisothiazolinone/Methylisothiazolinone Mixture
|
|
|
|
Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.1,2It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) forS. aureus,P. aeruginosa,A. niger, andC. albicans, respectively.2MCIT/MIT can elicit contact sensitization.3Formulations containing MCIT/MIT have been used for controlling microbial growth in industrial and household products.
1.Frenzel, E., Schmidt... |
|
T82280
|
Gly-Gly-Arg
|
|
|
|
Gly-Gly-Arg为一种三肽，其功能为孵化卵中的“泵信息素”。该化合物能诱导腹足泵活动，具有10 nM的阈值浓度，并展现出58.3%的最大百分比响应。在潮下甲壳类动物中，Gly-Gly-Arg作为信息素发挥作用，控制幼虫的释放。 |
|
T75970
|
Melanin Concentrating Hormone, salmon TFA
|
|
|
|
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是在硬骨鱼的垂体中发现的 19 个氨基酸组成的神经肽，它调节食物摄入，能量平衡，睡眠状态和心血管系统。Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是 SLC-1/GPR24和 MCHR2的配体。 |
|
T37151
|
NVS-CECR2-1
NVS-CECR2-1
|
|
|
|
NVS-CECR2-1 is a potent inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2), a component of chromatin complexes that regulate gene expression controlling development. It binds CECR2 with high affinity (IC50 = 0.047 μM by Alpha screen, Kd = 0.80 μM by ITC). NVS-CECR2-1 demonstrates no crossreactivity in a panel of 48 bromodomains and has no major activity in kinase, protease, and receptor panels. It shows robust activity in cells by FRAP assay, due to its slow off-rate, and has n... |
|
T75789
|
CALP3 TFA
|
|
|
|
CALP3 TFA 是一种模拟 Ca2+ 的有效肽类 Ca2+ 通道阻断剂，能够激活 EF 手的 Ca2+ 结合蛋白。它通过影响钙调蛋白 (CaM)、Ca2+ 通道及泵的功能来模拟 [Ca2+]i 的增加，从而具备在控制 HIV 或缺血性神经元损伤等情况下调控细胞凋亡的能力。 |
|
T36988
|
N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone
|
|
|
|
N-(3-hydroxy-7-cis tetradecenoyl)-L-Homoserine lactone is a long-chain N-acyl-homoserine lactone (AHL) produced by some Gram-negative bacteria and is involved in quorum sensing. Quorum sensing enables bacteria to change gene expression based on cues from nearby bacteria and from eukaryotic hosts about nutrients, environmental conditions, or threats. Due to the benefit of quorum sensing for bacterial survival, quorum sensing molecules are potential targets for controlling bacterial infections. In... |
|
T72776
|
NR2F1 agonist 1
|
|
|
|
NR2F1 agonist 1 是一种核受体 NR2F1激动剂，可特异性激活恶性细胞的休眠程序。NR2F1 agonist 1 上调 NR2F1 和调节休眠的下游靶基因。NR2F1 agonist 1 通过 NR2F1 激活在头颈部鳞状细胞癌 (HNSCC) 中诱导神经嵴样生长抑制。NR2F1 agonist 1 在小鼠原发肿瘤模型中抑制肿瘤生长。 |
|
T79703
|
RyRs activator 3
|
Parasite |
Microbiology/Virology |
|
RyRs activator 3 (compound A4) 作为有效杀虫剂，针对斑小菜蛾 (M. separata) 及小菜蛾 (P. xylostella) 显示出较高效力，其对斑小菜蛾的 LC50 值达到 3.27 mg/L。通过与兰尼碱受体 (ryanodine receptor) 结合，RyRs activator 3 能增加细胞质中 Ca2+ 的浓度，从而产生生物毒性。 |
|
T35599
|
Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)
|
|
|
|
Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4). It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 μM. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial... |
|
T74467
|
Remdesivir de(ethylbutyl 2-aminopropanoate)
|
|
|
|
Remdesivir de(ethylbutyl 2-aminopropanoate) 是 Remdesivir 的一种杂质，后者为一种具有抗病毒活性的核苷类似物。在 HAE 细胞针对 SARS-CoV 和 MERS-CoV 的实验中，Remdesivir 的 EC50 值为 74 nM；在针对鼠肝炎病毒的延迟脑肿瘤细胞实验中，其 EC50 值为 30 nM。此外，Remdesivir 亦被认为具有针对 2019-nCoV (COVID-19) 的研究潜力。 |
|
T37745
|
N-pentadecanoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... |
|
T37631
|
tetranor-12(S)-HETE
|
|
|
|
12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetran... |
|
T37737
|
N-cis-octadec-9Z-enoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gene... |
|
T37738
|
N-cis-tetradec-9Z-enoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gene... |
|
T37878
|
N-tridecanoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... |
|
T37879
|
N-undecanoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... |
|
T37336
|
N-3-oxo-hexadec-11(Z)-enoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... |
|
T37743
|
N-octadecanoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... |
|
T37736
|
N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
|
|
|
|
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of whic... |
沪公网安备 31010602006700号