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Search Results for " caspase-10 "

Targets Recommended: Caspase

13

抑制剂 & 化合物

2

天然产物

17

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6005	Z-DEVD-FMK Caspase-3 Inhibitor	Caspase	Apoptosis; Proteases/Proteasome
	Z-DEVD-FMK (Caspase-3 Inhibitor) 是一种选择性、不可逆的 Caspase-3 抑制剂，IC50为 18 μM。它也抑制 caspase-6、caspase-7、caspase-8 和 caspase-10。
T30077	Anisperimus LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195	Caspase	Apoptosis; Proteases/Proteasome
	Anisperimus (LF 15-0195) 是一种免疫抑制剂，通过促进 DISC 水平的 caspase-8 和 caspase-10 激活来增强激活诱导的 T 细胞死亡，通过促进表达 Foxp3 的调节性 CD4 T 细胞的发育来预防中枢神经系统自身免疫。
T9118	KEA1-97	Apoptosis; Others; Caspase	Apoptosis; Others; Proteases/Proteasome
	KEA1-97 是一种选择性硫氧还蛋白-半胱天冬酶 3相互作用干扰剂，IC50为10 μM。它在不影响硫氧还蛋白活性的情况下, 破坏硫氧还蛋白与 caspase 3 的相互作用，激活半胱天冬酶，诱导细胞凋亡。
T6761	Ossirene AS101	IL Receptor; Caspase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Ossirene (AS101) 是一种免疫调节抑制剂，是一种新型 IL-1beta 转化酶抑制剂，可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化，有效抑制Caspase-1。
TQ0146	Ac-DEVD-CHO	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Ac-DEVD-CHO 是一种特异性 Caspase-3 抑制剂(Ki: 230 pM)。Ac-DEVD-CHO在 SLNT 诱导的细胞凋亡中有抑制作用。
T36331	Z-AEVD-FMK Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone
	Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 &#181M, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]
T78730	TNF-α-IN-11
	TNF-α-IN-11 (Compound 10)是一种TNF-α抑制剂, KD值为12.06 μM。该化合物通过结合TNF-α并阻断其诱发的caspase和NF-κB信号通路激活，来实现其抑制作用。其具体机制包括抑制IκBα磷酸化和NF κB p65的核转位，适用于研究TNF-α介导的自身免疫性疾病。
T74783	HDAC-IN-53	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-53是一种口服活性的选择性HDAC1-3抑制剂，其IC50分别为47 nM、125 nM和450 nM。该化合物不针对II类HDAC(HDAC4、5、6、7、9；IC50>10 μM)展现抑制作用。HDAC-IN-53能够诱导caspase依赖的细胞凋亡并在裸鼠中显著抑制人肿瘤异种移植物生长，同时抑制携带MC38结肠癌的免疫活性小鼠的肿瘤发展。
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot...
T36346	Ac-VEID-AMC (ammonium acetate salt)
	Ac-VEID-AMC is a fluorogenic substrate based on the caspase-6 cleavage site in lamin A at amino acids VEID during apoptosis.1It has also been reported to be cleaved by related proteases, including caspase-8.2Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. 1.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9...
T11864	Iptacopan LNP023	Others	Others
	Iptacopan (LNP023) 是一种与factor B 亲和力较高的抑制剂。
T65994	(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
	Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation...
T38309	LL-37 amide (trifluoroacetate salt)
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ...

化合物

Cat.No: T6005

Synonym: Caspase-3 Inhibitor

Target: Caspase

Cat.No: T30077

Synonym: LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195

Target: Caspase

Cat.No: T9118

Target: Apoptosis, Others, Caspase

Cat.No: T6761

Synonym: AS101

Target: IL Receptor, Caspase, Interleukin

Cat.No: TQ0146

Target: Apoptosis, Caspase

Cat.No: T36331

Synonym: Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

Cat.No: T78730

Cat.No: T74783

Target: HDAC

2-chloro Palmitic Acid

Cat.No: T36221

Ac-VEID-AMC (ammonium acetate salt)

Cat.No: T36346

Cat.No: T11864

Synonym: LNP023

Target: Others

(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

Cat.No: T65994

LL-37 amide (trifluoroacetate salt)

Cat.No: T38309

Cat. No.	Product Name	Target	Signaling Pathways
T2764	(S)-10-Hydroxycamptothecin 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡，可研究肝癌、胃癌、结肠癌和白血病。
TN1814	Juncusol 6-甲基灯心草二酚,灯心草酚	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 cells. Juncusol has anti-microbial activity, it shows significant activity against MRSA strains.

天然产物

(S)-10-Hydroxycamptothecin

Cat.No: T2764

Synonym: 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Cat.No: TN1814

Synonym: 6-甲基灯心草二酚,灯心草酚

Target: Caspase, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01256	Caspase-10 Protein, Human, Recombinant (His) CASP10,FAS-Associated Death Domain Protein Interleu...	Human	E. coli
	Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca...
TMPY-01289	DDR1 Protein, Human, Recombinant (His) RTK6,DDR,TRKE,PTK3,NTRK4,NEP,PTK3A,MCK10,EDDR1,HGK2...	Human	HEK293
	Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of...
TMPY-02831	Caspase-7 Protein, Human, Recombinant (His) ICE-LAP3,LICE2,MCH3,CASP-7,caspase 7, apoptosis-rel...	Human	E. coli
	Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are r...
TMPJ-00770	Granzyme B/GZMB Protein, Mouse, Recombinant (His) Gzmb,Cytotoxic cell protease 1,Fragmentin-2,CTLA-1,Granzyme ...	Mouse	Human Cells
	Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
TMPY-02944	TRAIL/TNFSF10 Protein, Rhesus, Recombinant tumor necrosis factor (ligand) superfamily, member 10	Rhesus	E. coli
	Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is common...
TMPY-03313	DDR1 Protein, Rat, Recombinant (His) discoidin domain receptor tyrosine kinase 1,Drd1,PTK3D,Cak	Rat	HEK293
	Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of...
TMPY-02784	TRAIL/TNFSF10 Protein, Mouse, Recombinant (aa 118-291, His) A330042I21Rik,tumor necrosis factor (ligand) superfamily, me...	Mouse	E. coli
	Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is common...
TMPY-02233	TRAIL/TNFSF10 Protein, Human, Recombinant TL2,CD253,tumor necrosis factor (ligand) superfamily, member...	Human	E. coli
	Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is common...
TMPY-02310	DDR1 Protein, Mouse, Recombinant (His) CD167a,discoidin domain receptor tyrosine kinase 1,AI323681,...	Mouse	HEK293
	Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of...
TMPY-04382	DDR1 Protein, Human, Recombinant (aa 444-913, His & GST) discoidin domain receptor tyrosine kinase 1,NEP,TRKE,DDR,EDD...	Human	Baculovirus-Insect Cells
	Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of...
TMPY-02506	DDR1 Protein, Mouse, Recombinant (hFc) AI323681,CD167a,Nep,Cak,PTK3A,6030432F18,discoidin domain re...	Mouse	HEK293
	Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of...
TMPY-03541	DDR1 Protein, Rat, Recombinant (hFc) Drd1,Cak,discoidin domain receptor tyrosine kinase 1,PTK3D	Rat	HEK293
	Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of...
TMPY-04442	DDR1 Protein, Mouse, Recombinant (His & GST) 6030432F18,Nep,Cak,AI323681,CD167a,discoidin domain receptor...	Mouse	Baculovirus-Insect Cells
	Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of...
TMPY-01751	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) TRAMP,TR3,WSL-1,TNFRSF12,DR3,WSL-LR,tumor necrosis factor re...	Human	HEK293
	Tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), also known as Death receptor 3 (DR3) or TNFRSF12 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. TNFRSF25/DR3/TNFRSF12 has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor pr...
TMPY-02300	BIN1 Protein, Human, Recombinant (His) AMPHL,bridging integrator 1,AMPH2,SH3P9	Human	E. coli
	Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased...
TMPY-05760	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated TRAMP,tumor necrosis factor receptor superfamily, member 25,...	Human	HEK293
	Tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), also known as Death receptor 3 (DR3) or TNFRSF12 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. TNFRSF25/DR3/TNFRSF12 has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor pr...
TMPY-00961	ADAM15 Protein, Human, Recombinant (His) MDC15,ADAM metallopeptidase domain 15	Human	HEK293
	ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentia...

重组蛋白

Caspase-10 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01256

Species: Human

Expression System: E. coli

DDR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01289

Species: Human

Expression System: HEK293

Caspase-7 Protein, Human, Recombinant (His)

Cat.No: TMPY-02831

Species: Human

Expression System: E. coli

Granzyme B/GZMB Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00770

Species: Mouse

Expression System: Human Cells

TRAIL/TNFSF10 Protein, Rhesus, Recombinant

Cat.No: TMPY-02944

Species: Rhesus

Expression System: E. coli

DDR1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03313

Species: Rat

Expression System: HEK293

TRAIL/TNFSF10 Protein, Mouse, Recombinant (aa 118-291, His)

Cat.No: TMPY-02784

Species: Mouse

Expression System: E. coli

TRAIL/TNFSF10 Protein, Human, Recombinant

Cat.No: TMPY-02233

Species: Human

Expression System: E. coli

DDR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02310

Species: Mouse

Expression System: HEK293

DDR1 Protein, Human, Recombinant (aa 444-913, His & GST)

Cat.No: TMPY-04382

Species: Human

Expression System: Baculovirus-Insect Cells

DDR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02506

Species: Mouse

Expression System: HEK293

DDR1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03541

Species: Rat

Expression System: HEK293

DDR1 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04442

Species: Mouse

Expression System: Baculovirus-Insect Cells

DR3/TNFRSF25 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01751

Species: Human

Expression System: HEK293

BIN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02300

Species: Human

Expression System: E. coli

DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05760

Species: Human

Expression System: HEK293

ADAM15 Protein, Human, Recombinant (His)

Cat.No: TMPY-00961

Species: Human

Expression System: HEK293

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