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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T60978	COX-2-IN-7
	COX-2-IN-7 (compound 4a) 是口服有效的COX-2 选择性抑制剂，其选择性高于 Celecoxib，IC50值为6.585 uM。COX-2-IN-7 在体内具有良好的抗炎和低致溃疡活性。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T79760	COX-2-IN-35	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-35（化合物7），作为选择性COX-2抑制剂，表现出4.37 nM的IC50，并展现抗炎活性。
T37628	Ibuprofen impurity 1
	Ibuprofen impurity 1 is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1]. [1]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.
T38215	1-Hydroxy-ibuprofen
	1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P. australis[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1]. [1]. Yujie He, et al. Metabolism of Ibuprofen by Phragmites australis: Uptake and Phytodegradation. Environ Sci Technol. 2017 Apr 18;51(8):4576-4584. [2]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin ...
T37634	17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
	Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).
T35791	Palmitic acid-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ...
T35597	Neuromedin U-23 (rat) (trifluoroacetate salt)
	Neuromedin U-23 (NMU-23) is a neuropeptide involved in diverse biological processes, including smooth muscle contraction, energy homeostasis, and nociception.1It is an agonist of neuromedin-U receptor 1 (NMUR1; EC50= 0.17 nM for the human receptor in a calcium mobilization assay using HEK293 cells) and NMUR2 (EC50= ~1.4-2 nM for arachidonic acid release in CHO cells expressing the human receptor).2,3NMU-23 (1 μM) induces contractions in isolated rat colon smooth muscle strips.4It decreases body ...

化合物

2,5-dimethyl Celecoxib

Cat.No: T35610

Synonym:

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

Neuromedin U-23 (rat) (trifluoroacetate salt)

Cat.No: T35597

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
TN1273	7,4'-Dihydroxyflavone 4',7-Dihydroxyflavone,7,4'-二羟基黄酮	NF-κB; COX; HDAC; CCR; NOD	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) 是从甘草中分离的类黄酮，是 eotaxin/CCL11抑制剂，抑制嗜酸性粒细胞趋化因子产生。它通过调节 NF-κB、STAT6 和 HDAC2，抑制 MUC5A 基因表达和粘液产生。
T3388	Calycosin-7-O-β-D-glucoside 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。
T5S0045	Isofraxidin 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶	MMP; ERK; p38 MAPK; TLR; COX	Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。
T6S1684	8-Gingerol	Antioxidant; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
	8-Gingerol 分离自姜的根状茎，是口服有效的 TRPV1激活剂，EC50值为5.0 µM。8-Gingerol 抑制 COX-2，还能抑制体外 H. pylori 的生长。