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Cat. No.	Product Name	Target	Signaling Pathways
T68042	CHF-4227 Chf4227,Chf 4227	Estrogen Receptor/ERR	Endocrinology/Hormones
	CHF-4227 是一种新型高效且具有选择性的雌激素受体调节剂，可降低胆固醇合低密度脂蛋白胆固醇浓度。
T33711L	Nolomirole HCl CHF 1035 HCl,CHF 1035,CHF1035,CHF1035 HCl,CHF-1035 HCl,CHF-1035,Nolomirole Hydrochloride	Dopamine Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Nolomirole HCl（CHF 1035）是一种具有口服活性的新型选择性多巴胺激动剂，对去甲肾上腺素的释放有抑制作用，可用于研究轻度慢性心力衰竭。
T38625	Tanimilast CHF-6001	PDE	Metabolism
	Tanimilast (CHF-6001) 是一种新型的高效选择性磷酸二酯酶 4 抑制剂，IC 50值为0.026 ± 0.006 nM。Tanimilast 具有强大的抗炎活性，适用于肺部局部用药。Tanimilast 用于研究阻塞性肺病。
T13992	CHF5407 SVT-47060	AChR	Neuroscience
	CHF5407（SVT-47060）是一种具有有效性和选择性的毒蕈碱 M3 受体拮抗剂，可长期作用于毒蕈碱受体。CHF5407 对支气管痉挛有作用，可用于研究呼吸系统疾病。
T30876	CHF 2819 Ganstigmine HCl,CHF-2819,Ganstigmine hydrochloride,CHF2819
	CH-5137291 is a pure AR antagonist with AR nuclear translocation inhibition activity. It suppresses castration and prevents the growth of prostate cancer cells.
T30875	CHF 1255 CHF1255,CHF-1255
	CHF 1255 is a potential drug for the treatment of heart failure.
T2262	Itanapraced CHF5074,CSP-1103	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Itanapraced (CHF5074) 是新型γ-secretase 调节剂，能够降低 Aβ42 (IC50=3.6 nM) 和 Aβ40 (IC50=18.4 nM) 分泌。
T30878	CHF-2993 CHF 2993,5NY5Q1OUZ3,UNII-5NY5Q1OUZ3,CHF2993
	CHF-2993 is a bio-active chemical.
T30879	CHF-5022 UNII-JO8EVV007Q,CHEMBL196246,CHF5022
	CHF-5022 is a nonsteroidal anti-inflammatory drug that selectively inhibits the production of beta-amyloid protein (1-42) (ABETA42).
T70572	CHF-2060
	CHF-2060 is a novel acetylcholinesterase inhibitor.
T27606	Indantadol HCl CHF-3381,CMP-3381,GT-3381,V-3381,CNP-3381,Indantadol	MAO; NMDAR	Metabolism; Neuroscience
	Indantadol HCl (CHF-3381) 是一种 NMDA 拮抗剂和非选择性 MAO 抑制剂。
T30877	CHF-1024 UNII-HPH2L3QA2F
	CH-5137291 is a pure AR antagonist with AR nuclear translocation inhibition activity. It inhibits castration and prevents the growth of prostate cancer cells.
T70376	CHF-6366
	CHF-6366是一种高效的M3毒蕈碱拮抗剂和β2肾上腺素能受体激动剂，具有pKi值分别为10.4和11.4。同时，CHF-6366作为一种弱钙离子通道抑制剂，其IC50约为50μM。该化合物能够抑制豚鼠的支气管收缩，适用于慢性阻塞性肺疾病研究。
T33711	Nolomirole CHF1025,CHF-1025,CHF 1025
	Nolomirole is a dopamine receptor agonist that reduces symptoms of congestive heart failure caused by monoclinine.
T70375	ZEN-2759	Epigenetic Reader Domain	Chromatin/Epigenetic
	ZEN-2759 是一种有效的 BET 小分子抑制剂，对 BRD4(BD1)、BRD4(BD2) 和 BRD4(BD1BD2) 有抑制作用。
T69233	Ganstigmine
	Ganstigmine is an acetylcholinesterase inhibitor for Alzheimer's disease.
T1461	Candesartan CV 11974,坎地沙坦	RAAS	Endocrinology/Hormones
	Candesartan (CV 11974) 是一种血管紧张素II 受体拮抗剂(IC50:0.26 nM)。
T71937	Nitrodenafil
	Nitrodenafil is a related compound of Sildenafil -- a phosphodiesterase inhibitor.
T5329	Trandolapril	Angiotensin-converting Enzyme (ACE)	Metabolism
	Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂，在高血压和充血性心力衰竭及心肌梗死领域有研究价值。
T71944	FGF/PDGF/VEGF RTK Inhibitor
	FGF/PDGF/VEGF RTK Inhibitor is a potent, reversible, atp-competitive inhibitor against pdgfrβ, fgfr-1, and vegfr-2 (ic50 = 20, 90, and 240 nm, respectively) and effectively suppresses vegf-stimulated proliferation of hmvecs (ec50 = 420 nm).
T70638	p38-α MAPK-IN-5
	p38-α MAPK-IN-5 是一种有效的 p38α抑制剂，对 p38α、p38 β、p38γ、p38δ 的 IC50分别为 0.1 nM、0.2 nM、944 nM、4100 nM。p38-α MAPK-IN-5 具有抗炎作用，并且具有用于哮喘和慢性阻塞性肺病 (COPD) 研究的潜力。
T18720	FCHFHS-ST7612AA1	Others	Others
	FCHFHS-ST7612AA1 is a part of antibody drug conjugates (ADCs) charged with HDAC inhibitor by a linker, shows antitumor activity[1].
T13195	Trandolapril D5 RU44570 D5	Others	Others
	Trandolapril D5 is a deuterium labeled Trandolapril. Trandolapril is an orally active inhibitor of angiotensin converting enzyme (ACE) for hypertension and congestive heart failure (CHF).
T30501	BMS-193884 BMS193884,BMS 193884
	BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension.
T36008	Nebentan potassium
	Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2]. Nebentan potassium inhibits the specific binding of [125I] endothelin-1 to endothelin ETA and ETB re...
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
T36007	Nebentan
	Nebentan (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2]. Nebentan inhibits the specific binding of [125I] endothelin-1 to endothelin ETA and ETB receptors in a concentration dep...

化合物

Cat.No: T68042

Synonym: Chf4227,Chf 4227

Target: Estrogen Receptor/ERR

Cat.No: T33711L

Synonym: CHF 1035 HCl,CHF 1035,CHF1035,CHF1035 HCl,CHF-1035 HCl,CHF-1035,Nolomirole Hydrochloride

Target: Dopamine Receptor, Norepinephrine

Cat.No: T38625

Synonym: CHF-6001

Target: PDE

Cat.No: T13992

Synonym: SVT-47060

Target: AChR

Cat.No: T30876

Synonym: Ganstigmine HCl,CHF-2819,Ganstigmine hydrochloride,CHF2819

Cat.No: T30875

Synonym: CHF1255,CHF-1255

Cat.No: T2262

Synonym: CHF5074,CSP-1103

Target: Beta Amyloid, Gamma-secretase

Cat.No: T30878

Synonym: CHF 2993,5NY5Q1OUZ3,UNII-5NY5Q1OUZ3,CHF2993

Cat.No: T30879

Synonym: UNII-JO8EVV007Q,CHEMBL196246,CHF5022

Cat.No: T70572

Cat.No: T27606

Synonym: CHF-3381,CMP-3381,GT-3381,V-3381,CNP-3381,Indantadol

Target: MAO, NMDAR

Cat.No: T30877

Synonym: UNII-HPH2L3QA2F

Cat.No: T70376

Cat.No: T33711

Synonym: CHF1025,CHF-1025,CHF 1025

Cat.No: T70375

Target: Epigenetic Reader Domain

Cat.No: T69233

Cat.No: T1461

Synonym: CV 11974,坎地沙坦

Target: RAAS

Cat.No: T71937

Cat.No: T5329

Target: Angiotensin-converting Enzyme (ACE)

FGF/PDGF/VEGF RTK Inhibitor

Cat.No: T71944

p38-α MAPK-IN-5

Cat.No: T70638

FCHFHS-ST7612AA1

Cat.No: T18720

Target: Others

Trandolapril D5

Cat.No: T13195

Synonym: RU44570 D5

Target: Others

Cat.No: T30501

Synonym: BMS193884,BMS 193884

Nebentan potassium

Cat.No: T36008

Cat.No: T71065

Cat.No: T36007

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