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Cat. No. | Product Name | Target | Signaling Pathways |
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T38286 |
C26 Sphingomyelin (d18:1/26:0)
C26 Sphingomyelin (d18:1/26:0) |
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C26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory condition characterized by excessive immune activation.3C26 sphingomyelin has been used a component of monolayers to study the influence of sphingomyelin acyl chain length on sphingomyelin-sterol interactions.4[Matreya, LLC.] 1.Wang, J.-R., Zhang, H., Yau, L.D., et al.Improved sphi... | |||
T1520 |
Aliskiren hemifumarate
阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B |
RAAS; Autophagy | Autophagy; Endocrinology/Hormones |
Aliskiren hemifumarate (CGP60536B) 一种可口服非肽肾素抑制剂,IC50为1.5 nM,具有抗高血压活性。 | |||
T69333 |
LX-5
|
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LX-5 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway. LX-5 de-represses a subset of endogenous genes repressed by DNA methylation. | |||
T29541 |
AC265347
AC-265347 |
CaSR | GPCR/G Protein |
AC265347 是一种有效的钙敏感受体 (CaSR) 激动剂和 ago-PAM 正变构调节剂,具有抗肿瘤活性,通过诱导分化抑制神经母细胞瘤肿瘤生长。AC265347 可用于研究神经母细胞瘤。 | |||
T7127 |
DC260126
|
Apoptosis; GPR | Apoptosis; Endocrinology/Hormones; GPCR/G Protein |
DC260126 是一种 GPR40 (FFAR1)拮抗剂,对棕榈酸酯诱导的内质网应激和凋亡有保护作用。它剂量依赖性地抑制亚油酸、油酸、棕榈油酸和月桂酸刺激的 GPR40 介导的 Ca2+升高,IC50分别 6.28、5.96、7.07和4.58 μM。 | |||
T72054 |
SLC26A3-IN-1
|
transporter | Metabolism |
SLC26A3-IN-1 是一种阴离子交换蛋白 SLC26A3 的抑制剂 ,IC50值为340 nM。SLC26A3 属于溶质载体 (SLC) 蛋白,是 SLC26 家族成员之一。SLC26 家族对氯化物、碳酸氢盐、硫酸盐和草酸盐具有广泛的阴离子特异性。SLC26A3 在腺瘤 (DRA) 中下调,参与氯化物和草酸盐的肠道吸收且与氯离子丢失性腹泻有关。 | |||
T2440 |
IC261
SU-5607 |
Apoptosis; Casein Kinase; CDK | Apoptosis; Cell Cycle/Checkpoint; Metabolism; Stem Cells |
IC261 (SU-5607) 是一种选择性的,ATP 竞争性的CK1抑制剂,可触发有丝分裂检查点控制。对Ckiδ、Ckiε、 Ckiα1 和Cdk5的IC50值分别为 1 μM、1 μM 、16 μM 和4.5mM。 | |||
T11141 |
E64FC26
|
Others | Others |
E64FC26 是一种有效的蛋白质二硫键异构酶 (PDI) 家族泛抑制剂,具有抗肿瘤活性,抑制 PDIA1、PDIA3、PDIA4、TXNDC5 和 PDIA6,可用于研究多发性骨髓瘤和胰腺癌。 | |||
T74815 | SLC26A3-IN-2 | ||
SLC26A3-IN-2 是一种口服有效的阴离子交换蛋白 SLC26A3的抑制剂 (IC50=360 nM)。SLC26A3 属于溶质载体 (SLC) 蛋白,属于 SLC26 家族。SLC26 家族对氯化物、碳酸氢盐、硫酸盐和草酸盐具有广泛的阴离子特异性。SLC26A3 在腺瘤 (DRA) 中下调,参与氯化物和草酸盐的肠道吸收。SLC26A3 功能突变的丧失与氯离子丢失性腹泻有关。 | |||
T39812 |
(E/Z)-E64FC26
(E/Z)-E64FC26 |
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(E/Z)-E64FC26 is a mixture complex comprising E-E64FC26 and Z-E64FC26. E-E64FC26 is a highly potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50 values of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. Furthermore, E64FC26 demonstrates anti-myeloma activity. | |||
T39757 |
EC2629
EC2629 |
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EC2629 is a highly potent folate- receptor-targeted DNA crosslinking agent. | |||
T78604 |
SLC26A3-IN-3
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SLC26A3-IN-3(化合物4az)是一种针对SLC26A3的抑制剂,IC50值为40 nM。该化合物主要应用于便秘和囊性纤维化的研究领域。 | |||
T33753 |
NSC265473
NSC-265473,NSC-305458,NSC305458,NSC 265473,NSC 305458 |
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NSC265473 is an ABCG2 substrate. | |||
T60942 | MC2652 | ||
MC2652 (compound 1a) 是 LSD1的有效抑制剂,在白血病细胞 MV4-11 和 NB4 中表现出高抑制作用。MC2652 对前列腺癌的 LNCaP 细胞表现出抗增殖活性。 | |||
T14092 |
AC260584
|
Others | Others |
AC260584 is an M1 muscarinic receptor allosteric agonist (pEC50: 7.6). | |||
T71190 | FLC26 | ||
FLC26 is a CK2 inhibitor with IC50 = 9 nM | |||
T78579 | NSC260594 | ||
NSC260594是一种化合物,具有诱导细胞凋亡(Apoptosis)的作用。它通过与Mcl-1蛋白的浅沟结合并下调Wnt信号蛋白,抑制Mcl-1的表达。此外,NSC260594能够识别HIV的G9-G10-A11-G12 RNA四环,防止5'-UTR中的Gag蛋白结合。它被认为对抑制肿瘤生长具有潜在作用,特别是在三阴性乳腺癌(TNBC)研究中。 | |||
T35874 |
CC260
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CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1]. In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1[1]. CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosph... | |||
T60627 |
ELOVL1-IN-2
|
Others | Others |
ELOVL1-IN-2 是一种被称为极长链脂肪酸 1 (ELOVL1) 酶延长抑制剂的化合物,对 ELOVL1 表现出微弱的抑制作用(IC50 为 21 μM),并在原代细胞中表现出中等效力。对 HEK293 C26 细胞进行测定(IC50 为 6.7 μM)[1]。 | |||
T20050 |
Cinnamamide
NSC 32953 |
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Cinnamamide is an amide of trans-cinnamic acid and a metabolite of Streptomyces. It also reduced tumor weight in a mouse model of C26 murine colon carcinoma, in vivo. | |||
T61229 |
VEGFR-2/DHFR-IN-2
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VEGFR-2/DHFR-IN-2 (compound 5b) is a dual inhibitor targeting VEGFR-2 and DHFR, with respective IC50 values of 0.623 μM and 9.085 μM. It demonstrates potent cytotoxicity against C26, HepG2, and MCF7 cancer cell lines, with IC50 values ranging from 3.59 μM to 8.38 μM. VEGFR-2/DHFR-IN-2 holds promise for cancer research [1]. | |||
T38278 |
9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic Acid
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9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is an ω-3 very long-chain polyunsaturated fatty acid. It has been used to study the desaturation and elongation of ω-3 polyunsaturated fatty acids. It is elongated to form C26:5 or acted on by δ6 desaturase to form C24:6. 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is found at low levels in mouse brain and spleen and levels decrease in the brain and spleen of old and exceptionally old mice. | |||
T61489 | VEGFR-2/DHFR-IN-1 | ||
VEGFR-2/DHFR-IN-1 (compound 8b) 是 VEGFR-2和DHFR 的抑制剂,其IC50值分别为 0.384 和 7.881 μM。VEGFR-2/DHFR-IN-1 对大肠埃希菌,粪链球菌,肠沙门氏菌,金黄色酿脓葡萄球菌,MSSA 和MRSA 显示了良好的抗菌活性,MIC 值分别为 16,16,16,8 和 16 μg/mL。VEGFR-2/DHFR-IN-1 对 C26,HepG2 和 CF7 癌细胞系具有良好的细胞毒性,IC50值为 2.97-7.12 μM。VEGFR-2/DHFR-IN-1 可用于癌症的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3844 |
Deltonin
三角叶薯蓣皂苷 |
ERK; Others; Akt; Endogenous Metabolite | Cytoskeletal Signaling; MAPK; Metabolism; Others; PI3K/Akt/mTOR signaling |
Deltonin 是从盾叶薯蓣中得到的一种甾体皂苷,抑制ERK1/2和AKT 的活化,具有抗肿瘤活性。 | |||
T13501 |
3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone
3-oxo-21-alpha-methoxy-24-25-26-27-tetranortirucall-7-ene-23-21-lactone |
Others | Others |
The compound 3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a cytotoxic tirucallane C26 triterpenoid that has been extracted from the stem barks of Aphanamixis grandifolia. |