Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AC260584 is an M1 muscarinic receptor allosteric agonist (pEC50: 7.6).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 2,730 | 6-8周 | ||
25 mg | ¥ 9,620 | 6-8周 | ||
50 mg | ¥ 12,500 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,980 | 6-8周 |
产品描述 | AC260584 is an M1 muscarinic receptor allosteric agonist (pEC50: 7.6). |
靶点活性 | M1:(pEC50)7.6 |
体外活性 | AC260584 is found to be a potent (pEC50=7.6-7.7) and efficacious (90-98% of carbachol) muscarinic M1 receptor agonist. AC260584 shows functional selectivity for the M1 receptor over the M2, M3, M4 and M5 muscarinic receptor subtypes. Its selectivity is found to be similar in native tissues expressing mAChRs to its profile in recombinant systems[1]. |
体内活性 | In rodents, AC260584 activates extracellular signal regulated kinase 1 and 2 (ERK1/2) phosphorylation in the hippocampus, prefrontal cortex and perirhinal cortex. The ERK1/2 activation is dependent upon muscarinic M1 receptor activation since it is not observed in M1 knockout mice. AC260584 also improves the cognitive performance of mice in the novel object recognition assay and its action is blocked by the muscarinic receptor antagonist pirenzepine. In addition, AC260584 is found to be orally bioavailable in rodents[1]. AC260584 at 3 and 10 mg/kg significantly increases dopamine release in the medial prefrontal cortex and hippocampus. However, only the high dose of AC260584, 10 mg/kg (s.c.), significantly increases acetylcholine release in these regions[2]. |
分子量 | 348.45 |
分子式 | C20H29FN2O2 |
CAS No. | 560083-42-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (143.49 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8699 mL | 14.3493 mL | 28.6985 mL | 71.7463 mL |
5 mM | 0.574 mL | 2.8699 mL | 5.7397 mL | 14.3493 mL | |
10 mM | 0.287 mL | 1.4349 mL | 2.8699 mL | 7.1746 mL | |
20 mM | 0.1435 mL | 0.7175 mL | 1.4349 mL | 3.5873 mL | |
50 mM | 0.0574 mL | 0.287 mL | 0.574 mL | 1.4349 mL | |
100 mM | 0.0287 mL | 0.1435 mL | 0.287 mL | 0.7175 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AC260584 560083-42-3 Others AC 260584 AC-260584 Inhibitor inhibitor inhibit