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13

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T2242	Wnt-C59 4-(2-甲基-4-吡啶基)-N-[4-(3-吡啶基)苯基]苯乙酰胺,C59	Wnt/beta-catenin; Porcupine	Cytoskeletal Signaling; Stem Cells
	Wnt-C59 (C59) 是一种高效的、口服具有活力的PORCN 抑制剂(IC50:74 pM)。
T72322	R 59-022 hydrochloride DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride	5-HT Receptor; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Neuroscience
	R 59-022 hydrochloride (DKGI-I hydrochloride) 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 hydrochloride 是一种 DGK 抑制剂 (IC50:2.8 µM),可抑制 OAG 磷酸化为 OAPA。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。
T16709	R 59-022 Diacylglycerol kinase inhibitor I,DKGI-I	Others	Others
	R 59-022 is a 5-HTR antagonist and activates protein kinase C (PKC). R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neu
T2116	AEE788 NVP-AEE 788	Apoptosis; EGFR; c-Fms; FLT; Bcr-Abl	Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AEE788 (NVP-AEE 788)是EGFR 和ErbB2的抑制剂，IC50值分别为2和6 nM。它已用于研究癌症、多形性胶质母细胞瘤以及脑和中枢神经系统肿瘤治疗的试验。
T76522	HCV Core Protein (59-68)
	HCVCore Protein (59-68) 是一种含有 HCV 核心蛋白 59-68 残基的肽。
T123989	Solanapyrone C
	Solanapyrone C 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T123989，CAS号为 88899-59-6。
T70424	EBI-907
	EBI-907 is a highly potent and orally efficacious B-RafV600E inhibitor. EBI-907 displays a low single-digit nanomolar activity (IC50 = 4.9 nM), which is >10-fold more potent than Vemurafenib (IC50 = 59 nM). EBI-907 also exhibits high potency in selectively inhibiting the proliferation of BRAF (V600E)-dependent cell lines (A375 and Colo205) and cellular Erk phosporylation, with superior activity to Vemurafenib. EBI-907, displaying potent activity against a number of important oncogenic kinases i...
T35988	CAY10564
	S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10564 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5.0, ...
T35987	CAY10563 CAY10563
	S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10563 is a member of a new class of S-nitrosothiol species that act as an NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5....
T38021	Obafluorin
	Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens.1 It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all). \|1. Pu, Y., Lowe, C., Sailer, M., et al. Synthesis, stability, and antimicrobial activity of (+)-obafluorin and related β-lactone antibiotics. J. Org. Chem. 59(13), 3642-3655 (1994).
T21295	BIX02189 BIX 02189	ERK; MEK	MAPK
	BIX02189 是一种有效的选择性 MEK5 和 ERK5 抑制剂，IC50分别为 1.5 和 59 nM。
T9470	HPK1-IN-7	MAPK	MAPK
	HPK1-IN-7 是一种口服有活性的、有效的HPK1(造血祖细胞激酶1, MAP4K1) 抑制剂，其IC50值为2.6 nM，具有强大的家族及激酶组选择性。它对 IRAK4 (59 nM) 和 GLK (140 nM) 具有选择性。当它与抗 PD1联合使用时，对 MC38 同基因肿瘤模型表现出极大的疗效。
T35712	Debutyldronedarone hydrochloride SR35021 hydrochloride
	N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h...

化合物

Cat.No: T2242

Synonym: 4-(2-甲基-4-吡啶基)-N-[4-(3-吡啶基)苯基]苯乙酰胺,C59

Target: Wnt/beta-catenin, Porcupine

R 59-022 hydrochloride

Cat.No: T72322

Synonym: DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride

Target: 5-HT Receptor, PKC

Cat.No: T16709

Synonym: Diacylglycerol kinase inhibitor I,DKGI-I

Target: Others

Cat.No: T2116

Synonym: NVP-AEE 788

Target: Apoptosis, EGFR, c-Fms, FLT, Bcr-Abl

HCV Core Protein (59-68)

Cat.No: T76522

Cat.No: T123989

Cat.No: T70424

Cat.No: T35988

Cat.No: T35987

Synonym: CAY10563

Cat.No: T38021

Cat.No: T21295

Synonym: BIX 02189

Target: ERK, MEK

Cat.No: T9470

Target: MAPK

Debutyldronedarone hydrochloride

Cat.No: T35712

Synonym: SR35021 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: T35779

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