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Search Results for " bleomycin "

23

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6116L	Bleomycin hydrochloride	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Bleomycin hydrochloride is a potent antitumor antibiotic that functions as a DNA synthesis inhibitor and DNA damaging agent.
T65016	Bleomycin A2
	Bleomycin A2，作为一种抗肿瘤抗生素，能促进DNA降解，同时也是一种天冬氨酸/天冬酰胺-β-羟化酶(AspH)的抑制剂，其IC50为1.47 μM。
T73606	Bleomycin B4
	Bleomycin B4 (Phleomycin F)，一种具有抗肿瘤活性的抗生素，常用于癌症研究。
T71445	Bleomycin Free Base
	Bleomycin Free Base is a complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
T74722	Demethyl bleomycin A2
	Demethyl bleomycin A2 是Bleomycin 的同源物。Demethyl bleomycin A2 的 DNA 裂解对5-Methylcytidine 不敏感。
T10110	3-CPs 3-Carbethoxypsoralen,3-Ethoxycarbonylpsoralen	Antibiotic	Microbiology/Virology
	3-CPs (3-Carbethoxypsoralen) 是一种博来霉素诱导的小鼠肺纤维化血清型荚膜多糖，属于补骨脂，可干扰抗体介导的细菌杀伤作用。3-CPs 可延缓博来霉素诱导的小鼠肺纤维化，可用于研究气道炎和哮喘。
T30778	CCG-257081 MRTF/SRF-IN-1,CCG257081,CCG 257081	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CCG-257081 (MRTF/SRF-IN-1) 是心肌素相关转录因子和血清反应因子 (MRTF/SRF) 的抑制剂,通过抑制 Rho/MRTF/SRF 通路来发挥作用。CCG-257081 已在多个小鼠模型中显示出预防博莱霉素诱导的纤维化的功效。CCG-257081 可用于预防癌症和纤维化的研究。
T36416	N1-Acetylspermine trihydrochloride N1-Acetylspermine (hydrochloride)	Others	Others
	N1-Acetylspermine trihydrochloride 是精胺的单乙酰化衍生物，精胺是一种内源性多胺。 N1-Acetylspermine trihydrochloride 可用于研究人体肉毒碱转运蛋白 SLC22A16 对抗癌多胺类似物博莱霉素 A5 的摄取。
T28177	NK3201 NK-3201,NK 3201
	NK3201, a specific chymase inhibitor, suppresses bleomycin-induced pulmonary fibrosis in hamsters.
T73662	Peplomycin
	Peplomycin (Bleomycin PEP; Pepleomycin) 是Bleomycin 的类似物，具有很高的抗肿瘤作用和较少的肺毒性。Peplomycin 可诱导多种皮肤异常，并诱导口腔鳞癌 SSCKN 细胞凋亡 (apoptosis)，诱导肺纤维化。
T28788	SK-216 SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor
	SK-216 is a specific PAI-1 inhibitor. SK-216 reduced the extent of angiogenesis in the tumors and inhibited VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro. SK-216 reduced the degree of bleomycin-induced pulmon
T73721	Phleomycin D1
	Phleomycin D1 (PLM D1)为Bleomycin/Phleomycin家族内的一种糖肽类抗生素，作用机制是通过结合DNA并切割之，从而引发细胞死亡。
T79642	IV-275	Epigenetic Reader Domain	Chromatin/Epigenetic
	IV-275为BRG1与BRM溴域的抑制剂，能够增强Temozolomide和Bleomycin所诱导的DNA损害。此外，IV-275可抑制GBM（Glioblastoma multiforme）细胞的侵袭性，并增强Temozolomide所诱导的细胞凋亡。
T82313	GK718	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	GK718为一HDAC1/3特异性抑制剂，IC50值分别为259 nM和139 nM。该化合物能提升细胞内乙酰化组蛋白H3含量，并能够抑制Bleomycin所诱导的小鼠肺纤维化现象。
T78202	IV-255	Epigenetic Reader Domain	Chromatin/Epigenetic
	IV-255为BRG1溴域的选择性小分子抑制剂，能增强Temozolomide及Bleomycin诱导的DNA损伤。此外，IV-255抑制GBM细胞侵袭，并强化Temozolomide诱导的细胞死亡与细胞凋亡活性。
T61612	ATX inhibitor 15
	ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. Additionally, ATX inhibitor 15 effectively inhibits ATX activity in vivo and suppresses the expression of pro-fibrotic genes. Furthermore, ATX inhibitor 15 exhibits protective effects in lung fibrosis induced by Bleomycin in mice [1].
T74632	TP0556351	MMP	Proteases/Proteasome
	TP0556351是一种高效且选择性地抑制基质金属蛋白酶2 (MMP2) 的化合物，其IC50值为0.2 nM。在Bleomycin诱导的肺纤维化小鼠模型中，该化合物能显著减少肺部胶原蛋白的含量，适用于特发性肺纤维化(IPF)的研究。
T36338	AAF-CMK (trifluoroacetate salt)
	Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 μM.
T36385	Ansatrienin A
	Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fl...
T82314	GK444	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	GK444（Compound 15a），一种针对HDAC1/2的抑制剂，IC50分别为HDAC1和HDAC2的100 nM与92 nM。其对Caco-2细胞的IC50为4.1μM，并能下调原代正常人肺成纤维细胞中TGF-β1刺激的COL1A1 mRNA水平。此外，GK444还能抑制博来霉素诱发的小鼠肺纤维化。
T36650	Ansatrienin B
	Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul...
T36659	Boromycin
	Boromycin is a boron-containing macrolide antibiotic that has been found in Streptomyces. Boromycin inhibits growth of B. subtilis (MIC = 0.05 μg/ml) and induces efflux of potassium ions from B. subtilis without affecting Na+/K+-ATPase activity. It decreases the synthesis of protein, RNA, and DNA in B. subtilis when used at a concentration of 0.05 μg/ml. It inhibits the growth of B. halodurans (MIC = 10 ng/ml) and inhibits the futalosine pathway of menaquinone synthesis in B. halodurans. Boromyc...
T65994	(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
	Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation...

化合物

Bleomycin hydrochloride

Cat.No: T6116L

Target: DNA/RNA Synthesis

Cat.No: T65016

Cat.No: T73606

Bleomycin Free Base

Cat.No: T71445

Demethyl bleomycin A2

Cat.No: T74722

Cat.No: T10110

Synonym: 3-Carbethoxypsoralen,3-Ethoxycarbonylpsoralen

Target: Antibiotic

Cat.No: T30778

Synonym: MRTF/SRF-IN-1,CCG257081,CCG 257081

Target: Rho, Ras

N1-Acetylspermine trihydrochloride

Cat.No: T36416

Synonym: N1-Acetylspermine (hydrochloride)

Target: Others

Cat.No: T28177

Synonym: NK-3201,NK 3201

Cat.No: T73662

Cat.No: T28788

Synonym: SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Cat.No: T73721

Cat.No: T79642

Target: Epigenetic Reader Domain

Cat.No: T82313

Target: HDAC

Cat.No: T78202

Target: Epigenetic Reader Domain

ATX inhibitor 15

Cat.No: T61612

Cat.No: T74632

Target: MMP

AAF-CMK (trifluoroacetate salt)

Cat.No: T36338

Cat.No: T36385

Cat.No: T82314

Target: HDAC

Cat.No: T36650

Cat.No: T36659

(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

Cat.No: T65994

Cat. No.	Product Name	Target	Signaling Pathways
T6116	Bleomycin Sulfate Blenoxane,硫酸博来霉素,硫酸博莱霉素,NSC125066	DNA/RNA Synthesis; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Bleomycin Sulfate (Blenoxane) 是一种糖肽抗生素，一种 DNA 合成抑制剂。Bleomycin Sulfate 可以引起 DNA 链断裂而不引起 RNA 链断裂。Bleomycin Sulfate 具有抗肿瘤活性。
T75508	Bleomycin A5
	Bleomycin A5 (Pingyangmycin)，一种具有口服活性的糖肽类抗生素，既是抗肿瘤剂、细胞凋亡诱导剂，又是细菌代谢产物。
T4953	Neotuberostemonine	NOS	Immunology/Inflammation
	Neotuberostemonine 是一种结核分枝杆菌根中主要的止咳生物碱，能够阻碍巨噬细胞的募集和活化，从而减轻博来霉素 (Bleomycin) 诱导的肺纤维化。
T6S0105	Peiminine 贝母素乙,Zhebeinone,Fritillarine,Raddeanine,Verticinone	Others; Autophagy	Autophagy; Others
	Peiminine (Raddeanine) 是浙贝母中的一种生物碱，具有抗炎症活性。
T21498	Phleomycin	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Phleomycin 是在链霉菌中发现的，引起 DNA 切割的抗癌糖肽抗生素之一。它类似于博来霉素，它结合并插入 DNA 以破坏双螺旋的完整性。
T2S0690	Ecliptasaponin A 早莲苷 A,旱莲苷A,Echinocystic acid-3-o-glucoside	Others	Others
	Ecliptasaponin A (Echinocystic acid-3-o-glucoside) 是一种墨旱莲 (Eclipta prostrate) 中分离得到的五环三萜皂苷。其中墨旱莲是一种具有多效作用的滋补草药，如抗炎、保肝、抗氧化和免疫调节。
T2762	Kasugamycin hydrochloride Kasumin,盐酸春雷霉素	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Kasugamycin hydrochloride (Kasumin) 是一种能结合 30s 和 70s 核糖体，但不能结合 50s 亚基的抗生素。它模拟 mRNA 核苷酸以破坏 tRNA 结合并抑制经典翻译起始。
TN3469	Aucuparin 2,6-dimethoxy-4-phenylphenol	NADPH-oxidase	Immunology/Inflammation
	Aucuparin (2,6-dimethoxy-4-phenylphenol) 是一种植物抗菌素，具有抗炎活性。在博来霉素 (BLM) 诱导的肺纤维化小鼠模型中，Aucuparin 抑制肺纤维化。在经ABTS 和FRAP 测定显示出明显的清除活性。 Aucuparin 对fmlp 诱导的人中性粒细胞产生超氧化物具有明显的抑制作用，其IC50为17.0μM。
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。
TN5879	Edgeworin
	Edgeworin is a DNA polymerase beta (pol beta) inhibitor, it inhibits both the lyase and polymerase activities of DNA polymerase beta; it can potentiate the inhibitory action of the anticancer drug bleomycin in cultured A549 cells via an inhibition of DNA
T36961	Malformin C
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but ...

天然产物

Bleomycin Sulfate

Cat.No: T6116

Synonym: Blenoxane,硫酸博来霉素,硫酸博莱霉素,NSC125066

Target: DNA/RNA Synthesis, Antibiotic

Cat.No: T75508

Neotuberostemonine

Cat.No: T4953

Target: NOS

Cat.No: T6S0105

Synonym: 贝母素乙,Zhebeinone,Fritillarine,Raddeanine,Verticinone

Target: Others, Autophagy

Cat.No: T21498

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Ecliptasaponin A

Cat.No: T2S0690

Synonym: 早莲苷 A,旱莲苷A,Echinocystic acid-3-o-glucoside

Target: Others

Kasugamycin hydrochloride

Cat.No: T2762

Synonym: Kasumin,盐酸春雷霉素

Target: Antibacterial, Antibiotic, Antifungal

Cat.No: TN3469

Synonym: 2,6-dimethoxy-4-phenylphenol

Target: NADPH-oxidase

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Cat.No: TN5879

Cat.No: T36961

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