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Search Results for " b-29 "

Targets Recommended: Wnt/beta-catenin

13

抑制剂 & 化合物

6

天然产物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9696	β-catenin-IN-2	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	β-catenin-IN-2 是有效的β-catenin 抑制剂。β-catenin-IN-2在结直肠癌中有研究的价值。
TP1231	β-Amyloid (29-40) Amyloid beta-protein(29-40),β-Amyloid 29-40
	β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties related to those of fusion peptides of viral proteins. The fusion of liposomes can be induced by th
T71997	CypD-IN-29
	CypD-IN-29 is a non-peptidic inhibitor of cyclophilin D as a neuroprotective agent in Aβ-induced mitochondrial dysfunction.
T82518	Dynorphin B 29 (pig) Leumorphin (pig)
	Dynorphin B 29 (Leumorphin) (pig) 是一种可与大脑及孤立组织系统中的多种受体交互作用的肽，并可被用于研究免疫反应。
T6318	AZ 628	Apoptosis; Raf	Apoptosis; MAPK
	AZ 628 是一种泛Raf 激酶抑制剂，抑制B-Raf、B-RafV600E 和c-Raf-1，IC50分别为 105、34和 29 nM。
T22272	Lifirafenib BGB-283,Beigene-283	EGFR; Raf	Angiogenesis; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors
	Lifirafenib (Beigene-283) 是新型高效的Raf 激酶和EGFR 抑制剂，对重组BRafV600E 和EGFR 的IC50值分别为 23 和 29 nM。
T63270	HPK1-IN-29
	HPK1-IN-29 是 HPK1 有效的抑制剂，其中造血祖细胞激酶 1 (HPK1) 是一种树突状细胞 (DC)、T 细胞和 B 细胞活化反应的负调节剂。HPK1-IN-29 能够提高人体的抗肿瘤免疫力，表现出研究免疫相关疾病，尤其是肿瘤的潜力。
T36913	17-Epiestriol
	17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16α-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor α (ERα) and ERβ with relative binding affinities of 29 and 80 compared with 17β-estradiol .2 1.Brinton, L.A., Trabert, B., Anderson, G.L., et al.Serum estrogens and estrogen metabolites and endometrial cancer risk among postmenopausal womenCancer Epidemiol. Biomarkers Prev.25(7)1081-1089(2016) 2.Kuiper, G.G.J.M., Lemme...
T83843	2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate sodium 2'(3')-ANT-GTP
	2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate（2'-ANT-GTP）及3'-ANT-GTP是荧光GTP衍生物，能够自发进行异构化。2'(3')-ANT-GTP在水中的激发波长为330 nm时，发射最大波长为428 nm。它抑制哺乳动物腺苷酸环化酶1（AC1；在锰存在下Ki=10 nM）、B. anthracis AC毒素水肿因子（在锰和镁存在下Kis分别为4.1 和 13 µM）及B. pertussis AC毒素CyaA（在锰存在下Ki=29 µM）。
T36096	Thiocoraline
	Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus,B. subtilis, andM. luteus(MICs = 0.05, 0.05, and 0.03 μg/ml, respectively) but not Gram-negativeE. coli,K. pneumoniae, orP. aeruginosa(MICs = >100 μg/ml for all).1Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 μg/ml, respectively), as well as RNA and DNA sy...
T36431	7,10-dihydroxy-8(E)-Octadecenoic Acid
	7,10-dihydroxy-8(E)-Octadecenoic acid is a hydroxy fatty acid and metabolite of oleic acid that is produced byP. aeruginosafrom vegetable oils.1It is active against the food-borne pathogenic bacteriaS. aureus,S. typhimurium,L. monocytogenes,B. subtilis, andE. coli(MIC50s = 31.3, 125, 125, 62.5, and 250 μg/ml, respectively), as well as the plant pathogenic bacteriaErwinia,R. solanacearum,C. glutamicum, andP. syringae(MIC90s = 125, 125, 250, and 500 μg/ml, respectively).2,1 1.Sohn, H.-R., Bae, J.-...
T36021	Flumequine-13C3 Flumequine-13C3
	Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl...
T14384	AZD8797 KAN-0440567,KAND567	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	AZD8797 (KAND567) 是一种可口服且具有选择性和有效性的人 CX3CR1 变构拮抗剂，对 CX3CR1 和 CXCR2 具有抑制作用，对SARS-CoV-2诱导的神经元损伤有潜在的保护作用，可防止癫痫发作后偏头痛模型大鼠痛觉过敏和小胶质细胞活化的恶化。

化合物

β-catenin-IN-2

Cat.No: T9696

Target: Wnt/beta-catenin

β-Amyloid (29-40)

Cat.No: TP1231

Synonym: Amyloid beta-protein(29-40),β-Amyloid 29-40

Cat.No: T71997

Dynorphin B 29 (pig)

Cat.No: T82518

Synonym: Leumorphin (pig)

Cat.No: T6318

Target: Apoptosis, Raf

Cat.No: T22272

Synonym: BGB-283,Beigene-283

Target: EGFR, Raf

Cat.No: T63270

Cat.No: T36913

2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate sodium

Cat.No: T83843

Synonym: 2'(3')-ANT-GTP

Cat.No: T36096

7,10-dihydroxy-8(E)-Octadecenoic Acid

Cat.No: T36431

Flumequine-13C3

Cat.No: T36021

Synonym: Flumequine-13C3

Cat.No: T14384

Synonym: KAN-0440567,KAND567

Target: CXCR

Cat. No.	Product Name	Target	Signaling Pathways
T2895	Lupeol Fagarasterol,羽扇豆醇,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol	Apoptosis; Androgen Receptor; Akt	Apoptosis; Cytoskeletal Signaling; Endocrinology/Hormones; PI3K/Akt/mTOR signaling
	Lupeol (Monogynol B) 是一个活跃的五环三萜，具有抗氧化剂、抗肿瘤和抗炎活性。它是一种雄激素受体抑制剂，可研究癌症，特别是雄激素依赖表型和去势抵抗表型的前列腺癌。
TN2117	Pulsatilloside E 3-O-B-D-葡萄糖( 1→4)-[ A -L-鼠李糖(1→2)]- A-L-阿拉伯糖 23-羟基羽扇豆20(29)-烯-28–酸- 28-O-鼠李糖(1→4)葡萄糖(1→6)葡萄糖苷,Pulchinenoside E,白头翁皂苷E	Others	Others
	Pulsatilloside E (Pulchinenoside E) 是一种从毛茛科白头翁Pulsatilla chinensis (Ranunculaceae)的根中分离出来的天然产物。
TC0036	Compound Lup-20(29)-en-3-yl acetate	IL Receptor; VEGFR; Others; TNF; COX	Angiogenesis; Apoptosis; Immunology/Inflammation; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Lup-20(29)-en-3-yl acetate 是 Lupeol 的衍生物，通过下调 TNF-α、IL-1β、MCP-1、COX-2、VEGF 和颗粒酶 B 来抑制类风湿性关节炎的进展。
TN1776	Isocucurbitacin B	Others	Others
	Isocucurbitacin B 对 HeLa 和 HT-29 人类癌细胞具有显着的抑制活性，IC50 值范围为 0.93 至 9.73uM。
TN5060	Stauntosaponin A	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
T81856	Marsdenoside B
	Marsdenoside B（化合物8）, 一种海芋属植物中的提取物，显示对MGC-803和HT-29肿瘤细胞系具有抑制作用，其IC50s 分别为25.6 μg/mL 和32.4 μg/mL。

天然产物

Cat.No: T2895

Synonym: Fagarasterol,羽扇豆醇,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol

Target: Apoptosis, Androgen Receptor, Akt

Pulsatilloside E

Cat.No: TN2117

Synonym: 3-O-B-D-葡萄糖( 1→4)-[ A -L-鼠李糖(1→2)]- A-L-阿拉伯糖 23-羟基羽扇豆20(29)-烯-28–酸- 28-O-鼠李糖(1→4)葡萄糖(1→6)葡萄糖苷,Pulchinenoside E,白头翁皂苷E

Target: Others

Compound Lup-20(29)-en-3-yl acetate

Cat.No: TC0036

Target: IL Receptor, VEGFR, Others, TNF, COX

Isocucurbitacin B

Cat.No: TN1776

Target: Others

Stauntosaponin A

Cat.No: TN5060

Target: ATPase, Potassium Channel, Sodium Channel

Cat.No: T81856

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05275	CD79B Protein, Human, Recombinant (His) B29,IGB,CD79b molecule, ...	Human	HEK293 Cells
	CD79B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.7 kDa and the accession number is P40259-1.
TMPJ-00113	CD79B Protein, Human, Recombinant (hFc) Immunoglobulin-Associated B29 Pro...	Human	HEK293 Cells
	CD79B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 45-65 KDa and the accession number is P40259.
TMPY-04761	Creatine kinase B Protein, Human, Recombinant (His) HEL-S-29,CKBB,HEL-211,creatine ki...	Human	Baculovirus Insect Cells
	CKB(Creatine kinase B type) contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. It belongs to the ATP:guanido phosphotransferase family. CKB consists of a homodimer of two identical brain-type CK-B subunits. CKB is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell. There, CKB forms tightly coupled microcompartments ...
TMPY-00476	ITGB1 Protein, Human, Recombinant (His) VLAB,integrin, beta 1 (fibronecti...	Human	HEK293 Cells
	ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. This gene encodes a beta subunit, which is a type 1 transmembrane protein of the integrin beta chain family. ITGB1 is a heterodimeric cell-surface receptor involved in cell functions such as proliferation, migration, invasion, and survival. ITGB1 has been recognized to play a major role in tumor growth, invasion, and metastasis. Using luciferase assays, the researcher identified ITGB1 as a direct target of miR-134. ITGB1 is a direct targe...
TMPK-00115	CD79B Protein, Human, Recombinant (His & Avi) Ig-beta,CD79B,IGB,CD79b ...	Human	HEK293 Cells
	CD79B (also known as B29, Ig beta and B cell antigen receptor complex-associated protein beta-chain) is a 36-40 kDa member of the Ig-Superfamily. It is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruit...
TMPY-02265	CD79B Protein, Mouse, Recombinant (His) CD79b molecule, immunoglobulin-associated ...	Mouse	HEK293 Cells
	CD79B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.4 kDa and the accession number is P15530.
TMPJ-00862	CD79B Protein, Mouse, Recombinant (hFc) Ig-Beta,B-Cell-Specific Glycoprotein B...	Mouse	HEK293 Cells
	CD79B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-65 KDa and the accession number is P15530.
TMPJ-00112	CD79B Protein, Human, Recombinant (His & Avi), Biotinylated Immunoglobulin-Associated B29 Pro...	Human	HEK293 Cells
	CD79B Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 30-40 KDa and the accession number is P40259.
TMPJ-00118	CD79B Protein, Rhesus macaque, Recombinant (hFc) B-Cell Antigen Receptor Complex-Associated Protein ...	Rhesus	HEK293 Cells
	CD79B Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-60 KDa and the accession number is H9ZFT8.
TMPJ-00786	ITGB1 Protein, Human, Recombinant (aa 21-728, His) Integrin Beta-1,VLA-4 Subunit β,Fib	Human	HEK293 Cells
	Integrin β-1 (ITGB1) belongs to the integrin β chain family. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. ITGB1 is an integrin unit associated with very late antigen receptors, which contains one VWFA domain. It is known to conjoin with α-3 subunit to create α3β1 complex that reacts to such molecules as netrin-1 and ree...
TMPK-01413	H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi) H-2K,OVA,MHC,H2-K1	Mouse	HEK293 Cells
	Ovalbumin (OVA) has been historically a popular source of such antigens, since OVA can induce both humoral and cellular immune responses based on well-characterised peptide epitopes. The OVA257-264 octapeptide was one of the frst OVA epitopes to be characterised, it has an amino acid sequence SIINFEKL, which is recognised by cytotoxic T lymphocytes. SIINFEKL forms fbrillar assemblies similar to other peptide hydrogels. Te immunoactive properties of this peptide can therefore be related to its se...
TMPK-01416	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated MHC,SARS-CoV-2 epitope	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
TMPK-01412	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi) SARS-CoV-2 epitope,MHC	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.

重组蛋白

CD79B Protein, Human, Recombinant (His)

Cat.No: TMPY-05275

Species: Human

Expression System: HEK293 Cells

CD79B Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00113

Species: Human

Expression System: HEK293 Cells

Creatine kinase B Protein, Human, Recombinant (His)

Cat.No: TMPY-04761

Species: Human

Expression System: Baculovirus Insect Cells

ITGB1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00476

Species: Human

Expression System: HEK293 Cells

CD79B Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00115

Species: Human

Expression System: HEK293 Cells

CD79B Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02265

Species: Mouse

Expression System: HEK293 Cells

CD79B Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00862

Species: Mouse

Expression System: HEK293 Cells

CD79B Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00112

Species: Human

Expression System: HEK293 Cells

CD79B Protein, Rhesus macaque, Recombinant (hFc)

Cat.No: TMPJ-00118

Species: Rhesus

Expression System: HEK293 Cells

ITGB1 Protein, Human, Recombinant (aa 21-728, His)

Cat.No: TMPJ-00786

Species: Human

Expression System: HEK293 Cells

H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi)

Cat.No: TMPK-01413

Species: Mouse

Expression System: HEK293 Cells

HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01416

Species: Human

Expression System: HEK293 Cells

HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01412

Species: Human

Expression System: HEK293 Cells

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