38
15
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1460 |
Dicyclomine hydrochloride
|
AChR | Neuroscience |
Dicyclomine hydrochloride 是口服活性毒蕈碱胆碱能受体拮抗剂。它是一种抗痉挛试剂,在体内可缓解胃肠道平滑肌痉挛。它对 M1 受体亚型和 M2 受体亚型,Ki 分别为5.1和54.6nM,在刷状缘膜和基底质膜中均表现出较高的亲和力。 | |||
T3034 |
Eprazinone dihydrochloride
Resplen,Mucitux,Eftapan,NSC 317935,盐酸依普拉酮,依普拉酮二盐酸,Eprazinone 2HCl |
Others; Neurokinin receptor | GPCR/G Protein; Neuroscience; Others |
Eprazinone dihydrochloride (NSC 317935) 是一种具有镇咳和粘液溶解作用的粘液溶解剂。它是神经激肽 1 受体的配体,可改善肺功能和动脉血氧分压,可用于慢性支气管炎的研究。 | |||
T0703 |
Flavoxate hydrochloride
Flavoxate HCl,盐酸黄酮哌酯,NSC-114649,DW61,Rec-7-0040 |
AChR | Neuroscience |
Flavoxate hydrochloride (DW61) 是一种毒蕈碱受体 AChR 拮抗剂, IC50为 12.2 μM。 | |||
T6375 |
Alibendol
cebera,EB 1856,阿利苯多 |
Others | Others |
Alibendol (cebera) 具有促胆汁分泌及抗痉挛的作用。 | |||
T3272 |
Metamizole magnesium
Metamizolemagnesiumsalt,安乃近镁 |
Antibiotic | Microbiology/Virology |
Metamizole magnesium (Metamizolemagnesiumsalt) 是一种止痛药,可以解痉。 | |||
T68853 |
Diproteverine HCl
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Diproteverine HCl 是具有抗心绞痛特性的新型钙拮抗剂,具有解痉活性和血管活性。 | |||
T2138 |
Oxyphencyclimine Hydrochloride
盐酸奥克西利平,Spazamin,Daricon,Ulcociclinina |
AChR | Neuroscience |
Oxyphencyclimine Hydrochloride (Ulcociclinina) 是一种合成的叔胺和抗毒蕈碱剂,具有抗痉挛和抗分泌活性。 | |||
T7603 |
Pinaverium bromide
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Pinaverium bromide 是一种具有解痉作用的钙通道阻滞剂,可有效缓解疼痛、腹泻和肠道不适。 | |||
T0023 |
Valethamate bromide
Ediposin,Epidozin,戊沙溴铵,Epidosin,Resitan |
Others | Others |
Valethamate bromide (Resitan) 是快速作用的抗胆碱能解痉和肌萎缩剂,是一种酯,能够改善宫颈扩张加速分娩。 | |||
T0072 |
Adiphenine hydrochloride
Adiphenine HCl,盐酸阿地芬宁,Spasnil,Patrovina,Sentiv |
AChR | Neuroscience |
Adiphenine hydrochloride (Patrovina) 是一种烟碱样受体抑制剂,可用作解痉药,对α1、α3β4、α4β2和α4β4的IC50值分别为 1.9、1.8、3.7 和 6.3 µM。 | |||
T2387 |
Glycopyrrolate
Gastrodyn,Glycopyrronium bromide,Robinul,Glycopyrrolate bromide,格隆溴铵 |
AChR | Neuroscience |
Glycopyrrolate (Glycopyrrolate bromide) 是一种毒蕈碱拮抗剂,在某些胃肠道疾病中用作解痉剂,并与某些麻醉剂一起减少唾液分泌。 | |||
T1472 |
Trospium chloride
Spasmex,Sanctura,曲司氯铵,曲司氯胺 |
AChR | Neuroscience |
Trospium chloride (Spasmex) 是一种可口服的特异竞争性毒蕈碱胆碱能受体拮抗剂,可与毒蕈碱受体 M1、M2 和 M3 高亲和力结合,具有抗毒蕈碱活性。 | |||
T1475 |
Fesoterodine fumarate
Toviaz,SPM 907,富马酸非索罗定 |
AChR | Neuroscience |
Fesoterodine fumarate (Toviaz) 是可口服的,非亚型选择性的竞争性毒蕈碱受体拮抗剂,用于膀胱过度活动症,对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。 | |||
T0786 |
Clidinium bromide
克利溴铵,Ro 2-3773 |
AChR | Neuroscience |
Clidinium bromide (Ro 2-3773) 是季胺抗毒蕈碱剂,可通过减少胃酸和减慢肠道速度,缓解痉挛和腹部疼痛的症状。 | |||
T68599 |
Orphenadrine
Orphenadrine (free base) |
Sodium Channel; NMDAR; AChR | Membrane transporter/Ion channel; Neuroscience |
Orphenadrine 是一种非竞争性的 N-甲基-D-天冬氨酸(NMDA)受体拮抗剂,以浓度依赖性方式抑制克隆的 HERG 通道,在 HEK 细胞中产生0.85μM 的 IC。Orphenadrine 是中枢和外周毒蕈碱受体的拮抗剂,通过孔残基 Y652或 F656突变阻断衰减。 Orphenadrine 具有抗痉挛、镇痛和抗胆碱能活性,对在体外和体内对谷氨酸神经毒性具有保护作用。Orphenadrine 对钠离子通道具有抑制作用,可用来治疗帕金森。 | |||
T69234 | Piperilate HCl | ||
Piperilate HCl is an antispasmodic, antimuscarinic agent. It is a muscarinic cholinergic receptor antagonist. | |||
T0346L |
Camylofin Hydrochloride
Camylofin HCl,Acamylophenine hydrochloride,Acamylophenine HCl,Belosin,Avocan |
||
Camylofin HCl is an antispasmodic used in labor treatment and is also used to deliver drug therapy for ulcerative colinitis. | |||
T23829 |
Btm 1042
Btm1042,Btm-1042 |
||
Btm 1042 is an antispasmodic drug. It has been found to depress twitch responses in the ileum of guinea pigs. | |||
T26614 |
Ambucetamide
Bersen,Meritin,Dibutamid |
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Ambucetamide is an antispasmodic, it may inhibit or diminish the spontaneous rhythmical activity of the human myometrium. | |||
T24443 |
Medazomide
Medazomidum,L 1777,L1777,L-1777 |
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Medazomide is a antispasmodic drug. | |||
T25339 |
Dipiproverine
|
||
Dipiproverine 是α-氨基酸酯类化合物,是一种解痉化合物。它被用作抗胆碱能药物。 | |||
T25189 |
Butopiprine
Butopiprinum |
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Butopiprine 是一种镇咳药,具有解痉、局部麻醉和镇咳活性。 | |||
T21050 |
Pridinol
|
||
Pridinol is an antispasmodic and muscle relaxant. | |||
T24517 |
Nafiverine
UNII-WLT400RC9Q,Nafiverina,Nafiverinum,EINECS 225-766-5 |
||
Nafiverine is a new antispasmodic. The effectiveness of an intramuscular administration of nafiverine was comparable to that of an intravenous administration. | |||
T28883 |
Sultroponium
A118,A-118,A 118 |
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Sultroponium may be used as an anticholinergic agent or antispasmodic. | |||
T24887 |
Tiropramide
CR-605 |
||
Tiropramide is an antispasmodic drug. It also useful to inhibit the contractile response of the urinary bladder and in managing abdominal pain in IBS. | |||
T62889 |
Fenoverine
|
||
Fenoverine 是一种抗痉挛药物,对钙通道电流表现出抑制作用,可以引发横纹肌溶解。 | |||
T23918 |
Cularine
|
||
Cularine is an isoquinoline alkaloid from the Fumariaceae family. It displays non-specific antispasmodic activity on guinea-pig and human airways. | |||
T71236 |
Oxybutynin R-isomer HCl
|
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Oxybutynin R-isomer , also known as Aroxybutynin, is a muscarinic receptor antagonist. Aroxybutynin is the optically avtice inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells. Oxybutynin exerts direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. It exhibits one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. No blo... | |||
T25325 |
Dicyclonon
LAB 145-138H,BAS 145-138 |
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Dicyclonon is a muscarinic antagonist utilized as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It has some local anesthetic properties and is utilized in biliary, gastrointestinal, | |||
T61309 |
(R)-Oxybutynin
|
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(R)-Oxybutynin (Aroxybutynin) is an orally active muscarinic receptor antagonist, which exhibits antimuscarinic, antispasmodic, and anticholinergic activity. This compound, being the (R)-isomer of Oxybutynin, competitively antagonizes Carbachol-induced contractions. It is particularly useful in researching neurogenic bladder dysfunction-related incontinence [1] [2] [3]. | |||
T69150 | Anisodine | ||
Anisodine, also known as Daturamine, is an antispasmodic and anticholinergic drug used in the treatment of acute circulatory shock. Anisodine acts as a muscarinic acetylcholine receptor antagonist and α1-adrenergic receptor agonist. | |||
T25339L |
Dipiproverine hydrochloride
L.D. 935,LD 935 |
||
Dipiproverine 是 Dipiproverine 的盐酸盐形式。Dipiproverine 是α-氨基酸酯类化合物,一种解痉化合物,它被用作抗胆碱能药物。 | |||
T60577 |
Cycrimine
|
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Cycrimine 是毒蕈碱胆碱能受体(mAChR)M1的口服活性拮抗剂,可降低帕金森模型中乙酰胆碱的水平。Cycrimine 具有解痉活性,可用于研究行为和精神障碍。 | |||
T69363 | Emepronium bromide | ||
Emepronium bromide is an anticholinergic drug used in urology as an antispasmodic. It can cause ulceration of esophagus, so it should be taken in orthostatic position with sufficient amounts of liquids. It is a muscarinic antagonist used mainly in the treatment of urinary syndromes. It is incompletely absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. | |||
T70153 | Pipoxolan hydrochloride | ||
Pipoxolan (HCl) is an antispasmodic drug. In vivo, the drug inhibited the contractions of intestines caused by neostigmine, barium chloride or injection of acetylcholine. The drug possesses ganglioplegic action and inhibited the decrease in blood pressure caused by stimulation of the vagus nerve. The drug is marketed under tradename Rowapraxin worldwide for the treatment of spasms and colics in the gastrointestinal tract, gallbladder and urogenital area, bronchial spasms, spastic menstrual cramp... | |||
T69661 |
Pipoxolan (free base)
|
||
Pipoxolan (free base) is an antispasmodic drug. In vivo, the drug inhibited the contractions of intestines caused by neostigmine, barium chloride or injection of acetylcholine. The drug possesses ganglioplegic action and inhibited the decrease in blood pressure caused by stimulation of the vagus nerve. The drug is marketed under tradename Rowapraxin worldwide for the treatment of spasms and colics in the gastrointestinal tract, gallbladder and urogenital area, bronchial spasms, spastic menstrual... | |||
T60751 | Dicyclomine | ||
Dicyclomine (Dicycloverine) 是口服有效的毒蕈碱胆碱能受体拮抗剂,它是一种解痉剂,可缓解体内胃肠道平滑肌痉挛。Dicyclomine 对 M1 受体亚型和 M2 受体亚型具有高亲和力,在刷状缘膜和基底质膜中的Ki 值分别为5.1 nM 和54.6 nM 。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TQ0275 |
LysoPC(14:0/0:0)
|
Others; Endogenous Metabolite | Metabolism; Others |
LysoPC(14:0/0:0) 是一种溶血磷脂,它是单甘油磷脂,其中甘油取代位点被磷酸胆碱占据。LysoPC(14:0/0:0) 有抗痉挛作用。 | |||
T2981 |
Xanthoxylin
Brevifolin,Xanthoxyline,花椒素,2'-Hydroxy-4',6'-dimethoxyacetophenone |
Others; Antifungal | Microbiology/Virology; Others |
Xanthoxylin (Brevifolin)e 是从Zanthoxylum simulans 中分离出来的是一种冰片和樟脑味化合物,有抗真菌和抗癫痫作用。 | |||
TN1084 |
1,3,5,8-Tetrahydroxyxanthone
Desmethylbellidifolin,去甲基雏叶龙胆酮 |
Anti-infection | Microbiology/Virology |
1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) 是一种天然黄酮,从 Gentianella acuta 中提取得到。它具有镇痉作用和抗炎作用。 | |||
TN1264 |
3'-O-Methylbatatasin III
|
Antifungal | Microbiology/Virology |
3'-O-Methylbatatasin III 是一种来自兰科植物白芨的天然化合物,具有抗生素活性和解痉活性。3'-O-Methylbatatasin III 具有抗真菌活性。 | |||
T5581 |
6-(γ,γ-Dimethylallylamino)purine
N6-(2-lsopentenyl)adenine,三刺皂荚碱,Triacanthine |
Others | Others |
6-(γ,γ-Dimethylallylamino)purine (Triacanthine) 是植物生长调节剂。 | |||
T0525 |
Flopropione
夫洛丙酮,Phloropropiophenone |
5-HT Receptor; Transferase | GPCR/G Protein; Metabolism; Neuroscience |
Flopropione (Phloropropiophenone) 是一种解痉剂,用作 5-HT1A 受体拮抗剂,也是儿茶酚-O-甲基转移酶抑制剂。 | |||
T8178 |
Acetagastrodin
乙酰天麻素,Acegastrodine |
Others | Others |
Acetagastrodin (Acegastrodine) 是一种抗氧化剂,也是合成 DBPG 的中间体。 | |||
T8787 |
Drotaverine hydrochloride
|
PDE | Metabolism |
Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂,也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂,可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果,但无抗胆碱能的效果。 | |||
TN1528 |
Cotoin
|
AChE | Neuroscience |
Cotoin 是从 Garcinia virgate 茎皮中分离出的一种天然产物。Cotoin 具有解痉活性,可降低孤立的兔肠的音调和收缩。它部分抑制乙酰胆碱、毛果芸香碱和 BaCl 对分离肠的影响。 | |||
T6S1369 |
Vitexin
牡荆素,Apigenin-8-C-glucoside |
Antioxidant | oxidation-reduction |
Vitexin 是一种存在于多种药用植物(如榕树、螺旋藻)中的 c-糖基化的黄酮。 它具有广泛的药理作用,包括抗氧化,抗癌,抗炎,抗痛觉过敏和神经保护作用。 | |||
T6718 |
Zingerone
Gingerone,Vanillylacetone,姜酮,NSC 15335 |
NF-κB | NF-κB |
Zingerone (Vanillylacetone) 是一种从生姜中得到的无毒的甲氧基苯酚,具有抗炎、抗糖尿病、抗脂质过敏、抗腹泻、抗痉挛和抗肿瘤等活性。它作为抗有丝分裂剂,能够抑制神经母细胞瘤的生长。它能够缓解氧化应激和炎症,下调 NF-κB 介导的信号通路。 | |||
T6S1684 |
8-Gingerol
|
Antioxidant; Antibacterial; TRP/TRPV Channel | Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction |
8-Gingerol 分离自姜的根状茎,是口服有效的 TRPV1激活剂,EC50值为5.0 µM。8-Gingerol 抑制 COX-2,还能抑制体外 H. pylori 的生长。 | |||
T3S2259 |
Methyl eugenol
4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物,存在于植物叶子、果实、根茎中,当植物相应的部位因食草动物进食而受损时,就会释放。它可用于消灭雄性东方果蝇。 | |||
T10195 |
7-O-Geranylscopoletin
7-Geranyloxy-6-methoxycoumarin |
Others | Others |
7-O-Geranylscopoletin is a natural coumarin from the root of Atalantia monophylla. Various parts of this plant have been used for folk medicine for several purposes such as the treatment of chronic rheumatism, antispasmodic, paralysis, hemiplegia, and sti | |||
T14192 |
α-Amyrin acetate
Α-香树精乙酯,α-Amyrin acetate |
Others | Others |
α-Amyrin acetate 是一种具有抗炎活性、抗痉挛特性和松弛作用的三萜类化合物。 |