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Search Results for " amyloid beta-peptide "

46

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14284	β-Amyloid (25-35) β-Amyloid peptide(25-35),Aβ25-35,BETA-淀粉样蛋白片断25-35,Amyloid beta-peptide(25-35)	Beta Amyloid	Neuroscience
	β-Amyloid (25-35) (Aβ25-35) 是一种阿尔茨海默氏淀粉样蛋白β肽的Aβ(25-35) 片段，在培养细胞中显示出神经毒性作用。
T7680	GSNKGAIIGLM(131602-53-4(free base)) Amyloid beta-peptide(25-35),BETA-淀粉样蛋白片断25-35	Beta Amyloid	Neuroscience
	GSNKGAIIGLM(131602-53-4(free base)) (Amyloid beta-peptide(25-35)) 是阿尔茨海默病淀粉样蛋白 β-肽的片段 Aβ(25-35)。
TP1359L	Amyloid β Peptide (42-1)(human) acetate Amyloid β Peptide (42-1)(human) acetate(317366-82-8 free base)	Beta Amyloid	Neuroscience
	Amyloid β Peptide (42-1)(human) acetate 是淀粉样蛋白 β 肽 (1-42) 的无活性形式。Amyloid β Peptide (42-1)(human) acetate 是由 42 个氨基酸组成的肽，其在阿尔茨海默病的发病机制中起关键作用。
T7562	β-Amyloid (31-35) 异亮氨酰-异亮氨酰-甘氨酰-亮氨酰-蛋氨酸,β-Amyloid 31-35(TFA),β-Amyloid 31-35	Beta Amyloid	Neuroscience
	β-Amyloid (31-35) (β-Amyloid 31-35) 是一种天然 Amyloid-β 肽的最短序列，具有神经毒性。
T35499	β-Amyloid (1-42), (rat/mouse) (TFA) Amyloid β-peptide (1-42) (human) TFA,166090-74-0 TFA
	β-Amyloid (1-42), (rat/mouse) (TFA) 是由 42 个氨基酸组成的多肽片段，可用于研究阿尔茨海默症。
T4398	LX2343	Beta Amyloid; Beta-Secretase; BACE; PI3K; Autophagy	Autophagy; Neuroscience; PI3K/Akt/mTOR signaling
	LX2343 是一种非 ATP 竞争性 PI3K 抑制剂，IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂，IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。
T6562	Latrepirdine dihydrochloride Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin	Beta Amyloid; 5-HT Receptor; Adrenergic Receptor; GluR; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Latrepirdine dihydrochloride (Dimebolin dihydrochloride) 是一种具有口服活性和神经活性的多种药物靶点的拮抗剂，可刺激淀粉样前体蛋白分解代谢和 β-淀粉样蛋白分泌。
T37368	Amyloid-β (1-8) Peptide
	Amyloid-β (1-8) is a wild-type control for the mutation-containing amyloid-β (1-8, A2V) peptide .
T7644	DPN Diarylpropionitrile,2,3-双(4-羟苯基)丙腈	Apoptosis; Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones
	DPN (Diarylpropionitrile) 是一种非甾体雌激素受体 ERβ选择性配体，其 EC50值为 0.85 nM。DPN 在许多神经系统疾病具有神经保护作用。
T37370	Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
	Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) and Aβ (1-42) fibrils. Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM....
TP1441	β-Amyloid (1-40) (rat) Amyloid β-peptide (1-40) rat,β淀粉样肽(1-40)(鼠)
	Rat form of the beta-Amyloid (1-40) peptide
TP1359	β-Amyloid (42-1), human Amyloid β Peptide (42-1)(human)
	β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42) which plays a key role in the pathogenesis of Alzheimer disease.
T37472	TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
	TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-residue protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease. Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers. TAMRA-Amyloid-β (1-42) peptide is a labeled form of Aβ42 containing carboxytetramethyl rhodamine (TAMRA), which displays excitation/emission maxima of 543/572 nm, respectively.
T37367	Amyloid-β (1-42) Peptide (trifluoroacetate salt)
	Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4 1.Wolfe, M.S.Therapeutic strategi...
TP1007	β-Amyloid (1-42), human 大豆肽,β-Amyloid (1-42), human,Amyloid β-Peptide (1-42) human	Beta Amyloid	Neuroscience
	β-Amyloid (1-42), human 是一种由 42 个氨基酸组成的肽，在阿尔茨海默病的发病机制中起关键作用。
TP1230	β-Amyloid (1-42), (rat/mouse) β-Amyloid (1-42), rat,Amyloid β-peptide (1-42) (rat)
	Amyloid (1-42), rat is a polypeptide composed of 42 amino acids. It is toxic to hippocampal slices and can be used in the study of alzheimer's disease.
T37200	Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
	Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand. It has been used to identify Aβ42 interaction partners in rat hippocampal synaptosomal membranes.
T37369	Amyloid-β (1-8, A2V) Peptide Amyloid-β (1-8, A2V) Peptide
	Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V). An Aβ (1-40) (Aβ40) A2V peptide increases the production of Aβ and the rate and amount of amyloid fibril formation in vitro, effects that can be reduced by coincubation with wild-type Aβ40. Aβ40 and Aβ42 levels are increased in CHO ...
TP1214L	β-Amyloid 15-21 acetate Beta-Amyloid (15-21) acetate	Beta Amyloid	Neuroscience
	β-Amyloid 15-21 acetate (Beta-Amyloid(15-21) acetate) 是 Amyloid-β 肽的片段，可用于神经系统疾病的研究。该片段参与β折叠形成。
T3155	SMER28	Autophagy	Autophagy
	SMER28 是一种自噬小分子增强剂，通过不依赖于 mTOR 的机制诱导哺乳动物细胞中独立于雷帕霉素的自噬，并阻止淀粉样蛋白 β 肽的积累。
TP1733	Beta-Amyloid(1-14),mouse,rat
	Beta-Amyloid(1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. This peptide is amino acids 1 to 14 fragment of Beta-Amyloid peptide.
TP1719	β-Amyloid (33-40) β-Amyloid 33-40
	β-Amyloid (33-40) is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein.
TP1225	β-Amyloid (22-35) β-Amyloid 22-35,Amyloid β-Protein (22-35)
	β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells. Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide.
TP1586	β-Amyloid (35-42) β-Amyloid 35-42
	β-Amyloid (35-42) is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein.
TP1500	β-Amyloid (1-17) β-Amyloid 1-17
	This synthetic peptide consists of amino acids 1 to 17 of beta amyloid protein. This peptide can be employed in beta amyloid solubility studies.
TP1692	β-Amyloid (13-27) β-Amyloid 13-27
	β-Amyloid (13-27) is a peptide consisting of amino acid of 13 to 27 of beta amyloid protein. This synthetic peptide consists of amino acids 26 to 40 of beta amyloid protein. It can be used to study the kinetics of beta amyloid formation.
TP1544	β-Amyloid (22-40) β-Amyloid 22-40
	This synthetic peptide consists of amino acids 22 to 40 of beta amyloid protein. This peptide sequence is often used in beta amyloid structure and aggregation studies.
TP1645	β-Amyloid (1-9) β-Amyloid 1-9
	This is an N-terminal fragment of beta amyloid. It consists of amino acid residues 1 to 9. Truncated beta amyloid peptide (10-40) still forms amyloid fibrils and shows fibril polymorphism.
T22932	LPYFD-NH2	Others	Others
	neuroprotective peptide that binds to amyloid beta (Aβ)
T76588	(Asp37)-Amyloid β-Protein (1-42)
	(Asp37)-Amyloid β-Protein (1-42) 是野生型 Amyloid-beta (1-42) 肽的 G37D 突变体。
TP1538	β-Amyloid (1-20) β-Amyloid 1-20
	This synthetic peptide consists of amino acids 1 to 20 of beta amyloid protein.
TP1599	β-Amyloid (1-34) β-Amyloid 1-34
	This is a fragment of beta-amyloid peptide. It has amino acids 1 through 34.
TP1214	β-Amyloid 15-21 Beta-Amyloid (15-21)
	β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formation.
T83540	(Gly22)-amyloid beta-protein(1-40)
	(Gly22)-amyloid beta-protein(1-40) (Arctic variant Ab40ARC (E22G)) 是用于阿尔茨海默病研究的肽。
TP1494	β-Amyloid (4-10) β-Amyloid 4-10
	Antibodies corresponding to beta-amyloid (4-10) are effective in vivo inhibitors of cytotoxicity, amyloid plaque formation and special memory disturbances in mice. This peptide does not elicit an inflammatory response.
TP1231	β-Amyloid (29-40) Amyloid beta-protein(29-40),β-Amyloid 29-40
	β-Amyloid (29-40) is a fragment of Amyloid-β peptide.Alzheimer's beta amyloid peptide (29-40/42) C-terminal fragments have physical and chemical properties related to those of fusion peptides of viral proteins. The fusion of liposomes can be induced by th
TP2177	Amyloid Precursor C-Terminal Peptide	Others	Others
	Amyloid precursor c-terminal peptide has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn. APP is best known as the precursor molecule whose proteolysis generates beta-amyloid (Aβ), a 37 to 49 amino acid peptide whose am
T83539	(Pyr11)-Amyloid β-Protein (11-40)
	(Pyr11)-Amyloid β-Protein (11-40) (A beta 11pE-40) 作为一种肽，主要应用于阿尔茨海默病相关研究。
T83508	[Arg6]-β-Amyloid (1-42), england mutation
	[Arg6]-β-Amyloid (1-42), england mutation 是具有生物活性的肽类化合物。β-Amyloid (1-42)中的英国 (H6R) 突变被认为与Alzheimer病的常染色体显性遗传形式有关，此突变影响了位点H6的相互作用。
T35498	β-Amyloid (1-14),mouse,rat
	β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: stru...
T81299	Remternetug LY3372993
	Remternetug为一种人源化IgG1-kappa型单克隆抗体，针对APP (Aβ42 N3pGlu)的特定焦谷氨酸形式。该抗体能够特异性识别并结合形成淀粉样斑块的Aβ聚集体。
T80701	β Amyloid (1-16) rat
	β-Amyloid (1-16) rat 是β-淀粉样肽 (Abeta) 金属结合域的片段，含有三个与人类相异的氨基酸替代，因此在大鼠和小鼠中降低了 AD 样神经退行性变的易感性。
T83507	[Asn23] β-Amyloid (1-40), Iowa mutation
	[Asn23] β-Amyloid (1-40), Iowa mutation 是一种与重度大脑淀粉样蛋白血管病 (CAA) 相关的生物活性肽。该突变涉及 APP 694 位点的错义突变，Asp 23 位置的天冬酰胺被天冬酰氨酸取代。这种变异的 β-Amyloid 肽倾向于更快聚集，并形成有害的原纤维。
T83506	[Asn23]-beta-Amyloid (1-42), iowa mutation
	[Asn23]-beta-Amyloid (1-42), iowa mutation 是具有生物活性的肽，与阿尔茨海默病中的一种严重神经病理状况——大脑淀粉样蛋白血管病 (CAA) 密切相关。这种变异是由于在 APP 694 位点发生了错义突变，其中 Asp 23 被 Asn 取代，导致的。该变异形式的β-淀粉样肽倾向于更快聚集，形成具有毒性的原纤维。
T83509	[Arg6]-β-Amyloid (1-40), england mutation
	[Arg6]-β-Amyloid (1-40), England mutation 是具有生物活性的肽，与多种家族性常染色体显性阿尔茨海默病相关。特别地，这种英国突变，即位于第6位的His被Arg所替换，已报告可提高寡聚体形成动力学，加速初级纤维的种子化过程。此类寡聚体对神经元培养细胞展现出较高毒性。
T82243	hAChE-IN-5	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	hAChE-IN-5（化合物49）是一种同时针对hAChE和hBuChE的有效抑制剂，其IC50值均为0.17 μM。此外，hAChE-IN-5对GSK3β同样展现出良好的抑制活性，IC50值为0.21 μM。作为tau蛋白聚集和Aβ1-42自聚集的抑制剂，hAChE-IN-5能够结合PAS，进而阻止Aβ依赖的神经毒性。其能穿透血脑屏障（BBB），显示出成为多靶点抗阿尔茨海默病药物研究的潜力。

化合物

β-Amyloid (25-35)

Cat.No: T14284

Synonym: β-Amyloid peptide(25-35),Aβ25-35,BETA-淀粉样蛋白片断25-35,Amyloid beta-peptide(25-35)

Target: Beta Amyloid

GSNKGAIIGLM(131602-53-4(free base))

Cat.No: T7680

Synonym: Amyloid beta-peptide(25-35),BETA-淀粉样蛋白片断25-35

Target: Beta Amyloid

Amyloid β Peptide (42-1)(human) acetate

Cat.No: TP1359L

Synonym: Amyloid β Peptide (42-1)(human) acetate(317366-82-8 free base)

Target: Beta Amyloid

β-Amyloid (31-35)

Cat.No: T7562

Synonym: 异亮氨酰-异亮氨酰-甘氨酰-亮氨酰-蛋氨酸,β-Amyloid 31-35(TFA),β-Amyloid 31-35

Target: Beta Amyloid

β-Amyloid (1-42), (rat/mouse) (TFA)

Cat.No: T35499

Synonym: Amyloid β-peptide (1-42) (human) TFA,166090-74-0 TFA

Cat.No: T4398

Target: Beta Amyloid, Beta-Secretase, BACE, PI3K, Autophagy

Latrepirdine dihydrochloride

Cat.No: T6562

Synonym: Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin

Target: Beta Amyloid, 5-HT Receptor, Adrenergic Receptor, GluR, Autophagy, Histamine Receptor

Amyloid-β (1-8) Peptide

Cat.No: T37368

Cat.No: T7644

Synonym: Diarylpropionitrile,2,3-双(4-羟苯基)丙腈

Target: Apoptosis, Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy

Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)

Cat.No: T37370

β-Amyloid (1-40) (rat)

Cat.No: TP1441

Synonym: Amyloid β-peptide (1-40) rat,β淀粉样肽(1-40)(鼠)

β-Amyloid (42-1), human

Cat.No: TP1359

Synonym: Amyloid β Peptide (42-1)(human)

TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Cat.No: T37472

Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Cat.No: T37367

β-Amyloid (1-42), human

Cat.No: TP1007

Synonym: 大豆肽,β-Amyloid (1-42), human,Amyloid β-Peptide (1-42) human

Target: Beta Amyloid

β-Amyloid (1-42), (rat/mouse)

Cat.No: TP1230

Synonym: β-Amyloid (1-42), rat,Amyloid β-peptide (1-42) (rat)

Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Cat.No: T37200

Amyloid-β (1-8, A2V) Peptide

Cat.No: T37369

Synonym: Amyloid-β (1-8, A2V) Peptide

β-Amyloid 15-21 acetate

Cat.No: TP1214L

Synonym: Beta-Amyloid (15-21) acetate

Target: Beta Amyloid

Cat.No: T3155

Target: Autophagy

Beta-Amyloid(1-14),mouse,rat

Cat.No: TP1733

β-Amyloid (33-40)

Cat.No: TP1719

Synonym: β-Amyloid 33-40

β-Amyloid (22-35)

Cat.No: TP1225

Synonym: β-Amyloid 22-35,Amyloid β-Protein (22-35)

β-Amyloid (35-42)

Cat.No: TP1586

Synonym: β-Amyloid 35-42

β-Amyloid (1-17)

Cat.No: TP1500

Synonym: β-Amyloid 1-17

β-Amyloid (13-27)

Cat.No: TP1692

Synonym: β-Amyloid 13-27

β-Amyloid (22-40)

Cat.No: TP1544

Synonym: β-Amyloid 22-40

β-Amyloid (1-9)

Cat.No: TP1645

Synonym: β-Amyloid 1-9

Cat.No: T22932

Target: Others

(Asp37)-Amyloid β-Protein (1-42)

Cat.No: T76588

β-Amyloid (1-20)

Cat.No: TP1538

Synonym: β-Amyloid 1-20

β-Amyloid (1-34)

Cat.No: TP1599

Synonym: β-Amyloid 1-34

β-Amyloid 15-21

Cat.No: TP1214

Synonym: Beta-Amyloid (15-21)

(Gly22)-amyloid beta-protein(1-40)

Cat.No: T83540

β-Amyloid (4-10)

Cat.No: TP1494

Synonym: β-Amyloid 4-10

β-Amyloid (29-40)

Cat.No: TP1231

Synonym: Amyloid beta-protein(29-40),β-Amyloid 29-40

Amyloid Precursor C-Terminal Peptide

Cat.No: TP2177

Target: Others

(Pyr11)-Amyloid β-Protein (11-40)

Cat.No: T83539

[Arg6]-β-Amyloid (1-42), england mutation

Cat.No: T83508

β-Amyloid (1-14),mouse,rat

Cat.No: T35498

Cat.No: T81299

Synonym: LY3372993

β Amyloid (1-16) rat

Cat.No: T80701

[Asn23] β-Amyloid (1-40), Iowa mutation

Cat.No: T83507

[Asn23]-beta-Amyloid (1-42), iowa mutation

Cat.No: T83506

[Arg6]-β-Amyloid (1-40), england mutation

Cat.No: T83509

Cat.No: T82243

Target: GSK-3

Cat. No.	Product Name	Target	Signaling Pathways
TN1038	Galgravin	Apoptosis	Apoptosis
	Galgravin 是望春花中的一种天然产物，具有抗炎和体外细胞毒活性，能诱导白血病细胞凋亡。

天然产物

Cat.No: TN1038

Target: Apoptosis

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