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抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T70985	GL-1001 disodium tetrahydrate	Others	Others
	GL-1001 disodium tetrahydrate is an ACE2 inhibitor.
T70987	AT-1001	Others	Others
	AT-1001 is an α3β4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with α3β4 nAChR. Importantly, AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding. When tested in a nucleus accumbens (NAcs) synaptosomal prepar...
T7802	M1001	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	M1001 是较弱的HIF-2α激动剂，直接与 HIF-2α PAS-B 结构域结合，Kd=667 nM，能够提高 HIF-2α-ARNT 复合体之间的稳定性。
T8470	BMS-1001	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-1001 是一种有效的 PD-1/PD-L1 相互作用抑制剂（IC50：2.25 nM，在均相时间分辨荧光结合试验中）。
T5163	SR1001	ROR	Metabolism
	SR1001 是选择性RORα及RORγt 的反向激动剂，其Ki 分别为 172 和 111 nM。
T7741	DS-1001b	Dehydrogenase; Isocitrate Dehydrogenase (IDH)	Metabolism
	DS-1001b 是IDH-1(异柠檬酸脱氢酶-1) 突变体抑制剂。
T6922	ORY1001 RG-6016,ORY-1001 (RG-6016) 2HCl,ORY-1001,ORY 1001	Histone Demethylase	Chromatin/Epigenetic
	ORY1001 (ORY 1001) 是一种具有口服活性的选择性赖氨酸特异性去甲基化酶 LSD1/KDM1A 抑制剂，对相关的 FAD 依赖性氨氧化酶具有高选择性，IC50 <20 nM。
T6329	3-Aminobenzamide 3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	3-Aminobenzamide (PARP-IN-1) 是一种有效的 PARP 抑制剂，在 CHO 细胞中，对 PARP 的 IC50值约为 50 nM。它是再灌注过程中氧化剂诱导的肌细胞功能障碍的介质。
T5825	Iadademstat dihydrochloride ORY-1001(trans)	Histone Demethylase	Chromatin/Epigenetic
	Iadademstat dihydrochloride (ORY-1001(trans)) 是一种不可逆的选择性赖氨酸特异性脱甲基酶 1A(KDM1A/LSD1) 抑制剂，用于治疗急性白血病。
T10565	BMS-1001 hydrochloride	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-1001 hydrochloride 是一种人 PD-L1/PD-1免疫检查点的抑制剂，具有口服活性且细胞毒性低。
T38392	JAMI1001A	Others	Others
	JAMI1001A is a positive allosteric modulator of the AMPA receptor, effectively modulating the deactivation and desensitization of both flip and flop receptor isoforms.
T62527	INO-1001	Others	Others
	INO-1001 是一种有效的、选择性聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂，具有抗肿瘤活性。INO-1001 是一种有效的辐射敏感性增强剂，能够利用干扰 DNA 修复机制，进而提高辐射诱导的细胞杀伤，使坏死细胞死亡。
T69080	T1001	Others	Others
	T1001 is an antagonist of hypoxia-inducible factor-2α subunit (HIF-2α) which displaces residue M252 from inside the HIF-2α PAS-B pocket toward the ARNT subunit to weaken heterodimerization.
T70113	ATM-1001	Others	Others
	ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets.
T70986	GL-1001 sodium salt	Others	Others
	GL-1001 sodium salt is an ACE2 inhibitor.
TP1001	γ-Glu-Phe γ-Glutamylphenylalanine
	γ-Glu-Phe (γ-Glutamylphenylalanine) is a γ-3 glutamyl dipeptide found in sourdough.it is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commerc
T69185	INO-1001 methanesulfonate	Others	Others
	INO-1001 methanesulfonate is an isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties.
T72216	DPM-1001 trihydrochloride	Others	Others
	DPM-1001 trihydrochloride 是一种有效的，特异性的，具有口服活性的，且非竞争性的蛋白酪氨酸磷酸酶 (PTP1B) 抑制剂，其 IC50为 100 nM。DPM-1001 trihydrochloride 是特异性 PTP1B 抑制剂 MSI-1436 (IC50=600 nM) 的类似物。DPM-1001 trihydrochloride 具有抗糖尿病特性。
T36949	Niaprazine	5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Niaprazine 是有效的组胺 H1 受体拮抗剂，具有抗组胺和抗血清素活性。Niaprazine 在睡眠障碍方面有研究的价值。
T28269	ORY-1001 free base RG 6016,ORY-1001,ORY 1001,ORY1001,RG-6016,RG6016	Others	Others
	ORY-1001 is a KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/dose dependent me2H3K4 accumulation a

化合物

GL-1001 disodium tetrahydrate

Cat.No: T70985

Target: Others

Cat.No: T70987

Target: Others

Cat.No: T7802

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T8470

Target: PD-1/PD-L1

Cat.No: T5163

Target: ROR

Cat.No: T7741

Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)

Cat.No: T6922

Synonym: RG-6016,ORY-1001 (RG-6016) 2HCl,ORY-1001,ORY 1001

Target: Histone Demethylase

3-Aminobenzamide

Cat.No: T6329

Synonym: 3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001

Target: PARP

Iadademstat dihydrochloride

Cat.No: T5825

Synonym: ORY-1001(trans)

Target: Histone Demethylase

BMS-1001 hydrochloride

Cat.No: T10565

Target: PD-1/PD-L1

Cat.No: T38392

Target: Others

Cat.No: T62527

Target: Others

Cat.No: T69080

Target: Others

Cat.No: T70113

Target: Others

GL-1001 sodium salt

Cat.No: T70986

Target: Others

Cat.No: TP1001

Synonym: γ-Glutamylphenylalanine

INO-1001 methanesulfonate

Cat.No: T69185

Target: Others

DPM-1001 trihydrochloride

Cat.No: T72216

Target: Others

Cat.No: T36949

Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

ORY-1001 free base

Cat.No: T28269

Synonym: RG 6016,ORY-1001,ORY 1001,ORY1001,RG-6016,RG6016

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T71479	Kahweol oleate	Others	Others
	Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.

天然产物

Cat.No: T71479

Target: Others

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