Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZM39923 hydrochloride (JAK3 Inhibitor IV) 是一种 JAK3抑制剂,pIC50值为 7.1。它也抑制组织型转谷氨酞胺酶 (TGM2) 的活性,IC50值为 10 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 223 | 现货 | ||
5 mg | ¥ 493 | 现货 | ||
10 mg | ¥ 822 | 现货 | ||
25 mg | ¥ 1,630 | 现货 | ||
50 mg | ¥ 2,990 | 现货 | ||
100 mg | ¥ 4,390 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 885 | 现货 |
产品描述 | ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase. |
体外活性 | The selectivity of Rotigotine for D3 (pKi 9.2) receptors is higher 10-fold than D2/D4/D5 (pKi 8.5-8.0) and 100-fold than D1 receptors (pKi 7.2). Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. In functional studies, Rotigotine behaves as a full agonist at all dopamine receptors but notably, the potency for stimulation of D1 receptors is similar to that for D2/D3 receptors (pEC50 respectively: 9.0, 9.4-8.6, 9.7). Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+ toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone. |
别名 | JAK3 Inhibitor IV, ZM 39923 HCl |
分子量 | 367.91 |
分子式 | C23H25NO·HCl |
CAS No. | 1021868-92-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 8 mg/mL (21.74 mM)
DMSO: 28 mg/mL (76.1 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 2.7181 mL | 13.5903 mL | 27.1806 mL | 67.9514 mL |
5 mM | 0.5436 mL | 2.7181 mL | 5.4361 mL | 13.5903 mL | |
10 mM | 0.2718 mL | 1.359 mL | 2.7181 mL | 6.7951 mL | |
20 mM | 0.1359 mL | 0.6795 mL | 1.359 mL | 3.3976 mL | |
DMSO | 50 mM | 0.0544 mL | 0.2718 mL | 0.5436 mL | 1.359 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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