Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-6776 是一种具有口服活性的选择性USP7抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 685 | 现货 | ||
5 mg | ¥ 1,690 | 现货 | ||
10 mg | ¥ 2,680 | 现货 | ||
25 mg | ¥ 4,830 | 现货 | ||
50 mg | ¥ 6,880 | 现货 | ||
100 mg | ¥ 9,280 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,830 | 现货 |
产品描述 | GNE-6776 is a selective USP7 inhibitor. |
体外活性 | GNE-6776 non-covalently targets USP7 12?? distant from the catalytic cysteine. GNE-6776 attenuates ubiquitin binding and thus inhibits USP7 deubiquitinase activity. GNE-6776 interacts with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways.GNE-6776 selectively inhibits recombinant USP7 relative to 36 other deubiquitinases. GNE-6776 remains selective even at 100?μM, a more than sixfold higher concentration than used in cellular assays. GNE-6776 significantly inhibits USP7 while remaining selective against 44-47 other detected deubiquitinases. |
体内活性 | Although efficacious exposure is only transiently achieved, GNE-6776 causes modest, although significant, EOL-1 xenograft growth delay. |
别名 | GEN6776 |
分子量 | 348.4 |
分子式 | C20H20N4O2 |
CAS No. | 2009273-71-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 310 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GNE-6776 2009273-71-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB GEN-6776 Deubiquitinase DUBs GEN 6776 Inhibitor GEN6776 inhibit GNE 6776 GNE6776 inhibitor