PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	Product Name	CAS No.	Purity
T12457	PI3K-IN-6 化合物 T12457	1842380-77-1	98%
T12457	PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).
T12456	PI3K-IN-10 化合物 T12456	2211922-64-2	98%
T12456	PI3K-IN-10 is a potent inhibitor of pan-PI3K .
T10660	CAL-130 化合物 T10660	1431697-74-3	98%
T10660	CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
T12275	NVP-QAV-572 化合物 T12275	957209-68-6	98%
T12275	NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).
TN1504	Citreorosein 化合物Citreorosein	481-73-2	98%
TN1504	Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
TMA0291	Dehydroglyasperin D 化合物 TMA0291	517885-72-2	98%
TMA0291	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN3726	Cudraflavone B 化合物 TN3726	19275-49-1	98%
TN3726	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
TN4046	Excisanin A 化合物 TN4046	78536-37-5	98%
TN4046	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T12455	PI3K/HDAC-IN-1 化合物 T12455	2361418-52-0	98%
T12455	PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).
T13311	Vps34-IN-2 化合物 T13311	1523404-29-6	98%
T13311	Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).
T12465	PI3Kγ inhibitor 2 化合物 T12465	1315538-79-4	98%
T12465	PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).
TN3655	Cimiside E 化合物 TN3655	154822-57-8	98%
TN3655	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 化合物 TN3218	100667-52-5	98%
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
TN3806	Dehydroglyasperin C 化合物 TN3806	199331-35-6	98%
TN3806	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
T12464	PI3Kγ inhibitor 1 化合物 T12464	1172118-03-4	98%
T12464	PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.
T5166	Leniolisib 化合物Leniolisib	1354690-24-6	99.97%
T5166	Leniolisib (CDZ173) 是一种高效的，选择性的 PI3Kδ抑制剂，有用于免疫缺陷类疾病的研究潜力。
T16422	P110δ-IN-1 化合物ME-401	1595129-71-7	99.95%
T16422	P110δ-IN-1 (PWT-143) 是一种有效的、选择性的P110δ抑制剂，其 IC50=8.4 nM。
T4079	LY-294002 hydrochloride 化合物LY-294002 hydrochloride	934389-88-5	99.95%
T4079	LY-294002 hydrochloride (NSC 697286) 是一种合成的 PI3Kα/δ/β 分子抑制剂（IC50：0.5/0.57/0.97 μM，在无细胞试验中）；在溶液中比 Wortmannin 更稳定，也是自噬体形成的阻断剂。
T6087	AZD 6482 化合物AZD6482	1173900-33-8	99.95%
T6087	AZD 6482 (AZD6482) 是一种有效的选择性p110β抑制剂，IC50为 0.69 nM。它也是 PI3Kβ 抑制剂，IC50 为 10 nM。
T3692	GNE-477 化合物GNE 477	1032754-81-6	99.95%
T3692	GNE-477 是一种高效的双重PI3K(IC50=4 nM)、mTOR(Ki=21 nM) 抑制剂。