PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	Product Name	CAS No.	Purity
T81453	PITCOIN4 化合物 PITCOIN4		98%
T81453	PITCOIN4，一种II类PI3K-C2α高选择性抑制剂，具有对PI3K-C2α纳米摩尔级别的显著抑制活性。
T81467	PI3Kδ-IN-18 化合物 PI3Kδ-IN-18		98%
T81467	Se15作为PI3Kδ选择性抑制剂展现出高度效力，具有小于0.1nM的IC50值，主要应用于自身免疫反应研究领域。
T81468	PI3Kδ-IN-17 化合物 PI3Kδ-IN-17	2768181-63-9	98%
T81468	PI3Kδ-IN-17 (Compound S5) 是一种PI3Kδ抑制剂，其IC50值为2.82 nM。该化合物在SU-DHL-6细胞中对增殖活性具有显著抑制效果，IC50为0.035 μM。
T81469	PI3Kα-IN-14 化合物 PI3Kα-IN-14		98%
T81469	PI3Kα-IN-14（复合物F8）是一款高度选择性的PI3Kα抑制剂，其IC50值为0.14 nM 。此化合物能显著降低线粒体膜的完整性，并在U87-MG细胞中引起G1期细胞周期的停滞以及凋亡现象。此外，PI3Kα-IN-14在不同来源的肿瘤细胞系中均展现出明显的抗增殖能力，其中PC-3的IC50为0.28 μM，HC...
T81470	PI3K/mTOR Inhibitor-14 化合物 PI3K/mTOR Inhibitor-14	2919684-77-6	98%
T81470	PI3K/mTOR Inhibitor-14（化合物 Y-2）是一种针对PI3K和mTOR的双重抑制剂，其IC50值分别为171.4 nM 和10.1 nM ，具备抗肿瘤活性。
T81499	PH14 化合物 PH14		98%
T81499	PH14，作为一种PI3K/HDAC双重抑制剂，对PI3Kα和HDAC3表现出强效抑制能力，其IC50值分别为20.3 nM 和24.5 nM 。该化合物不仅具备抗增殖特性，还能有效诱导Jeko-1细胞走向凋亡，是研究癌症（例如淋巴瘤）的有力工具。
TN4263	Isoangustone A 化合物 TN4263	129280-34-8	98%
TN4263	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
T12460	PI3K/mTOR Inhibitor-1 化合物 T12460	1949802-49-6	98%
T12460	PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)
T12461	PI3Kdelta inhibitor 1 化合物 T12461	2242109-74-4	98%
T12461	PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.
TN1376	α-Solanine α-茄碱	20562-02-1	98%
TN1376	Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
TN3691	Communic acid 化合物 TN3691	2761-77-5	98%
TN3691	Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
TN4652	Niazimicin 化合物 TN4652	147821-49-6	98%
TN4652	Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in...
T13389	ZD-0892 化合物 T13389	171964-73-1	98%
T13389	ZD-0892 is a selective and poten neutrophil elastaset inhibitor(human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 and 200 nM, respectivel...
T28297	Parsaclisib hydrochloride 化合物Parsaclisib HCl	1995889-48-9	98%
T28297	Parsaclisib hydrochloride (INCB050465 HCl) 是一种选择性的、有效的，具有口服活性的 PI3Kδ抑制剂，IC50=1 nM。它相对于其他 PI3K I 类同工型的选择性约为 20000 倍。它可用于复发或难治性 B 细胞恶性肿瘤的研究。
T6850	GSK2292767 化合物GSK2292767	1254036-66-2	98%
T6850	GSK2292767 是选择性的PI3Kδ的抑制剂，pIC50=10.1。它的选择性比其他 PI3K 亚型高的 500 倍以上。它可用于研究呼吸系统疾病。
T2S0606	Bakkenolide A 蜂斗菜内酯A	19906-72-0	98%
T2S0606	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
TN1347	8-Prenylkaempferol 化合物8-Prenylkaempferol	28610-31-3	98%
TN1347	8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
TQ0313	NVP-BAG956 化合物NVP-BAG956	853910-02-8	98%
TQ0313	NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).
T10660L	CAL-130 Hydrochloride 化合物 T10660L	1431697-78-7	98%
T10660L	CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
TN2328	Zeylenone 山椒子烯酮	193410-84-3	98%
TN2328	Zeylenone 是一种来自 Uvaria grandiflora的环己烯氧化物，具有抗肿瘤和抗癌细胞增殖活性，通过 PI3K/AKT/mTOR 和 MAPK/ERK 信号通路抑制宫颈癌细胞增殖，诱导细胞凋亡 (apoptosis)。