37
20
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20366 |
beta-Nicotyrine
bata-碱二烯,Nicotyrine,alpha-Nicotyrine |
Others | Others |
beta-Nicotyrine 是一种 Nicotine 的代谢物。它是一种微量的烟草生物碱,提取自普通烟草植物的叶子和香烟烟雾冷凝物。 | |||
T27679 |
JNJ-39393406
|
AChR | Neuroscience |
JNJ-39393406 是一种 α7 尼古丁乙酰胆碱受体正异位调节剂,可用于研究烟草依赖和阿尔茨海默病。 | |||
T1366 |
3-Pyridylacetic acid hydrochloride
|
DPP-4 | Proteases/Proteasome |
3-Pyridylacetic acid hydrochloride (3-PAA-HCl)尼克酸的高同系物,是尼古丁(和其它烟草生物碱)的分解产物,还可与胺、醇和羧酸等反应,也可在反应中作为酸催化剂。 | |||
T11668 |
IQB-782
|
Others | Others |
IQB-782 是一种粘液溶解剂,具有粘液溶解祛痰活性。IQB-782 抑制凝血酶活化性纤维蛋白溶解抑制剂,保护大鼠免受烟草烟雾引起的呼吸道阻塞,可降低体外胃粘蛋白悬浮液的粘度,可用于研究阻塞性肺疾病。 | |||
T20533 |
NNK
Nicotine-derived nitrosamine ketone |
Lipoxygenase | Metabolism |
NNK (Nicotine-derived nitrosamine ketone) 是尼古丁亚硝化衍生物。它可以激活 ERK1/2和 PKCα,并在 Ser70 激活 Bcl2磷酸化,以及在 Thr58和 Ser62激活 c-Myc。它可用于构建肺癌小鼠模型,以及诱导人肺癌细胞的增殖和存活。 | |||
T36696 |
DMBA
|
||
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adductsin vivo, and it has been commonly used to induce tumor formation in various rodent models.2,3,1DMBA increase... | |||
T20781 |
Maleic hydrazide
Antergon,Antyrost,Hydrazide maleique,Burtolin,抑芽丹 |
||
Maleic hydrazide, a herbicide, inhibits the sprouting in vegetables and stored root crops, prevents sucker production in tobacco plants, controls the growth of foliage, and grass. | |||
T10318 |
Anatabine dicitrate
|
NF-κB | NF-κB |
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of the amyloid precursor protein. | |||
T36709 |
N’-Nitrosonornicotine
|
||
N’-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N’-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N’-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2 1.Hecht, S.... | |||
T31573 |
DPX-3778
|
||
DPX-3778 is the triethanolamine salt of 3-(p-chlorophenyl)-6-methoxy-s-triazine-2,4(1H,3H) dione, at concentrations of 0.124-2.48 μM enhanced ca. 4-5-fold the proliferation of tobacco (Nicotiana tabacum L. cv. Wisconsin 38) callus cultured in the presence | |||
T35434 |
β-Cembrenediol
|
||
β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate. β-CBT inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro (IC50 = 21.9 μM). It inhibits tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation in vivo. β-CBT is also released into soil by flue-cured tobacco plants and exerts autotoxicity as well as phytotoxic activity against L.... | |||
T68289 |
Nicotine hemicitrate
|
||
Nicotine hemicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. | |||
T68439 |
Nicotine dicitrate
|
||
Nicotine dicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. | |||
T37276 |
2,5-Deoxyfructosazine (hydrochloride)
|
||
2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL... | |||
T23228 |
(R,S)-Anatabine (tartrate) (2743-90-0 free base)
(R,S)-Anatabine (tartrate) |
Others | Others |
Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers, and eggplants. Anatabine is an Aβ inhibitor. (R,S)-Anatabine (tart | |||
T70383 |
Fenamidone
|
||
Fenamidone is a foliar fungicide used on grapes, ornamentals, potatoes, tobacco, and vegetables. It exerts its fungicidal effects by acting as a Qo inhibitor. | |||
T10308 | AMPD2 inhibitor 1 | Others | Others |
AMPD2 inhibitor 1 is an inhibitor of adenosine monophosphate deaminase 2 (AMPD2), used in the research of salt craving, sugar craving, umami craving, and addictions including tobacco, drug, nicotine and alcohol addictions. | |||
T6060L |
Anabasine HCl
BB-NC-0036,CCG-38440,H-8174,AR-1H7273,ZX-BK000320,ST-24041653 |
||
Anabasine HCl is used as a clinical biomarker for tobacco smoke exposure and as an insecticide. It is also a depolarizing NMJ blocker, aromatase inhibitor, nAChr antagonist, and teratogen found in species of Nicotiana. | |||
T79270 |
TMV-IN-6
|
||
TMV-IN-6(Compound 4g)是抗病毒和杀真菌剂,其作用机制为结合烟草花叶病毒(TMV)CP,从而抑制病毒组装,并干扰TMVCP与RNA的组装过程。 | |||
T74713 | TMV-IN-3 | ||
TMV-IN-3是烟草花叶病毒(TMV)的抑制剂,属于查尔酮衍生物类。该化合物对TMV展现出抗病毒活性,其EC50为120.3 μg/mL,适用于感染、炎症以及肿瘤等研究领域。 | |||
T82666 |
Crustacean cardioactive peptide
CCAP |
||
CCAP(Crustacean cardioactive peptide)为一种具有调节昆虫心脏功能的非极性肽,由9个氨基酸组成,最初自tobacco hawkmoth(Manduca sexta)中分离。其结构特征包括第3位与第9位氨基酸的半胱氨酸残基形成的二硫键,以及羧基末端的氨化。 | |||
T69439 |
Nicotine tartrate
|
||
Nicotine tartrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. | |||
T69804 |
Nicotine monomethiodide
|
||
Nicotine monomethiodide is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. | |||
T79269 |
TMV-IN-5
|
||
TMV-IN-5(化合物1a)是一种具有抗植物病毒/真菌活性的化合物。该物质能够通过与烟草花叶病毒(TMV)的CP结合,有效抑制病毒组装,有潜力用于农药开发。 | |||
T62309 |
Antiviral agent 14
|
||
Antiviral agent 14 是一种抗病毒剂,能够抑制烟草花叶病毒 (TMV) (EC50: 135.5 μg/mL),和黄瓜花叶病毒 (CMV) (EC50: 178.6 μg/mL)。 | |||
T71811 |
Lobaric acid
|
||
Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the h... | |||
T36415 |
N-Nitroso-N-methyl-4-Aminobutyric Acid
|
||
N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.1It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.2NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.3 | |||
T74712 | TMV-IN-2 | ||
TMV-IN-2,一种烟草花叶病毒(TMV)抑制剂,属于查尔酮衍生物类别。其对TMV显示出抗病毒活性,其半数有效浓度(EC50)为89.9 μg/mL。该化合物可应用于感染、炎症以及肿瘤的科学研究领域。 | |||
T73379 | TMV-IN-1 | ||
TMV-IN-1为查尔酮衍生物,兼具烟草花叶病毒(TMV)的抑制作用。该化合物对TMV展现出有效活性,其EC50值为70.7 μg/mL与60.8 μg/mL。TMV-IN-1主要用于感染、炎症和肿瘤相关研究。 | |||
T75028 | TMV-IN-4 | ||
TMV-IN-4(compound 3)是一种针对烟草花叶病毒(TMV)的抑制剂。该化合物通过与TMV解旋酶交互作用,能够诱导植物产生抗性并提高对TMV感染的耐受性。TMV-IN-4还可增强过氧化物酶和超氧化物歧化酶活性,从而提升烟草的TMV抗性。 | |||
T70625 |
Nicotine lactate
|
||
Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and Duboisia hopwoodii) and is widely used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it acts as a receptor antagonist. | |||
T79806 |
5-HT2A&5-HT2C agonist-1
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT2A&5-HT2C agonist-1 (Example 2) 是一种选择性的5-HT2A和5-HT2C受体激动剂,其IC50值分别为196 nM和0.9 nM。本化合物主要应用于研究抑郁症、酒精依赖、烟草和可卡因成瘾、炎症、丛集性头痛、PTSD、癫痫等中枢神经系统相关疾病。 | |||
T79805 |
5-HT2 agonist-1 free base
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT2 agonist-1 (Compound 24) free base 是一种作用于5-HT2A, 5-HT2B和5-HT2C受体的激动剂,其IC50值分别为10 nM, 8.3 nM和1.6 nM。该化合物主要应用于研究抑郁症、酒精依赖、烟草及可卡因成瘾、炎症、丛集性头痛、创伤后应激障碍(PTSD)、癫痫以及其他中枢神经系统相关疾病。 | |||
T79804 |
5-HT2 agonist-1
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT2 agonist-1 (Compound 24) 是一种选择性5-HT2A, 5-HT2B和5-HT2C激动剂,其IC50值分别为10 nM, 8.3 nM和1.6 nM。5-HT2 agonist-1 free base主要用于研究治疗抑郁症、酗酒、吸烟与可卡因依赖、炎症、丛集性头痛、创伤后应激障碍(PTSD)、癫痫以及其他中枢神经系统疾病。 | |||
T78135 |
Nicotelline
Nicotellin |
||
Nicotelline(Nicotellin)是一种与尼古丁相关的生物碱,作为人类cDNA表达的细胞色素P-450 2A6(CYP2A6)的弱抑制剂,不显著抑制该酶介导的香豆素7-羟基化反应,在300 μM浓度下效果更是如此。此外,Nicotelline还被用作烟草烟雾中颗粒物(PM)的示踪剂和生物标记物。 | |||
T69230 | AZD-1236 | ||
AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished ... | |||
T37202 |
CC4
CC4 |
||
High affinity and subtype selective α6β2 and α4β2 partial agonist (Ki values are 12 and 26nM for rat α6β2 and α4β2 receptors respectively). Has low affinity for α3β4 and α7 receptors (Ki values are 4.8 and 13 μM for human α3β4 and rat α7 receptors respectively). Stimulates dopamine release from striatal slices in vitro. Attenuates nicotine-induced self-administration and conditional place preference in rats. Sala et al (2013) CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7671 |
Myosmine
麦司明,麦斯明 |
Others; AChR | Neuroscience; Others |
Myosmine 是存在于木贼中的一种烟草生物碱,对 a4b2 烟碱乙酰胆碱受体具有低亲和力,Ki 值为 3300 nM。 | |||
TN6848 |
Piperonylic acid
胡椒酸,2H-1,3-benzodioxole-5-carboxylic acid |
P450 | Metabolism |
Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) 是一种具有亚甲二氧基活性的天然分子,与反式肉桂酸结构相似,可作为选择性反式肉桂酸 4-羟化酶的灭活剂。 | |||
TN1130 |
Yadanziolide A
鸦胆子素 H,鸦胆子内酯A |
Antiviral | Immunology/Inflammation |
Yadanziolide A 来源于 Brucea javanica 干燥的种子。它具有强的抗病毒作用,能够抗烟草花叶病毒(IC50:5.5 μM)。它具有抗肿瘤活性。 | |||
T3236 |
Solanesol
Betulanonaprenol,茄尼醇,Nonaisoprenol |
Others; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; Others |
Solanesol (Betulanonaprenol) 是主要存在于茄科植物中的脂肪族萜烯醇,有抗炎、神经保护和抗菌活性。 | |||
T13857 |
(R,S)-Anatabine
|
Others | Others |
(R,S)-Anatabine 是一种茄科植物中发现的次要烟草生物碱,可用于烟草使用中特定标记物的检测。 | |||
T7224 |
Anabasine
(+)-假木贼碱,硫苯咪唑砜,(S)-Anabasine,(-)-Anabasine |
AChR | Neuroscience |
Anabasine ((S)-Anabasine) 是一种从烟草中提取的生物碱。Anabasine 是一种烟碱乙酰胆碱受体的全激动剂 (nAChRs),具有杀虫活性。Anabasine 促使内源表达人肌型 nAChRs 的 TE671 细胞去极化。 | |||
T3158 |
Harmane
Loturine,Harman,Aribine,哈尔满碱 |
Adrenergic Receptor; Monoamine Oxidase; Imidazoline Receptor | GPCR/G Protein; Neuroscience |
Harmane (Loturine) 是一种在咖啡和烟草烟雾中发现的 β-咔啉生物碱,是有效的神经毒素,可引起严重的动作震颤和精神病学表现。它还是选择性的单胺氧化酶抑制剂,具有致突变作用,对 MAO A/B 的 IC50值分别为 0.5 和 5 μM。 | |||
T1202 |
Cotinine
(-)-Cotinine,S-(-)-Cotinine,(S)-Cotinine,NIH-10498,可替宁 |
Endogenous Metabolite; AChR | Metabolism; Neuroscience |
Cotinine (NIH-10498) 是烟草中的生物碱, 也是尼古丁的主要代谢物。Cotinine (NIH-10498) 是测量烟草烟雾成分的生物指标。 | |||
T67319 |
2',4'-Dimethylacetophenone
|
Endogenous Metabolite | Metabolism |
2',4'-Dimethylacetophenone 是一种可用于生物研究的化学物。该化合物可用于气相色谱法检测烟草化合物中的醛固酮香气,可以用于保护食品。 | |||
T2904 |
Sclareolide
香紫苏内酯,Norambreinolide |
Others; Antibacterial | Microbiology/Virology; Others |
Sclareolide (Norambreinolide) 是一种从Salvia sclarea 的花中分离得到的天然产物,具有抗菌和细胞毒性作用。 | |||
T35455 |
N-Nitrosodiethylamine
Diethylnitrosamine,NDEA |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
N-Nitrosodiethylamine (NDEA) 是致癌物质二烷基硝胺。它主要存在于水、烟草烟雾、腌制食品、油炸食品以及许多酒精饮料中。它与 DNA 修复/复制相关的核酶的变化相关。 | |||
TN6395 |
Citrusin B
|
||
Citrusin B exhibits moderate in vitro inhibitory effect on tobacco mosaic virus replication with IC50 values 0.26 mmol L⁻1. | |||
TN4655 | Nicotine 1'-N-oxide | Others | Others |
Nicotine 1'-N-oxide is a natural product from tobacco smoke. | |||
T19122 | 3-Methylvaleric Acid | Others; Endogenous Metabolite | Metabolism; Others |
3-Methylvaleric Acid 是一种食用级香料,存在于烟草中。3-Methylvaleric Acid 可增强 CHO-K1细胞和HEK293细胞中的细胞内cAMP 积累和CRE-荧光素酶活性。 | |||
T39918 |
(±)-Phrymarolin II
|
||
(±)-Phrymarolin II is a promising new class of plant virus (tobacco mosaic virus) inhibitors. | |||
TN1436 |
Methyl 4-Hydroxyphenylacetate
对羟基苯乙酸甲酯,4-羟基苯乙酸甲酯 |
Antifection | Microbiology/Virology |
Methyl 4-Hydroxyphenylacetate has potent inhibitory activity against tobacco mosaic virus (TMV). | |||
TN5942 |
Dammarenediol II
达玛烯二醇II,Dammar-24-ene-3,20-diol |
||
Dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy, it can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber forma | |||
T19128 | 3-Pyridineacetic acid | Others | Others |
3-Pyridineacetic acid is a homolog of nicotinic acid, a breakdown product of nicotine and other tobacco alkaloids. | |||
T79994 |
7-Deoxy-trans-dihydronarciclasine
|
||
7-Deoxy-trans-dihydronarciclasine 作为生物碱,担任烟草花叶病毒(TMV)抑制剂(IC50: 1.80 μM),亦具有抗神经炎症作用,能够降低Tg2576小鼠大脑皮质中Aβ与APP水平。 | |||
T36489 |
Malformin A
|
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Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferati... |