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Search Results for " sulfhydryl "

33

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16251	N-Succinimidyl-S-acetylthioacetate SATA,N-丁二酸，S-乙酰基巯基乙二醇酯	Others	Others
	N-Succinimidyl-S-acetylthioacetate (SATA) 是蛋白质修饰剂，它能够以受保护的形式将巯基添加到蛋白质和其他含胺分子中。
T19780	2,2′-Dipyridyl disulfide 2,2'-Dipyridyl disulfide,OPSS,2,2'-二硫二吡啶,Aldrithiol 2,Orthopyridyl disulfide	Others	Others
	2,2′-Dipyridyl disulfide (Aldrithiol 2) 是肽化学中的常用试剂，是测定巯基的有用试剂，常用于氧化还原缩合以形成肽键或用于偶联反应以形成二硫键连接的异二聚体。
T3088	N-Ethylmaleimide 1-Ethyl-1H-pyrrole-2,5-dione,n-乙基马来酰亚胺,Ethylmaleimide,NEM	Cysteine Protease; DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Proteases/Proteasome; Ubiquitination
	N-Ethylmaleimide (NEM) 是烷基化自由巯基的试剂，是一种半胱氨酸蛋白酶抑制剂，用于实验生化研究。它也是一种去泛素化酶抑制剂，特异性抑制线粒体中的磷酸盐转运。
T20121	L-Albizziin NSC-132089,L-beta-Ureidoalanine,L-Albizziine,Albizzine,NSC 132089,Albizziin,L-脲基丙氨酸	Glutaminase	Proteases/Proteasome
	L-Albizziin (L-beta-Ureidoalanine) 是一种巯基试剂，是一种谷氨酰胺酶抑制剂，可用于研究癌症。
T19955	Biotin-HPDP Pyridyldisulfide-biotin,Pyridyldithiol-biotin	Others	Others
	Biotin-HPDP (Pyridyldithiol-biotin) 是一种巯基反应性生物素化试剂。
T21334	Bucillamine DE-019,Thiobutarit,Tiobutarit,布西拉明,SA96,DE 019,DE019	VEGFR; Antioxidant	Angiogenesis; oxidation-reduction; Tyrosine Kinase/Adaptors
	Bucillamine (DE019) 可防止高危器官移植中的缺血/再灌注损伤，抑制 VEGF 的产生。 Bucillamine 是一种具有抗风湿和抗血管生成特性的口服活性巯基供体和抗氧化剂。 Bucillamine 可用于脉络膜新生血管和类风湿性关节炎的研究。
T17389	AMAS	Others	Others
	AMAS 是一种不可裂解的异双功能交联剂，具有 NHS 酯和马来酰亚胺基团，可实现含胺和巯基分子的共价结合。
T1414	Sodium 2-mercaptoethanesulfonate Mitexan,美司那,美司钠,Uromitexan,Mesna,Mesnum,Mesnex	Others	Others
	Sodium 2-mercaptoethanesulfonate (Uromitexan) 是一种抗氧化剂，具有细胞保护作用。它可用于减轻由环磷酰胺引起的出血性膀胱炎。它广泛用作抗化学疗法毒性的全身保护剂。
T6741	SPDP SPDP Crosslinker	Others	Others
	SPDP 是一种短链交联剂，用于通过 NHS 酯和吡啶基二硫醇反应基团与半胱氨酸巯基形成可切割（可还原）的二硫键，实现胺与巯基的共轭。它是一种可降解的 ADC 连接剂，可用于合成抗体偶联药物。
T18728	Sulfo-SMCC sodium	Others	Others
	Sulfo-SMCC sodium 是一种异双功能、不可裂解的 ADC 交联剂，带有 N-羟基琥珀酰亚胺酯和马来酰亚胺基团，分别与伯胺和巯基反应。
T5030	Zofenopril calcium SQ26991,佐芬普利钙,Zofenopril (calcium)	RAAS; Reactive Oxygen Species	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Zofenopril calcium (SQ26991) 是一种抗氧化剂和血管紧张素转化酶 (ACE) 抑制剂。
T1484L	Perindopril erbumine 培哚普利叔丁胺,培哚普利叔丁胺盐,S9490-3,Perindopril tert-butylamine salt	Apoptosis; RAAS; MRP	Apoptosis; Endocrinology/Hormones; Immunology/Inflammation
	Perindopril erbumine (S9490-3) 是一种长效血管紧张素转换酶抑制剂。
T0893	Tinidazole 替硝唑,CP12574	Antibacterial; Antibiotic	Microbiology/Virology
	Tinidazole (CP12574) 是一种对厌氧菌和原生动物具有选择性抗菌活性的 5-硝基咪唑，是一种具有口服活性的抗菌剂。
T1756	Ilaprazole sodium IY-81149 sodium,艾普拉唑钠	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole sodium (IY-81149 sodium) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制 H+/K+-ATPase，在兔壁细胞制剂中的 IC50为 6 μM。它也是一种有效的 T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T26065	Rev 5975
	Rev 5975 is a non-sulfhydryl ACE-inhibitor.
T70884	Moexipril methyl ester
	Moexipril methyl ester is a long-acting, non-sulfhydryl angiotensine-converting enzyme inhibitor.
T26067	Rev 6207 Rev-6207
	Rev 6207 is a non-sulfhydryl ACE-inhibitor.
T20758	Trandolaprilat RU44403,RU-44403,Trandolaprilate,Trandolaprilatum,RU 44403
	Trandolaprilat is an inhibitor of non-sulfhydryl angiotensin-converting enzyme.
T26066	Rev 6134 Rev6134,Rev-6134
	Rev 6134 is an ACE-inhibitor with non-sulfhydryl containing.
T21269	Sulfo-EMCS
	Sulfo-EMCS is a heterobifunctional sulfhydryl- and amine-reactive crosslinker.
T19956	Iodoacetyl-LC-Biotin Iaa-Biotin
	Iodoacetyl-LC-Biotin reacts with sulfhydryl groups to form stable thioether linkages.
T19942	SBA Crosslinker SBA Cross-linker,SBA Cross linker
	SBA crosslinker is a sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. SBA protein crosslinker is non-cleavable and is among the shortest amine and sulfhydryl reactive crosslinking reagents known with a spacer arm length of on
T71555	Moexipril ethyl ester
	Moexipril ethyl ester is a long-acting, non-sulfhydryl angiotensine-converting enzyme inhibitor.
T19941	MBS Crosslinker MBS protein crosslinker
	MBS crosslinker is a non-cleavable, water-insoluble, heterobifunctional protein crosslinking reagent. The MBS protein crosslinker extended spacer arm analog is SMPB crosslinker SATA Protein Modifier can be used to add sulfhydryl groups to proteins or pept
T19437	MTSEA hydrobromide	Others	Others
	MTSEA hydrobromide is a sulfhydryl-reactive compound that modifies free cysteine residues to produce a positively charged side chain similar in size to lysine.
T19568	Sulfo-SMPB sodium	Others	Others
	Sulfo-SMPB sodium is a non-cleavable heterobifunctional chemical cross-linking reagent that combines N-hydroxysuccinimide ester and maleimide groups. This compound enables the covalent conjugation of molecules possessing amine and sulfhydryl functionalities.
T19943	SMPB Crosslinker SMPB Cross linker,SMPB Cross-linker
	SMPB crosslinker is a heterobifunctional protein crosslinking reagent that is reactive toward sulfhydryl and amino groups. The SMPB protein crosslinker is an extended chain length analog of MBS crosslinker. SMPB crosslinker's spacer arm is non-cleavable.
T81904	Lucifer yellow iodoacetamide dipotassium
	Lucifer yellow iodoacetamide dipotassium为一种反应性巯基荧光示踪剂，具备巯基与特定生物分子反应的能力，广泛应用于生物化学与分子生物学研究中。
T17834	DM4-SPDP	Others	Others
	DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drug conjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amine-to-sulfhydryl conjugation, leveraging NHS-ester and pyridyldithiol groups to establish cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].
T27974	Maleimide-PEG4-NHS MAL-PEG-NHS,Maleimide PEG NHS,Maleimido-Tetra(Ethylene Glycol)-Acetic Acid NHS ester,MAL-PEG4-NHS
	Maleimide-PEG4-NHS is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds formed through Maleimide-PEG4-NHS linker are stable and are not cleavable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond wh
T71768	CB10-277
	CB10-277 is a synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups.
T38351	DYn-2
	Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH). Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells. DYn-2 consists of 1,3-cyclohexanedione coupled to an alkyne moiety by a 3-carbon spacer. The cyclohexanedione group selectively reacts with protein sulfenic acid modifications. The a...
T68012	rebimastat
	Rebimastat 是基于巯基的第二代基质金属蛋白酶(MMP)抑制剂，具有潜在的抗肿瘤活性。利莫司他选择性抑制几种 MMPs (MMP 1、2、8、9和14)，从而诱导细胞外基质降解，抑制血管生成、肿瘤生长、侵袭和转移。

化合物

N-Succinimidyl-S-acetylthioacetate

Cat.No: T16251

Synonym: SATA,N-丁二酸，S-乙酰基巯基乙二醇酯

Target: Others

2,2′-Dipyridyl disulfide

Cat.No: T19780

Synonym: 2,2'-Dipyridyl disulfide,OPSS,2,2'-二硫二吡啶,Aldrithiol 2,Orthopyridyl disulfide

Target: Others

N-Ethylmaleimide

Cat.No: T3088

Synonym: 1-Ethyl-1H-pyrrole-2,5-dione,n-乙基马来酰亚胺,Ethylmaleimide,NEM

Target: Cysteine Protease, DUB

Cat.No: T20121

Synonym: NSC-132089,L-beta-Ureidoalanine,L-Albizziine,Albizzine,NSC 132089,Albizziin,L-脲基丙氨酸

Target: Glutaminase

Cat.No: T19955

Synonym: Pyridyldisulfide-biotin,Pyridyldithiol-biotin

Target: Others

Cat.No: T21334

Synonym: DE-019,Thiobutarit,Tiobutarit,布西拉明,SA96,DE 019,DE019

Target: VEGFR, Antioxidant

Cat.No: T17389

Target: Others

Sodium 2-mercaptoethanesulfonate

Cat.No: T1414

Synonym: Mitexan,美司那,美司钠,Uromitexan,Mesna,Mesnum,Mesnex

Target: Others

Cat.No: T6741

Synonym: SPDP Crosslinker

Target: Others

Sulfo-SMCC sodium

Cat.No: T18728

Target: Others

Zofenopril calcium

Cat.No: T5030

Synonym: SQ26991,佐芬普利钙,Zofenopril (calcium)

Target: RAAS, Reactive Oxygen Species

Perindopril erbumine

Cat.No: T1484L

Synonym: 培哚普利叔丁胺,培哚普利叔丁胺盐,S9490-3,Perindopril tert-butylamine salt

Target: Apoptosis, RAAS, MRP

Cat.No: T0893

Synonym: 替硝唑,CP12574

Target: Antibacterial, Antibiotic

Ilaprazole sodium

Cat.No: T1756

Synonym: IY-81149 sodium,艾普拉唑钠

Target: Proton pump, TOPK

Cat.No: T26065

Moexipril methyl ester

Cat.No: T70884

Cat.No: T26067

Synonym: Rev-6207

Cat.No: T20758

Synonym: RU44403,RU-44403,Trandolaprilate,Trandolaprilatum,RU 44403

Cat.No: T26066

Synonym: Rev6134,Rev-6134

Cat.No: T21269

Iodoacetyl-LC-Biotin

Cat.No: T19956

Synonym: Iaa-Biotin

SBA Crosslinker

Cat.No: T19942

Synonym: SBA Cross-linker,SBA Cross linker

Moexipril ethyl ester

Cat.No: T71555

MBS Crosslinker

Cat.No: T19941

Synonym: MBS protein crosslinker

MTSEA hydrobromide

Cat.No: T19437

Target: Others

Sulfo-SMPB sodium

Cat.No: T19568

Target: Others

SMPB Crosslinker

Cat.No: T19943

Synonym: SMPB Cross linker,SMPB Cross-linker

Lucifer yellow iodoacetamide dipotassium

Cat.No: T81904

Cat.No: T17834

Target: Others

Maleimide-PEG4-NHS

Cat.No: T27974

Synonym: MAL-PEG-NHS,Maleimide PEG NHS,Maleimido-Tetra(Ethylene Glycol)-Acetic Acid NHS ester,MAL-PEG4-NHS

Cat.No: T71768

Cat.No: T38351

Cat.No: T68012

Cat. No.	Product Name	Target	Signaling Pathways
T1085L	Glutathione oxidized Bi(glutathion-S-yl),Oxidized glutathione,L-谷胱甘肽(氧化型),氧化型谷胱甘肽,L-Glutathione oxidized,Glutathione disulfide,L(-)-Glutathione,GSSG	Reactive Oxygen Species; Endogenous Metabolite; Glutathione reductase	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Glutathione oxidized (L(-)-Glutathione) 是氧化型谷胱甘肽，谷胱甘肽是细胞内一种主要的抗氧化剂和解毒剂。
T1630	Tiopronin Thiopronine,硫普罗宁,Acadione,Captimer	ROS	Immunology/Inflammation
	Tiopronin (Acadione) 是可扩散的抗氧化剂，是重金属中毒的解毒剂和辐射防护剂。它可控制胱氨酸沉淀和排泄的速度，有用于胱氨酸尿症、类风湿性关节炎和肝病的研究潜力。
T15467	Helenalin	Others	Others
	Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.
T75671	Senecionine acetate
	Senecionine acetate (O-Acetylsenecionine)为吡咯烷核生物碱，通过使游离巯基失活，抑制线粒体及其区域内Ca2+的螯合。
T10928	Cytochalasin A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhy

天然产物

Glutathione oxidized

Cat.No: T1085L

Synonym: Bi(glutathion-S-yl),Oxidized glutathione,L-谷胱甘肽(氧化型),氧化型谷胱甘肽,L-Glutathione oxidized,Glutathione disulfide,L(-)-Glutathione,GSSG

Target: Reactive Oxygen Species, Endogenous Metabolite, Glutathione reductase

Cat.No: T1630

Synonym: Thiopronine,硫普罗宁,Acadione,Captimer

Target: ROS

Cat.No: T15467

Target: Others

Senecionine acetate

Cat.No: T75671

Cat.No: T10928

Target: HIV Protease

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