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Search Results for " skin infections "

32

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5189	Omadacycline PTK 0796,Amadacycline	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Omadacycline (Amadacycline) 是一种具有口服活性的氨基甲基环素抗菌剂，是四环素类抗生素。它与 30S 核糖体亚基结合，抑制细菌蛋白质合成。它可用于研究急性细菌性皮肤和皮肤结构感染，感染性肺炎和尿路感染。
T1495	Cefaclor monohydrate Cefaclor,头孢克洛一水物,头孢克洛一水合物,Cefaclorum,Cefachlor	Antibacterial; Antibiotic	Microbiology/Virology
	Cefaclor monohydrate (Cefaclorum) 是一种抗生素，可特异性地结合青霉素结合蛋白。
T6436	Cefaclor Panoral,Kefral,Cefaclorum,头孢克洛	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Cefaclor (Panoral) 是一种可特异性结合青霉素结合蛋白的抗生素。
T14179	Aliconazole	Antifungal	Microbiology/Virology
	Aliconazole 是一种具有抗真菌活性的咪唑衍生物，可用于研究皮肤感染。
T19794	Temafloxacin 替马沙星,Omniflox	Antibiotic	Microbiology/Virology
	Temafloxacin (Omniflox) 是一种喹诺酮类广谱抗菌剂，对革兰氏阳性菌、革兰氏阴性菌和厌氧菌均有效。
T0087L	Sulfacetamide sodium Sulamyd sodium,磺乙酰胺钠盐,磺胺醋酰钠	Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology
	Sulfacetamide sodium (Sulamyd sodium) 是磺胺类抗感染剂，可局部用于口服治疗尿路感染和皮肤感染。
T7902	Ozenoxacin 奥泽沙星,T-3912	Antibacterial	Microbiology/Virology
	Ozenoxacin (T-3912) 是一种非氟喹诺酮抗菌剂，对大多数从在皮肤和软组织感染中分离的微生物有活性。
T0897	Nitrofurazone NFZ,呋喃西林,Nitrofural,Furacilin	Dehydrogenase; Antibacterial; Glutathione reductase; Antibiotic	Metabolism; Microbiology/Virology; oxidation-reduction
	Nitrofurazone (Furacilin) 是一种抗生素。
T4985	Neticonazole Hydrochloride	Antifungal	Microbiology/Virology
	Neticonazole hydrochloride 是一种咪唑衍生物，具有抗感染和抗癌作用。它也是一种长效抗真菌剂。
T0979	Dequalinium chloride Dequafungan,地喹氯铵,Danical,Decabis	Potassium Channel; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel
	Dequalinium chloride (Decabis) 是一种apamin 敏感型的钾离子通道选择性阻断剂。
T10797	Chlormidazole hydrochloride Clomidazole hydrochloride	Antifungal	Microbiology/Virology
	Chlormidazole hydrochloride (Clomidazole hydrochloride) 是一种抗真菌剂，抑制多种真菌和部分革兰氏阳性球菌，可治疗指甲和皮肤的真菌和细菌感染。
T7725	Albaconazole W 0027,UR-9825,UR9825,W-0027	P450; Antifungal	Metabolism; Microbiology/Virology
	Albaconazole (W-0027)是一种小分子真菌细胞色素P450家族成员51 (fungal CYP51A1)抑制剂。它可用于治疗真菌感染、皮肤和肌肉骨骼疾病，可用于研究外阴阴道念珠菌病、Chagas病和泌尿生殖系统疾病。
T0314	Hexylresorcinol 己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol	Apoptosis; Tyrosinase; Antibacterial; Parasite	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然产物，具有抗菌、驱虫、防腐和抗肿瘤活性。它是一种可逆、非竞争性的 α-葡萄糖苷酶抑制剂，有抗 DNA 氧化损伤的保护作用。它可诱导鳞癌细胞凋亡。
T0133	Cefdinir FK-482,头孢地尼,CI-983,PD 134393	Glutathione Peroxidase; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology
	Cefdinir (FK-482) 是头孢菌素类中的一种半合成广谱抗生素，对几种革兰氏阴性和革兰氏阳性细菌引起的感染有效。它可研究耳，鼻窦，喉咙和皮肤的常见细菌感染。
T15095	Dehydroemetine	Others; Parasite	Microbiology/Virology; Others
	Dehydroemetine 是一种有效的抗原虫剂，是二盐酸艾美汀的合成类似物，可用于预防和治疗阿米巴感染和疾病，具有治疗伴有皮肤损伤的利什曼原虫感染和耐甲硝唑阿米巴病的作用。
T20693	Oxiconazole Oxiconazolum,Ro13-8996,Ro 13-8996,Ro-13-8996
	Oxiconazole, an antifungal medicine, is used to treat certain kinds of yeast or fungal infections of the skin.
T23622	Acorafloxacin HCl JNJ-32729463,JNJ-Q2 hydrochloride,Acorafloxacin hydrochloride,JNJ 32729463,JNJ-Q2 HCl
	Acorafloxacin is a broad-spectrum fluoroquinolone antibacterial drug being developed for the treatment of acute bacterial skin and skin structure infections and community-acquired pneumonia.
T10420	Avarofloxacin JNJ-Q2	Others	Others
	Avarofloxacin (JNJ-Q2) is a broad-spectrum fluoroquinolone antibacterial drug being developed for the treatment of acute bacterial skin and community-acquired pneumonia and skin structure infections.
T30789	Cefovecin Sodium UK 287,074-02,UK-287,074-02,C13142,D01681,UK287,074-02
	Cefovecin Sodium(Convenia) is an antibiotic of the cephalosporin class, licensed for the treatment of skin infections in cats and dogs.
T37881	Oritavancin(LY-333328)
	Oritavancin is a novel semisynthetic glycopeptide antibiotics. On August 6, 2014, the FDA approved oritavancin for treatment of skin infections. Oritavancin possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible Gram-positive bacteria, including Staphylococcus aureus, MRSA, enterococci, and streptococci.
T78112	Voxvoganan trihydrochloride LTX-109 trihydrochloride
	Voxvoganan (LTX-109) trihydrochloride为有效的局部抗菌剂，特别是针对S. aureus，其MIC为2-4 μg/mL。该化合物主要用于研究细菌性皮肤感染和真菌感染。
T10071	Itch-Targeting Compound 1	Others	Others
	Itch-Targeting Compound 1是一种止痒化合物，对昆虫叮咬的反应、对环境过敏原的反应、皮肤感染、外部恶臭或肾透析患者发生的瘙痒均可有效预防或治疗。
T36441	Contezolid acefosamil sodium
	Contezolid acefosamil sodium (MRX-4) is a novel orally active oxazolidinone antibiotic under investigation for the treatment of complicated skin and soft tissue infections (cSSTI) caused by drug-resistant Gram-positive bacteria. It possesses strong efficacy against these pathogens while significantly minimizing the risks of myelosuppression and monoamine oxidase inhibition (MAOI) [1][2].
T74144	Zifanocycline
	Zifanocycline (KBP-7072) 为半合成第三代氨甲基环素类抗生素，通过抑制细菌核糖体功能而发挥作用。它对革兰氏阳性菌和革兰氏阴性菌[包括多重耐药病原体]显示出广泛的体外抗菌活性。适用于口服和注射形式，Zifanocycline 主要用于研究治疗急性细菌性皮肤及其结构感染、社区获得性细菌性肺炎以及复杂腹腔感染。
T75256	Cefilavancin
	Cefilavancin (TD-1792) 为有效的多价糖肽-头孢类异二聚体 antibiotic，针对革兰氏阳性 bacteria 显示良好抗性。该化合物在皮肤感染的研究中得到应用。
T80731	Zifanocycline TFA KBP-7072 TFA
	Zifanocycline TFA (KBP-7072) 是一种半合成的氨基糖苷类抗生素，具有口服活性并能抑制细菌核糖体功能。它对广泛的革兰氏阳性菌和阴性菌示出了体外抗菌活性，包括多种耐药病原体。Zifanocycline TFA 适用于急性细菌性皮肤及皮肤结构感染、社区获得性细菌性肺炎和复杂的腹腔感染的研究。
T74717	12-Hydroxynevirapine
	12-Hydroxyvirapine (12-hydroxy-NVP; 12-OH-NVP) 是奈韦拉平的主要氧化代谢产物。奈韦拉平是一种非核苷类逆转录酶抑制剂，适用于 HIV-1感染，会引起特异性肝毒性和轻度至重度皮疹。12-Hydroxynevirapine 是一种非反应性代谢物，可被肝脏和皮肤中的磺基转移酶 (SULT) 生物激活，产生活性物质 12-Sulphoxy-nevirapine。
T60238	Acloproxalap
	Acloproxalap 是一种基于喹啉的醛清除剂，可用于研究有毒醛积累的疾病，如眼部、皮肤等炎症性疾病，肺炎等呼吸系统疾病，器官疾病以及病毒感染相关性综合症等。
T83758	SAAP 148 TFA Synthetic Antimicrobial and Antibiofilm Peptide 148
	SAAP 148是一种抗菌肽。在体外，它对多种耐多药的细菌有活性。在体内，SAAP 148（0.125-2% w/w）能减少小鼠A. baumannii或耐甲氧西林金黄色葡萄球菌（MRSA）感染模型中皮肤菌落形成单位（CFUs）的数量。
T73859	Methicillin sodium hydrate
	Methcillin sodium hydrate 是一种窄谱 β-内酰胺类抗生素，通过抑制青霉素结合蛋白 (penicillin-binding proteins,PBP) 发挥作用。Methcillin sodium hydrate 对青霉素耐药性的金黄色葡萄球菌Staphylococcus aureu 和表皮葡萄球菌Staphylococcus epidermidis 有活性。Methcillin sodium hydrate 可用于研究皮肤感染、骨髓炎和心内膜炎等疾病。
T70642	Lanopepden camsylate
	Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the trea...
T74591	Ceftaroline fosamil (hydrate)(acetate)
	Ceftaroline fosamil hydrate acetate 是一种高效的头孢菌素类抗生素(antibiotic)，对多种病原体有广谱活性，特别是针对革兰氏阳性病原体，如耐甲氧西林金黄色葡萄球菌(MRSA)和耐多药肺炎链球菌，以及常见的革兰氏阴性微生物。此外，Ceftaroline fosamil hydrate acetate 在治疗复杂皮肤及皮肤结构感染(cSSSIs)和社区获得性肺炎(CABP)方面表现出显著的抗感染活性。

化合物

Cat.No: T5189

Synonym: PTK 0796,Amadacycline

Target: ribosome, Antibacterial, Antibiotic

Cefaclor monohydrate

Cat.No: T1495

Synonym: Cefaclor,头孢克洛一水物,头孢克洛一水合物,Cefaclorum,Cefachlor

Target: Antibacterial, Antibiotic

Cat.No: T6436

Synonym: Panoral,Kefral,Cefaclorum,头孢克洛

Target: Others, Antibacterial, Antibiotic

Cat.No: T14179

Target: Antifungal

Cat.No: T19794

Synonym: 替马沙星,Omniflox

Target: Antibiotic

Sulfacetamide sodium

Cat.No: T0087L

Synonym: Sulamyd sodium,磺乙酰胺钠盐,磺胺醋酰钠

Target: Antibacterial, Antibiotic, Autophagy

Cat.No: T7902

Synonym: 奥泽沙星,T-3912

Target: Antibacterial

Cat.No: T0897

Synonym: NFZ,呋喃西林,Nitrofural,Furacilin

Target: Dehydrogenase, Antibacterial, Glutathione reductase, Antibiotic

Neticonazole Hydrochloride

Cat.No: T4985

Target: Antifungal

Dequalinium chloride

Cat.No: T0979

Synonym: Dequafungan,地喹氯铵,Danical,Decabis

Target: Potassium Channel, PKC

Chlormidazole hydrochloride

Cat.No: T10797

Synonym: Clomidazole hydrochloride

Target: Antifungal

Cat.No: T7725

Synonym: W 0027,UR-9825,UR9825,W-0027

Target: P450, Antifungal

Hexylresorcinol

Cat.No: T0314

Synonym: 己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol

Target: Apoptosis, Tyrosinase, Antibacterial, Parasite

Cat.No: T0133

Synonym: FK-482,头孢地尼,CI-983,PD 134393

Target: Glutathione Peroxidase, Antibacterial, Antibiotic

Cat.No: T15095

Target: Others, Parasite

Cat.No: T20693

Synonym: Oxiconazolum,Ro13-8996,Ro 13-8996,Ro-13-8996

Acorafloxacin HCl

Cat.No: T23622

Synonym: JNJ-32729463,JNJ-Q2 hydrochloride,Acorafloxacin hydrochloride,JNJ 32729463,JNJ-Q2 HCl

Cat.No: T10420

Synonym: JNJ-Q2

Target: Others

Cefovecin Sodium

Cat.No: T30789

Synonym: UK 287,074-02,UK-287,074-02,C13142,D01681,UK287,074-02

Oritavancin(LY-333328)

Cat.No: T37881

Voxvoganan trihydrochloride

Cat.No: T78112

Synonym: LTX-109 trihydrochloride

Itch-Targeting Compound 1

Cat.No: T10071

Target: Others

Contezolid acefosamil sodium

Cat.No: T36441

Cat.No: T74144

Cat.No: T75256

Zifanocycline TFA

Cat.No: T80731

Synonym: KBP-7072 TFA

12-Hydroxynevirapine

Cat.No: T74717

Cat.No: T60238

Cat.No: T83758

Synonym: Synthetic Antimicrobial and Antibiofilm Peptide 148

Methicillin sodium hydrate

Cat.No: T73859

Lanopepden camsylate

Cat.No: T70642

Ceftaroline fosamil (hydrate)(acetate)

Cat.No: T74591

Cat. No.	Product Name	Target	Signaling Pathways
T0971	Dirithromycin Dirithromycinum,地红霉素,ASE 136,LY237216,Diritromicina,Dirithromycine	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Dirithromycin (LY237216) 是一种红霉素衍生物，是一种具有口服活性的半合成大环内酯类抗生素。它用于治疗许多不同类型的细菌感染。
T0281	Meclocycline sulfosalicylate salt 磺基水杨酸甲氯环素,Meclutin,Mecloderm,甲环素磺基水杨酸盐,Meclan Cream	Antibacterial; Antibiotic	Microbiology/Virology
	Meclocycline sulfosalicylate salt (Mecloderm) 是一种具有广谱抗菌活性的四环素抗生素，可预防皮肤细菌感染。
TN5284	Sodium Houttuyfonate Houttuynin sodium bisulfite,新鱼腥草素钠	NF-κB; Antibacterial; Antifungal	Microbiology/Virology; NF-κB
	Sodium Houttuyfonate (Houttuynin sodium bisulfite) 是亚硫酸氢钠与鱼腥草结合而成的活性化合物，具有抗真菌、抗菌、抗炎和心血管保护活性，主要用于治疗化脓性皮肤感染、呼吸道感染，包括老年患者的肺炎和慢性支气管炎。
T1289	Fusidic acid sodium salt Sodium fusidate,夫西地酸钠,Fusidate Sodium,Fucidin,SQ-16360	Others; CAT; Antibacterial; Antibiotic	Microbiology/Virology; Others; oxidation-reduction
	Fusidic acid sodium salt (SQ-16360) 是一种Fusidium coccineum 属甾体类抑菌抗生素。它阻止核糖体释放翻译延长因子G 来抑制细菌生长。
T25998	Pseudomonic acid D Pseudomonic D
	Pseudomonic acid D is a topical antibiotic agent used against superficial skin infections such as impetigo or folliculitis.
T80356	Bombinin H2
	Bombinin H2, 源自Bombina variegata蛾皮肤的抗菌肽。

天然产物

Cat.No: T0971

Synonym: Dirithromycinum,地红霉素,ASE 136,LY237216,Diritromicina,Dirithromycine

Target: ribosome, Antibacterial, Antibiotic

Meclocycline sulfosalicylate salt

Cat.No: T0281

Synonym: 磺基水杨酸甲氯环素,Meclutin,Mecloderm,甲环素磺基水杨酸盐,Meclan Cream

Target: Antibacterial, Antibiotic

Sodium Houttuyfonate

Cat.No: TN5284

Synonym: Houttuynin sodium bisulfite,新鱼腥草素钠

Target: NF-κB, Antibacterial, Antifungal

Fusidic acid sodium salt

Cat.No: T1289

Synonym: Sodium fusidate,夫西地酸钠,Fusidate Sodium,Fucidin,SQ-16360

Target: Others, CAT, Antibacterial, Antibiotic

Pseudomonic acid D

Cat.No: T25998

Synonym: Pseudomonic D

Cat.No: T80356

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