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8

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TD0102	1,3-Diphenylisobenzofuran DPBF	Others	Others
	1,3-Diphenylisobenzofuran (DPBF) 是一种荧光探针，对单线态氧(1O2) 的具有高特异性，可形成内过氧化物并分解成 1,2-dibenzoylbenzene，可用于活性氧生成的检测。
T20548	Parabanic acid NSC9789,NSC-9789,NSC 9789
	Parabanic acid is the oxidation product of uric acid by singlet oxygen.
T38970	Hematoporphyrin monomethyl ether
	Hematoporphyrin monomethyl ether (HMME), a second-generation porphyrin-related photosensitizer, is a highly selective and low-toxicity compound known for its singular form and high yield of singlet oxygen. It finds extensive application in diagnosing and treating various tumors, including lung cancer, bladder cancer, nevus flammeus, and brain glioma.
T35549	Elsinochrome A
	Elsinochrome A is a perylenequinone fungal metabolite that has been found inHypomycesand has anticancer activity.1Photoactivation of elsinochrome A induces the production of singlet oxygen and apoptosis in R366.4 rhesus monkey embryonic stem cells and HCe-8693 colorectal carcinoma cells when used at concentrations ranging from 1 to 100 μM. 1.Ma, L., Tai, H., Li, C., et al.Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem ...
T34393	Rostaporfin SnET2,tin etiopurpurin dichloride,tin ethyl etiopurpurin dichloride,Purlytin,Sn(IV) etiopurpurin
	Rostaporfin (also known as REM-001, tin ethyl etiopurpurin, Sn(IV) etiopurpurin, Purlytin, SnET2), is a synthetic purpurin with photosensitizing activity. Rostaporfin preferentially accumulates in tumor cells due to an increased rate of metabolism. Upon e
T77235	Methylene Violet 3RAX
	Methylene Violet 3RAX 是一种吩嗪染料，用于染色细胞的线粒体。Methylene Violet 3RAX 可以改变DNA 的分子结构，破坏DNA 的模块，诱导活性单线态氧的产生。Methylene Violet 3RAX 对人红细胞AChE 和人血浆BChE 具有抑制作用，Kis 分别为 1.58 和 0.51 μM。Methylene Violet 3RAX 具有研究PDT (光动力疗法) 中线粒体靶向作用的潜在光敏剂的潜力。
T74629	Benz-AP
	Benz-AP 是一种高效光敏剂，能产生单线态氧并与 hCES2 活性呈负相关。在 hCES2 低表达的癌细胞中，Benz-AP 表现出较高的光毒性。采用双光子激发(TPE)技术，Benz-AP 能够生成 ROS，有效杀死癌细胞和肿瘤球体。
T36176	AMK (hydrochloride)
	AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7...

化合物

1,3-Diphenylisobenzofuran

Cat.No: TD0102

Synonym: DPBF

Target: Others

Cat.No: T20548

Synonym: NSC9789,NSC-9789,NSC 9789

Hematoporphyrin monomethyl ether

Cat.No: T38970

Cat.No: T35549

Cat.No: T34393

Synonym: SnET2,tin etiopurpurin dichloride,tin ethyl etiopurpurin dichloride,Purlytin,Sn(IV) etiopurpurin

Methylene Violet 3RAX

Cat.No: T77235

Cat.No: T74629

AMK (hydrochloride)

Cat.No: T36176

Cat. No.	Product Name	Target	Signaling Pathways
T0626	Uric Acid 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate	Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase	Immunology/Inflammation; Metabolism; NF-κB
	Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。
T40607	2,4,6-Trimethylphenol Mesitol	Others	Others
	2,4,6-Trimethylphenol (Mesitol) 是一种与有机物 (3DOM*) 反应的探针化合物，可在水溶液中被单线态氧快速氧化。
TN1274	4-Allylcatechol 2-羟基胡椒酚,4-Allylpyrocatechol,Hydroxychavicol	Others	Others
	4-Allylcatechol (Hydroxychavicol) 是合成黄樟素的一种中间体。
T4S0171	Transcrocetin trans-Crocetin,藏红花酸,藏红花,8,8'-Diapocarotenedioic Acid,Crocetin	Others; Endogenous Metabolite; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	Transcrocetin (8,8'-Diapocarotenedioic Acid) 是来源于藏红花 (Crocus sativus L.) 的活性化合物，是一种能够透过血脑屏障的，高亲和力的NMDA 受体拮抗剂。
T41242	Uric acid sodium	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Uric acid sodium 是氧自由基 (oxygen radical) 的清除剂，是一种有效的、常见的抗氧化剂，有助于维持机体血压稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，对脂质过氧化有抑制作用，与痛风性关节病的发病机理和草酸钙结石的形成有关。
TN6584	Pallidol
	Pallidol is a potent and selective singlet oxygen quencher in aqueous systems, it may be used in singlet oxygen-mediated diseases as a pharmacological agent.
TN4263	Isoangustone A	MMP; GSK-3; NF-κB; ROS; Akt; PI3K; CDK; JNK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-ÎºB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
TMA0291	Dehydroglyasperin D	GSK-3; p38 MAPK; ROS; Akt; COX; PI3K; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet o...

天然产物

Cat.No: T0626

Synonym: 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate

Target: Reactive Oxygen Species, Endogenous Metabolite, Phosphorylase

2,4,6-Trimethylphenol

Cat.No: T40607

Synonym: Mesitol

Target: Others

4-Allylcatechol

Cat.No: TN1274

Synonym: 2-羟基胡椒酚,4-Allylpyrocatechol,Hydroxychavicol

Target: Others

Cat.No: T4S0171

Synonym: trans-Crocetin,藏红花酸,藏红花,8,8'-Diapocarotenedioic Acid,Crocetin

Target: Others, Endogenous Metabolite, iGluR

Uric acid sodium

Cat.No: T41242

Target: Reactive Oxygen Species

Cat.No: TN6584

Cat.No: TN4263

Target: MMP, GSK-3, NF-κB, ROS, Akt, PI3K, CDK, JNK

Dehydroglyasperin D

Cat.No: TMA0291

Target: GSK-3, p38 MAPK, ROS, Akt, COX, PI3K, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

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