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Cat. No.	Product Name	Target	Signaling Pathways
T74869	SiRNA Negative Control
	SiRNA Negative Control 是 21个核苷酸的 siRNA，可作为阴性对照使用。
T19080	DOPE 1,2-二油酰-SN-甘油-3-磷酰乙醇胺	Others	Others
	DOPE (DOPE) 是一种阳离子脂质体的中性辅助脂质 (helper lipid)，能够与阳离子磷脂结合，增强裸 siRNA 的转染效率。
T0717L	Enoxacin 依诺沙星,NSC 629661,AT 2266,Pd107779,CI 919	DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Enoxacin (NSC-629661) 是一种可干扰DNA 复制的氟喹诺酮，抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。它是特异性癌症生长抑制剂，可有效抑制革兰氏阳性和阴性细菌。
T0717	Enoxacin hydrate CI-919 hydrate,Enoxacin Sesquihydrate,依诺沙星半水合物,AT-2266 hydrate,依诺沙星倍半水合物	DNA gyrase; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Enoxacin hydrate (AT-2266 hydrate) 是氟喹诺酮，可干扰DNA 复制，抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。它是特异性癌症生长抑制剂，抑制革兰氏阳性和阴性细菌。
T5823	D-Lin-MC3-DMA	Others	Others
	D-Lin-MC3-DMA 是一种递送 siRNA 载体，是一种可离子化的氨基脂质类化合物。
T31546	DLinDAP D-Lin-DAP,D-LinDAP	Others	Others
	DLinDAP (D-LinDAP) 是一种可离子化的阳离子脂质，可用于 SiRNA 的递送。
T15139	DLin-KC2-DMA	Others	Others
	DLin-KC2-DMA 是一种可用于siRNA 传递的阳离子，也是一种可电离的脂质。
T13254L	UNC10217938A HCl UNC10217938A HCl(1347749-97-6 Free base),UNC7938 HCl	Others	Others
	UNC10217938A HCl (UNC7938 HCl) 是具有寡核苷酸 (oligonucleotides) 增强作用的 3-deazapteridine 类似物，通过调节寡核苷酸在细胞内的运输和从内体中的释放来增强寡核苷酸的作用。UNC10217938A HCl 还增强了 siRN 和反义寡核苷酸的作用。
T8902	DOTMA Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium	Others	Others
	DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) 作为 tetra-methylated DOTA 类似物，是一种阳离子脂类，被用作基因治疗的非病毒载体。它已被用作脂质体的成分，可用于封装 siRNA、microRNA 和寡核苷酸，并用于体外基因转染。在体外和体内均表现出良好的基因转染效果。DOTMA 诱导脂质体上的正电荷，从而促进脂质体与细胞膜的有效相互作用。
T15140	DLinDMA	Others	Others
	DLinDMA 是一种稳定的核酸脂质颗粒 (SNALPs) 中的关键脂质成分，是一种可电离的阳离子脂质。它可用于siRNA 递送的研究。
T9098	DMG-PEG 2000 DMG-PEG2000	Others	Others
	DMG-PEG 2000 (DMG-PEG2000) 可用于脂质纳米颗粒制备，用于口服质粒 DNA 的体内传递途径，提高纳米颗粒的黏液渗透性和传递效率。它也可用于 siRNA 转染的脂质体的制备，能够提高转染效率。
T64293	SLN124
	SLN124 是一种 GalNac-siRNA，靶向跨膜丝氨酸蛋白酶 6 (Tmprss6)，由与 TMPRSS6-siRNA 结合的三聚体 GalNAc 配体组成。SLN124 具有潜力用做 siRNA 剂，恢复铁调素表达并使 β-地贫中铁稳态正常化。
T74447	503O13
	503O13是一种可降解的可电离脂质，用于 siRNA 递送。
T37027	MHAPC-Chol
	MHAPC-Chol is a cationic cholesterol. MHAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in MHAPC-chol accumulation in the liver.
T74423	Xalnesiran sodium
	Xalnesiran (sodium) 是用于治疗慢性乙型肝炎 (HBV) 的 siRNA。
T39304	Vutrisiran ALN-TTRsc02
	Vutrisiran (ALN-TTRsc02) is an investigational, liver-directed small interfering ribonucleic acid (siRNA) compound designed for research on transthyretin (TTR)-mediated amyloidosis.
T82481	Elebsiran sodium VIR-2218 sodium
	Elebsiran sodium为针对乙型肝炎病毒(HBV)及丁型肝炎病毒(HDV)感染的siRNA抗病毒化合物。
T75155	Bamosiran
	Bamosiran 是一种靶向 β-肾上腺素受体2 (β-adrenergic receptor 2)的 siRNA，用于降低眼压
T38918	Revusiran ALN-TTRSC
	Revusiran (ALN-TTRSC) is a first-generation short interfering RNA (siRNA) that specifically targets transthyretin (TTR) mRNA. It is utilized in TTR-mediated amyloidosis research.
T37035	HAPC-Chol
	HAPC-Chol is a cationic cholesterol. HAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in HAPC-chol accumulation in the lungs.
T40203	AZD-CO-Ph-PEG4-Ph-CO-AZD AZD-CO-Ph-PEG4-Ph-CO-AZD
	AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker, commonly employed in the synthesis of antibody-siRNA conjugates.
T73742	98N12-5
	98N12-5 是一种新型的可电离脂质，用于siRNA 在体内高效传递到肝脏。
T74313	MVL5
	MVL5 是一种不可降解的多价阳离子脂质。MVL5 是一种高效的 DNA 和 siRNA 载体。
T38679	DODAP
	DODAP, an ionizable cationic lipid, serves as a vital component in liposome formation. Its applications encompass the capability to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery, among others.
T39293	Tivanisiran SYL1001,Tivanisiran
	Tivanisiran (SYL1001) is a siRNA developed specifically to inhibit the expression of transient receptor potential vanilloid 1 (TRPV1) to explore its implications in dry eye disease research.
T39122	Inclisiran ALN-PCSsc
	Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) compound that effectively suppresses PCSK-9 transcription. It proves promising in the investigation of hyperlipidemia and cardiovascular disease (CVD).
T73741	CLinDMA
	CLinDMA 是一种阳离子脂质，可引起炎症反应。CLinDMA 可用于合成 LNP201。LNP201 是一种脂质体组件，用于 siRNA 的全身递送。
T74431	Cemdisiran
	Cemdisiran 是一种 GalNAc 偶联的 siRNA 干扰，通过抑制肝脏补体5 (C5)蛋白的产生来研究补体介导的疾病。
T37018	OH-Chol
	OH-Chol is a cationic cholesterol derivative.1 OH-Chol, as a component of lipoplexes with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intrat...
T74248	AS-Inclisiran
	AS-Inclisiran为Inclisiran的反义链。Inclisiran（ALN-PCSsc）为双链小干扰RNA（siRNA）分子，目的在于抑制PCSK-9的转录，适用于高脂血症及心血管疾病（CVD）的研究。
T75154	ATU027
	ATU027, 一种可沉默血管内皮中PKN3表达的siRNA, 已在小鼠癌症模型中证明能有效抑制局部肿瘤侵袭及淋巴结和肺转移。
T74249	AS(3n-2)-Inclisiran
	AS(3n-2)-Inclisiran 是 Inclisiran 的反义链，其在 2 bp 的间隔后有3n 个随机位点。Inclisiran 是一种双链小干扰 RNA (siRNA) 分子，可抑制PCSK-9的转录。
T74876	GalNAc unconjugated/naked Inclisiran
	GalNAc unconjugated/naked Inclisiran 是一种未偶联GalNAc的双链小干扰RNA (siRNA) 分子，具有抑制PCSK-9转录功能。该化合物主要应用于高脂血症及心血管疾病(CVD)的研究领域。
T74550	Cemdisiran, terminal sugar modification-
	Cemdisiran（终端糖基修饰）是一种靶向C5 mRNA的siRNA，通过N-乙酰半乳糖胺缀合增强RNAi活性，能够抑制肝脏中补体成分C5的生成。
T37017	OH-C-Chol
	OH-C-Chol is a cationic cholesterol derivative. OH-C-Chol, as a component of lipoplexes with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver.
T39273	Lumasiran ALN-G01
	Lumasiran (ALN-G01), a siRNA product, inhibits hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes this enzyme and thereby prevents the synthesis of oxalate, the toxic metabolite directly linked to the clinical manifestations of Primary hyperoxaluria type 1 (PH1).
T38804	Patisiran sodium
	Patisiran sodium is a double-stranded small interfering RNA (siRNA) that selectively targets a specific sequence within the transthyretin (TTR) messenger RNA (mRNA). By doing so, it effectively blocks the hepatic synthesis of both mutant and wild-type TTR. Patisiran sodium has significant applications in the field of hereditary TTR amyloidosis research.
T75156L	Bevasiranib sodium
	Bevasiranib sodium 是一种siRNA，可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用，而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。
T39123	Givosiran ALN-AS1,Givosiran
	Givosiran (ALN-AS1) is a small interfering RNA (siRNA) compound that specifically targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA (mRNA) to downregulate its expression. By doing so, Givosiran effectively inhibits the accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. This compound holds significant potential for further research on acute intermittent porphyria.
T74737	mono-Pal-MTO
	Mono-Pal-MTO 是米托蒽醌 (MTO) 与棕榈酸结合的棕榈基脂质，其抗癌活性得以显著提升。当摩尔比1:1时，将mono-Pal-MTO与di-Pal-MTO的纳米颗粒组合使用，可有效递送siRNA至细胞内，进一步增强其抗癌效果。
T75156	Bevasiranib
	Bevasiranib 是一种siRNA，可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用，而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。
T74738	di-Pal-MTO
	di-Pal-MTO，一种棕榈油基脂质，由抗癌活性分子米托蒽醌(MTO)与棕榈油酸以1:1的摩尔比结合形成。当以纳米颗粒形式将mono-Pal-MTO与di-Pal-MTO联合使用时，能有效递送siRNA至细胞内，并显著增强抗癌活性。
T74553	YSK 05
	YSK 05是一种对pH敏感的阳离子脂质，能够改善非病毒载体的胞内转运效率。YSK 05-MEND显示出显著的基因沉默活性和溶血性。通过聚乙二醇化处理，YSK 05有效克服了对内体逃逸的抑制，从而在体外和体内均显著增强了siRNA的传递效率。
T75158	Olpasiran
	Olpasiran 是一种siRNA，可减少肝脏中脂蛋白 lipoprotein(a) 的合成。
T34707	SST-02 SST 02,SST02
	SST-02 is a potent cationic lipid for siRNA-Lipid Nanoparticles. SST-02 possesses a simple chemical structure and is synthesized just in one step. SST-02 showed an ID50 of 0.02 mg/kg in the factor VII (FVII) model. Rats administered with 3 mg/kg of SST-02
T37586	DMHAPC-Chol
	DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells when used at lipid concentrations greater than 20 μM. DMHAPC-Chol, as part of a lipoplex with DOPE , has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to delive...
T38469	(Rac)-Z-Phe-Phe-FMK Cathepsin L-IN-2	Beta Amyloid; Cysteine Protease	Neuroscience; Proteases/Proteasome
	(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) 是一种 cathepsin L 抑制剂，抑制 β-淀粉样蛋白诱导凋亡变化的倾向。(Rac)-Z-Phe-Phe-FMK 通过 siRNA 敲低 LC3B 表达可抑制 PI 诱导的 IkappaBalpha 降解。
T83848	VnP-16 TFA
	VnP-16是一种合成肽段，对应vitronectin的氨基酸270-281，vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时，能促进人类成骨细胞的附着和扩散，此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内，VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。
T36359	Dios-Arg (trifluoroacetate salt)
	Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the cav...

化合物

SiRNA Negative Control

Cat.No: T74869

Cat.No: T19080

Synonym: 1,2-二油酰-SN-甘油-3-磷酰乙醇胺

Target: Others

Cat.No: T0717L

Synonym: 依诺沙星,NSC 629661,AT 2266,Pd107779,CI 919

Target: DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic

Enoxacin hydrate

Cat.No: T0717

Synonym: CI-919 hydrate,Enoxacin Sesquihydrate,依诺沙星半水合物,AT-2266 hydrate,依诺沙星倍半水合物

Target: DNA gyrase, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic

Cat.No: T5823

Target: Others

Cat.No: T31546

Synonym: D-Lin-DAP,D-LinDAP

Target: Others

Cat.No: T15139

Target: Others

UNC10217938A HCl

Cat.No: T13254L

Synonym: UNC10217938A HCl(1347749-97-6 Free base),UNC7938 HCl

Target: Others

Cat.No: T8902

Synonym: Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium

Target: Others

Cat.No: T15140

Target: Others

Cat.No: T9098

Synonym: DMG-PEG2000

Target: Others

Cat.No: T64293

Cat.No: T74447

Cat.No: T37027

Xalnesiran sodium

Cat.No: T74423

Cat.No: T39304

Synonym: ALN-TTRsc02

Elebsiran sodium

Cat.No: T82481

Synonym: VIR-2218 sodium

Cat.No: T75155

Cat.No: T38918

Synonym: ALN-TTRSC

Cat.No: T37035

AZD-CO-Ph-PEG4-Ph-CO-AZD

Cat.No: T40203

Synonym: AZD-CO-Ph-PEG4-Ph-CO-AZD

Cat.No: T73742

Cat.No: T74313

Cat.No: T38679

Cat.No: T39293

Synonym: SYL1001,Tivanisiran

Cat.No: T39122

Synonym: ALN-PCSsc

Cat.No: T73741

Cat.No: T74431

Cat.No: T37018

Cat.No: T74248

Cat.No: T75154

AS(3n-2)-Inclisiran

Cat.No: T74249

GalNAc unconjugated/naked Inclisiran

Cat.No: T74876

Cemdisiran, terminal sugar modification-

Cat.No: T74550

Cat.No: T37017

Cat.No: T39273

Synonym: ALN-G01

Patisiran sodium

Cat.No: T38804

Bevasiranib sodium

Cat.No: T75156L

Cat.No: T39123

Synonym: ALN-AS1,Givosiran

Cat.No: T74737

Cat.No: T75156

Cat.No: T74738

Cat.No: T74553

Cat.No: T75158

Cat.No: T34707

Synonym: SST 02,SST02

Cat.No: T37586

(Rac)-Z-Phe-Phe-FMK

Cat.No: T38469

Synonym: Cathepsin L-IN-2

Target: Beta Amyloid, Cysteine Protease

Cat.No: T83848

Dios-Arg (trifluoroacetate salt)

Cat.No: T36359

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