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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8574 |
SPHINX
|
Others | Others |
SPHINX 是新一代的 SPRK1抑制剂。 | |||
T2253 |
TCS PIM-1 1
3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮,SC 204330 |
Pim | Chromatin/Epigenetic; JAK/STAT signaling |
TCS PIM-1 1 (SC 204330) 是一种特异性有效的 ATP 竞争性 Pim-1 激酶抑制剂,IC50为 50 nM,对 MEK1/MEK2 和 Pim-2 表现出良好的特异性,IC50值大于 20000 nM。 | |||
T23146 |
PHA 568487 free base
PHA 568487 |
AChR | Neuroscience |
PHA 568487 free base 是一种选择性的 α7 烟碱乙酰胆碱受体激动剂,可用于减缓神经炎症。 | |||
T8925 |
Glu-urea-Lys
|
||
Glu-urea-Lys 是一种靶向 PSMA 的分子支架,可用于研究前列腺特异性膜抗原的前列腺癌成像剂。 | |||
T75098 |
HIF-PHD-IN-3
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
HIF-PHD-IN-3 是一种有效的 hiPSC-CM 心脏保护支架,对 HIF-PHD 有潜在的抑制作用,可调节血红素加氧酶-1,可用于研究贫血。 | |||
T23002 |
ML-335
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
ML-335 是μ-δ异构体靶向激动剂,是一种μOR-δOR 偏向配体,可以作为开发独特类型(异构体偏倚)药物的支架。ML-335是MOR(μ阿片受体)/DOR(δ阿片受体)异构体, 具有抗伤害感受活性和抑制疼痛的活性。 | |||
Fr14395 |
2,2'-Bipyridine
|
||
2,2'-Bipyridine 是一种独特的生物活性天然产物分子支架,常用于许多螯合配体的核心结构。2,2'-Bipyridine 在催化中心的排列中起到桥梁的作用。2,2'-Bipyridine 具有良好的氧化还原稳定性和升糖活性。 | |||
T64374 |
QN523
|
Autophagy | Autophagy |
QN523是一种具有类药物性质的新型支架,在12个癌症细胞系中显示出强大的体外细胞毒性。QN523在胰腺癌症异种移植模型中显示出显著的体内疗效。自噬是QN523发挥作用的主要机制。 | |||
Fr13587 |
7-Chloro-4-(piperazin-1-yl)quinoline
|
||
7-Chloro-4-(piperazin-1-yl)quinolone 结构是药物化学中的重要支架,它单独或与其他活性药效团混合显示出多种药理特性。7-Chloro-4-(piperazin-1-yl)quinolone 是有效的sirtuin 抑制剂,并且抑制 5-羟色胺的摄取,IC50值为 50 μM。7-Chloro-4-(piperazin-1-yl)quinolone 对恶性疟原虫 D10 和 K1 菌株表现出抗疟疾活性,IC50分别为 1.18 μM 和 0.97 μM。 | |||
T40111L |
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 是一种基于间苯二酚二Ph醚支架的程序性细胞死亡-1(PD-1)/程序性细胞死亡配体1(PD-L1)抑制剂, 抑制 PD-1/PD-L1 相互作用,IC50 值为 39.2 nM.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 包含靶蛋白 PD-1/PD-L1 配体和 PROTAC linker。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 可用于合成 PROTAC PD-1/PD-L1 degrader-1。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 具有抗癌活性。BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride 可作为稀释剂,用于用于直接压缩制备片剂。 | |||
T68396 |
AC1NOD4Q
|
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AC1NOD4Q is a novel blocker of hox antisense intergenic rna (hotair) by abrogating the scaffold interaction with ezh2 | |||
TNU0870 |
5-(2-Hydroxyethyl)uracil
|
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5-(2-Hydroxyethyl)uracil bolongs toIntermediates and Building Blocks - Nucleoside base, Nucleophile; Heterocylic Compounds - Pyrimidine; Scaffold and Template. | |||
T68365 |
Indimitecan HCl
|
||
Indimitecan HCl is a TOP1 inhibitor chemical scaffold. | |||
T26183 | Selenalysine | ||
Selenalysine is a lantipeptides used as a scaffold for drug development. | |||
TNU1018 |
6-Amino-4-chloropyrazolo[3,4-d]pyrimidine
|
||
6-Amino-4-chloropyrazolo[3,4-d]pyrimidine bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
TNU1278 |
2,6-Dichloro-2',3',5'-triacetyl-purine riboside
|
||
2,6-Dichloro-2',3',5'-triacetyl-purine riboside is a Nucleoside Derivative - Halo-nucleoside; Scaffold and Template. | |||
TNU1017 |
3,6-Dibromopyrazolo[3,4-d]pyrimidin-4(5H)-one
|
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3,6-Dibromopyrazolo[3,4-d]pyrimidin-4(5H)-one bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
TNU1020 |
6-Amino-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine
|
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6-Amino-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
TNU0121 |
5-Pyrrolidinomethyluridine
|
||
5-Pyrrolidinomethyluridine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside; Scaffold and Template. | |||
TNU1013 |
6-Chloro-7-fluoro-7-deazapurine
|
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6-Chloro-7-fluoro-7-deazapurine bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
TNU1075 |
2-Iodo-2’-deoxyadenosine
|
||
2-Iodo-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside; 2-Modified purine nucleoside; Scaffold and Template. | |||
T12934 |
SMAP-2
DT-1154 |
Phosphatase | Metabolism |
SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhibits the growth of KRAS-mutant lung cancers . | |||
TNU0632 |
5’-O-(p-Toluoyl)-2’-O-acetyl-3’-deoxy-3’-fluoro-6-chloroinosine
|
||
5'-O-(p-Toluoyl)-2'-O-acetyl-3'-deoxy-3'-fluoro-6-chloroinosine is a Nucleoside Derivative - Fluoro-modified nucleoside, Halo-nucleoside, 3'-Modified nucleoside; Scaffold and Template. | |||
TNU1016 |
6-Bromopyrazolo[3,4-d]pyrimidin-4(5H)-one
|
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6-Bromopyrazolo[3,4-d]pyrimidin-4(5H)-one bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
TNU0879 |
6-Chloro-2-iodo-9-(2,3,5-tri-O-acetyl)-beta-D-ribofuranosyl-9H-purine
|
||
6-Chloro-2-iodo-9-(2,3,5-tri-O-acetyl)-beta-D-ribofuranosyl-9H-purine is a Nucleoside Derivative - Halo-nucleoside; Scaffold and Template. | |||
TNU1074 |
2-Bromo-2’-deoxyadenosine
|
||
2-Bromo-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside; 2-Modified purine nucleoside; Scaffold and Template. | |||
T20799 |
Lobenzarit
Lobenzaritum |
||
Lobenzarit, an immunomodulator, is most frequently used to treat arthritis. Its chemical scaffold has been repurposed to tryptophan biosynthesis in Mycobacterium tuberculosis | |||
TNU1034 |
4-Amino-6-bromo-5-cyano-1-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine
|
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4-Amino-6-bromo-5-cyano-1-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a Nucleoside Derivative - 7-Deaza-purine nucleoside, 8-Modified-purine nucleoside, Halo-nucleoside; Scaffold and Template. | |||
TNU0275 |
8-Aza-7-bromo-7-deazaguanosine
|
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8-Aza-7-bromo-7-deazaguanosine is a Nucleoside Derivative - 7-Deaza-8-aza-purine nucleoside; Halo-nucleoside; Scaffold and Template. | |||
TNU0872 |
5-(3-Hydroxypropyl)uracil
|
||
5-(3-Hydroxypropyl)uracil bolongs toIntermediates and Building Blocks - Nucleoside base, Nucleophile; Heterocylic Compounds - Pyrimidine; Scaffold and Template. | |||
TNU0877 |
N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl propanamide
|
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N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl propanamide belongs to Heterocyclic Compounds - Purine; Intermediates and Building Blocks - Nucleoside base, Electrophile; Scaffold and Template. | |||
TNU0871 |
5-(2-Hydroxyethyl)-2-thiouracil
|
||
5-(2-Hydroxyethyl)-2-thiouracil bolongs toIntermediates and Building Blocks - Nucleoside base, Nucleophile; Heterocylic Compounds - Pyrimidine; Scaffold and Template. | |||
TNU1279 |
5-(2-Hyroxyethyl)-2’,3’-di-O-toluoyl-2’-deoxyuridine
|
||
5-(2-Hyroxyethyl)-2',3'-di-O-toluoyl-2'-deoxyuridine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside; Scaffold and Template. | |||
T38420 |
GCPII-IN-1
|
||
GCPII-IN-1 is a potent inhibitor scaffold targeting glutamate carboxypeptidase II (GCPII), also known as prostate-specific membrane antigen (PSMA). It exhibits a high affinity for GCPII, with a binding affinity (K i ) of 44.3 nanomolar (nM). | |||
TNU1073 |
6-Chloro-2-bromo-9-(2,3,5-tri-O-acetyl)-beta-D-ribofuranosyl-9H-purine
|
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6-Chloro-2-bromo-9-(2,3,5-tri-O-acetyl)-beta-D-ribofuranosyl-9H-purine is a Nucleoside Derivative - Halo-nucleoside; Scaffold and Template. | |||
TNU1015 |
4-Amino-6-bromo-5-cyano-7H-pyrrolo[2,3-d]pyrimidine
|
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4-Amino-6-bromo-5-cyano-7H-pyrrolo[2,3-d]pyrimidine bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
T14608 | Biotin-PEG6-Mal | Others | Others |
Biotin-PEG6-Mal is a biotinylated PROTAC linker derived from a polyethylene glycol (PEG) scaffold. It serves as an essential component for the synthesis of PROTACs, which are targeted protein degraders[1]. | |||
TNU1019 |
6-Amino-4-methoxypyrazolo[3,4-d]pyrimidine
|
||
6-Amino-4-methoxypyrazolo[3,4-d]pyrimidine bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
TNU0983 |
2-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuanosyl)-9H-purine
|
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2-Amino-6-chloro-9-(3-deoxy-beta-D-ribofuanosyl)-9H-purine is a Nucleoside Derivative - 3'-Deoxy nucleoside, Halo-nucleoside; Scaffold and Template. | |||
TNU0981 |
9-(2’-O-Acetyl-5’-O-benzoyl-3’-deoxy-beta-D-ribofuranosyl)-6-chloropurine
|
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9-(2'-O-Acetyl-5'-O-benzoyl-3'-deoxy-beta-D-ribofuranosyl)-6-chloropurine is a Nucleoside Derivative - 3'-Deoxy nucleoside, Halo-nucleoside; Scaffold and Template. | |||
TNU0878 |
N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl propanamide
|
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N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl propanamide belongs to Heterocyclic Compounds - Purine; Intermediates and Building Blocks - Nucleoside base, Electrophile; Scaffold and Template. | |||
TNU0982 |
2-Amino-6-chloro-9-(3-deoxy-2-O-acetyl-5-O-benzoyl-beta-D-ribofuanosyl)-9H-purine
|
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2-Amino-6-chloro-9-(3-deoxy-2-O-acetyl-5-O-benzoyl-beta-D-ribofuanosyl)-9H-purine is a Nucleoside Derivative - 3'-Deoxy nucleoside, Halo-nucleoside; Scaffold and Template. | |||
T40392 | BMS-986121 | ||
BMS-986121, a positive allosteric modulator (PAM) of the μ opioid receptor. This compound is based on a novel chemical scaffold, introducing a new chemotype for μ receptor PAMs. | |||
TNU0090 |
2-Amino-6-chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine
|
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2-Amino-6-chloro-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine is a Nucleoside Derivative - Fluoro-modified nucleoside, Halo-nucleoside, 3'-Modified nucleoside; Scaffold and Template. | |||
TNU0760 |
9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-2-chloro-6-(thiophen-3-yl)purine
|
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9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-2-chloro-6-(thiophen-3-yl)purine is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purine nucleoside, Halo-nucleoside, 3'-Modified nucleoside; Scaffold and Template. | |||
T36240 |
AP219
|
||
AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion. | |||
TNU0088 |
2-Chloro-6-(furan-2-yl)purine-beta-D-(3’-deoxy-3’-fluoro)riboside
|
||
2-Chloro-6-(furan-2-yl)purine-beta-D-(3'-deoxy-3'-fluoro)riboside is a Nucleoside Derivative - Fluoro-modified nucleoside, 6-Modified purine nucleoside, Halo-nucleoside, 3'-Modified nucleoside; Scaffold and Template. | |||
TNU0103 |
4-Amino-5-iodo-7-(2-b-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
|
||
4-Amino-5-iodo-7-(2-b-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a Nucleoside Derivative - 7-Deaza-purine nucleoside; 2'-Modified nucleoside; Halo-nucleoside; Scaffold and Template. | |||
TNU0102 |
4-Chloro-7-(2-b-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d] pyrimidine
|
||
4-Chloro-7-(2-b-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d] pyrimidine is a Nucleoside Derivative - 7-Deaza-purine nucleoside; 2'-Modified nucleoside; Halo-nucleoside; Scaffold and Template. | |||
T80743 |
Z-APF-CMK
|
||
Z-APF-CMK为特异性CRNSP (Ca2+-调节的核支架蛋白酶) 抑制剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8116 |
Azulene
甘菊蓝,奥苷菊环,Bicyclo[5.3.0]Decapentaene |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Azulene (Bicyclo[5.3.0]Decapentaene) 是萘的异构体,具有高抗HIV 活性。它是从洋甘菊精油中分离出来的一种化学支架。 | |||
T4S1616 |
Sanggenon D
桑根酮D,Sanggenone D |
NOS; COX; GABA Receptor | Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it can inhibit NO production from lipopolysaccharide (LPS)-induced RAW 264.7 ce | |||
T7962 |
Coumalic acid
香豆酸,Cumalic Acid |
Others | Others |
Coumalic acid (Cumalic Acid) 可以由苹果酸制备。它可用于香料、调味剂及化妆品工业生产中。它作为聚合物组分以及具有抗支气管和疟疾活性的活性分子支架。 | |||
T5901 |
3-Hydroxy-2-methylpyridine
|
Others | Others |
3-Hydroxy-2-methylpyridine 是分离自可可碱提取物,可用于合成嘧啶。 | |||
T32326 |
Juvabione
|
||
Juvabione is the methyl ester of todomatuic acid, both of which are sesquiterpenes (C15) found in the wood of true firs of the genus Abies. They exist as part of a mixture of sesquiterpenes based on the bisabolane scaffold. Sesquiterpenes of this family, | |||
T82799 |
C-2′-Decoumaroylaloeresin G
|
||
C-2′-Decoumaroylaloeresin G (化合物8)为一种色酮糖苷,源自芦荟属植物。 |