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Cat. No. | Product Name | Target | Signaling Pathways |
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T16873 |
SERCA2a activator 1
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
SERCA2a activator 1 是一种肌肉/内质网 Ca2+ 依赖性 ATPase 2a 激活剂。 SERCA2a activator 1 降低受磷蛋白抑制并增强心脏的收缩和舒张功能。 | |||
T1198 |
Tetracaine hydrochloride
盐酸丁卡因,Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl |
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Tetracaine hydrochloride (Amethocalne HCl) 是一种钙通道蛋白抑制剂,可阻断肌浆网中 Ca2+的电压敏感释放。它主要用作眼科的止痒剂和局部用药,可用于表面和脊髓麻醉。 | |||
T8863 |
VK-II-36
|
Others | Others |
VK-II-36 是 carvedilol 的类似物,能够在不阻断 β 受体的情况下抑制肌浆网钙释放。它能够抑制早期和延迟后去极化诱发的触发活动,可用于局灶性室性心律失常的研究。 | |||
T24239 |
K201
K-201,JTV 519,JTV-519,K 201 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
K201 (JTV-519) 是一种 Ca2+ 依赖性阻滞剂,通过稳定兰尼碱受体来防止缺血性心脏和骨骼肌 (SkM) 中的肌质网异常 Ca(2+) 泄漏。 | |||
T8452 |
Dantrolene
|
Others | Others |
Dantrolene 是一种肌肉松弛剂,是人红细胞谷胱甘肽还原酶的非竞争性抑制剂,其Ki 和IC50值分别为 111.6 μM 和 52.3 μM。它是兰尼碱受体拮抗剂及Ca2+信号稳定剂。它可用于研究恶性高热、亨廷顿病、肌肉痉挛和其他神经阻滞剂恶性综合征。 | |||
T1435 |
Praziquantel
吡喹酮,Pyquiton,Droncit,Biltricide |
Calcium Channel; Antibiotic; Parasite | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Praziquantel (Droncit) 是一种外消旋混合物,由 (R)-Praziquantel 和 (S)-Praziquantel 组成。它可研究血吸虫病。 | |||
T4054 |
Dantrolene sodium hemiheptahydrate
Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,丹曲林钠五水合物,Sodium dantrolene |
Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Dantrolene sodium hemiheptahydrate (Sodium dantrolene) 是一种钙通道蛋白抑制剂, 抑制钙离子从肌浆释放, 它是一种乙内酰脲衍生物和直接作用的骨骼肌松弛剂。 | |||
T4996 |
Atosiban
阿托西班,RWJ22164,RW22164 |
Oxytocin Receptor; Vasopressin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Atosiban (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。 | |||
T5148 |
Atosiban acetate
RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班 |
Oxytocin Receptor; Vasopressin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Atosiban acetate (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。 | |||
T68320 |
L594881 HCl
|
||
L594881, also known as 3',4'-Dichlorobenzamil or DCB, is an inhibitor of Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels. L594881 can inhibit Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels. | |||
T26383 |
3',4'-Dichlorobenzamil HCl
|
||
3',4'-Dichlorobenzamil HCl is an inhibitor of Na+ transport, Na+/Ca2+ exchanger, sarcoplasmic reticulum Ca2+ release channels. | |||
T15599 |
Istaroxime hydrochloride
PST2744 hydrochloride |
Others | Others |
Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator. | |||
T80554 |
Myoregulin
MLN peptide |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Myoregulin(MLN peptide)为调节蛋白家族成员,作用于肌肉性能调控,通过影响细胞内钙处理机制实现其功能。它直接与SERCA相互作用,抑制Ca2+进入肌浆网。 | |||
T26830 |
BK 129
BK-129,BK129 |
||
BK 129 is a local anesthetic with relaxant properties. BK 129 inhibits Ca2+ entry into the smooth muscle cell and Ca2+ release from sarcoplasmic reticulum. | |||
T80555 |
Myoregulin TFA
MLN peptide TFA |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Myoregulin (MLN peptide) TFA,作为调节蛋白家族成员,通过干预细胞内钙处理机制来调控肌肉功能。该化合物直接作用于肌浆网 Ca2+-ATPase (SERCA),抑制其将Ca2+传输至肌浆网。 | |||
T11731 |
JTV-519 free base
K201 free base |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and serves as a partial agonist of ryanodine receptors in striated muscle. | |||
T11732 |
JTV-519 hemifumarate
K201 hemifumarate |
MELK | PI3K/Akt/mTOR signaling |
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. | |||
T68366 |
Azumolene sodium dihydrate
|
||
Azumolene sodium dihydrate is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. | |||
T80063 |
Imperatoxin A
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Imperatoxin A,源自非洲蝎Pandinus imperator毒液的一种肽毒素,作为Ca2+-释放通道/兰尼碱受体(RyRs)的激活剂,促进Ca2+从肌浆网流入细胞。 | |||
T80556 |
wt hMLN
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
wt hMLN为抑制SR Ca2+泵(SERCA)的微量蛋白,对骨骼肌钙稳态具有关键作用。 | |||
T75372 |
BODIPY FL Thapsigargin
|
||
BODIPY FL Thapsigargin 作为一种高效绿色荧光染料,主要抑制细胞内肌浆/内质网中的serca型Ca2+泵。其应用焦点在于探究Thapsigargin在活细胞中的结合位置。储存需避光处理。 | |||
T72004 |
Azumolene sodium anhydrous
|
||
Azumolene sodium anhydrous is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. Azumolene, an equipotent dantrolene analog, inhibits a component of SOCE coupled to activation of RyR1 by caffeine and ryanodine, whereas the SOCE component induced by thapsigargin is not affected. | |||
T11731L |
JTV-519 Formate
JTV-519 Formate (145903-06-6 Free base) |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
JTV-519 Formate 是一种 Ca2+ 依赖性的肌质网 Ca2+ 刺激的 ATP 酶 (SERCA) 阻断剂,同时也是横纹肌中兰尼碱受体 (ryanodine receptors) 的部分激动剂。JTV-519 Formate 显示出抗心律失常作用,是一种心脏保护剂。 | |||
T80247 |
Caloxin 3A1
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Caloxin 3A1是生物活性肽,属于caloxins系列,特指抑制外质膜(Plasma membrane, PM) Ca2+泵的化合物。具体作用通过抑制质膜钙泵(PMCA)并保持对肌浆网Ca2+泵无影响;同时,该肽不干预ATP合成酰基磷酸中间产物的形成。 | |||
T69975 | Istaroxime oxalate | ||
Istaroxime, also known as PST-2744, is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Na+/K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium/calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. Additionally, Istaroxime increases intracellular calcium by improving the efficacy by which intracellular calcium triggers sarco... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0302 |
Thapsigargin
毒胡萝卜素 |
Apoptosis; SARS-CoV; Calcium Channel | Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Thapsigargin 属于天然产物,是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂,也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。 | |||
T14293 |
Annonacin
|
Others | Others |
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pu |