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29

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1724	SCR7 pyrazine SCR7,SCR7 吡嗪	Apoptosis; DNA/RNA Synthesis; CRISPR/Cas9	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SCR7 pyrazine (SCR7) 是一种 DNA 连接酶 IV 抑制剂，以连接酶 IV 依赖的方式阻断非同源末端连接。它也是 CRISPR/Cas9的增强子，可提高 Cas9 介导的同源性定向修复的效率。它诱导细胞凋亡，具有抗癌活性。
T3340	SCR7	Apoptosis; DNA/RNA Synthesis; CRISPR/Cas9	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SCR7 是一种特异性 DNA 连接酶 IV 抑制剂，可阻断非同源末端连接。它是一种不稳定的形式，可以自动循环成稳定形式的 SCR7 pyrazine。它也是CRISPR/Cas9的增强子，可提高 Cas9 介导的同源性定向修复的效率。它诱导细胞凋亡并具有抗癌活性。
T5965	Ditiocarb sodium Sodium diethyldithiocarbamate,二乙基二硫代氨基甲酸钠	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Ditiocarb sodium (Sodium diethyldithiocarbamate) 是一种铜胶结率的促进剂。它可降低HIV 感染。
T8509	Danicopan ACH-4471	Complement System	Immunology/Inflammation
	Danicopan (ACH-4471) 是一种可口服的小分子 D 因子选择性抑制剂，对人 D 因子具有高结合亲和力，Kd 值为 0.54 nM。它可抑制补体替代途径 (APC) 的活性，具有阻断阵发性夜间血红蛋白尿 (PNH) 和非典型溶血性尿毒症综合征 (aHUS) 的补体替代途径的潜力。
T0040	Quinestrol W-3566,Ethinylestradiol 3-cyclopentyl ether,炔雌醇环戊醚,EE2CPE	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Quinestrol (Ethinylestradiol 3-cyclopentyl ether) 是合成的雌激素，用于乳腺癌和前列腺癌的相关研究的潜力。
T71551	KAI-1678
	KAI-1678 is an inhibitor of epsilon protein kinase C (εPKC). KAI-1678 is effective in the treatment of postoperative pain following total hip or total knee replacement.
T29949	AMB
	AMB is an AB-PINACA analog characterized by the replacement of a primary amine with a methoxy group.
T32193	Iron sorbitex Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572
	Iron Sorbitex is used for the treatment of Iron Sorbitex deficiency anemia in patients with chronic kidney disease. Iron Sorbitex can be used as an Iron Sorbitex replacement product used for the treatment of Iron Sorbitex deficiency anemia in patients wit
T20946	Bismuth oxide Bismuth sesquioxide,Bismuth trioxide,Bismutum-oxydatum,Bismuthous oxide
	Bismuth(III) oxide is a common starting point for bismuth chemistry. It is usually obtained as a by-product of the smelting of copper and lead ores. Bismuth trioxide is commonly used as a replacement of red lead to produce the “Dragon's eggs” effect in fi
T20849	Hydroxy-PEG3-acid
	Hydroxy-PEG3-acid is a PEG derivative containing a hydroxyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functi
T20973	Thiol-C2-PEG2-OH Thiol-PEG3-alcohol,HS-PEG3-OH
	Thiol-PEG3-alcohol is a PEG derivative containing a hydroxyl group and a thiol group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
T81656	Nomlabofusp
	Nomlabofusp，作为一种TAT-cpp (1-12)类的细胞渗透性多肽，主要应用于Frataxin替代疗法的研究领域。
T20850	Hydroxy-PEG14-acid
	Hydroxy-PEG14-acid is a PEG derivative containing a hydroxyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive funct
T33271	Medrogestone R-13615,AY-62022,Medrogesterone,Colpro,Prothil
	Medrogestone is progesterone that is already used in hormone replacement therapy to treat menopausal symptoms and in the treatment of gynaecological conditions.
T80994	Therapeutic agent-1
	Therapeutic agent-1 是一种杂芳基化合物，用于戈谢病的葡萄糖脑苷脂酶活性酶替代疗法。
T32120	Hydroxy-PEG1-methylamine
	Hydroxy-PEG1-methylamine is a PEG derivative containing a hydroxyl group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive funct
T82477	Elosulfase alfa Chondrosulfatase,Chondrosulfatases,BMN 110,Chondroitinase,Chondroitin sulfatase
	Elosulfase alfa (BMN 110)为人N-acetylgalactosamine-6-sulfatase (GALNS)之重组版本，用于作为IVA型黏多糖贮积症（MPS IVA），亦即Morquio A综合症的酶替代治疗。
T24666	Propargyl-PEG14-alcohol
	Propargyl-PEG14-alcohol is a PEG derivative containing a hydroxyl group and a propargyl group. PEG Linkers are useful in the development of antibody drug conjugates. The hydroxyl group enables further derivatization or replacement with other reactive func
T20860	Hydroxy-PEG12-t-butyl ester
	Hydroxy-PEG12-t-butyl ester is a PEG derivative containing a hydroxyl group and a t-butyl ester. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Under acidic conditions, the t-butyl protected carbox
T37437	C17 Ceramide (d18:1/17:0)
	C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzyme replacement therapy for the genetic disease metachromatic leukodystrophy.
T22551	ACSF	Others	Others
	ACSF is often used as a replacement of CSF for perfusion of brain slices to preserve interneurons. ACSF is invented to reduce the incidence of cerebral edema and further suppress brain cell disorders. And ACSF is often used as an irrigation fluid or perfu
T32121	Hydroxy-PEG3-NHS
	Hydroxy-PEG3-NHS is a PEG derivative containing a hydroxyl group with an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. T
T36304	Fluorescein-NAD+
	Fluoroscein NAD+ is a substrate for ADP-ribosylation, providing a convenient non-isotopic alternative to radiolabelled NAD for use in PARP assays. Allows direct measurement of NAD-dependent enzymes, such as PARP, by fluorescence microscopy. This product is a replacement for R&D Systems product 4673-500-01 81 μg is supplied as 250 μl of a 0.25 mM solution in water.
T37129	MRS 2905
	Potent and selective P2Y14 receptor agonist (EC50 = 0.92 nM). Exhibits >2000-fold selectivity over P2Y6. Das et al (2010) Human P2Y14 receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups J.Med.Chem. 53 471 PMID:19902968 \|Lazarowski et al (2015) UDP-sugars as extracellular signaling molecules: cellular and physiologic consequences of P2Y14 receptor activation. Mol.Pharmacol. 88 151 PMID:25829059
T70222	Ethonafide
	Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerat...
T78520	CYT296	Others	Others
	CYT296是一种靶向染色质去凝集的化合物，能增强定义因子(OSKM)介导诱导多能干细胞(iPSC)的生成，并通过诱导小鼠胚胎成纤维细胞(MEFs)染色质的开放状态来促进体细胞的重编程，适用于细胞替代治疗和药物筛选的研究领域。
T37215	5α,6β-Dihydroxycholestanol
	5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase. It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors in a concentration-dependent manner. It also binds to voltage-gated sodium (Nav) channels and decreases action potentials in hippocampal neurons in vitro when used at a concentration of 10 uM. It increases survival of spinal cord motoneurons, cortical neurons, a...
T69994	BIM-46050
	BIM-46050 is a potent and specific inhibitor of human farnesyltransferase. BIM-46050 is free acidic form of BIM-46068. The IC50 values for in vitro inhibition of human brain FTase indicate that BIM-46050 and the ester form BIM-46068 are potent inhibitors of farnesyltransferase. Their potencies are in the nanomolar range and compare favorably with the compounds B581, FTI-277 and L745,631. B581 is an analog of the tetrapeptide Cys-Val-Phe-Met obtained by replacement of the amino-terminal amide bon...
T68219	Peraclopone
	Peraclopone is a hypolidemic drug. It is an inhibitor of 7-Dehydrocholesterol reductase. Peraclopone potently inhibits the final step in cholesterol biosynthesis. Feeding this agent to rats leads to a rapid replacement of membrane cholesterol with its immediate precursor 7-dehydrocholesterol, and a dramatic reduction in plasma sterol concentration. Peraclopone caused a dose-dependent decrease in cholesterol and a concomitant accumulation of provitamin D3 (7-dehydrocholesterol) in the skin, which...

化合物

Cat.No: T1724

Synonym: SCR7,SCR7 吡嗪

Target: Apoptosis, DNA/RNA Synthesis, CRISPR/Cas9

Cat.No: T3340

Target: Apoptosis, DNA/RNA Synthesis, CRISPR/Cas9

Ditiocarb sodium

Cat.No: T5965

Synonym: Sodium diethyldithiocarbamate,二乙基二硫代氨基甲酸钠

Target: HIV Protease

Cat.No: T8509

Synonym: ACH-4471

Target: Complement System

Cat.No: T0040

Synonym: W-3566,Ethinylestradiol 3-cyclopentyl ether,炔雌醇环戊醚,EE2CPE

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: T71551

Cat.No: T29949

Cat.No: T32193

Synonym: Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572

Cat.No: T20946

Synonym: Bismuth sesquioxide,Bismuth trioxide,Bismutum-oxydatum,Bismuthous oxide

Hydroxy-PEG3-acid

Cat.No: T20849

Thiol-C2-PEG2-OH

Cat.No: T20973

Synonym: Thiol-PEG3-alcohol,HS-PEG3-OH

Cat.No: T81656

Hydroxy-PEG14-acid

Cat.No: T20850

Cat.No: T33271

Synonym: R-13615,AY-62022,Medrogesterone,Colpro,Prothil

Therapeutic agent-1

Cat.No: T80994

Hydroxy-PEG1-methylamine

Cat.No: T32120

Elosulfase alfa

Cat.No: T82477

Synonym: Chondrosulfatase,Chondrosulfatases,BMN 110,Chondroitinase,Chondroitin sulfatase

Propargyl-PEG14-alcohol

Cat.No: T24666

Hydroxy-PEG12-t-butyl ester

Cat.No: T20860

C17 Ceramide (d18:1/17:0)

Cat.No: T37437

Cat.No: T22551

Target: Others

Hydroxy-PEG3-NHS

Cat.No: T32121

Fluorescein-NAD+

Cat.No: T36304

Cat.No: T37129

Cat.No: T70222

Cat.No: T78520

Target: Others

5α,6β-Dihydroxycholestanol

Cat.No: T37215

Cat.No: T69994

Cat.No: T68219

Cat. No.	Product Name	Target	Signaling Pathways
T2752	2'-Deoxyadenosine monohydrate	Others; Endogenous Metabolite	Metabolism; Others
	2'-Deoxyadenosine monohydrate 是化学合成中的砌块，是一种脱氧核糖核苷。
T3130	Testosterone phenylpropionate Testosterone hydrocinnamate,苯丙酸睾酮,Retandrol,Testosterone 17-phenylpropionate	Others	Others
	Testosterone phenylpropionate (Testosterone 17-phenylpropionate) 是一种长效雄激素。d3-Testosterone phenylpropionate 可用作内标物。
T4884	alpha-D-glucose α-D-Glucose,α-葡萄糖,alpha-Glucose,α-Dextrose	Others; Endogenous Metabolite	Metabolism; Others
	alpha-D-glucose (α-Dextrose) 是内源性代谢产物的一种。
T3033	Deoxycorticosterone acetate 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮	Glucocorticoid Receptor; Endogenous Metabolite; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience
	Deoxycorticosterone acetate (Cortexone acetate) 是肾上腺产生的类固醇激素，具有盐皮质激素活性，并作为醛固酮的前体。
T4712	H-D-cis-Hyp-OH 顺式-4-羟基-D-脯氨酸,D-allo-Hydroxyproline,cis-4-Hydroxy-D-proline	Others; Endogenous Metabolite	Metabolism; Others
	H-D-cis-Hyp-OH (D-allo-Hydroxyproline) 是一种合成构象受限的 PNA 腺嘌呤单体的前体，能够用于 D-丙氨酸脱氢酶的特异性和动力学的研究。
T4238	Glycocyamine 乙酸胍,2-Guanidinoacetic acid,Guanidoacetic acid	Others; Endogenous Metabolite	Metabolism; Others
	Glycocyamine (2-Guanidinoacetic acid) 是一种肌酸的前体，能够为鸟类的体内平衡提供能量，也能够成为食用精氨酸的替代物。
T4798	N-Acetyl-L-leucine	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-leucine 是内源性代谢产物的一种。
T0887	D-Glucose Dextrose,D-无水葡萄糖,Glucopyranose,Grape sugar,葡萄糖,D(+)-Glucose	Endogenous Metabolite	Metabolism
	D-Glucose (Glucopyranose) 是一种单糖。D-Glucose 是甜味剂，是一般代谢的关键组成部分，并作为与细胞代谢状态以及生物和非生物应激反应有关的关键信号分子。
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T37298	Spinacine	Endogenous Metabolite	Metabolism
	Spinacine 是人内源性代谢产物。
T21296	Desmopressin acetate trihydrate Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine
	Desmopressin acetate is a synthetic replacement for vasopressin, which reduces urine production. Medical use of Desmopressin acetate includes: (a) bed wetting; (b) diabetes insipidus; (c) nighttime urination; (d) clotting disorders.
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...

天然产物

2'-Deoxyadenosine monohydrate

Cat.No: T2752

Target: Others, Endogenous Metabolite

Testosterone phenylpropionate

Cat.No: T3130

Synonym: Testosterone hydrocinnamate,苯丙酸睾酮,Retandrol,Testosterone 17-phenylpropionate

Target: Others

alpha-D-glucose

Cat.No: T4884

Synonym: α-D-Glucose,α-葡萄糖,alpha-Glucose,α-Dextrose

Target: Others, Endogenous Metabolite

Deoxycorticosterone acetate

Cat.No: T3033

Synonym: 醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮

Target: Glucocorticoid Receptor, Endogenous Metabolite, Adrenergic Receptor

Cat.No: T4712

Synonym: 顺式-4-羟基-D-脯氨酸,D-allo-Hydroxyproline,cis-4-Hydroxy-D-proline

Target: Others, Endogenous Metabolite

Cat.No: T4238

Synonym: 乙酸胍,2-Guanidinoacetic acid,Guanidoacetic acid

Target: Others, Endogenous Metabolite

N-Acetyl-L-leucine

Cat.No: T4798

Target: Others, Endogenous Metabolite

Cat.No: T0887

Synonym: Dextrose,D-无水葡萄糖,Glucopyranose,Grape sugar,葡萄糖,D(+)-Glucose

Target: Endogenous Metabolite

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

Cat.No: T37298

Target: Endogenous Metabolite

Desmopressin acetate trihydrate

Cat.No: T21296

Synonym: Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

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