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Search Results for " p42 "

10

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2026	CYM5442	S1P Receptor; LPL Receptor	GPCR/G Protein
	CYM5442 是高选择性和口服活性的鞘氨醇 1-磷酸受体激动剂，EC50为 1.35 nM。它激活依赖 S1P1的 p42/p44-MAPK 磷酸化，具有视网膜神经保护作用，可轻松穿过中枢神经系统。
T6258	Zibotentan ZD4054	Apoptosis; Endothelin Receptor	Apoptosis; GPCR/G Protein
	Zibotentan (ZD4054) 是一种选择性的，具有口服活性的内皮素 A (ETA) 受体拮抗剂，Ki 为 13 nM。它具有抗癌作用，可研究去势抵抗性前列腺癌。
T12268	NTP42	Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism
	NTP42 是血栓素 A2 (TXA2) 受体的拮抗剂，IC50为 3.278 nM，可用于肺动脉高压的相关研究。
T12982	SP4206	IL Receptor	Immunology/Inflammation
	SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively)
T69821	AMP423
	AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with structural similarity to the pro-oxidant anti-tumor agent imexon. AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6 B-cell lymphoma tumors, with a median tumor growth delay (T-C) of 21 days (P = 0.0002) and 5 days (P = 0.004), respectively, and a median tumor growth inhibition (T/C) of 33.3% (P = 0.03) and 82% (P = 0.01), respectively. In non-tumor-bearing mice, AMP423 was not myelosuppressive.
T4431	Olodanrigan PD-126055,EMA401	RAAS	Endocrinology/Hormones
	Olodanrigan (EMA401) 是具有口服活性、高选择性及外周受限的血管紧张素 Ⅱ 类型 2 受体(AT2R)拮抗剂。它的缓解疼痛的机制可能是：抑制增强的 AngII/AT2R 诱导的 p38 和 p42/p44 MAPK 激活，进而阻碍 DRG 神经元的过度兴奋性及 DRG 神经元的萌发。它可用于研究神经性疼痛。
T4092	AG126 Tyrphostin AG126,AG 126	ERK; COX	Immunology/Inflammation; MAPK; Neuroscience
	AG126 (Tyrphostin AG126) 是一种酪氨酸激酶抑制剂，可阻止丝裂原活化蛋白激酶 p42MAPK(ERK2) 的激活。
T6108	Ki16425 Debio 0719	LPA Receptor; LPL Receptor	GPCR/G Protein
	Ki16425 (Debio 0719) 是一种竞争性、有效和可逆的 LPA1、LPA2 和 LPA3 拮抗剂，Ki 分别为 0.34、6.5 和 0.93 μM。它可抑制LPA 诱导的 HEK293A 细胞中 YAP/TAZ 的去磷酸化，降低LPA 诱导的 p42/p44 MAPK 激活。
T41144	CYM5442 hydrochloride CYM 5442 hydrochloride
	CYM 5442 hydrochloride is a potent and selective S1P1agonistin vitro(EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.
T3650	STO-609 acetate	CaMK	Neuroscience
	STO-609 acetate 是选择性的、细胞可渗透的 Ca2+-钙调蛋白依赖性蛋白激酶激酶抑制剂（Ki：80/15 ng/ml，对于 CaM-KKα/KKβ）；竞争 ATP 结合位点。它比 CaMK1/2/4、PKC、MLCK、PKA 和 p42 MAPK 显示 > 80 倍的选择性。

化合物

Cat.No: T2026

Target: S1P Receptor, LPL Receptor

Cat.No: T6258

Synonym: ZD4054

Target: Apoptosis, Endothelin Receptor

Cat.No: T12268

Target: Prostaglandin Receptor, PPAR

Cat.No: T12982

Target: IL Receptor

Cat.No: T69821

Cat.No: T4431

Synonym: PD-126055,EMA401

Target: RAAS

Cat.No: T4092

Synonym: Tyrphostin AG126,AG 126

Target: ERK, COX

Cat.No: T6108

Synonym: Debio 0719

Target: LPA Receptor, LPL Receptor

CYM5442 hydrochloride

Cat.No: T41144

Synonym: CYM 5442 hydrochloride

STO-609 acetate

Cat.No: T3650

Target: CaMK

Cat. No.	Product Name	Target	Signaling Pathways
T26590	Albofungin Antibiotic P42-1,Antibiotic P42-C
	Albofungin is a xanthone isolated from A. tumemacerans.
T13679	Enniatin B	ERK	MAPK
	Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes.
T13680	Enniatin B1 恩镰孢菌素 B1	ERK	MAPK
	Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes.

天然产物

Cat.No: T26590

Synonym: Antibiotic P42-1,Antibiotic P42-C

Cat.No: T13679

Target: ERK

Cat.No: T13680

Synonym: 恩镰孢菌素 B1

Target: ERK

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