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52

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T25492	Hepln-13 Hepln 13,Hepln13	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Hepln-13 是具有口服活性的Hepsin 抑制剂(IC50:0.33 µM)。它可用于研究转移性前列腺癌。
TP1253	Argireline 六胜肽,Acetyl hexapeptide-3,阿基瑞林	Others	Others
	Argireline (Acetyl hexapeptide-3) 是可渗透皮肤的、无毒的抗皱肽。它对神经肌肉接头处依赖 Ca2+的神经递质释放具有显著的抑制作用。它具有抗皱和抗衰老的活性。
T6456	CRT0044876 NSC 69877,7-NO2-ICA,7-硝基吲哚-2-甲酸,NSC 69877,7-Nitroindole-2-Carboxylic Acid	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	CRT0044876 (7-NO2-ICA) 是一种高选择性的嘌呤/嘧啶核苷核酸内切酶 1 抑制剂，IC50约为 3 μM。它也是 APE1 所属的核酸外切酶 III 家族的特异性抑制剂，可抑制 APE1 的 AP 内切酶、3′-磷酸二酯酶和 3′-磷酸酶活性，可增强几种 DNA 碱基靶向化合物的细胞毒性。
T5314	pyridoxal isonicotinoyl hydrazone 吡哆醛异烟酰肼,PIH	Others	Others
	pyridoxal isonicotinoyl hydrazone (PIH) 是亲脂的三价铁螯合剂，具有高铁螯合特性。
T19232	CMC-Na (Viscosity:800-1200 mPa.s) 羧甲基纤维素钠,CMC-Na (Viscosity:800-1200 mPa.s)	Others	Others
	Sodium carboxymethyl cellulose (CMC-Na) (Viscosity:800-1200 mPa.s) 是一种水溶性纤维素，常用作动物实验的助溶剂，对动物基本没有毒性。
T8669	3,3',4,4'-Benzophenonetetracarboxylic dianhydride	Others	Others
	3,3',4,4'-Benzophenonetetracarboxylic dianhydride 是一种化合物，用于生产聚酰亚胺薄膜和粘合剂的聚酰亚胺前体。它是一种无毒材料，对人体健康没有已知的不良影响。
T0914	Metacetamol 酰胺苯酚,3-Acetamidophenol	Others	Others
	Metacetamol (3-Acetamidophenol) 是对乙酰氨基酚的衍生物，为其无毒区域异构体，是一种非处方镇痛剂和解热剂，也可用作有机合成中间体。
T14319	Aripiprazole Lauroxil	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Aripiprazole lauroxil 是一种长效注射剂 (LAI) 的抗精神病药物，是阿立哌唑的 N-酰氧基甲基前药形式。它能够被体内酯酶裂解为 N-羟甲基阿立哌唑(月桂酸)，再裂解为阿立哌唑，无毒性。
T14922	Cefodizime	Antibacterial; Antibiotic	Microbiology/Virology
	Cefodizime 是一种新型头孢菌素抗生素，具有广泛的生物活性。Cefodizime 对肾脏没有毒性且具有良好的耐受性和免疫调节活性，具有抗菌活性，可用于研究呼吸系统和泌尿系统的严重感染。
T15602	ITX3	Others; Rho	Cell Cycle/Checkpoint; Others
	ITX3 是特异的、无毒的、有活性的、具有选择性的TrioN RhoGEF 抑制剂，IC50 值为 76 μM。 ITX3具有抗癌作用，能抑制trion 介导的GTP 在RhoG 和Rac1上的交换，抑制ngf 介导的PC12细胞神经突的生长和trion 诱导的REF52成纤维细胞结构的形成。
T38063	N-Acetyl lysyltyrosylcysteine amide	Glutathione Peroxidase	Metabolism
	N-Acetyl lysyltyrosylcysteine amide 是一种无毒的髓过氧化物酶 (MPO) 三肽抑制剂，具有有效性，可逆性和特异性。N-Acetyl lysyltyrosylcysteine amide 在体内可有效抑制 MPO 产生。N-Acetyl lysyltyrosylcysteine amide 减轻中风后大脑的神经元损伤，并保留脑组织和神经功能。N-Acetyl lysyltyrosylcysteine amide 抑制MPO依赖性次氯酸 (HOCl) 的生成，蛋白质硝化和 LDL 氧化。N-Acetyl lysyltyrosylcysteine amide 可用于研究支气管发育不良。
T33923	Pentyl rhamnoside Selectiose
	Pentyl rhamnoside is a new non-toxic cosurfactant to formulate microemulsions.
T34391	Rosmarinine
	Rosmarinine is a non-toxic pyrrolizidine alkaloid.
T16082	Mivotilate YH439	Others	Others
	Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent.
T71501	GBS-149
	GBS-149 is a novel non-toxic and mammalian-specific LINE-1 inhibitor.
T22255	Amastatin	Others	Others
	Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 µM .
T33388	Mimosine methyl ester L-Mimosine methyl ester
	Mimosine methyl ester is a toxic non-protein amino acid chemically similar to tyrosine, that was first isolated from Mimosa pudica.
T11051	DIQ3	Others	Others
	DIQ3 is non-toxic to normal human cell lines and is an effective anti-cancer agent.
T31437	Dicobalt edetate Ba-2724,Ba2724,Ba 2724,Kelocyanor
	Cobalt edylic acid is a cobalt compound whose mechanism is that cyanide binds cobalt to form a relatively non-toxic complex.
T30582	BRD56491 BRD-56491,BRD 56491
	BRD56491 is a non-toxic reactive oxygen species (ROS) enhancer that strongly elevates markers of oxidative stress without causing cell death.
T61470	NMDA receptor antagonist 5
	NMDA receptor antagonist 5 (Compound 10e), a potent and non-toxic NMDA receptor antagonist, exhibits brain permeability. It is of significance in studying neurological disorders [1].
T30581	BRD5459 BRD-5459,BRD 5459
	BRD5459 is a kind of reactive oxygen species enhancer that is non-toxic or leads to genotype selective cell death. Brd5459 can selectively kill cancer cells in various in vitro and in vivo models.
T28110	MRZ-99030 EG 030,EG030,EG-030,MRZ 99030
	MRZ-99030 is an Aβ aggregation modulator. MRZ-99030 triggers a non-amyloidogenic aggregation pathway, thereby reducing the amount of intermediate toxic soluble oligomeric Aβ species.
T60855	Elastase-IN-1
	Elastase-IN-1 (Compound Q11) 是无毒的弹性蛋白酶抑制剂，IC50值为 0.897 μM。
T13609L	Chlorazanil	Others	Others
	Chlorazanil 是一种三嗪衍生物，也是一种口服有效的新型非毒性利尿剂，可以阻止钠和氯在远曲小管的吸收。
T15379	GGsTop Nahlsgen	Others	Others
	GGsTop is a non-toxic and irreversible inhibitor of γ glutamyl transpeptidase (GGT) (Ki: 170 μM for Human GGT). GGsTop protects hepatic ischemia-reperfusion injury in the rat model. GGsTop shows Kons of 150±10 and 51±3 /(M·s) against E.coli GGT and human GGT, respectively.
T39322	Temporin A
	Temporin A, a short alpha-helical antimicrobial peptide derived from the skin of Rana temporaria, exhibits a wide-ranging efficacy against Gram-positive bacteria. It directly interacts with the cell membrane of microorganisms and remains non-toxic to erythrocytes at antimicrobial concentrations. Additionally, Temporin A demonstrates antifungal properties against yeast-like Candida albicans.
T73356	Ac32Az19
	Ac32Az19 是一种有效、无毒、高选择性的 BCRP 抑制剂，在BCRP 过度表达的HEK293/R2细胞中，EC50值为13 nM。
T74526	Antifungal agent 29
	Antifungal agent 29 (化合物 9d) 是一种有效的、选择性的、无毒的抗真菌剂。Antifungal agent 29 对新隐球菌具有抗真菌活性 (MIC≤ 0.23 μM)。
T3694L	Tebanicline tosylate
	Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine. Like epibatidine, tebanicline showed potent analgesic activity against neuropat
T23207	Q-VD(OMe)-OPh	Others	Others
	Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone) is a broad-spectrum caspase inhibitor, provides a cost-effective, non-toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new
T62697	BuChE-IN-3
	BuChE-IN-3 (Compound C4) 是一种 BuChE 的有效抑制剂 (IC50: 8.3 nM)。BuChE-IN-3 具有温和的抗氧化能力、无毒、亲脂性和神经保护效果。
T34029	Phosmet oxon R-1571,R 1571,ENT 25707,ENT-25707,R1571
	Phosmet oxon is a toxic metabolite of phosmet, a phthalimide-derived, non-systemic, organophosphate insecticide used on plants and animals. It is mainly used on apple trees for control of codling moth, though it is also used on a wide range of fruit crops
T76244	Amp1EP9
	Amp1EP9为一抗菌肽，作为开发有效无毒抗菌活性分子的强大工具，具备针对多重耐药细菌感染进行研究的潜力。
T35521	Aflatoxin G2-13C17 Aflatoxin G2-13C17
	Aflatoxin G2-13C17is intended for use as an internal standard for the quantification of aflatoxin G2by GC- or LC-MS. Aflatoxin G2is a mycotoxin that has been found inAspergillus.1It is lethal to ducklings (LD50= 2.83 mg/kg) but is non-toxic to rats when administered at a dose of 200 mg/kg.2 1.Bennett, J.W., and Klich, M.MycotoxinsClin. Microbiol. Rev.16(3)497-516(2003) 2.Wogan, G.N., Edwards, G.S., and Newberne, P.M.Structure-activity relationships in toxicity and carcinogenicity of aflatoxins a...
T74494	Antitumor agent-63
	Antitumor agent-63（Compound 40），一种20 (S)-O-linked camptothecin (CPT) 糖复合物，作为抗肿瘤剂，对正常细胞展现出无毒性。该化合物表现出高稳定性和低topoisomeraseI (Topo I)直接抑制活性。
T63472	HDAC6-IN-4
	HDAC6-IN-4 (C10) 是一种口服具有活力的、高度选择性的、有效的、无明显毒性的 HDAC6 抑制剂 (IC50: 23 nM)。HDAC6-IN-4 能够诱导肿瘤细胞凋亡 (apoptosis)，表现出高效的抗肿瘤效果。
T40341	SARS-CoV-2-IN-11
	SARS-CoV-2-IN-11 is a highly potent and non-toxic inhibitor of the 3C-like protease (3CLpro) of SARS-CoV-2, demonstrating IC50 and EC50 values of 0.17 nM and 1.45 nM, respectively. This compound targets the essential viral replication enzyme, 3CLpro, making it an attractive candidate for intervention strategies. SARS-CoV-2-IN-11 holds significant promise in the development of specific antivirals against SARS-CoV-2.
T63628	AChE-IN-19
	AChE-IN-19 是 AChE 的高效抑制剂 (IC50: 0.56 μM)，对 Aβ 聚集也表现出抑制作用。AChE-IN-19 表现出神经保护作用，对 SH-SY5Y 细胞几乎没有毒性。AChE-IN-19 能够用于研究阿尔兹海默症。
T61462	EV-A71-IN-1
	EV-A71-IN-1 is a potent inhibitor of the human enterovirus A71 (EV-A71) capsid protein, with an EC50 of 0.27 μM against EV-A71. Acting as a capsid binder, EV-A71-IN-1 disrupts the crucial interaction between the viral VP1 protein and the host receptor hSCARB2. It displays broad-spectrum antiviral activity against various human enteroviruses, while being non-toxic to human cells (CC50 > 56.2 μM) [1].
T78305	Briquilimab JSP-191
	Briquilimab (JSP-191) 是针对 CD117 (c-Kit) 的无毒人源化单克隆抗体，用于消耗造血干细胞 (HSC)。它被应用于重度联合免疫缺陷 (SCID) 治疗中，以清空宿主骨髓生态位，为供体造血干细胞移植及免疫重建创造条件。
T82388	Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone	Caspase	Apoptosis; Proteases/Proteasome
	Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone 是一种细胞渗透性且无毒的抑制剂，它能与活化的caspase-3在凋亡细胞内不可逆结合。该抑制剂的荧光强度可通过流式细胞仪、微孔板读数器或荧光显微镜检测。
T40340	SARS-CoV-2-IN-10
	SARS-CoV-2-IN-10 is a powerful and non-toxic inhibitor of SARS-CoV-2 3CL protease, with IC50 and EC50 values of 0.13 nM and 1.03 nM, respectively. The SARS-CoV-2 3C-like protease (3CLpro) is a critical enzyme for viral replication and serves as an ideal target for intervention. By targeting the SARS-CoV-2 3CL protease, SARS-CoV-2-IN-10 has the potential to facilitate the development of effective antiviral drugs specific to SARS-CoV-2.
T79559	Mtb-IN-4
	Mtb-IN-4（化合物17h）是一种异恶唑类化合物，显示出针对结核分枝杆菌（Mtb）的抗活性，其IC50值为0.70 μM。它能阻断巨噬细胞内Mtb的呼吸和生物膜形成，并可以增强抗生素异烟肼（INH）对耐INH Mtb突变体的抑制效果。
T11934	Macitentan-d4 Macitentan D4,ACT-064992 D4	Endothelin Receptor	GPCR/G Protein
	Macitentan-d4 (ACT-064992 D4) 是一种 Macitentan 氘代物，可被当作非多肽 ETA 和 ETB (内皮素受体)双拮抗剂。Macitentan-d4 比 Macitentan 毒性更低，半衰期更长，可用于研究由内皮素受体介导介导的疾病。
T36475	TunR2
	TunR2 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. Unlike tunicamycin, TunR2 is non-toxic toS. cerevisiae(MIC = >10 μg/ml) and does not inhibit glycosylation in a protein N-glycosylation assay. TunR2 also has reduced antiproliferative activity against MDA-MB-231 and CHO cells compared wi...
T11896	LV-320	Cysteine Protease	Proteases/Proteasome
	LV-320 是一种有效且非竞争性的ATG4B 抑制剂，其IC50值为 24.5 μM，Kd 值为 16 μM。 LV-320 抑制ATG4B 的酶促活性，阻断细胞自噬，并且稳定无毒，在体内具有活性。
T78964	Antileishmanial agent-17	Parasite	Microbiology/Virology
	Antileishmanial agent-17是香豆素杂化化合物，展现出优越的抗利什曼原虫活性(IC50<0.78 μM)，同时对VERO细胞具备安全性。该化合物通过抑制叶酸代谢途径发挥效用，且在对抗利什曼原虫不同生长阶段表现显著，其IC50值分别对前鞭毛体为0.40 μM，对无鞭毛体为0.68 μM。
T63735	SP inhibitor 1
	SP inhibitor 1 是体外无毒浓度 (0.3250<5.98 μM) 的 SARS-CoV-2 复制抑制剂。SP inhibitor 1 是 SARS-CoV-2 刺突蛋白 (SP) 的选择性抑制剂，能够作用于 SP 蛋白 (IC50: 3.26 μM)、Mpro 蛋白 (IC50>25 μM)和 PLpro 蛋白 (IC50>25 μM)，具有细胞抗病毒作用。
T69657	GS-441524 HCl
	GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations ...

化合物

Cat.No: T25492

Synonym: Hepln 13,Hepln13

Target: c-Met/HGFR

Cat.No: TP1253

Synonym: 六胜肽,Acetyl hexapeptide-3,阿基瑞林

Target: Others

Cat.No: T6456

Synonym: NSC 69877,7-NO2-ICA,7-硝基吲哚-2-甲酸,NSC 69877,7-Nitroindole-2-Carboxylic Acid

Target: DNA/RNA Synthesis

pyridoxal isonicotinoyl hydrazone

Cat.No: T5314

Synonym: 吡哆醛异烟酰肼,PIH

Target: Others

CMC-Na (Viscosity:800-1200 mPa.s)

Cat.No: T19232

Synonym: 羧甲基纤维素钠,CMC-Na (Viscosity:800-1200 mPa.s)

Target: Others

3,3',4,4'-Benzophenonetetracarboxylic dianhydride

Cat.No: T8669

Target: Others

Cat.No: T0914

Synonym: 酰胺苯酚,3-Acetamidophenol

Target: Others

Aripiprazole Lauroxil

Cat.No: T14319

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T14922

Target: Antibacterial, Antibiotic

Cat.No: T15602

Target: Others, Rho

N-Acetyl lysyltyrosylcysteine amide

Cat.No: T38063

Target: Glutathione Peroxidase

Pentyl rhamnoside

Cat.No: T33923

Synonym: Selectiose

Cat.No: T34391

Cat.No: T16082

Synonym: YH439

Target: Others

Cat.No: T71501

Cat.No: T22255

Target: Others

Mimosine methyl ester

Cat.No: T33388

Synonym: L-Mimosine methyl ester

Cat.No: T11051

Target: Others

Dicobalt edetate

Cat.No: T31437

Synonym: Ba-2724,Ba2724,Ba 2724,Kelocyanor

Cat.No: T30582

Synonym: BRD-56491,BRD 56491

NMDA receptor antagonist 5

Cat.No: T61470

Cat.No: T30581

Synonym: BRD-5459,BRD 5459

Cat.No: T28110

Synonym: EG 030,EG030,EG-030,MRZ 99030

Cat.No: T60855

Cat.No: T13609L

Target: Others

Cat.No: T15379

Synonym: Nahlsgen

Target: Others

Cat.No: T39322

Cat.No: T73356

Antifungal agent 29

Cat.No: T74526

Tebanicline tosylate

Cat.No: T3694L

Cat.No: T23207

Target: Others

Cat.No: T62697

Cat.No: T34029

Synonym: R-1571,R 1571,ENT 25707,ENT-25707,R1571

Cat.No: T76244

Aflatoxin G2-13C17

Cat.No: T35521

Synonym: Aflatoxin G2-13C17

Antitumor agent-63

Cat.No: T74494

Cat.No: T63472

SARS-CoV-2-IN-11

Cat.No: T40341

Cat.No: T63628

Cat.No: T61462

Cat.No: T78305

Synonym: JSP-191

Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone

Cat.No: T82388

Target: Caspase

SARS-CoV-2-IN-10

Cat.No: T40340

Cat.No: T79559

Cat.No: T11934

Synonym: Macitentan D4,ACT-064992 D4

Target: Endothelin Receptor

Cat.No: T36475

Cat.No: T11896

Target: Cysteine Protease

Antileishmanial agent-17

Cat.No: T78964

Target: Parasite

Cat.No: T63735

Cat.No: T69657

Cat. No.	Product Name	Target	Signaling Pathways
T5757	Loganetin	Antibacterial	Microbiology/Virology
	Loganetin 是无毒的天然产物，来源于Cornus officinalis Sieb. et Zucc.，可用于耐多药革兰氏阴性菌感染的研究。
T4S1521	1,4-Dicaffeoylquinic acid 1,4-二咖啡酰奎宁酸,洋蓟素	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	1,4-Dicaffeoylquinic acid 是一种苯丙素类物质，从苍耳子中获得，可以减少 LPS 诱导的 TNF-α 的生成，具有抗炎活性。
T3321	Oleanonic acid 3-Oxooleanolic acid,3-Oxoolean-12-en-28-oic Acid,Oleanonic Acid,齐墩果酮酸,3-Ketooleanolic Acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Oleanonic acid (3-Ketooleanolic Acid) 是一种三萜，可以抑制 HIV-1 对细胞的感染。它具有保肝作用，并具有抗肿瘤和抗病毒特性。
T8100	Azetidine-2-carboxylic acid	Others	Others
	Azetidine-2-carboxylic acid 是脯氨酸的非蛋白原氨基酸同系物，可以在常见的甜菜中获得。在许多物种中，它能够错误地掺入蛋白质中代替脯氨酸，是一种致毒和致畸剂。
T5279	Ethylmalonic acid alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸	Others; Endogenous Metabolite	Metabolism; Others
	Ethylmalonic acid (alpha-Carboxybutyrate) 是潜在有毒物质，非致癌性，与神经性厌食和甲氧基脱羧酶缺乏症有关。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T15703	Lactimidomycin	Others	Others
	Lactimidomycin, isolated from Streptomyces, is an inhibitor of eukaryotic translation elongation. It is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Lactimidomycin has an antiproliferative effect on tumor cell lines. It i
T75447	Asperaculane B
	Asperaculane B，一种真菌代谢产物，以IC50 7.89 µM抗恶性疟原虫传播，同时以IC50 3 µM抑制无性恶性疟原虫的发育，对人类细胞无毒。

天然产物

Cat.No: T5757

Target: Antibacterial

1,4-Dicaffeoylquinic acid

Cat.No: T4S1521

Synonym: 1,4-二咖啡酰奎宁酸,洋蓟素

Target: HIV Protease

Cat.No: T3321

Synonym: 3-Oxooleanolic acid,3-Oxoolean-12-en-28-oic Acid,Oleanonic Acid,齐墩果酮酸,3-Ketooleanolic Acid

Target: HIV Protease

Azetidine-2-carboxylic acid

Cat.No: T8100

Target: Others

Ethylmalonic acid

Cat.No: T5279

Synonym: alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸

Target: Others, Endogenous Metabolite

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

Cat.No: T15703

Target: Others

Cat.No: T75447

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