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Search Results for " monooxygenase "

22

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19654	Guanoclor 胍氯酚,VATENSOL	Others	Others
	Guanoclor (VATENSOL) 也称为guanochlor，是一种交感神经药物。已知它与猪肾膜中的非肾上腺素能位点结合。
T13383	Zamicastat BIA 5-1058	BCRP; Hydroxylase; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Zamicastat (BIA 5-1058) 是多巴胺 β-羟化酶 (DBH) 抑制剂，可透过血脑屏障引起中枢和周边效应，具有降血压作用。它也是一种浓度依赖性的双重 P-gp 和 BCRP 抑制剂，IC50值分别为 73.8 和 17.0 μM。
T7877	Thiacetazone 氨硫脲,Diazam,Thioacetazone,Neustab,Neotibil	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Thiacetazone (Diazam) 是一种氨基硫脲抗结核剂，也是一种具有口服活性抗生素。它具有抗菌作用，可抑制结核分枝杆菌 H37Rv 的生长，MIC 值为 0.1 μg/mL。
T6604	Nepicastat hydrochloride Nepicastat HCl,内匹司他盐酸盐,RS-25560-197 hydrochloride,SYN-117 hydrochloride,Nepicastat (SYN-117) HCl	Hydroxylase	Metabolism
	Nepicastat hydrochloride (RS-25560-197 hydrochloride) 是一种选择性的，有效的，口服活性的多巴胺 β 羟化酶(dopamine-beta-hydroxylase)抑制剂，对牛和人多巴胺 β 羟化酶的IC50分别为IC50=8.5 nM 和IC50=9 nM。Nepicastat HCl 可以穿过血脑屏障。
T20373	1-Phenylpyrrole NSC16581,NSC-16581,1-苯基吡咯,NSC 16581	Others	Others
	1-Phenylpyrrole (NSC-16581) 可抑制大鼠肝脏微粒体中 CYP450 依赖性单加氧酶活性。
T20700	Racemetirosine	Others	Others
	Racemetirosine 是一种酪氨酸 3-单加氧酶抑制剂，因此会抑制儿茶酚胺的合成。
T0293	Metyrapone 美替拉酮,甲吡酮,NSC-25265,Su-4885	Others; P450; Dehydrogenase; Autophagy	Autophagy; Metabolism; Others
	Metyrapone (NSC-25265) 是 STEROID 11-BETA-MONOOXYGENASE 酶抑制剂。它被用作库欣综合征诊断中下丘脑-垂体反馈机制的测试。
TP1344	Luciferase	Others	Others
	Luciferase 是一种在生物发光细菌中发现的依赖黄素的单加氧酶。 Luciferase 是识别和表征功能变体的宝贵工具，可用于研究基因表达、细胞内信号传导、转录因子、受体活性和蛋白质折叠。
T28202	NSC-152035 Racemetirosine methyl ester HCl,NSC 152035,Racemetirosine methyl ester hydrochloride
	NSC-152035 is an inhibitor of tyrosine 3-monooxygenase.
T13258	UPF-648 sodium salt	Others	Others
	UPF-648 sodium salt is an inhibitor of kynurenine 3-monooxygenase (KMO) and exhibits highly active at 1 uM (81 ± 10% KMO inhibition).
T32743	Licodione
	Licodione is a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone.
T70041	GSK065
	GSK065 is a potent inhibitor of kynurenine-3-monooxygenase (KMO).
T0293L	Metyrapone Tartrate SU 4885,Metopirone tartrate,SU-4885,SU4885
	Metyrapone Tartrate is an inhibitor of the STEROID 11-beta-monooxygenase enzyme which is used as a test for feedback hypothalamic-pituitary mechanism in the diagnosis of Cushing SYNDROME.
T15426	GSK180	Hydroxylase	Metabolism
	GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
T11470	GSK 366	Hydroxylase	Metabolism
	GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
T13258L	UPF-648	Others	Others
	UPF-648 is a potent kynurenine 3-monooxygenase inhibitor. It also shows highly active at 1 uM (81 ± 10% KMO inhibition).
T63613	JM6
	JM6 是弱犬尿氨酸 3-单加氧酶 (kynurenine 3-monooxygenase, KMO) 抑制剂，能够作用于小鼠 KMO (IC50: 19.85 μM)。JM6 能够用于研究阿尔茨海默病。
T80635	Gentisuric acid	Drug Metabolite	Metabolism
	Gentisuric Acid，作为Aspirin的代谢产物同时也是α-酰胺化单加氧酶（PAM）的底物，可抵御Mitomycin C导致的DNA损伤。
T37659	5-hydroxy Omeprazole
	5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+/K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxygenase. [2][3] CYP2C19 polymorphisms significantly influence the metabolism of omeprazole, and individuals may be classified as homozygous extensive metabolizers, heterozygous extensive metabolizers, and poor metabolizers.[1]
T82190	H-Met-Val-OH
	H-Met-Val-OH是一种游离N端蛋氨酸的二肽。该化合物对cDNA表达的FMO1和FMO3表现活性，并可能在神经突起生长中有应用。
T13460	(+)-Cevimeline hydrochloride hemihydrate (+)-AF102B hydrochloride hemihydrate,(+)-SNI-2011	Others	Others
	(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011) 是一种有效的 mAChR 激动剂。
T13421	(-)-Cevimeline hydrochloride hemihydrate (-)-SNI-2011,(-)-AF102B hydrochloride hemihydrate	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) 是一种新型mAChR 激动剂，是一种治疗干燥综合征口干症的候选治疗药物。

化合物

Cat.No: T19654

Synonym: 胍氯酚,VATENSOL

Target: Others

Cat.No: T13383

Synonym: BIA 5-1058

Target: BCRP, Hydroxylase, P-gp

Cat.No: T7877

Synonym: 氨硫脲,Diazam,Thioacetazone,Neustab,Neotibil

Target: Others, Antibacterial, Antibiotic

Nepicastat hydrochloride

Cat.No: T6604

Synonym: Nepicastat HCl,内匹司他盐酸盐,RS-25560-197 hydrochloride,SYN-117 hydrochloride,Nepicastat (SYN-117) HCl

Target: Hydroxylase

1-Phenylpyrrole

Cat.No: T20373

Synonym: NSC16581,NSC-16581,1-苯基吡咯,NSC 16581

Target: Others

Cat.No: T20700

Target: Others

Cat.No: T0293

Synonym: 美替拉酮,甲吡酮,NSC-25265,Su-4885

Target: Others, P450, Dehydrogenase, Autophagy

Cat.No: TP1344

Target: Others

Cat.No: T28202

Synonym: Racemetirosine methyl ester HCl,NSC 152035,Racemetirosine methyl ester hydrochloride

UPF-648 sodium salt

Cat.No: T13258

Target: Others

Cat.No: T32743

Cat.No: T70041

Metyrapone Tartrate

Cat.No: T0293L

Synonym: SU 4885,Metopirone tartrate,SU-4885,SU4885

Cat.No: T15426

Target: Hydroxylase

Cat.No: T11470

Target: Hydroxylase

Cat.No: T13258L

Target: Others

Cat.No: T63613

Gentisuric acid

Cat.No: T80635

Target: Drug Metabolite

5-hydroxy Omeprazole

Cat.No: T37659

Cat.No: T82190

(+)-Cevimeline hydrochloride hemihydrate

Cat.No: T13460

Synonym: (+)-AF102B hydrochloride hemihydrate,(+)-SNI-2011

Target: Others

(-)-Cevimeline hydrochloride hemihydrate

Cat.No: T13421

Synonym: (-)-SNI-2011,(-)-AF102B hydrochloride hemihydrate

Target: ALK

Cat. No.	Product Name	Target	Signaling Pathways
TN1576	Diallyl disulfide	IL Receptor; NOS; NF-κB	Immunology/Inflammation; NF-κB
	Diallyl disulfide 能够抑制人角鲨烯单加氧酶，抑制角鲨烯环氧化的 IC50为 400 μM。它也具有抗肿瘤作用，同miR-200b 和miR-22联合使用可增强该作用。
T6S0923	Hypericin Hypericine,金丝桃素,Cyclosan	Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Hypericin (Cyclosan) 是贯叶连翘的提取物，有抗菌、抗病毒、抗肿瘤和抗抑郁作用。
T4829	3-Hydroxyphenylacetic acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Hydroxyphenylacetic acid 是内源性代谢产物的一种。
T11680	Isoasatone A	P450	Metabolism
	Isoasatone A 是一种具有抗虫作用的天然产物，分离自Heterotropa takaoiM。它作用于细胞色素 P450 单加氧酶和谷胱甘肽转移酶，产生抗S. litura 作用。
TN1078	Seneciphylline 千里光菲灵碱,千里光非灵	P450; GST	Metabolism; oxidation-reduction
	Seneciphylline 是一种有毒的吡咯烷核生物碱，存在于千里光植物中。它显著增加了环氧水合酶和谷胱甘肽-S-转移酶的特性，但导致细胞色素 P-450 和相关单加氧酶特性的抑制。
T78483	Benzydamine N-Oxide
	Benzydamine N-Oxide，作为Benzydamine的代谢产物，主要用于测定含黄素单加氧酶（flavin-containing monooxygenase）的活性。
T80656	Cannflavin A
	Cannflavin A，源自大麻(Cannabis sativa L)，具备抗癌、神经保护及抗炎活性。该化合物有效抑制Aβ1-42的聚集，并阻断犬尿氨酸-3-单加氧酶(KMO)的活性，进而通过caspase-3裂解途径激活细胞凋亡(apoptosis)。

天然产物

Diallyl disulfide

Cat.No: TN1576

Target: IL Receptor, NOS, NF-κB

Cat.No: T6S0923

Synonym: Hypericine,金丝桃素,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

3-Hydroxyphenylacetic acid

Cat.No: T4829

Target: Others, Endogenous Metabolite

Cat.No: T11680

Target: P450

Cat.No: TN1078

Synonym: 千里光菲灵碱,千里光非灵

Target: P450, GST

Benzydamine N-Oxide

Cat.No: T78483

Cat.No: T80656

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