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Search Results for " modulatory "

17

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9148	KA2507	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	KA2507 是一种具有口服活性的选择性HDAC6抑制剂，其IC50值为 2.5 nM。它有抗肿瘤活性和免疫调节作用。
T22711	DCB 3,3'-dichlorobenzaldazine	Others; GluR	Neuroscience; Others
	DCB (3,3'-dichlorobenzaldazine) 是 mGluR5 的变构配体，显示出 3,3'-二甲氧基苯扎嗪 (DMeOB) 的负调节作用。 DCB 在 3,3'-二氟苯扎嗪 (DFB) 的帮助下阻断 mGluR 的正变构调节。
T34114	Posatirelin BRN 6006446,Posatirelinum,BRN-6006446,RGH-2202,BRN6006446	AChR	Neuroscience
	Posatirelin (BRN6006446) 是一种对单胺能和胆碱能系统具有调节活性和神经营养作用的合成肽，可用于研究血管性痴呆。
TP2324	Thymulin	Immunology/Inflammation related	Immunology/Inflammation
	Thymulin 是一种肽类激素，主要由胸腺上皮细胞产生，具有免疫调节和抗炎作用。
T12110	MRZ 2-514 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one	NMDAR	Neuroscience
	MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) 是 NMDA receptor(glycineB) 的拮抗剂，Ki=33 μM。
T15275	Fenobam	GluR	Neuroscience
	Fenobam 是可口服的、可穿过血脑屏障的 mGluR5拮抗剂，具有抗焦虑活性，在大鼠和人重组 mGlu5 受体上的 Kd 值分别 54 和 31 nM。它有反向激动剂活性，可阻断 mGlu5 受体活性，IC50为 84 nM。
T15286	Flindokalner BMS-204352	Potassium Channel	Membrane transporter/Ion channel
	Flindokalner (BMS-204352) 是一种钾离子通道调节剂。它是大电导钙激活 K 通道正向调节剂。它是在 HEK293 细胞中表达的所有神经元 Kv7通道亚型的正调节剂。它在 Kv7.1 通道 (Ki=3.7 μM) 处显示负调节活性，并充当 GABAA 受体的负调节剂。它在体内显示出抗焦虑功效。
T25474	GW-Amide Glycyl-tryptophanamide,GW Amide
	GW-Amide is a molluscan neuropeptide that exhibits potent modulatory effects on molluscan muscles.
T68612	DM175
	DM175 is a novel partial FXR agonist, causing specific modulatory effects on FXR activity that clearly differ from classical FXR agonists.
T25453	Glaspimod F 107647,SK&,F-107647,F107647
	Glaspimod is a synthetic hematoregulatory peptide. It shares biological and/or modulatory activities with natural hematopoetic cytokines.
T15618	JNJ-46281222	GluR	Neuroscience
	JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).
T12828	Salicortin	NF-κB; JNK	MAPK; NF-κB
	Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activity.
T61322	KA2507 monohydrochloride
	KA2507 hydrochloride is a powerful and specific HDAC6 inhibitor, possessing an IC50 value of 2.5 nM. It displays no substantial toxicities while demonstrating significant antitumor efficacy and immune modulatory effects [1].
T23808	BMS-986169
	BMS-986169 is a GluN2B Receptor Negative Allosteric Modulator. BMS-986169 showed a high binding affinity for the GluN2B subunit allosteric modulatory site (Ki: 4.03-6.3 nM) and selectively inhibited GluN2B receptor function in Xenopus oocytes expressing h
T74747	Tamuzimod
	Tamuzimod 是一个强大的免疫调节剂.Tamuzimod 具有S1P 受体调节活性乙C50小于 1μ米。
T69422	Flupirtine HCl
	Flupirtine HCl is the salt form of Flupirtine, also known as W-2964, an aminopyridine that functions as a centrally acting non-opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the names Katadolon, Trancolong, Awegal, Efiret, Trancopal Dolo, and Metanor. Like nefopam, it is unique among analgesics in that it is a non-opioid, non-NSAID, non-steroidal centrally acting analgesic. Flupirtine is a selective neuronal potassium channel opener that also has NMDA re...
T74600	Keap1-Nrf2-IN-9
	Keap1-Nrf2-IN-9（compound 11）是一种有效Keap1-Nrf2PPI抑制剂，IC50为0.575 µM。该化合物能够提升Nrf2靶基因表达，涉及血红素加氧酶1 (Hmox1)、谷胱甘肽S转移酶P (GstP) 以及谷氨酸-半胱氨酸连接酶的催化(Gclc)与调节(Gclm)亚基。在ARPE19细胞中，Keap1-Nrf2-IN-9展现出无细胞毒活性。

化合物

Cat.No: T9148

Target: HDAC

Cat.No: T22711

Synonym: 3,3'-dichlorobenzaldazine

Target: Others, GluR

Cat.No: T34114

Synonym: BRN 6006446,Posatirelinum,BRN-6006446,RGH-2202,BRN6006446

Target: AChR

Cat.No: TP2324

Target: Immunology/Inflammation related

Cat.No: T12110

Synonym: 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one

Target: NMDAR

Cat.No: T15275

Target: GluR

Cat.No: T15286

Synonym: BMS-204352

Target: Potassium Channel

Cat.No: T25474

Synonym: Glycyl-tryptophanamide,GW Amide

Cat.No: T68612

Cat.No: T25453

Synonym: F 107647,SK&,F-107647,F107647

Cat.No: T15618

Target: GluR

Cat.No: T12828

Target: NF-κB, JNK

KA2507 monohydrochloride

Cat.No: T61322

Cat.No: T23808

Cat.No: T74747

Cat.No: T69422

Keap1-Nrf2-IN-9

Cat.No: T74600

Cat. No.	Product Name	Target	Signaling Pathways
T4S0554	Theaflavine-3,3'-digallate TFBG,theaflavin digallate,3,3’-二没食子酸酯茶黄素	Others	Others
	Theaflavine-3,3'-digallate (theaflavin digallate) 和乳酸一起可以减少单纯疱疹病毒的传播。
T4808	Agmatine sulfate Agmatine sulfate salt,硫酸胍基丁胺	Endogenous Metabolite; NO Synthase; Imidazoline Receptor	Immunology/Inflammation; Metabolism; Neuroscience
	Agmatine sulfate (Agmatine sulfate salt) 是咪唑啉受体的内源性激动剂和一氧化氮合酶抑制剂。它靶向神经递质系统，离子通道和一氧化氮合成。
TN4112	Garciniaxanthone E	Others	Others
	The synthetic caged Garcinia xanthone cluvenone induces cell stress and apoptosis and has immune modulatory activity.
TN4725	Oxychelerythrine	Antifection	Microbiology/Virology
	Oxychelerythrine shows high modulatory activity enhancing the susceptibility of the S. aureus ATCC 6538 to all the tested antibiotics from two to four-fold. It also shows antifeeding activities against Tribolium castaneum adults, with the EC50 of 192.32 p
T4752	1-Aminocyclopropane-1-carboxylic acid 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite; NMDAR	Metabolism; Neuroscience
	1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。

天然产物

Theaflavine-3,3'-digallate

Cat.No: T4S0554

Synonym: TFBG,theaflavin digallate,3,3’-二没食子酸酯茶黄素

Target: Others

Agmatine sulfate

Cat.No: T4808

Synonym: Agmatine sulfate salt,硫酸胍基丁胺

Target: Endogenous Metabolite, NO Synthase, Imidazoline Receptor

Garciniaxanthone E

Cat.No: TN4112

Target: Others

Oxychelerythrine

Cat.No: TN4725

Target: Antifection

1-Aminocyclopropane-1-carboxylic acid

Cat.No: T4752

Synonym: 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC

Target: Endogenous Metabolite, NMDAR

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