Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8485 |
THIQ
|
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
THIQ 是一种选择性黑皮质素 4 受体 (MC4R) 激动剂,对 hMC4R 和 rMC4R 的 IC50 分别为 1.2 和 0.6 nM。 | |||
TP1898 |
HS024
HS 024 |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
HS024 是一种选择性的MC4受体拮抗剂,可增加食物摄入,对 MC4、MC5、MC3 和 MC1 的Ki 分别为 0.29、3.29、5.45 和 18.6 nM。 | |||
T7589 |
Afamelanotide acetate
afamelanotide |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Afamelanotide acetate 是一种合成的 α-黑素细胞刺激激素类似物和一流的黑皮质素-1 受体激动剂,用于治疗红细胞生成性原卟啉症。 | |||
TP1889 |
MCL0020
MCL 0020 |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
MCL0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂,IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症,在体内表现出抗焦虑样活性。 | |||
T5464 |
JNJ-10229570
JNJ10229570,UNII-N9IX402L35,JNJ 10229570 |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
JNJ-10229570 (UNII-N9IX402L35) 是肾上腺皮质受体 1 和肾上腺皮质受体 5 的拮抗剂,可抑制皮脂腺分化和皮质特异性脂质的产生,其抑制125I-NDP-α-MSH 和人类细胞中 MC1R 和 MC5R 结合的IC50值分别为 270 nM 和 200 nM。 | |||
T7608 |
Bremelanotide Acetate
bremelanotide,PT-141 Acetate |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Bremelanotide Acetate (PT-141 Acetate) 是 α-MSH 的合成肽类似物,是黑素皮质素受体 MC3R 和 MC4R 的激动剂,有用于性功能障碍的研究潜力。 | |||
TP1097 |
Melanotan I
美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I |
Others | Others |
Melanotan I 是一种非特异性黑素皮质激素受体 (MCR) 激动剂, 是一种 α- 黑素细胞刺激激素 (α-MSH) 类似物,皮下注射可增加黑色素在皮肤中的含量。Melanotan I 可用于辅助美黑。Melanotan I 可用于预防阳光诱发皮肤癌,可用于研究黑色素瘤和男性勃起功能障碍。 | |||
T7813 |
α-MSH
MSH, amide,CZEN-002,美拉诺坦,α-Melanocyte-Stimulating Hormone (MSH), amide |
Melanocortin Receptor; Adenylyl cyclase | GPCR/G Protein; Neuroscience |
α-MSH (MSH, amide) 是一种内源性神经肽,是一种内源性黑皮质素受体 4 (MC4R) 激动剂,具有抗炎和解热活性。 | |||
T7769 |
Nonapeptide-1
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5 |
Others | Others |
Nonapeptide-1 (Melanostatine™ 5) 可以抑制黑色素的合成,这使得它对治疗某些皮肤病很感兴趣。 | |||
T7627 |
Adrenocorticotropic Hormone (ACTH) (4-10), human
Adrenocorticotropic Hormone (ACTH) (4-10),ACTH (4-10), human,Acth (4-10) |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Adrenocorticotropic Hormone (ACTH) (4-10), human 是黑皮质素 4 型受体 (melanocortin 4 receptor, MC4R) 激动剂。 | |||
T9596 |
AP1189 acetate
|
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
AP1189 acetate 是黑皮质素 1 和黑皮质素 3 受体的偏向激动剂。 | |||
TP1953L |
PG 931 acetate
PG 931 acetate (667430-81-1 Free base) |
Melanin-concentrating Hormone Receptor (MCHR) | GPCR/G Protein |
PG 931 acetate 是一种强效的黑素皮质素4(MC4)受体的激动剂。 | |||
TP1324 |
Melanotan (MT)-II
美拉诺坦 II,美拉诺坦 (MT)-II |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Melanotan (MT)-II 是一种可注射用的多肽荷尔蒙,是合成的黑皮质素受体激动剂,能够促进晒黑。 | |||
T23516 |
VU590
|
Potassium Channel | Membrane transporter/Ion channel |
VU590 是一种具有高效性和中等选择性的肾外髓质钾 ROMK (Kir1.1) 抑制剂。VU590 抑制 Kir7.1,可调节子宫肌层收缩力和黑皮质素信号传导。 | |||
TP1011L |
ACTH (1-17) acetate
|
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
ACTH (1-17) acetate 是一种有效的人黑皮质素 1 (MC1) 受体激动剂,具有高亲和力 (Ki = 0.21 nM)。 | |||
T69526 |
PF-07258669
|
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
PF-07258669 是一种选择性黑皮质素 4 受体 (MC4) 拮抗剂,可用于研究恶病质和食欲衰退。 | |||
T8231 |
Adrenocorticotropic Hormone (ACTH) (1-39), human
ACTH (1-39), human,丝拉克肽 |
Others | Others |
Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH (1-39), human) 是黑皮质素受体激动剂。 | |||
TP1004L |
Beta-MSH (1-22) (human) acetate
Beta-MSH (1-22) (human) acetate (17908-57-5 Free base),醋酸Β-促黑激素(人) |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Beta-MSH (1-22) (human) acetate (Beta-MSH (1-22) (human) acetate (17908-57-5 Free base)) 是一种 22 肽,是一种内源性黑皮质素 4 受体 (MC4-R) 激动剂。 | |||
T7627L |
Adrenocorticotropic Hormone (ACTH) (4-10) TFA
Adrenocorticotropic Hormone (ACTH) (4-10) TFA(4037-01-8(free base)),Acth (4-10) |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Adrenocorticotropic Hormone (ACTH) (4-10) TFA (Acth (4-10)) 是一种有效的黑皮质素 (MC4R) 受体激动剂。 | |||
T16879L |
SHU 9119 acetate
SHU 9119 acetate (168482-23-3 free base) |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
SHU 9119 acetate 是众所周知的人黑皮质素 3 和 4 (hMC3R, hMC4R) 受体拮抗剂和部分 hMC5R 激动剂。人 MC3R、MC4R 和 MC5R 的 IC50 值分别为 0.23、0.06 和 0.09 nM。 | |||
T12882L |
Setmelanotide Acetate(920014-72-8 free base)
RM-493 Acetate,IRC-022493 Acetate,BIM-22493 Acetate |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) 是黑皮质素 4 受体 (MC4R) 的选择性激动剂(人和大鼠 MC4R,EC50 分别为 0.27 nM 和 0.28 nM)。 | |||
TP2212L |
a-MSH, amide Acetate(581-05-5 free base)
|
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
a-MSH, amide Acetate(581-05-5 free base) 是一种内源性黑皮质素受体 4 (MC4R) 激动剂,具有抗炎和解热活性。 α-MSH 是阿片黑皮质素原 (POMC) 的翻译后衍生物。 | |||
TP1893L1 |
[D-Trp8]-γ-MSH acetate(321351-81-9 free base)
|
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
[D-Trp8]-γ-MSH acetate(321351-81-9 free base) 是选择性黑皮质素 3 (MC3) 受体激动剂(对人 MC3、MC5 和 MC4 受体的 IC50 值分别为 6.7、340 和 600 nM)。显示有抗炎功效。 | |||
TP1952L |
PG 106 acetate
PG 106 acetate(944111-22-2 Free base) |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
PG 106 acetate 是一种有效的特异性人黑皮质素 3 (hMC3) 受体拮抗剂,IC50 为 210 nM。 PG 106 acetate 对 hMC5 受体和 hMC4 受体没有活性,hMC4 受体的 EC50 为 9900 nM。 | |||
TP2015L |
HS 014 acetate(207678-81-7 free base)
|
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
HS 014 acetate(207678-81-7 free base) 是一种有效的选择性黑皮质素 MC4 受体拮抗剂(克隆的人 MC4、MC1、MC3 和 MC5 受体的 Ki 值分别为 3.16、108、54.4 和 694 nM)。体内中枢给药后增加大鼠的食物摄入和小鼠的伤害感受。还抑制室旁下丘脑中 IL-1β 诱导的 Fos 表达。 | |||
T25310 |
Dersimelagon
MT-7117 |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Dersimelagon (MT-7117) (MT-7117) 是一种具有口服活性的选择性黑皮质素 1 受体(MC1R) 激动剂,对人 (h)、食蟹猴 (cm)、小鼠 (m) 和大鼠 (r) MC1R 的 EC50 值分别为 8.16、3.91、1.14 和 0.251 nM。Dersimelagon 对 hMC1R 和 hMC4R 表现出良好的亲和力,Ki 值分别为 2.26 和 32.9 nM。Dersimelagon 可用于皮肤色素沉着的研究。 | |||
T22989 | ML 00253764 hydrochloride | Others | Others |
melanocortin MC4 receptor antagonist | |||
T28635 |
RY764
RY 764,RY-764 |
||
RY764 is a potent and selective agonist of melanocortin subtype-4 receptor. | |||
T10251 |
Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA
ACTH (1-39) (mouse, rat) TFA |
Others | Others |
Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist. | |||
T12072 |
ML-00253764 hydrochloride
|
Others | Others |
ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively). | |||
T24495 |
MPCI
|
||
MPCI is a selective melanocortin-4 receptor antagonist. | |||
T10230 |
MC-4R Agonist 1
|
Others | Others |
MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R) and can be used in the research of sexual dysfunction, obesity, and diabetes. | |||
T12944 |
SNT-207707
|
Others | Others |
SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor). | |||
TP1242 |
1-39-Corticotropin (human)(TFA)
Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) |
||
Adrenocorticotropic Hormone (ACTH) (1-39) human(TFA),a member of the melanocortin family, is a melanocortin receptor agonist. It stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and | |||
T33419 |
MK-0493 HCl
MK 0493,MK-0493,MK0493 |
||
MK-0493 is a novel, potent, and selective agonist for melanocortin receptor 4 (MC4R). | |||
T16879 |
SHU 9119
|
Others | Others |
SHU 9119 is an effective human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist (IC50: 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively). | |||
T12415 | PF-00446687 | Others | Others |
PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM). | |||
T27986 |
MCL0129
MCL-0129,MCL 0129 |
||
MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia. | |||
TP1004 |
β-Melanocyte Stimulating Hormone (MSH), human
Beta-MSH (1-22) (human) |
||
Stimulating -Melanocyte Stimulating Hormone (MSH), human TFA, is a 22 peptide and is an endogenous melanocortin-4 receptor.MC4 - R) agonists. | |||
TP1010 |
ACTH (1-17) (TFA) (7266-47-9 free base)
α1-17-ACTH TFA,ACTH (1-17) (TFA) |
||
ACTH (1-17) TFA is a corticotrophin analogue and an effective human melanocortin 1 (MC1) receptor agonist with Ki value of 0.21 nM. | |||
T16086 | MK-0493 | Others | Others |
MK-0493 is an effective and selective agonist of the melanocortin receptor 4 (MC4R). It also demonstrated significant reductions in energy intake. | |||
TP1041 |
Setmelanotide TFA
IRC-022493 TFA,BIM-22493 TFA,Setmelanotide TFA,RM-493 TFA |
||
Setmelanotide TFA (RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist. | |||
T12946 |
SNT-207858
|
Others | Others |
SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor. | |||
T75965 |
β-Melanocyte Stimulating Hormone (MSH), human TFA
|
||
β-Melanocyte Stimulating Hormone (MSH), human TFA,为一种具有22个氨基酸残基的肽类化合物,是内源性黑皮质素-4 受体(melanocortin-4 receptor; MC4-R)的激动剂。 | |||
T75977 |
ACTH (1-17) (TFA)
|
||
ACTH (1-17) TFA 是促肾上腺皮质激素类似物,是一种有效的人黑皮素受体 (human melanocortin 1 (MC1) receptor) 激动剂,Ki 值为 0.21 nM。 | |||
T12945 |
SNT-207858 free base
|
Others | Others |
SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor). | |||
T69607 | Dersimelagon phosphate | ||
Dersimelagon phosphate is a selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients. | |||
T20467 |
Bremelanotide
PT-141,PT141,PT 141 |
||
Bremelanotide is a synthetic peptide analog of alpha-MSH and is an agonist at melanocortin receptors including the MC3R and MC4R. | |||
T68328 |
Modimelanotide
|
||
Modimelanotide is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development for the treatment of acute kidney injury. It acts as a non-selective melanocortin receptor agonist. | |||
TP2154 |
RO27-3225 TFA (274682-89-2 free base)
RO27-3225 TFA |
Others | Others |
RO27-3225 TFA is a potent and selective agonist of melanocortin 4 receptor (MC4R; EC50: 1 nM and 8 nM for MC4R and MC1R) with neuroprotective and anti-inflammatory effects. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. |