keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SHU 9119 is an effective human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist (IC50: 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively). 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 SHU 9119 acetate 的水溶性和稳定性通常比游离态更好。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 μg | ¥ 1,340 | 35日内发货 | ||
1 mg | ¥ 2,110 | 35日内发货 |
SHU 9119 的其他形式现货产品:
产品描述 | SHU 9119 is an effective human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist (IC50: 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively). |
靶点活性 | MC3R:0.23 nM, MC5R:0.23 nM, MC4R:0.23 nM |
体内活性 | SHU9119 treatment potently increases metabolic efficiency. SHU9119 markedly increases mRNA levels of genes promoting lipogenesis and TAG storage in adipocytes, including stearoyl-CoA desaturase-1, lipoprotein lipase, acetyl-CoA carboxylase α, and fatty acid synthase. The blockade of CNS-Mcr via chronic intracerebroventricular infusion of SHU9119 (24 nmol/d for 7 days) increases food intake in ad libitum-fed rats compared with control. Weight gain of SHU9119 treated rats is significantly higher than control. SHU9119 increases food intake (+30%) and body fat (+50%) and decreases EE by a reduction in fat oxidation (?42%). SHU9119 impairs the uptake of VLDL-TG by BAT. SHU9119 reduces uncoupling protein-1 levels in BAT (?60%) and induces large intracellular lipid droplets, indicative of severely disturbed BAT activity [2][3]. |
分子量 | 1074.258 |
分子式 | C54H71N15O9 |
CAS No. | 168482-23-3 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 20 mg/mL (18.62 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 0.9309 mL | 4.6544 mL | 9.3088 mL | 23.2719 mL |
5 mM | 0.1862 mL | 0.9309 mL | 1.8618 mL | 4.6544 mL | |
10 mM | 0.0931 mL | 0.4654 mL | 0.9309 mL | 2.3272 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SHU 9119 168482-23-3 Others SHU-9119 SHU9119 Inhibitor inhibitor inhibit