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Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA

产品编号 T10251 CAS T10251

别名: ACTH (1-39) (mouse, rat) TFA

Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist. 在相同实验条件下，摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性，但盐形式 ACTH (22-39) acetate 的水溶性和稳定性通常比游离态更好。

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Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA Chemical Structure

Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA, CAS T10251

规格	价格/CNY	货期
1 mg	￥ 2,320	待询
5 mg	￥ 9,150	待询
10 mg	待询	待询
50 mg	待询	待询

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Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA 的其他形式现货产品:

ACTH (22-39) acetate Adrenocorticotropic Hormone (ACTH) (4-10) TFA ACTH (1-17) acetate Acth (1-4) acetate(19405-50-6 free base)

其他形式的 Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA:

ACTH (22-39) acetate
现货
Adrenocorticotropic Hormone (ACTH) (4-10) TFA
现货
ACTH (1-17) acetate
现货
Acth (1-4) acetate(19405-50-6 free base)
现货
Acth (1-4)
询价
ACTH (1-14)
询价
ACTH (1-17)
询价
Adrenocorticotropic Hormone (ACTH) (1-39), rat
询价
ACTH (1-17) (TFA) (7266-47-9 free base)
询价
Adrenocorticotropic Hormone (ACTH) (4-10), human
询价
ACTH (11-24)
询价
ACTH (34-39)
询价
ACTH (22-39)
询价
ACTH (4-11)
询价
ACTH (1-13)
询价
ACTH (1-14) TFA (25696-21-3 free base)
询价

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist.
体外活性	ACTH 1-39 (100-400 nM) has no toxic effect on neurons, while ACTH provides protection from excitotoxic neuronal death induced by glutamate (100 μM), NMDA (1 mM), AMPA (50 μM), and kainate (25 μM). ACTH at 400 nM provides substantial protection in each case. ACTH at either 200 or 400 nM protects neurons from quinolinic acid (25 μM). There is also protection by ACTH from cell death induced by 2 μM H2O2, which gives rise to reactive oxygen species (ROS), with significantly more protection at 400 nM ACTH compared to 200 nM. ACTH gives modest protection against the rapid release of nitric oxide (NO) by NOC-12 but not slow release by NOC-18. ACTH (200 or 400 nM) protects neurons from cytotoxic effects of staurosporine (10-20 nM), a classic inducer of cell death via apoptosis. ACTH reduces cell death from 80% to 55% [1].
体内活性	The icv injection of ACTH significantly reduces cumulative food intake over the observation period compared with the saline/IgG group. The injection of ACTH Ab into the PVN abolishes the anorexigenic effect of ACTH. Infusion icv of ACTH significantly decreases cumulative food intake in rats that receive α-MSH Ab into the PVN and ACTH icv, and food intake is as low as in the group treated with ACTH icv and IgG into the PVN. Injection of either ACTH Ab or α-MSH Ab into the PVN significantly increases cumulative food intake compared with IgG-treated animals [2].
动物实验	Male Wistar rats (weight range 225-250 g at purchase) are used throughout the study. Animals receive a PVN application of ACTH Ab (2 μg/rat) or IgG (2 μg/rat); administration of either ACTH (1 nM/rat) or saline icv is performed 5 min later [2].

别名	ACTH (1-39) (mouse, rat) TFA
分子量	4696.18
分子式	C212H316F3N57O59S
CAS No.	T10251

存储

keep away from moisture　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Lisak RP, et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp Neurol. 2015 Nov;273:161-7. 2. Schulz C, et al. Endogenous ACTH, not only alpha-melanocyte-stimulating hormone, reduces food intake mediated by hypothalamic mechanisms. Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E237-44.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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