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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9920 |
Evolocumab
|
Others | Others |
Evolocumab 是人源化单克隆抗体PCSK9的抑制剂。它与循环的 PCSK9 蛋白结合,使得PCSK9与 LDLR 结合受到抑制。它可用研究于高胆固醇血症以及动脉粥样硬化性心血管疾病的研究。 | |||
T4509 |
Inositol nicotinate
Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,肌醇烟酸酯,Dilexpal,Inositol hexanicotinate |
Others | Others |
Inositol nicotinate (Mesotal) 是一种血管扩张剂,可用于研究外周动脉疾病。 | |||
T31611 |
Eldacimibe
WAY-ACA-147,UNII-4PBL76O2G8,ANA 147,ACA 147 |
Acyltransferase | Metabolism |
Eldacimibe (WAY-ACA-147) 是一种ACAT2抑制剂,可用于治疗心血管疾病和内分泌与代谢疾病,研究动脉粥样硬化和高胆固醇血症。 | |||
T27832 |
Lifibrol
U 83860,K-12148,K-12.148,U-83860,K12148 |
Lipid | Metabolism |
Lifibrol (U-83860) 是一种胆固醇合成抑制剂。Lifibrol 具有抗胆固醇和降血脂的作用,可促进高胆固醇血症和混合型高脂血症患者体内低密度脂蛋白载脂蛋白 B-100 的转化。 | |||
T25276 |
Crilvastatin
PMD387,PMD 387,PMD-387 |
HMG-CoA Reductase | Metabolism |
Crilvastatin (PMD 387) 是一种新型非竞争性羟甲基戊二酰辅酶 A 还原酶抑制剂,具有降胆固醇活性,可抑制遗传性高胆固醇血症大鼠的胆固醇吸收。 | |||
T76739 |
Bococizumab
RN316,PF-04950615 |
Others | Others |
Bococizumab(PF-04950615) 是一种针对PCSK9的人源化mAb,也是一种在肝脏中合成PCSK9的抑制剂,可降低低密度脂蛋白胆固醇 (LDL-C) 在血液中的含量。Bococizumab 可用于治疗高胆固醇血症。 | |||
T76941 |
Carotuximab
DE-122,TRC105 |
TGF-beta/Smad; Immunology/Inflammation related | Immunology/Inflammation; Stem Cells |
Carotuximab(DE-122)是一种新型内胆苷抗体,具有强大的抗血管生成活性和抗炎活性。Carotuximab 可阻断内皮糖蛋白 (CD105) 及其下游 Smad 信号通路。Carotuximab 具有免疫调节和抗肿瘤作用,可预防高胆固醇血症和高血糖诱导的人内皮功能障碍。 | |||
T30977 |
Clofibride
|
||
Clofibrin is a kind of hypolipidemic drug, which can reduce Hypertriglyceride and hypercholesterolemia. | |||
T27565 |
Hyzetimibe
HS25,HS 25,HS-25 |
||
Hyzetimibe, a cholesterol absorption blocker, is used potentially for the treatment of hypercholesterolemia. | |||
T26182 |
Seladelpar lysine
MBX-8025 lysine dihydrate,MBX-8025 Lysine,MBX 8025 Lysine MBX8025 Lysine |
||
Seladelpar lysine, a selective PPAR-δ agonist, is used for the therapy of Homozygous Familial Hypercholesterolemia (HoFH). | |||
T28440 |
PPD 10558
PPD-10558,RBx10558,RBx-10558,PPD10558,RBx 10558 |
||
PPD 10558, a HMG-CoA reductase inhibitor, is used potentially for treatment of primary hypercholesterolemia. | |||
T81918 |
Lodelcizumab
|
||
Lodelcizumab为单克隆抗体,应用于高胆固醇血症研究。 | |||
T77113 | Ongericimab | ||
Ongericimab (JS002),一种人源化抗PCSK9单克隆抗体,可用于高胆固醇血症和高脂血症的研究,具有降脂功效。 | |||
T79052 | PCSK9-IN-16 | ||
PCSK9-IN-16,有效的PCSK9抑制剂,用于治疗高胆固醇血症及其他心血管疾病。 | |||
T35724 |
4-hydroxy Atorvastatin (calcium salt)
|
||
4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin. | |||
T27245 |
(RS)-Eflucimibe
F12511,L-0081,F-12511,L0081 |
||
Eflucimibe is an ACAT inhibitor. Eflucimibe regulates endogenous hypercholesterolemia in a synergistic manner in New Zealand rabbits fed a casein-enriched diet. In vivo, orally administered Eflucimibe displayed high potency and efficacy as an antihypercholesterolemic compound in different cholesterol-fed animals (guinea-pig, rat, rabbit). | |||
T77058 | Lerodalcibep | ||
Lerodalcibep (LIB003) 是一种重组融合蛋白,由PCSK9结合域 (adnectin) 与人血清白蛋白组成。作为降脂剂,Lerodalcibep 适用于高胆固醇血症和心血管疾病的研究。 | |||
T61430 | S-2E | ||
S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2]. | |||
T82695 |
Colestilan
MCI-196,Colestimide |
||
Colestilan (MCI-196),一种口服活性的非吸收、非钙基磷酸盐粘合剂,同时为非金属阴离子交换树脂,主要应用于高胆固醇血症的研究。 | |||
T74720 |
Mipomersen
|
||
Mipomersen (ISIS 301012 free base) 是载脂蛋白 B(apoB)的反义寡核苷酸抑制剂。Mipomersen 具有抗HCV 的作用,可降低HCV 的感染性。Mipomersen 可用于纯合子家族性高胆固醇血症 (HoFH) 的研究。 | |||
T60579 | CEase-IN-1 | ||
CEase-IN-1 (Compound A1H3) 是胆固醇酯酶(CEase)有效的、选择性的抑制剂,IC50值为 0.36 μM,它可用于研究高胆固醇血症。 | |||
T74730 | SPC4061 | ||
SPC4061 是一种反义核苷酸,是有效的 PCSK9抑制剂。SPC4061 靶向 PCSK9 的锁定核酸 (LNA),可用于高胆固醇血症和相关疾病的研究。 | |||
T63697 | THR-β agonist 3 | ||
THR-β agonist 3 是 THR-β 的有效激动剂。THR-β agonist 3 对代谢疾病表现出研究潜力,例如肥胖、高脂血症、高胆固醇血症、糖尿病和其他病症如脂肪变性和非酒精性脂肪性肝炎 (NASH)、动脉粥样硬化和其他相关病症和疾病。 | |||
T63515 |
THR-β agonist 4
|
||
THR-β agonist 4 是 THR-β 的有效激动剂。THR-β agonist 4 对代谢疾病表现出研究潜力,如高脂血症、肥胖、高胆固醇血症、糖尿病和其他病症如脂肪变性和非酒精性脂肪性肝炎 (NASH)、动脉粥样硬化和其他相关病症和疾病 。 | |||
T79520 |
HMG-CoA Reductase-IN-1
|
||
HMG-CoA Reductase-IN-1是一种HMG-CoA还原酶抑制剂,显示出高HMGR抑制活性及OATP1B1亲和力,具有pIC50值8.54和pKm值1.98。该化合物适用于高胆固醇血症的研究。 | |||
TP1984 |
[D-Trp34]-Neuropeptide Y
|
||
Potent neuropeptide Y (NPY) Y5 receptor agonist (pEC50 values are 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Induces | |||
T77144 | Recaticimab | ||
Recaticimab (SHR-1209) 是一种针对 PCSK9 的人源化单克隆抗体。该药物通过结合 PCSK9 并促进其降解,增加肝细胞表面的低密度脂蛋白 (LDL) 受体数量,从而有效降低血浆 LDL 水平,实现降低血脂的效果。Recaticimab 对于治疗高胆固醇血症显示出潜在价值。 | |||
T76974 | Tafolecimab | ||
Tafolecimab (IBI-306) 是一种人源 lgG2 单克隆抗体,可特异性结合 PCSK-9并通过抑制 PCSK-9 介导的低密度脂蛋白受体的内吞作用降低 LDL-C 水平,进而增强对 LDL-C 的清除,导致 LDL-C 水平降低。Tafolecimab 可用于高胆固醇血症的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21383 |
D-Thyroxine
Dethyrona,Detyroxin,Dextroid,Dextrothyroxine;Biotirmone,Dextroxin,Biotirmone,Debetrol,Dextrothyroxine |
Others | Others |
D-Thyroxine (Dextroxin) 是一种甲状腺激素,对 TSH 的分泌具有抑制作用,可用于研究高胆固醇血症。 | |||
T2968 |
Hyodeoxycholic acid
NSC 60672,猪去氧胆酸,α-Hyodeoxycholic Acid,HDCA |
FXR; Endogenous Metabolite; GPCR19 | GPCR/G Protein; Metabolism |
Hyodeoxycholic acid (NSC 60672) 是由肠道菌群在小肠中形成的次级胆汁酸,是TGR5(GPCR19)的激动剂, CHO 细胞中的EC50=31.6 µM。它已用于研究高胆固醇血症的治疗。 | |||
T17056 |
Tetrahydrobiopterin
Sapropterin,BH4,(Rac)-Sapropterin |
NOS; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
Tetrahydrobiopterin (BH4) 是芳香族氨基酸羟化酶的辅因子, 也是一氧化氮合酶 (NOS) 的必需辅因子,可用于研究如高血压、高胆固醇血症、糖尿病等内皮功能障碍。 | |||
T3874 |
Diosgenin glucoside
延龄草苷,地索苷,Disogluside,Trillin |
Apoptosis; Others; Autophagy | Apoptosis; Autophagy; Others |
Diosgenin glucoside (Trillin) 是一种来自蒺藜的皂苷元类天然产物,可通过调节自噬和减轻细胞凋亡来保护脊髓免受损伤。它通过调节小胶质细胞 M1 极化提供神经保护,和其他具有类似活性的合成糖苷可用于治疗高胆固醇血症和动脉粥样硬化。 | |||
TN4987 |
Semialactone
|
Others | Others |
Semialactone shows inhibitory activities on human acyl-CoA:cholesterol acyltransferase(hACAT)1 with IC50 values of 79.1 uM and on human hACAT2 with IC50 values of 76.9 uM, it may be effective in the prevention and treatment of hypercholesterolemia or athe |