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21

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6452	Closantel Sodium	Antibacterial; Parasite	Microbiology/Virology
	Closantel sodium 是抗寄生虫活性的卤化水杨酰苯胺。它是高度特异性的盘尾丝虫几丁质酶抑制剂。
T7093	Rafoxanide 碘醚柳胺,雷复尼特	CDK; Parasite	Cell Cycle/Checkpoint; Microbiology/Virology
	Rafoxanide 是口服活性水杨酰苯胺类驱虫剂。它作为抗寄生虫剂，可用于控制羊和牛的 Hemonchus 种和 Fasciola 种的感染。
T0237	Closantel 氯氰碘柳胺,R-31520,氯生太尔	Antibacterial; Parasite	Microbiology/Virology
	Closantel (R-31520) 是抗寄生虫活性的卤化水杨酰苯胺。它是高度特异性盘尾丝虫几丁质酶抑制剂。
T1171L	Methylprednisolone Aceponate MPA,SH 440,SH-440,SH440,Advantan,醋丙甲泼尼龙	Others	Others
	Methylprednisolone Aceponate (SH 440) 是一种非卤化皮质类固醇，是一种有效的抗炎剂。
T5111	4-Bromomethyl-2-cyanobiphenyl	Others	Others
	4-Bromomethyl-2-cyanobiphenyl 是一种卤代苯甲腈，用于喹喔啉血管紧张素 II 受体拮抗剂的蛋白质结合研究。
T28284	P22074 P-22074	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	P22074是一种USP7抑制剂。它不像其卤代相关化合物那样是一种活跃的拮抗剂。P22074 具有抗肿瘤活性。
T0876	Clioquinol Chinoform,Iodochlorhydroxyquin,氯碘羟喹	Mitophagy; Antibiotic; Autophagy; Antifungal	Autophagy; Microbiology/Virology
	Clioquinol (Iodochlorhydroxyquin) 是一种局部抗真菌药，具有抗肿瘤活性。它作为口服抗菌剂，可研究腹泻和皮肤感染。
T9549	Chiniofon Loretin,Ferron,8-hydroxy-7-iodo-5-quinolinesulfonate,quiniophen,喹碘方	Others	Others
	Chiniofon (Ferron) 是一种卤代 8-羟基喹啉，用作抗阿米巴药物。该类抗阿米巴药物通过抑制肠道共生菌发挥抗阿米巴作用，影响阿米巴痢疾，但对肠外阿米巴寄生虫无作用。
T0954	Halothane Narcotane,氟烷,Anestan	Potassium Channel; Chloride channel; GABA Receptor; NMDAR	Membrane transporter/Ion channel; Neuroscience
	Halothane (Anestan) 可以减弱内皮依赖性舒张作用。
T16785	Ropidoxuridine IPdR	Others	Others
	Ropidoxuridine (IPdR) 是一种新型的、可口服的卤化胸苷类似物，有望成为人类肿瘤的增敏剂。Ropidoxuridine 是一种可口服且具有生物可利用的IUdR(5-碘-2'-脱氧尿苷)前药。
T19658	Enflurane NSC115944,Ethrane,NSC-115944,恩氟烷,Efrane,NSC 115944	Others	Others
	Enflurane (Efrane) 是一种挥发性麻醉剂，是 Chara australis 高电导 Ca2+ 激活的 K+ 通道的有效抑制剂。安氟醚是通过顶空气相色谱-质谱法监测卤化挥发性麻醉剂的内标。它可以快速调整麻醉深度，而脉搏或呼吸频率几乎没有变化。
T8785	HALOFUGINONE LACTATE	DNA/RNA Synthesis; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Stem Cells
	HALOFUGINONE LACTATE 是 febrifugine 的卤化衍生物，它是一种天然的含有喹唑啉酮的化合物，存在于中草药 D. febrifuga 中。Halofuginone 以 ATP 依赖性方式抑制脯氨酰-tRNA 合成酶，Ki 为 18.3 nM。 Halofuginone 是 I 型胶原合成的特异性抑制剂，通过抑制 TGF-β 活性来减轻骨关节炎 (OA)
T32310	Johnstonol
	Johnstonol is an specifically halogenated epoxide obtained from the red alga.
T40382	Dibromoacetaldehyde
	Dibromoacetaldehyde, a halogenated byproduct found in drinking water, exhibits genotoxicity.
T40725	1,3-Dibromo-1,3-dichloroacetone
	1,3-Dibromo-1,3-dichloroacetone is a chemical compound that acts as a disinfection byproduct (DBP) of halogenated ozone-chlorine and ozone-chloramine, particularly at heightened bromide concentrations, when used as secondary disinfectants.
T39162	1,1,1,3-Tetrachloroacetone
	1,1,1,3-Tetrachloroacetone, a halogenated compound, is known to form ozone-chlorine and ozone-chloramine disinfection byproducts (DBPs) when elevated bromide levels are present in water treated with chlorine or chloramine as secondary disinfectants.
T10137	4-Bromo A23187 4-Bromo A23187	Others	Others
	4-Bromo A23187 is a halogenated analog of the calcium ionophore A-23187. 4-Bromo A23187 is a calcium modulator and induces apoptosis in different cells.
T13728	Hydrocortisone buteprate HBP,Hydrocortisone probutate	Others	Others
	Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders.
T39052	1,1-Dibromo-3-chloroacetone
	1,1-Dibromo-3-chloroacetone is an ozone-chlorine and ozone-chloramine disinfection byproduct (DBP) which is halogenated. It is formed at high bromide levels when chlorine or chloramine is utilized as a secondary disinfectant.
T40639	1,1,3-Tribromo-3-chloroacetone
	1,1,3-Tribromo-3-chloroacetone is a chemical compound that acts as a halogenated disinfection byproduct (DBP) when elevated bromide levels are present during the use of chlorine or chloramine as a secondary disinfectant. Its formation is attributed to the reaction between ozone-chlorine and ozone-chloramine.
T36195	CAY10744
	CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY1074...

化合物

Closantel Sodium

Cat.No: T6452

Target: Antibacterial, Parasite

Cat.No: T7093

Synonym: 碘醚柳胺,雷复尼特

Target: CDK, Parasite

Cat.No: T0237

Synonym: 氯氰碘柳胺,R-31520,氯生太尔

Target: Antibacterial, Parasite

Methylprednisolone Aceponate

Cat.No: T1171L

Synonym: MPA,SH 440,SH-440,SH440,Advantan,醋丙甲泼尼龙

Target: Others

4-Bromomethyl-2-cyanobiphenyl

Cat.No: T5111

Target: Others

Cat.No: T28284

Synonym: P-22074

Target: DUB

Cat.No: T0876

Synonym: Chinoform,Iodochlorhydroxyquin,氯碘羟喹

Target: Mitophagy, Antibiotic, Autophagy, Antifungal

Cat.No: T9549

Synonym: Loretin,Ferron,8-hydroxy-7-iodo-5-quinolinesulfonate,quiniophen,喹碘方

Target: Others

Cat.No: T0954

Synonym: Narcotane,氟烷,Anestan

Target: Potassium Channel, Chloride channel, GABA Receptor, NMDAR

Cat.No: T16785

Synonym: IPdR

Target: Others

Cat.No: T19658

Synonym: NSC115944,Ethrane,NSC-115944,恩氟烷,Efrane,NSC 115944

Target: Others

HALOFUGINONE LACTATE

Cat.No: T8785

Target: DNA/RNA Synthesis, TGF-beta/Smad

Cat.No: T32310

Dibromoacetaldehyde

Cat.No: T40382

1,3-Dibromo-1,3-dichloroacetone

Cat.No: T40725

1,1,1,3-Tetrachloroacetone

Cat.No: T39162

Cat.No: T10137

Synonym: 4-Bromo A23187

Target: Others

Hydrocortisone buteprate

Cat.No: T13728

Synonym: HBP,Hydrocortisone probutate

Target: Others

1,1-Dibromo-3-chloroacetone

Cat.No: T39052

1,1,3-Tribromo-3-chloroacetone

Cat.No: T40639

Cat.No: T36195

Cat. No.	Product Name	Target	Signaling Pathways
T82799	C-2′-Decoumaroylaloeresin G
	C-2′-Decoumaroylaloeresin G (化合物8)为一种色酮糖苷，源自芦荟属植物。

天然产物

C-2′-Decoumaroylaloeresin G

Cat.No: T82799

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