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22

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9625	Sandalore	Apoptosis	Apoptosis
	Sandalore 通过减少细胞凋亡和增加外根鞘中延长生长期的生长因子 IGF-1 的产生来延长人类头发的生长。 Sandalore 是嗅觉受体 OR2AT4 的选择性激动剂。
TP2364	Acetyl tetrapeptide-3 Kollaren 6,Uxi hair growth peptide,Folixyl
	Acetyl tetrapeptide-3 is a bioactive chemical.
T8135	Minoxidil sulfate Minoxidil sulphate,U-58838,米诺地尔硫酸盐	Potassium Channel	Membrane transporter/Ion channel
	Minoxidil sulfate (U-58838) 是米诺地尔的硫酸代谢物，是ATP 敏感的 K+通道激动剂。它被认为是血管扩张试剂，在动物实验模型中，促进头发生长。
TP2496	Octapeptide-2 Acetate Octapeptide-2 Acetate(1374396-34-5 Free base)	Others	Others
	Octapeptide-2 Acetate 作为一种促进毛发生长的活性物质，是一种双层封装的仿生肽，有助于促进细胞生长和迁移。它通过激活毛囊的干细胞来促进头发生长。它比天然蛋白质更稳定且作用时间更长。
T15014	CTPB	Histone Acetyltransferase	Chromatin/Epigenetic
	CTPB 是一种有效的 p300 组蛋白乙酰转移酶 (HAT) 活化剂，可用于制备毛发生长促进剂和/或脱发治疗剂。
T40811	Eflornithine RMI71782,α-difluoromethylornithine,DFMO,依氟乌氨酸,MDL71782
	Eflornithine is an irreversible inhibitor that specifically targets the enzyme ornithine decarboxylase. It serves as a therapeutic medication for two conditions: the treatment of African trypanosomiasis and the management of excessive facial hair growth in women.
T0451	Minoxidil 米诺地尔,U10858	Potassium Channel; COX	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Minoxidil (U10858) 是一种是 ATP 敏感的钾通道 (KATP) 开放剂，可作为有效的口服降压药和外周血管舒张药，促进血管扩张并促进头发的生长。Minoxidil 还是一种大豆脂氧合酶的有效抑制剂，IC50为 20 μM。
T24897	TP0427736 TP427736,TP-0427736,TP-427736	TGF-beta/Smad	Stem Cells
	TP0427736 是一种有效的选择性 ALK5 抑制剂，IC50 为 2.72 nM，比对 ALK3 的抑制作用高 300 倍。 TP0427736 可降低人外根鞘细胞中 TGF-β 诱导的生长抑制，并延长小鼠毛囊中的生长期。
T21249L	Myristoyl Pentapeptide-17 Acetate Myristoyl Pentapeptide-17 Acetate(959610-30-1 Free base)	Others	Others
	Myristoyl Pentapeptide-17 Acetate 是一种小肽。促进关键成分的输送，从而有效促进睫毛生长，使睫毛变长变浓密，强韧秀发，显着强化眼部表情。
TP2497	Myristoyl Tetrapeptide-12 Acetate 醋酸肉蔻酰四胜肽-12,Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base)	Others	Others
	Myristoyl Tetrapeptide-12 Acetate (Myristoyl Tetrapeptide-12 Acetate (959610-24-3 Free base)) 是肉豆蔻酸和 Tetrapeptide-12 的反应产物，是一种刺激头发和睫毛生长并增强睫毛和/或眉毛外观的肽。 Myristoyl tetrapeptide-12 可以增加角质形成细胞的增殖，改善外观、紧致弹性和皮肤厚度。
T40789	Eflornithine hydrochloride MDL71782hydrochloride,RMI71782hydrochloride,盐酸依氟乌氨酸,DFMO hydrochloride,α-difluoromethylornithinehydrochloride
	Eflornithine hydrochloride, a specific and irreversible inhibitor of ornithine decarboxylase enzyme, is a medication used for the treatment of African trypanosomiasis and excessive facial hair growth in women.
T21249	Myristoyl Pentapeptide-17 Myr-KLAKK-NH2
	Myristoyl Pentapeptide-17 is a small peptide. It promotes the delivery of key ingredients, thus effectively promotes the growth of eyelashes, lengthens and thickens the eyelashes, fortifies the hair and noticeably intensifies eye expression.
T34657	SL-017 ACPSL-017,S-017,ACP-SL-017,ACP-SL017
	SL-017 (ACP-SL-017, ACPSL-017, ACP-SL-017) is a Hypocrellin-B (Hb) derivative and photosensitization agent that may be used to treat abnormal hair growth. SL017 targets the mitochondria and causes the mitochondrial membrane potential to collapse, producin
T81611	Oligopeptide-74
	Oligopeptide-74为促进头发生长的生物活性肽，报道显示其作为化妆品组分。
T80628	Myristoyl tetrapeptide-12	TGF-beta/Smad	Stem Cells
	Myristoyl tetrapeptide-12 直接激活SMAD2，并促使SMAD3与DNA结合。该化合物能有效促进毛发，特别是睫毛的生长。
T38442	17,17-(Ethylenedioxy)androst-4-en-3-one
	17,17-(Ethylenedioxy)androst-4-en-3-one (4- androstene- 3, 17- dione- 17- cyclic ethylene ketal) is an effective ingredient in cosmetics, which can be used for acne and promote hair growth research. 17,17-(Ethylenedioxy)androst-4-en-3-one can inhibit the reductase activity and inhibit the bond of a receptor protein and 5α-DHT.
T82681	Copper tripeptide-3 AHK-Cu
	AHK-Cu 是一种生物活性肽，具促进毛发生长功能，已作为化妆品成分使用。
T81729	Myristoyl pentapeptide-4
	Myristoyl pentapeptide-4是一款用作化妆品成分的生物活性肽，其特性包括促进毛发生长。
T74107	GP4G
	GP4G (Diguanoside tetraphosphate) 是一种对称的双二磷核苷，可以从Artemia salina 的囊肿中分离出来。GP4G 是一种上皮细胞和毛发生长调节剂。
T81404	Prezatide copper Bisprezatide copper,PC 1020,Iamin
	Prezatide Copper（亦称Iamin）具有促进伤口愈合的多重特性，且用于抑制脱发。
T80206	Oligopeptide-41	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Oligopeptide-41是一种生物活性肽，具有促进毛发生长的功能，并已作为化妆品成分使用。
T80204	Octapeptide-2	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Octapeptide-2, 已报道作为化妆品成分，是一种具促进毛发生长功能的生物活性肽。

化合物

Cat.No: T9625

Target: Apoptosis

Acetyl tetrapeptide-3

Cat.No: TP2364

Synonym: Kollaren 6,Uxi hair growth peptide,Folixyl

Minoxidil sulfate

Cat.No: T8135

Synonym: Minoxidil sulphate,U-58838,米诺地尔硫酸盐

Target: Potassium Channel

Octapeptide-2 Acetate

Cat.No: TP2496

Synonym: Octapeptide-2 Acetate(1374396-34-5 Free base)

Target: Others

Cat.No: T15014

Target: Histone Acetyltransferase

Cat.No: T40811

Synonym: RMI71782,α-difluoromethylornithine,DFMO,依氟乌氨酸,MDL71782

Cat.No: T0451

Synonym: 米诺地尔,U10858

Target: Potassium Channel, COX

Cat.No: T24897

Synonym: TP427736,TP-0427736,TP-427736

Target: TGF-beta/Smad

Myristoyl Pentapeptide-17 Acetate

Cat.No: T21249L

Synonym: Myristoyl Pentapeptide-17 Acetate(959610-30-1 Free base)

Target: Others

Myristoyl Tetrapeptide-12 Acetate

Cat.No: TP2497

Synonym: 醋酸肉蔻酰四胜肽-12,Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base)

Target: Others

Eflornithine hydrochloride

Cat.No: T40789

Synonym: MDL71782hydrochloride,RMI71782hydrochloride,盐酸依氟乌氨酸,DFMO hydrochloride,α-difluoromethylornithinehydrochloride

Myristoyl Pentapeptide-17

Cat.No: T21249

Synonym: Myr-KLAKK-NH2

Cat.No: T34657

Synonym: ACPSL-017,S-017,ACP-SL-017,ACP-SL017

Oligopeptide-74

Cat.No: T81611

Myristoyl tetrapeptide-12

Cat.No: T80628

Target: TGF-beta/Smad

17,17-(Ethylenedioxy)androst-4-en-3-one

Cat.No: T38442

Copper tripeptide-3

Cat.No: T82681

Synonym: AHK-Cu

Myristoyl pentapeptide-4

Cat.No: T81729

Cat.No: T74107

Prezatide copper

Cat.No: T81404

Synonym: Bisprezatide copper,PC 1020,Iamin

Oligopeptide-41

Cat.No: T80206

Target: EGFR

Cat.No: T80204

Target: Reactive Oxygen Species

Cat. No.	Product Name	Target	Signaling Pathways
T2902	Costunolide Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯	Apoptosis; Endogenous Metabolite; Telomerase	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Costunolide (Costus lactone) 是一种天然的倍半萜内酯，具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性，可诱导乳腺癌细胞周期阻滞和凋亡。
TN3973	Epinodosin	Others	Others
	Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings.
TN1689	Glabranine 光甘草宁,Glabranin	Antifection	Microbiology/Virology
	Glabranin has antimicrobial activity, it shows significant activities on DPPH free radical with the IC50 value of 240.20 ug/ml. Glabranin or a derivative thereof could be used to stimulate hair growth. Glabranine exerts a dose-dependent inhibitory effect
TN4604	Myricanone	BCL; HSP; NF-κB; ROS; Caspase; STAT	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Metabolism; NF-κB; Proteases/Proteasome; Stem Cells
	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation by down-regulation of NF-ÎºB and STAT3 signalling cascades. Myricanone shows in vitro testost

天然产物

Cat.No: T2902

Synonym: Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯

Target: Apoptosis, Endogenous Metabolite, Telomerase

Cat.No: TN3973

Target: Others

Cat.No: TN1689

Synonym: 光甘草宁,Glabranin

Target: Antifection

Cat.No: TN4604

Target: BCL, HSP, NF-κB, ROS, Caspase, STAT

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