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Search Results for " glucagon "

163

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T15389L	Glucagon (1-29), bovine, human, porcine hydrochloride 盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride	Glucocorticoid Receptor; Glucagon Receptor	Endocrinology/Hormones; GPCR/G Protein
	Glucagon (1-29), bovine, human, porcine hydrochloride 是一种由胰腺 α 细胞产生的多肽激素。它可激活 HNF4α 并促进 HNF4α 磷酸化，促进糖异生。
TP1863L	Glucagon (19-29), human acetate	Glucagon Receptor	GPCR/G Protein
	Glucagon (19-29), human acetate 是一种从胰高血糖素加工而来的 COOH 末端片段，是一种有效的胰岛素分泌抑制剂。
TQ0239	PF-06291874 Glucagon receptor antagonists-4	Glucagon Receptor	GPCR/G Protein
	PF-06291874 (Glucagon receptor antagonists-4) 是口服有活性的胰高血糖素受体非肽类拮抗剂。它正用于研究 2 型糖尿病。
T36638	[Des-His1,Glu9]-Glucagon amide TFA [Des-His1,Glu9]-Glucagon amide TFA
	[Des-His1,Glu9]-Glucagon amide TFA is a potent peptide antagonist targeting the glucagon receptor, featuring a pA2 value of 7.2. It holds potential utility in diabetes pathogenesis research[1].
T15389	Glucagon (1-29), bovine, human, porcine 胰高血糖素,Porcine glucagon,Glucagon	Others	Others
	Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.
T37223	Glucagon Receptor Antagonist I
	Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions.
TP2033	[Des-His1,Glu9]-Glucagon amide des-His1-[Glu9]-Glucagon (1-29) amide
	Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hy
T78059	Glucagon (Human) Hyperglycemic-glycogenolytic factor,Glukagon	Others	Others
	Glucagon 对蛋白质和氨基酸的代谢产生显著的调节作用。它抑制了氨基酸与肝脏、肌肉以及胰腺蛋白的结合，增加氮的排出，并促进肝脏内尿素的合成。同时，Glucagon 增加了肝脏中转氨酶和尿素循环酶的浓度，提高了肝脏对氨基酸的摄取，并加强了氨基酸与肝糖原之间的结合，从而降低了血液中的氨基酸浓度。
T11413	Glucagon receptor antagonists-1	Others	Others
	Glucagon receptor antagonist -1 is a highly effective glucagon receptor antagonist.
T36580	Glucagon Receptor Antagonist Inactive Control
	Glucagon Receptor Antagonist Inactive Control 是一种 Glucagon 受体拮抗剂，可用于生命科学领域的相关研究。其产品编号为 T36580，CAS号为 362482-00-6。
TP1863	Glucagon (19-29), human
	Glucagon is a 29-amino-acid peptide hormone liberated in the alpha cells of the islets of Langerhans. Glucagon-producing alpha cells represent one of the earliest populations of detectable islet cells in the developing endocrine pancreas.
T11416	Glucagon receptor antagonists-5	Others	Others
	Glucagon receptor antagonists-5 is an orally bioavailable indazole-based glucagon receptor antagonist (Ki: 32 nM). It has potential for the treatment of type 2 diabetes mellitus (T2DM).
T11415	Glucagon receptor antagonists-3	Others	Others
	Glucagon receptor antagonist -3 is a highly effective glucagon receptor antagonist.
T11414	Glucagon receptor antagonists-2	Others	Others
	Glucagon receptor antagonist -2 is a highly effective glucagon receptor antagonist.
TP1148L	Glucagon-like peptide 1 (1-37), human acetate	Glucagon Receptor	GPCR/G Protein
	Glucagon-like peptide 1 (1-37), human acetate 是一种高效的 GLP-1 受体激动剂。
TP1487	Glucagon-Like Peptide (GLP) II, human
	Glucagon-like peptide 2 (GLP-2) is a recently identified intestinal epithelium-specific growth factor that has been shown to reduce the severity of inflammatory disorders of the intestine in rodent models. Currently Glucagon-Like Peptide 2 is used as a po
TQ0124	BETP	Glucagon Receptor	GPCR/G Protein
	BETP 是胰高血糖素样肽 (GLP-1) 受体激动剂，能够抑制人和大鼠的GLP-1受体，其EC50值分别为 0.66 μM 和 0.755 μM。
T80030	Oxyntomodulin (bovine, porcine) (TFA) Glucagon-37 (bovine, porcine) (TFA)
	Oxyntomodulin (bovine, porcine) TFA为含37个氨基酸的肽类激素，作为胰高血糖素样肽1 (GLP-1) 受体的激动剂。
TP1148	Glucagon-like peptide 1 (1-37), human HuGLP-1
	Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.Pancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on food intake in rats and does not en
T82306	Glucagon (22-29)
	Glucagon (22-29) 作为Glucagon (19–29)的部分激动剂，能特异性抑制肝质膜 Ca2+泵，其作用机制与腺苷酸环化酶激活无关。
T11845	LGD-6972	Glucagon Receptor	GPCR/G Protein
	LGD-6972 是口服有活性的胰高血糖素受体选择性拮抗剂，能够用于研究 2 型糖尿病。
TP1147	Glucagon-like peptide 1 (1-37), human TFA HuGLP-1 TFA
	Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor, it is a kind of pancreatic hormone synthesized by post-translational processing of proglucagon.
T80453	GLP-1 (1-36) amide (human, rat) Glucagon-like Peptide 1 (1-36) amide (human, rat)
	GLP-1(1-36) amide (human, rat)（人类及大鼠的胰高血糖素样肽1（1-36）酰胺）是GLP-1(7-36)酰胺的一种分子变体。该化合物能激发[14C]氨基吡啶在大鼠胃壁细胞的酶分散体中积累。
T7364	NNC-0640	Glucagon Receptor	GPCR/G Protein
	NNC-0640 是人类胰高血糖素受体阴性变构调节剂(IC50:69.2 nM)。
T76326	[Des-His1,Glu9] Glucagon
	[Des-His1,Glu9] Glucagon 是一种有效的胰高血糖素受体系统多肽拮抗剂。[Des-His1,Glu9] Glucagon 增强胰岛细胞在葡萄糖刺激下释放胰岛素。[Des-His1,Glu9] Glucagon 可用于糖尿病的研究。
T82309	GLP-1 (1-36) amide (human, rat) (TFA) Glucagon-like Peptide 1 (1-36) amide (human, rat) (TFA)
	GLP-1(1-36) amide (human, rat) TFA为胰高血糖素样肽1(GLP-1)-(7-36)酰胺的分子变体，能够促进[14C]氨基吡啶在大鼠壁细胞的酶分散体中的积累。
TP1157	GLP-2(1-33)(human) GLP-2 (human),Glucagon-like peptide 2 (human)
	GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium.
T8748	Exendin-4 acetate	Glucagon Receptor	GPCR/G Protein
	Exendin-4 acetate 是一种长效的 glucagon-likepeptide-1 受体激动剂(IC50:3.22 nM)，是一种由39个氨基酸组成的多肽。。
TP2252	GLP-1 (9-36) amide	Glucagon Receptor	GPCR/G Protein
	GLP-1(9-36)amide 是胰高血糖素样肽-1 (7-36) amide 的主要代谢产物，对人胰腺 GLP-1受体具有拮抗作用。
T83550	(Asp28)-Glucagon (1-29) (human, rat, porcine)
	'(Asp28)-Glucagon (1-29) (human, rat, porcine)' 为胰高血糖素的一种改良型结构，在第28位氨基酸残基上天冬氨酸（Asp）替换原有残基，显著提高了该化合物在生理pH条件下的溶解性，且保持了与天然胰高血糖素相同的生物活性。
T76332	Biotinyl-Glucagon (1-29), human, bovine, porcine
	Biotinyl-Glucagon (1-29), human, bovine, porcine 为带生物素标记的Glucagon衍生物，此肽类激素由胰腺α细胞分泌，功能是提升血液中的葡萄糖与脂肪酸浓度。
T0178	Saxagliptin hydrate 沙格列汀单水化合物,Onglyza hydrate,BMS-477118 hydrate	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Saxagliptin hydrate (Onglyza hydrate) 是一种选择性，竞争性，可逆性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin hydrate 能够用于 2 型糖尿病的研究。
T6203	Saxagliptin BMS-477118,沙克列汀,Onglyza,沙格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Saxagliptin (BMS-477118) 是一种选择性，可逆性，竞争性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin 能够用于 2 型糖尿病的研究。
T19850	Semaglutide 索玛鲁肽,司美格鲁肽,索马鲁肽	Glucagon Receptor	GPCR/G Protein
	Semaglutide 是人胰高血糖素样肽-1受体激动剂，是一种人胰高血糖素样肽-1 的长效类似物。它有用于 2 型糖尿病研究的潜力。
T3984	GLP-1(7-36), amide MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide	Glucagon Receptor	GPCR/G Protein
	GLP-1(7-36), amide (MKC 253) 是一种生理性肠降血糖素，能够刺激胰岛素分泌。
T76628	(Met(O)27)-Glucagon (1-29) (human, rat, porcine)
	'(Met(O)27)-Glucagon (1-29) (human, rat, porcine) 为修饰版胰高血糖素。在大鼠肝细胞内，其促进葡萄糖合成的活性虽与天然胰高血糖素相似，但呈现出较低效率，暗示蛋氨酸对于胰高血糖素与其肝脏受体绑定具有关键性作用。'
T76330	Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide
	Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide 是一种带有生物素标签的Glucagon-like peptide-1-(7-36)，后者为一种具备提升胰岛素释放功能，从而表现出抗糖尿病活性的胃肠道肽。
T3422	GRA Ex-25 GRA-Ex-25	Glucagon Receptor	GPCR/G Protein
	GRA Ex-25 (GRA-Ex-25) 是glucagon 受体抑制剂，其对大鼠和人的 glucagon 受体的IC50值分别为 56 和 55 nM。
T3967	Exendin-4 艾塞那肽,Exenatide,Exenatide Acetate	Glucagon Receptor	GPCR/G Protein
	Exendin-4 (Exenatide) 是一种长效的 glucagon-likepeptide-1 受体激动剂(IC50: 3.22 nM)，是一种由 39 个氨基酸组成的多肽。
T26712	AZD-1656 AZD 1656	Glucokinase	Metabolism
	AZD-1656 是口服有效的葡萄糖激酶选择性激活剂，EC50为 60 nM。AZD1656在2 型糖尿病中有研究的价值。
TP1039	Secretin (33-59), rat 大鼠SECRETIN肽,Secretin (rat)	Glucagon Receptor	GPCR/G Protein
	Secretin (33-59), rat (Secretin (rat)) 是由 27 个氨基酸组成的多肽。Secretin (33-59), rat 可作用于分泌素受体，能够增强胰腺的碳酸盐、酶和钾离子的分泌。
T6876	Liraglutide 利拉鲁肽,Liraglutidum,利拉糖肽,Victoza,Liraglutida,NN2211	Glucagon Receptor	GPCR/G Protein
	Liraglutide (Liraglutida) 是胰高血糖素样肽-1 受体激动剂，用于 2 型糖尿病的研究。
TP1469	Lixisenatide acetate (320367-13-3 free base) Lixisenatide acetate	Glucagon Receptor	GPCR/G Protein
	Lixisenatide acetate 是一种胰高血糖素样肽 1 受体的激动剂，可用于研究 2 型糖尿病。
TP2100	Avexitide Exendin-3 (9-39) amide,Exendin (9-39),艾塞那肽	Glucagon Receptor	GPCR/G Protein
	Avexitide (Exendin-3 (9-39) amide) 是一种特异竞争性的glucagon-like peptide-1 (GLP-1)受体拮抗剂。
T76085	Glucagon-Like Peptide 1 (GLP-1) (7-36)-Lys (Biotin), amide, human
	Glucagon-Like Peptide 1 (GLP-1) (7-36)-Lys (Biotin), amide, human 是一种被 C 端标记的生物素化 GLP-1(7-36) 酰胺。
T2316	Omarigliptin MK-3102,奥格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Omarigliptin (MK-3102) 是高效选择性 DPP4抑制剂，IC50=为1.6nM。
TP1376	GLP-1(7-37) acetate(106612-94-6 free base) GLP-1(7-37) acetate	Others; Glucagon Receptor	GPCR/G Protein; Others
	GLP-1(7-37) acetate 是肠道胰岛素激素，能够促进葡萄糖诱导的胰岛素分泌。
T60047	V-0219	Glucagon Receptor	GPCR/G Protein
	V-0219 是 GLP-1 的正变构调节剂，可用于肥胖相关糖尿病的研究。
T9579	GLP-1 receptor agonist 9	Glucagon Receptor	GPCR/G Protein
	1H-Benzimidazole-6-carboxylic acid 是GLP-1 receptor 激动剂。
T8947	dasiglucagon acetate dasiglucagon acetate(1544300-84-6 free base)	Others	Others
	dasiglucagon acetate 是一种用于糖尿病低血糖治疗的新型胰高血糖素类似物。它已证明在水性制剂中的溶解度和稳定性。药代动力学研究表明，与传统的重组胰高血糖素相比，它的胰高血糖素具有更高的吸收率和更长的血浆消除半衰期。

化合物

Glucagon (1-29), bovine, human, porcine hydrochloride

Cat.No: T15389L

Synonym: 盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride

Target: Glucocorticoid Receptor, Glucagon Receptor

Glucagon (19-29), human acetate

Cat.No: TP1863L

Target: Glucagon Receptor

Cat.No: TQ0239

Synonym: Glucagon receptor antagonists-4

Target: Glucagon Receptor

[Des-His1,Glu9]-Glucagon amide TFA

Cat.No: T36638

Synonym: [Des-His1,Glu9]-Glucagon amide TFA

Glucagon (1-29), bovine, human, porcine

Cat.No: T15389

Synonym: 胰高血糖素,Porcine glucagon,Glucagon

Target: Others

Glucagon Receptor Antagonist I

Cat.No: T37223

[Des-His1,Glu9]-Glucagon amide

Cat.No: TP2033

Synonym: des-His1-[Glu9]-Glucagon (1-29) amide

Glucagon (Human)

Cat.No: T78059

Synonym: Hyperglycemic-glycogenolytic factor,Glukagon

Target: Others

Glucagon receptor antagonists-1

Cat.No: T11413

Target: Others

Glucagon Receptor Antagonist Inactive Control

Cat.No: T36580

Glucagon (19-29), human

Cat.No: TP1863

Glucagon receptor antagonists-5

Cat.No: T11416

Target: Others

Glucagon receptor antagonists-3

Cat.No: T11415

Target: Others

Glucagon receptor antagonists-2

Cat.No: T11414

Target: Others

Glucagon-like peptide 1 (1-37), human acetate

Cat.No: TP1148L

Target: Glucagon Receptor

Glucagon-Like Peptide (GLP) II, human

Cat.No: TP1487

Cat.No: TQ0124

Target: Glucagon Receptor

Oxyntomodulin (bovine, porcine) (TFA)

Cat.No: T80030

Synonym: Glucagon-37 (bovine, porcine) (TFA)

Glucagon-like peptide 1 (1-37), human

Cat.No: TP1148

Synonym: HuGLP-1

Glucagon (22-29)

Cat.No: T82306

Cat.No: T11845

Target: Glucagon Receptor

Glucagon-like peptide 1 (1-37), human TFA

Cat.No: TP1147

Synonym: HuGLP-1 TFA

GLP-1 (1-36) amide (human, rat)

Cat.No: T80453

Synonym: Glucagon-like Peptide 1 (1-36) amide (human, rat)

Cat.No: T7364

Target: Glucagon Receptor

[Des-His1,Glu9] Glucagon

Cat.No: T76326

GLP-1 (1-36) amide (human, rat) (TFA)

Cat.No: T82309

Synonym: Glucagon-like Peptide 1 (1-36) amide (human, rat) (TFA)

GLP-2(1-33)(human)

Cat.No: TP1157

Synonym: GLP-2 (human),Glucagon-like peptide 2 (human)

Exendin-4 acetate

Cat.No: T8748

Target: Glucagon Receptor

GLP-1 (9-36) amide

Cat.No: TP2252

Target: Glucagon Receptor

(Asp28)-Glucagon (1-29) (human, rat, porcine)

Cat.No: T83550

Biotinyl-Glucagon (1-29), human, bovine, porcine

Cat.No: T76332

Saxagliptin hydrate

Cat.No: T0178

Synonym: 沙格列汀单水化合物,Onglyza hydrate,BMS-477118 hydrate

Target: Proteasome, DPP-4

Cat.No: T6203

Synonym: BMS-477118,沙克列汀,Onglyza,沙格列汀

Target: Proteasome, DPP-4

Cat.No: T19850

Synonym: 索玛鲁肽,司美格鲁肽,索马鲁肽

Target: Glucagon Receptor

GLP-1(7-36), amide

Cat.No: T3984

Synonym: MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide

Target: Glucagon Receptor

(Met(O)27)-Glucagon (1-29) (human, rat, porcine)

Cat.No: T76628

Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide

Cat.No: T76330

Cat.No: T3422

Synonym: GRA-Ex-25

Target: Glucagon Receptor

Cat.No: T3967

Synonym: 艾塞那肽,Exenatide,Exenatide Acetate

Target: Glucagon Receptor

Cat.No: T26712

Synonym: AZD 1656

Target: Glucokinase

Secretin (33-59), rat

Cat.No: TP1039

Synonym: 大鼠SECRETIN肽,Secretin (rat)

Target: Glucagon Receptor

Cat.No: T6876

Synonym: 利拉鲁肽,Liraglutidum,利拉糖肽,Victoza,Liraglutida,NN2211

Target: Glucagon Receptor

Lixisenatide acetate (320367-13-3 free base)

Cat.No: TP1469

Synonym: Lixisenatide acetate

Target: Glucagon Receptor

Cat.No: TP2100

Synonym: Exendin-3 (9-39) amide,Exendin (9-39),艾塞那肽

Target: Glucagon Receptor

Glucagon-Like Peptide 1 (GLP-1) (7-36)-Lys (Biotin), amide, human

Cat.No: T76085

Cat.No: T2316

Synonym: MK-3102,奥格列汀

Target: Proteasome, DPP-4

GLP-1(7-37) acetate(106612-94-6 free base)

Cat.No: TP1376

Synonym: GLP-1(7-37) acetate

Target: Others, Glucagon Receptor

Cat.No: T60047

Target: Glucagon Receptor

GLP-1 receptor agonist 9

Cat.No: T9579

Target: Glucagon Receptor

dasiglucagon acetate

Cat.No: T8947

Synonym: dasiglucagon acetate(1544300-84-6 free base)

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3896	Shanzhiside methyl ester 三栀子甙甲酯,山芝皂苷甲酯	Glucagon Receptor	GPCR/G Protein
	Shanzhiside methyl ester 是一种小分子胰高血糖素样肽 1 受体激动剂，分离自轮状乳杆菌，能够诱导抗异常性痛觉耐受。
T37526	2-Oleoylglycerol 2-Oleoyl Glycerol,2-OG,2-Monoolein	GPR	Endocrinology/Hormones; GPCR/G Protein
	2-Oleoylglycerol 是一种存在于棕榈仁、葵花籽和米糠中的脂质。2-Oleoylglycerol 可当作一种 GPR119 激动剂，具有神经保护作用，可诱导胰高血糖素样肽 1 (GLP-1) 分泌。2-Oleoylglycerol 可用于非酒精性脂肪性肝炎造模。
T37298	Spinacine	Endogenous Metabolite	Metabolism
	Spinacine 是人内源性代谢产物。
TN4997	Serpentine	IGF-1R	Tyrosine Kinase/Adaptors
	Serpentine 是一种玫瑰花根中的生物碱，可用作胰岛素增敏剂，以协助胰岛素降低血糖。Serpentine 可激活 AMPK 磷酸化，从而刺激C2C12细胞对葡萄糖的摄取。Serpentine 可增加了肌肉组织中GSK-3β mRNA的表达，从而增强葡萄糖摄取。Serpentine 显著增加胰高血糖素分泌和肝糖异生。在高脂肪饮食/链脲佐菌素（HFD/STZ）诱导的糖尿病小鼠中，Serpentine 显著延长了胰岛素的降血糖时间，显著降低了外源性胰岛素的使用，抑制了内源性胰岛素的分泌。

天然产物

Shanzhiside methyl ester

Cat.No: T3896

Synonym: 三栀子甙甲酯,山芝皂苷甲酯

Target: Glucagon Receptor

2-Oleoylglycerol

Cat.No: T37526

Synonym: 2-Oleoyl Glycerol,2-OG,2-Monoolein

Target: GPR

Cat.No: T37298

Target: Endogenous Metabolite

Cat.No: TN4997

Target: IGF-1R

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