36
13
Cat. No. | Product Name | Target | Signaling Pathways |
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T9768L |
Ninerafaxstat trihydrochloride
Ninerafaxstat trihydrochloride(2254741-41-6 Free base) |
Others | Others |
Ninerafaxstat trihydrochloride 将细胞代谢由脂肪酸氧化转变为葡萄糖氧化。 Ninerafaxstat trihydrochloride 改善整体线粒体呼吸并减少脂肪酸氧化,从而抑制癌细胞的增殖和生长。 | |||
T37992 |
15-Methyl Palmitic Acid
15-Methylpalmitic acid,15-Methylhexadecanoic acid |
||
15-methyl Palmitic Acid 是一种一种甲基化脂肪酸,广泛存在于动物脂质中,可能于调节脂肪代谢有关。 | |||
T12408 |
Perhexiline maleate
|
Others; Mitochondrial Metabolism | Metabolism; Others |
Perhexiline maleate 是一种口服活性的 CPT1和 CPT2抑制剂,可降低脂肪酸的代谢。Perhexiline maleate 对大鼠心脏和肝脏CPT 1的IC50值分别为77 和 148 μM。 | |||
T0988 |
Trimetazidine dihydrochloride
盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F |
Autophagy; Fatty Acid Synthase | Autophagy; Metabolism |
Trimetazidine dihydrochloride (Vastarel F) 是细胞保护性抗缺血剂,也用作缺血性心脏病或心绞痛的血管扩张剂,具有抗氧化,抗炎,抗伤害和胃保护作用。它可通过抑制脂肪酸代谢提高心肌葡萄糖利用率。 | |||
T68196 |
Aminocarnitine
|
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Aminocarnitine is an inhibitor of fatty acid oxidation that acts as a hypoglycemic and antiketogenic compound. It alters lipidic metabolism by inhibiting carnitine acetyltransferase (CAT) and carnitine palmitoyltransferase (CPT). | |||
T32598 |
Lauroyl-coenzyme A
Dodecanoyl-coa,Coenzyme A, lauroyl-,Lauroyl-coa |
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Lauroyl-coenzyme A can function as an acyl group carrier, acetyl-CoA. It can be used as an intermediate in lipid metabolism and is involved in lipid biosynthesis and fatty acid transport. | |||
T9768 |
Ninerafaxstat
|
Others | Others |
Ninerafaxstat 可以将细胞代谢从脂肪酸氧化转变为葡萄糖氧化,降低脂肪酸氧化,改善线粒体呼吸。 | |||
T83563 |
(2E,9Z)-Octadeca-2,9-dienoic acid
|
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(2E,9Z)-Octadeca-2,9-dienoic acid 是具有多不饱和特性的脂肪酸,适用于研究脂氧合酶依赖的代谢过程。 | |||
T40826 |
5(S)-HPETE
|
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5(S)-Hydroperoxyeicosatetraenoic acid (5(S)-HpETE) is a monohydroperoxy polyunsaturated fatty acid (PUFA) generated by the enzymatic conversion of arachidonic acid via 5-lipoxygenase (5-LO). Subsequently, 5(S)-HpETE undergoes metabolism to form leukotriene A4 (LTA4), which serves as a pivotal intermediate in the synthesis of leukotrienes (LTs). | |||
T61341 | A-908292 | ||
A-908292 is a highly potent and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), displaying an impressive IC50 of 38 nM. This compound serves as a valuable tool in the investigation of fatty acid metabolism [1]. | |||
T16322 |
Nicodicosapent
|
Others | Others |
Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol metabolism proteins such as PCSK9, H | |||
T74171 |
Crotonyl-CoA
|
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Crotonyl-CoA,丁酸发酵、赖氨酸和色氨酸代谢中的关键中间体,对脂肪酸和氨基酸的代谢至关重要。 | |||
T37407 |
Arachidonoyl-L-carnitine (chloride)
C20:4 Carnitine,Arachidonoyl-L-carnitine (chloride) |
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Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism. It does so by accepting acyl groups from fatty acids complexed with coenzyme A, which yields esterified carnitine or acylcarnitines that enable the transport of fatty acyl groups into the inner mitochondrial matrix. β-Oxidation of fatty acids in mitochondria is inhibited by uncoupling conditions, thus changes in circulating levels of various acylcarnitines have been used to identify alte... | |||
T75292 | Biotin sodium | ||
Biotin (Vitamin B7) sodium 是一种水溶性维生素 B,是人体五种羧化酶的辅酶,参与脂肪酸、异亮氨酸和缬氨酸的合成,并参与糖异生。Biotin sodium 是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢的必需物质。 | |||
T36765 |
Palmitelaidic Acid methyl ester
|
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Palmitoleic acid is a common constituent of the triglycerides of human adipose tissue. Palmitoleic acid-based diets raise low-density lipoprotein cholesterol and diminish high-density lipoprotein cholesterol, even when dietary intake of cholesterol is maintained at a low level. Palmitelaidic acid is the trans isomer of the 16:1 fatty acid palmitoleic acid. While its effects on cholesterol levels are poorly studied, palmitelaidic acid can have very different effects from those of palmitoleic acid... | |||
T13483 |
RP 54275
2-Octadecyl-1H-indole-5-carboxylic acid |
Others | Others |
RP 54275 是一种天然存在的脂肪酸衍生物,一种新的降胆固醇化合物。它可以激活过氧化物酶体增殖物激活受体γ(PPARγ)途径,该途径参与脂质代谢、炎症和细胞分化的调节。 | |||
T69622 | Ritivixibat | ||
Ritivixibat为回肠胆汁酸转运蛋白(IBAT)抑制剂,同时也是胆汁酸调节剂,主要适用于心血管疾病、脂肪酸代谢及葡萄糖利用障碍、胃肠道和肝脏疾病的研究。 | |||
T35698 |
Octanoic Acid-13C
|
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Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d... | |||
T38070 |
Arachidonic Acid-biotin
|
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Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-uptake of free arachidonate are all important aspects of cell signalling and inflammation. Arachidonic acid-biotin was designed to allow arachidonic acid to be detected in complex... | |||
T38389 |
Prostaglandin D2 Ethanolamide
Prostaglandin D2 Ethanolamide |
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Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of minia... | |||
T36052 |
Lipoxin A4 methyl ester
LXA4 methyl ester |
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Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 μM.[2] LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural... | |||
T37234 |
(±)14(15)-EpETE
|
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoi... | |||
T73918 |
Lauroyl coenzyme A lithium
|
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Lauroyl coenzyme A lithium salt 是一种辅酶 A。辅酶 A 作为酰基载体,即乙酰辅酶 A。十二烷酰辅酶 A (C12-CoA) 是一种长链 (C-12) 饱和脂肪酰辅酶 A,用作脂质代谢的中间体,参与脂质生物合成和脂肪酸转运。月桂酰辅酶 A 是底物用于 FAM34A 蛋白和萤火虫荧光素酶的产物。 | |||
T35496 |
(±)13(14)-EpDPA
|
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Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 μM. (±)13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models. (±)13(14)-EpDPA and other epoxy m... | |||
T35493 |
(±)10(11)-EpDPA
|
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Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 μM. (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in infla... | |||
T60510 | Perhexiline | ||
Perhexiline 是一种口服活性的 CPT1和 CPT2抑制剂,可降低脂肪酸的代谢。Perhexiline 可以穿过血脑屏障 (BBB)具有抗癌活性。Perhexiline 诱导肝细胞中的线粒体功能障碍和细胞凋亡。因此,Perhexiline 可用于研究癌症和心绞痛等心血管疾病。 | |||
T37238 |
(±)19(20)-EpDPA
|
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic... | |||
T77228 | Polyoxyethylene Sorbitan Monostearate | ||
Polyoxyethylene Sorbitan Monostearate 是一种由饱和脂肪酸硬脂酸 (C18:0) 构成的酯,广泛应用作药用辅料,包括表面活性剂、乳化剂、增溶剂和润湿剂。作为药用助剂,其主要作用是改善药物制剂的稳定性、溶解性和加工性,同时对药物的吸收、分布、代谢和消除 (ADME) 过程具有影响。 | |||
T37235 |
(±)16(17)-EpDPA
(±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA |
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahex... | |||
T37971 |
12-oxo-13-HOME
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12-oxo-13-HOME is an oxylipin derived from linoleic acid .1It is formedviaa 13-HpODE intermediate that is produced by lipoxygenase-mediated metabolism of linoleic acid.2,3,112-oxo-13-HOME has been found in corn and sunflower seedlings.4 1.Ogorodnikova, A.V., Gorina, S.S., Mukhtarova, L.S., et al.Stereospecific biosynthesis of (9S,13S)-10-oxo-phytoenoic acid in young maize rootsBiochim. Biophys. Acta1851(9)1262-1270(2015) 2.Veldink, G.A., and Vliegenthart, J.F.G.The enzymic conversions of 13-hydr... | |||
T76124 | Acyl coenzyme A synthetase | ||
Acyl coenzyme A synthetase (ACS),一种生化研究中常用的酶,主要通过两步硫酯化反应激活脂肪酸与辅酶A结合,形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径,以及参与TCA循环中的有氧呼吸提供了关键中间物。 | |||
T81182 |
Secretin (swine)
|
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Secretin (swine)为源自猪的神经内分泌激素,由十二指肠黏膜S细胞产生,具有27个氨基酸的多肽结构,并针对分泌素受体起作用。此激素在各类成熟肠内分泌细胞亚群中表达,受脂肪酸的促进。它主要激发胰腺释放水和碳酸氢盐,同时在消化系统、中枢神经系统和能量代谢方面具有广泛应用。 | |||
T35813 |
CAY10592
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Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARδ receptor agonists, though relatively obscure, have recently been reported to elevate high-density lipoprotein (HDL) cholesterol and lower plasma triglyceride (TG) levels in obese insulin resistant rhesus monkeys. CAY10592 is a full PPARδ agonist (EC50 = 30 nM) ... | |||
T79357 |
PF-07238025
|
Endogenous Metabolite | Metabolism |
PF-07238025是一种BCKDC激酶(BDK)抑制剂,具有EC50值为19 nM。它通过稳定BDK和BCKDH复合体中的E2亚基相互作用,阻碍E1亚基的磷酸化过程,从而抑制了BCKDH的活性。由于BDK的磷酸化作用是控制支链氨基酸(BCAA)降解过程中的限速步骤,PF-07238025的作用与包括心力衰竭(HF)、2型糖尿病(T2DM)、非酒精性脂肪肝病(NAFLD)及肥胖在内的多种代谢性疾病的发病机制相关。研究显示PF-07238025能在小鼠体内改善心脏代谢指标并提升葡萄糖耐量。 | |||
T35816 |
ZLY032
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ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic st... | |||
T36215 |
17R(18S)-EpETE
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17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T10857 |
Coenzyme A
|
Endogenous Metabolite | Metabolism |
Coenzyme A 是所有活细胞中必需的辅助因子,由泛酸,三磷酸腺苷和半胱氨酸合成的。Coenzyme A 与过氧化物酶 5 共价结合导致其过氧化物酶活性完全抑制,通过 DTT 还原能够逆转。Coenzyme A 及其硫酯衍生物是主要分解代谢,合成代谢途径和基因表达调控的关键参与者。 | |||
T0846 |
L-Carnitine
L(-)-Carnitine,Levocarnitine,左旋肉碱 |
Endogenous Metabolite; Fatty Acid Synthase | Metabolism |
L-Carnitine (L(-)-Carnitine) 是一种人内源性分子,在人体内以蛋氨酸和赖氨酸为底物进行生物合成,并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A 转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。 | |||
T5246 |
Trans-2-butene-1,4-dicarboxylic acid
trans-2-Butene-1,4-dicarboxylic Acid,3-Hexenedioic Acid,trans-3-Hexenedioic Acid,β-Hydromuconic Acid,反式-2-丁烯-1,4-二甲酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Trans-2-butene-1,4-dicarboxylic acid (3-Hexenedioic Acid) 是内源性代谢产物的一种。 | |||
T0894 |
Thiamine hydrochloride
盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride |
Apoptosis; HBV; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology |
Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。 | |||
T4867 |
Erucic acid
Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid |
PI3K; Endogenous Metabolite | Metabolism; PI3K/Akt/mTOR signaling |
Erucic acid (13(Z)-Docosenoic Acid) 是单不饱和脂肪酸,分离自萝卜的种子。Erucic acid 可以容易地穿过血脑屏障,使大脑中长链脂肪酸的积累正常化。Erucic acid 能够改善认知障碍并有效预防痴呆。 | |||
T5245 |
N-Isovaleroylglycine
N-异戊酰氨基乙酸,Isovaleroylglycine,N-Isovalerylglycine |
Others; Endogenous Metabolite | Metabolism; Others |
N-Isovaleroylglycine (Isovaleroylglycine) 是酰基甘氨酸,能够作为体重提高和肥胖的生物标记物。 | |||
T4843 |
2,2-Dihydroxyacetic acid
Formylformic acid,Glyoxylic acid monohydrate,乙醛酸水合物 |
Others; Endogenous Metabolite | Metabolism; Others |
2,2-Dihydroxyacetic acid (Formylformic acid) 是乙醛酸循环的中间体,使某些生物体能够将脂肪酸转化为碳水化合物。2,2-Dihydroxyacetic acid 被发现与原发性高草酸尿有关,这是一种先天性代谢错误。作为一种醛,乙醛酸酯也具有高活性,可以修饰蛋白质形成晚期糖基化产物(AGEs)。 | |||
T6480 |
D-Pantothenic acid
vitamin B5,pantothenate,D-泛酸 |
Others | Others |
D-Pantothenic acid (vitamin B5) 是必需的微量营养素,是辅酶 A 的前体,在很多生物过程中发挥关键作用,如调节碳水化合物,脂质,蛋白和核酸代谢。 | |||
TJO2758 |
D-Glucuronic acid
D-葡萄糖醛酸,Aldehydo-D-Glucuronic Acid |
Others; Endogenous Metabolite | Metabolism; Others |
D-Glucuronic acid (Aldehydo-D-Glucuronic Acid) 是一种从许多树胶中分离出的重要中间体。它对皮肤具有抗炎作用。它及其衍生物葡萄糖醛酸内酯作为预防人类健康的肝脏解毒剂。 | |||
T5215 |
N-(3-Phenylpropionyl)glycine
N-(3-苯基丙酰基)甘氨酸,Phenylpropionylglycine |
Others | Others |
N-(3-Phenylpropionyl)glycine (Phenylpropionylglycine) 是一种酰基甘氨酸。酰基甘氨酸通常是脂肪酸的次要代谢物。 | |||
T4947 |
3-Hydroxybutyric acid
Butanoic acid,3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物,在 I 型糖尿病中升高。它能够调节膜脂的性质。 | |||
T4854 |
Acetoacetic acid lithium salt
LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate,乙酰乙酸锂 |
Others; Endogenous Metabolite | Metabolism; Others |
Acetoacetic acid lithium salt (Lithium 3-Oxobutyrate) 是内源性代谢产物的一种。 | |||
T36051 |
Lipoxin A4
脂氧素 A4,LXA4 |
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Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 in inducing superoxide generation in human neutrophils at 0.1 μM.2 LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.[2],[3],[4] Analytical and biological comparisons of synth... |