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Search Results for " bicyclic "

20

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9609	GRK5-IN-2	GRK	GPCR/G Protein
	GRK5-IN-2 是基于吡啶的双环化合物，抑制 G 蛋白偶联受体激酶 5 。它调节胰岛素的表达和/或释放，在代谢疾病中有研究价值。
T9043	AS1810722	P450; STAT	JAK/STAT signaling; Metabolism; Stem Cells
	AS1810722 是口服有效的STAT6抑制剂，IC50为 1.9 nM。它是一种稠合双环嘧啶衍生物，对有良好的CYP3A4抑制作用，具有用于过敏性疾病，如哮喘和特应性疾病的研究潜力。
T1483	Citalopram hydrobromide Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,氢溴酸西酞普兰,Citalopram HBr	5-HT Receptor; Serotonin Transporter; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Citalopram hydrobromide (XU-62-320) 是一种选择性 5-羟色胺再摄取抑制剂，可选择性地抑制 CNS 神经元对 5-羟色胺的再摄取，从而增强中枢神经系统中的 5-羟色胺能活性，也具有抗抑郁活性。它抑制兔血小板中 5-HT 的摄取，IC50为 14 nM。
T26028	RA VII Methylether of TPC-A,RAVII,RA-VII
	RA VII is used as an antitumor bicyclic hexapeptide of plant origin.
T27886	LY 186826 LY-186826,LY186826
	LY 186826 is an antibacterial agent with bicyclic pyrazolidinone properties.
T40715	3-Butenoic acid 3-丁烯酸,Vinylacetic acid
	3-Butenoic acid, also known as Vinylacetic acid, is utilized in the synthesis of 3,6-dihydro-1,2-oxazine that possesses a bicyclic structure. This strained bicyclic compound, when combined with an external alkene, acts as a reactive substrate in domino metathesis reactions.
T31575	Drimane
	Drimane is a bicyclic sesquiterpene. It is the parent structure of many natural products with various biological activity.
T27882	LY 173013 LY-173013,LY173013
	LY 173013 is a bicyclic pyrazolidinone, it has antibacterial properties.
T26175	Salinamide A
	Salinamide A is an effective anti-inflammatory bicyclic depsipeptide.
T35653	2’-O,4’-C-Methyleneuridine
	2'-O,4'-C-Methyleneuridine (Compound 15a) is a bicyclic nucleoside. [1]. Sharma VK, et al. Chemoenzymatic convergent synthesis of 2'-O,4'-C-methyleneribonucleosides. J Org Chem. 2014 Jul 3;79(13):6336-41.
T74647	BT5528
	BT5528 是一种双环肽毒素结合物，一种EphA2激活剂。BT5528 由双环肽和AuristatinE 组成，是 BCY6099 的衍生物。BT5528 在大鼠模型中显示出强大的抗肿瘤活性，不导致出血或引起凝血毒性。
T19086	1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine	Others	Others
	1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
T37100	1,5,7-Triazabicyclo[4.4.0]dec-5-ene
	1,5,7-Triazabicyclo[4.4.0]dec-5-ene is a bicyclic guanidine base that can be used as a catalyst for a variety of base-mediated organic transformations, including Michael additions, Wittig reactions, Henry reactions, and transesterification reactions.
T31292	Decalin bicyclo[4.4.0]decane,decahydronaphthalene
	Decalin (decahydronaphthalene, also known as bicyclo[4.4.0]decane), a bicyclic organic compound, is an industrial solvent. A colorless liquid with an aromatic odor, it is used as a solvent for many resins or fuel additives. It is the saturated analog of n
T74161	Iboxamycin
	Iboxamycin，一种含有融合双环氨基酸残基的有效抗生素候选，具有高口服生物利用度，对于治疗小鼠革兰氏阳性和革兰氏阴性细菌感染显示出安全性和有效性。
T78530	BT8009	Others	Others
	BT8009是以Nectin-4为靶点的毒素偶联物，其对人Nectin-4细胞外结构域(ECD)的Kd值为2.5 nmol/L。该化合物由Nectin-4特异性双环肽、可裂解的连接子以及monomethylauristatin E (MMAE)构成，主要用于晚期及转移性尿路上皮癌研究。
T63781	SOS1-IN-5
	SOS1-IN-5 是一种嘧啶双环衍生物，是一种 SOS1 的有效抑制剂。SOS1-IN-5 能够干扰 RAS-SOS1相互作用，进而阻断 KRAS 的激活，表现出广谱抑制 KRAS 活性作用。SOS1-IN-5 对癌症疾病表现出研究潜力。
T29092	Valnivudine FV 100,FV100,FV-100
	Valnivudine 是 CF-1743 的前体，是一种口服有效和高效的抗带状疱疹 (HZ) 核苷类似物, 是一种双环核苷类似物 (BCNA). Valnivudine 具有抗病毒活性，可对水痘带状疱疹病毒 (VZV) 进行高度抑制。Valnivudine 在体内可以迅速广泛地转化为 CF-1743。
T80217	BT1718	MMP	Proteases/Proteasome
	BT1718是一种针对MT1-MMP的双功能抗癌肽，通过MT1-MMP靶向肿瘤来传递细胞毒性有效载荷Mertansine。作为一种多肽-毒素偶联物，其KD值为3 nM。MT1-MMP在多种晚期实体肿瘤如三阴性乳腺癌(TNBC)和非小细胞肺癌中呈现过表达。
T38020	O-Benzylhydroxylamine (hydrochloride)
	O-Benzylhydroxylamine is a building block.1,2It has been used in the synthesis of β-lactam inhibitor precursors and fluoroquinolone derivatives with antibiotic activity. 1.Bellettini, J.R., and Miller, M.J.A short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitorsTetrahedron Lett.38(2)167-168(1997) 2.Asadipour, A., Moshafi, M.H., Khosravani, L., et al.N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluationDaru.26(2)19...

化合物

Cat.No: T9609

Target: GRK

Cat.No: T9043

Target: P450, STAT

Citalopram hydrobromide

Cat.No: T1483

Synonym: Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,氢溴酸西酞普兰,Citalopram HBr

Target: 5-HT Receptor, Serotonin Transporter, Autophagy

Cat.No: T26028

Synonym: Methylether of TPC-A,RAVII,RA-VII

Cat.No: T27886

Synonym: LY-186826,LY186826

3-Butenoic acid

Cat.No: T40715

Synonym: 3-丁烯酸,Vinylacetic acid

Cat.No: T31575

Cat.No: T27882

Synonym: LY-173013,LY173013

Cat.No: T26175

2’-O,4’-C-Methyleneuridine

Cat.No: T35653

Cat.No: T74647

1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine

Cat.No: T19086

Target: Others

1,5,7-Triazabicyclo[4.4.0]dec-5-ene

Cat.No: T37100

Cat.No: T31292

Synonym: bicyclo[4.4.0]decane,decahydronaphthalene

Cat.No: T74161

Cat.No: T78530

Target: Others

Cat.No: T63781

Cat.No: T29092

Synonym: FV 100,FV100,FV-100

Cat.No: T80217

Target: MMP

O-Benzylhydroxylamine (hydrochloride)

Cat.No: T38020

Cat. No.	Product Name	Target	Signaling Pathways
T8242	Sabinene	Others	Others
	Sabinene 是香料添加剂，具有成为下一代飞机燃料成分的成分。
T5734	(+)-BORNEOL d-Borneol,(+)-冰片	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	(+)-BORNEOL (d-Borneol) 是一种天然的双环单萜，在中药中用于镇痛和麻醉；增强 GABA 受体活性，EC50 为 248 μM。
TN1114	Carabrone	Antibacterial; Antifection	Microbiology/Virology
	Carabrone 是分离自Carpesium abrotanoides 果实的一种倍半萜，表现出显著抗肿瘤活性和抗菌活性，如灰霉病菌Botrytis cinerea，炭疽病菌Colletotrichum lagenarium 和禾白粉菌Erysiphe graminis。
T2952	Camphor 樟脑,(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa	Influenza Virus; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Camphor (2-Camphanone) 是一种双环单萜酮，广泛存在于植物中，尤其是樟脑。它是一种激动剂，局部用作皮肤止痒剂和抗感染剂，具有抗病毒，镇咳和抗癌活性。
T8279	Isobornyl acetate	Others	Others
	Isobornyl acetate 是一种从柠檬草植物精油中提取的天然产物，属于双环单萜。它被用于多种应用，包括作为调味剂、香料成分和药物成分。
TN1641	(-)-Fenchone	Others; Antioxidant; Antifungal	Microbiology/Virology; Others; oxidation-reduction
	(-)-Fenchone 是一种双环单萜类化合物，广泛分布于植物中，可从Foeniculum vulgare 和Peumus boldus 中提取。(-)-Fenchone 具有广泛的生物活性，包括抗氧化，伤口愈合，止泻，抗真菌，抗伤害感受和支气管扩张剂活性。(-)-Fenchone 是一种潜在的抗肿瘤化合物。
T10109	3-Carene Delta-3-Carene	COX; Antifungal	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	3-Carene（Delta-3-Carene）是西部落叶松和花旗松中提取的双环单萜烯，可做为植物杀菌剂。3-Carene 对痛觉刺激引起的炎症浸润和 COX-2 过表达有抑制作用。3-Carene 具有抗伤害作用，能促进成骨细胞分化的早期标志物碱性磷酸酶的活性和表达。
T4799	Indole	Others; Endogenous Metabolite	Metabolism; Others
	Indole 它具有双环结构，由一个六元苯环和一个五元含氮吡咯环融合而成。它可以由细菌作为氨基酸色氨酸的降解产物产生。它自然存在于人类粪便中，有强烈的粪便气味。然而，在非常低的浓度下，它有一种花香，是许多花香(如橙花)和香水的成分。
T83591	(±)-7-epi-Kadsurenone
	(±)-7-epi-Kadsurenone 是一种新型木脂素，具备氢苯并呋喃结构以及双环[3.2.1]辛烷骨架。
T83554	(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one
	'(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one' 是倍半萜类内酯化合物。
T81095	Stenophyllol B
	Stenophyllol B (compound 4) 是一种具有双环及桥联三环骨架的三聚芪类化合物。该化合物最初在龙脑香科植物中被鉴定，随后在Hopea、Neobalanocarpus、Shorea、Stemonoporus以及Vateri等属的多种物种中发现。
T8291	2-Carene	Others	Others
	2-Carene 是一种天然存在的双环单萜，存在于许多精油中，如松树、雪松和柏树。它被发现具有抗炎、抗真菌和抗菌活性，以及抗氧化、抗肿瘤和抗过敏活性，还有神经保护、心脏保护和肝脏保护作用。
T75646	Moroidin
	Moroidin是一种双环八肽，隶属于荨麻疹科环肽科，有效抑制纯化的微管蛋白聚合，表现为微管蛋白聚合抑制剂。此外，Moroidin对包括A549人肺癌细胞在内的多种癌细胞显示出细胞毒性作用，能诱导细胞凋亡。
T36961	Malformin C
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but ...

天然产物

Cat.No: T8242

Target: Others

Cat.No: T5734

Synonym: d-Borneol,(+)-冰片

Target: GABA Receptor

Cat.No: TN1114

Target: Antibacterial, Antifection

Cat.No: T2952

Synonym: 樟脑,(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa

Target: Influenza Virus, TRP/TRPV Channel

Isobornyl acetate

Cat.No: T8279

Target: Others

Cat.No: TN1641

Target: Others, Antioxidant, Antifungal

Cat.No: T10109

Synonym: Delta-3-Carene

Target: COX, Antifungal

Cat.No: T4799

Target: Others, Endogenous Metabolite

(±)-7-epi-Kadsurenone

Cat.No: T83591

(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one

Cat.No: T83554

Cat.No: T81095

Cat.No: T8291

Target: Others

Cat.No: T75646

Cat.No: T36961

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