(+)-BORNEOL

规格	价格/CNY		货期	数量
50 mg	￥ 190	现货
1 mL * 10 mM (in DMSO)	￥ 150	现货

规格

价格/CNY

货期

数量

50 mg

￥ 190

现货

1 mL * 10 mM (in DMSO)

￥ 150

现货

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.483 mL	32.4149 mL	64.8298 mL	162.0746 mL
5 mM	1.2966 mL	6.483 mL	12.966 mL	32.4149 mL
10 mM	0.6483 mL	3.2415 mL	6.483 mL	16.2075 mL
20 mM	0.3241 mL	1.6207 mL	3.2415 mL	8.1037 mL
50 mM	0.1297 mL	0.6483 mL	1.2966 mL	3.2415 mL
100 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.6207 mL

可选溶剂

浓度体积质量

1 mg

5 mg

10 mg

25 mg

DMSO

1 mM

6.483 mL

32.4149 mL

64.8298 mL

162.0746 mL

5 mM

1.2966 mL

6.483 mL

12.966 mL

32.4149 mL

10 mM

0.6483 mL

3.2415 mL

6.483 mL

16.2075 mL

20 mM

0.3241 mL

1.6207 mL

3.2415 mL

8.1037 mL

50 mM

0.1297 mL

0.6483 mL

1.2966 mL

3.2415 mL

100 mM

0.0648 mL

0.3241 mL

0.6483 mL

1.6207 mL

中药材名称	中药材拉丁名	性	味	归经
杜仲叶	Eucommia ulmoides Oliv.	温	微辛	肝, 肾

中药材名称

中药材拉丁名

性

味

归经

杜仲叶

Eucommia ulmoides Oliv.

温

微辛

肝, 肾

中成药名称	处方组成	主治疾病	中成药类型
益寿大补酒	党参,茯苓,白芍,续断,当归,三七,杜仲叶,制何首乌,红花,黄芪,牛膝,山药,牡丹皮,泽泻,白术,熟地黄,人参	口服，一次20～30ml，一日1～2次。	补益药
杜仲冲剂	杜仲,杜仲叶	N/A	补益药
腰痛片	杜仲叶,补骨脂,续断,当归,白术,牛膝,肉桂,乳香,狗脊,赤芍,泽泻,土鳖虫	N/A	和血药
益寿强身膏	党参,人参,茯苓,炙黄芪,白术,山药,制何首乌,当归,熟地黄,川芎,泽泻,牡丹皮,牛膝,白芍,杜仲叶,续断,阿胶,红花,三七,炙甘草,黄精,陈皮	口服，一次15g，一日2次。	补益药
首乌强身片	制何首乌,墨旱莲,杜仲叶,豨莶草,牛膝,桑叶,女贞子,桑椹,金樱子,覆盆子	口服，一次3片。	补益药
强力定眩片	天麻,杜仲,野菊花,杜仲叶,川芎	口服，一次4～6片，一日3次。	祛风药
妇宝颗粒	地黄,忍冬藤,续断,杜仲叶,麦冬,莲房,川楝子,白芍,延胡索,甘草,侧柏叶,大血藤	用开水冲服，每袋10克规格：一次20克，一日2次；每袋5克规格：一次10克，一日2次。	清热药
杜仲颗粒	杜仲,杜仲叶	开水冲服，一次1袋，一日2次。	扶正药
杜仲平压片	杜仲叶	一次2片，一日2～3次，或遵医嘱。	补益药
长春益寿膏	天冬,麦冬,熟地黄,山药,牛膝,地黄,杜仲叶,制何首乌,茯苓,人参,木香,柏子仁,五味子,狗脊,花椒,泽泻,石菖蒲,远志,菟丝子,金樱子,枸杞子,覆盆子,地骨皮	开水冲服，一次30克，一日2次，早晚各1次。	补益药

杜仲平压胶囊	杜仲叶	口服，一次2粒，一日2~3次。	扶正药
杜仲平压分散片	杜仲叶	吞服，或用水分散后口服。一次2片，一日2～3次。	扶正药
强力定眩胶囊	天麻,杜仲,野菊花,杜仲叶,川芎	口服。一次4～6粒，一日3次。	扶正药
骨刺片	昆布,骨碎补,党参,桂枝,威灵仙,牡蛎,杜仲叶,鸡血藤,附子,制川乌,制草乌,延胡索,白芍,三七,马钱子	N/A	N/A
腰痛丸	杜仲叶,补骨脂,狗脊,续断,当归,赤芍,白术,牛膝,泽泻,肉桂,乳香,土鳖虫	用盐开水送服，一次9g，一日2次。	和血药
杜仲双降袋泡剂	杜仲叶,苦丁茶	开水泡服，一次1袋，一日2～3次。	清热药
绍兴大补酒	党参,山药,白术,熟地黄,川芎,杜仲叶,茯苓,当归,炙黄芪,玉竹,白芍,炙甘草	口服，一次15～30毫升，一日2次。	补益药
骨刺胶囊	昆布,骨碎补,党参,桂枝,威灵仙,牡蛎(煅),杜仲叶,鸡血藤,附片,制川乌,制草乌,延胡索(制),白芍,三七,马钱子粉	口服，一次3粒，一日3次，或遵医嘱。	补肾壮骨药
杜仲绞股蓝口服液	杜仲叶,菟丝子,淫羊,胶股蓝	口服，一日2～3次，一次10毫升。	扶正药

植物来源	天然产物 > 姜科 > 姜属
结构类型	天然产物 > 其他

产品描述	(+)-BORNEOL (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM.
靶点活性	GABA:248 μM(EC50)
体外活性	Aβ-induced cell cytotoxicity was inhibited by 100 μM of (-) and (+) borneol treatment. Treatment of borneol significantly decreased ROS generation (P < 0.01). The expression of HO-1 and nuclear translocation of Nrf2 were increased by Aβ treatment. This nuclear translocation of Nrf2 was further increased by administration of borneol. Compared with the Aβ treated group, the (+) borneol treated group significantly increased Bcl-2 expression with decreased expression of Bax[1].
体内活性	(+)-borneol (1.0 mg/kg) significantly ameliorated infarct size and neurological scoresvia reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in a dose dependent manner. Notably, (+)-borneol showed long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreased the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. Suggest that (+)-borneol could serve as a therapeutic target for ischemic stroke[2].
细胞实验	Oxidative stress was induced by administering 50 μM Aβ into SH-SY5Y cells. Neuroprotective effect of commercially available borneol was examined by determining cell viability with the MTT assay. Intracellular reactive oxygen species (ROS) generation was measured using a fluorometer with further examination of heme oxygenase-1 (HO-1) and nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) expression. Apoptosis was examined by measuring the ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax)[1].
动物实验	To mimic a typical human stroke, which does not undergo reperfusion, used a permanent MCAO in this study. For investigating the role of (+)-borneol in permanent cerebral ischemia, 45 male Sprague-Dawley rats were randomly divided into the sham group, the vehicle-treated group and the (+)-borneol-treated groups (1.0 mg/kg), with 15 rats in each group. The terminal half-life (t1/2) of borneol was 2 h following cerebral ischemia-reperfusion. We subjected the rats to pMCAO and administered drugs by tail intravenous injection 2 hours and 5 hours after pMCAO, respectively. The sham group and the vehicle-treated group were injected with vehicle administration. Neurologic scores were assessed at 48 hours after reperfusion[2].

别名	d-Borneol, (+)-冰片
分子量	154.25
分子式	C10H18O
CAS No.	464-43-7

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