首页工具

登录

搜索结果

Search Results for " atrial fibrillation "

29

抑制剂 & 化合物

3

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T0389	Dabigatran etexilate 达比加群酯,BIBR 1048	Thrombin	Proteases/Proteasome
	Dabigatran etexilate (BIBR 1048) 是一种 Dabigatran 前药，具有口服活性。它具有抗凝作用，能够预防心房颤动引起的静脉血栓栓塞和中风。
T5133	Dabigatran Etexilate Mesylate 甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate	Thrombin	Proteases/Proteasome
	Dabigatran Etexilate Mesylate (BIBR 1048MS) 是一种口服具有活性的 Dabigatran 前药，具有抗凝作用，能够预防心房颤动引起的静脉血栓栓塞和中风。
T30520	BMS-394136 BMS394136,BMS 394136,BMS394136;UNII-M694U7167K	Potassium Channel	Membrane transporter/Ion channel
	BMS-394136 (BMS 394136) 是一种 KV1.5 拮抗剂，可用于治疗心律失常、心房颤动等心血管疾病。
T26689	AVE-0118 AVE 0118,AVE0118	Potassium Channel	Membrane transporter/Ion channel
	AVE-0118 是一种钾通道阻滞剂，可抑制持续性心房颤动。
T30544	BMS-919373 BMS919373,BMS 919373	Potassium Channel	Membrane transporter/Ion channel
	BMS-919373是的钾通道Kv1.5（KCNA5）抑制剂，可用于心房颤动和急性冠状动脉综合征。
T68038	Celivarone	Potassium Channel	Membrane transporter/Ion channel
	Celivarone 是一种钾离子通道阻滞剂，可用于研究心律失常、心房扑动和心房颤动。
T28748	Selodenoson RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Selodenoson (RG-14202) 是一种选择性腺苷 A1 受体激动剂，可用于减慢心房颤动患者的心率，治疗心律失常。
T1073	Dronedarone hydrochloride Dronedarone HCl,SR33589,决奈达隆盐酸盐,盐酸决奈达隆	Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Dronedarone hydrochloride (SR33589) 是一种胺碘酮类似物，可抑制 Na+,K+andCa2+的电流，有可能治疗心房颤动。
T68730	AVE1231	Potassium Channel	Membrane transporter/Ion channel
	AVE1231 是一种 TASK-1 通道阻滞剂，抑制 TASK-1 ，可用于研究心房颤动。
T13021	Sulamserod RS-100302	5-HT Receptor	GPCR/G Protein; Neuroscience
	Sulamserod（RS 100302）是一种有效的 5-HT4 receptor 拮抗剂，具有抗心律失常活性，可用于研究心房颤动和心血管相关疾病。
T61913	Cavutilide	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Cavutilide具有抗心律失常活性，抑制 hERG K（+）通道，可用于研究心力衰竭和持续性心房颤动。
T6476	Dofetilide UK 68789,UK-68798,Tikosyn,多非利特	Potassium Channel	Membrane transporter/Ion channel
	Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂，作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。
T6295	Dabigatran BIBR 953,BIBR 953ZW,达比加群	Thrombin	Proteases/Proteasome
	Dabigatran (BIBR 953ZW) 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
T83979	Sulcardine 2HCl Sulcardine 2HCl（343935-60-4 Free base）,HBI-3000 2HCl	HER; Sodium Channel	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Sulcardine 2HCl 是一种多离子通道阻滞剂，具有抗心律失常作用，可阻断 hERG 和hNav1.5通道的特性，可用于研究心房颤动和室性心律失常。
T21373	Aprindine hydrochloride Fiboran,Amidonal,Aprinidine,Aprindin,Aprindine HCl,Aprindina,Fibocil
	Aprindine HCl is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally.
T30678	C1-resveratrol C1resveratrol,C1 resveratrol
	C1 resveratrol is a novel multifunctional derivative of resveratrol, which is used to treat atrial fibrillation.
T68893	Vanoxerine free base
	Vanoxerine, also known as GBR-12909; I-893, is a dopamine ruptake inhibitor potentially for the treatment of atrial fibrillation.
T30607	Budiodarone ATI2042,ATI-2042,ATI 2042
	Budiodarone（ATI-2042）is a chemical analog of an antiarrhythmic drug and amiodarone. Budedalone is promising as an antiarrhythmic agent for the prevention of atrial fibrillation.
T37821	AP 14145 hydrochloride
	KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM). Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model. Diness et al (2017) Termination of vernakalant-resistant atrial fibrillation by inhibition of small-conductance Ca2+-activated K+...
T62207	KVI-020
	KVI-020 是一种选择性的、口服具有活力的心房钾通道 Kv1.5 阻滞剂 (IC50: 480 nM)。KVI-020 对 hERG 表现出抑制作用 (IC50: 15100 nM)。 KVI-020 是一种有效的抗心律失常剂 (antiarrhythmic)，能够用于研究房颤 (AF)。
T79195	Cav 3.2 inhibitor 4	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cav 3.2 inhibitor 4 (compound 21) 是高效的选择性 T 型钙通道 (Cav3.2) 抑制剂，具有外周限制性，其 IC50 值为 0.6 μM，适用于心房颤动研究。
T62283	DDO-02005
	DDO-02005 是一种 Kv1.5 钙离子通道的有效抑制剂 (IC50: 0.72 μM)。DDO-02005 在 CaCl2-ACh 房颤大鼠模型中表现出良好的抗房颤效果，并能有效抵因抗乌头碱引发的心律失常。
T80039	ATX-II	Sodium Channel	Membrane transporter/Ion channel
	ATX-II为特定Na+通道调节剂，源自海葵(Anemonia sulcata)毒液。该化合物会使细胞培养物对Na+Halothane、Caffeine及Ryanodine敏感，并可诱发肺静脉心律失常及心房颤动。
T21391	Flecainide Tambocor,Apocard,Flecainida,Flecainidum
	Flecainide acetate is a class Ic antiarrhythmic agent, it is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia. It works by regulating the flow of
T39963	AP14145 hydrochloride
	AP14145 hydrochloride is a potent negative allosteric modulator of K Ca 2 (SK) channels, specifically targeting K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels with an IC 50 of 1.1 μM. Inhibition of AP14145 hydrochloride is highly influenced by S508 and A533 amino acids present in the channel. This compound effectively extends the atrial effective refractory period (AERP) in rats and exhibits antiarrhythmic properties in a Vernakalant-resistant porcine model of atrial fibrillation (AF).
T30192	Atecegatran metoxil Atecegatran fexenetil,AZD-0837,AZD 0837,AZD0837
	Atecegatran Metoxil (Atecegatran Fexenetil ,AZD0837) is an oral direct thrombin inhibitor,which currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillation. AZD0837 is a selective and re
T82936	ATX-II TFA	Sodium Channel	Membrane transporter/Ion channel
	ATX-II TFA为源自海葵(Anemonia sulcata)毒素的特定Na+通道调节剂，能使细胞培养物对Na+、Halothane、Caffeine和Ryanodine敏感，并可诱发肺静脉心律失常和心房颤动。
T61231	DDO-02005 free base
	DDO-02005 (free base) 是一种针对Kv1.5 钙离子通道的高效抑制剂，其IC50 值为0.72 μM。在CaCl2-ACh诱导的房颤大鼠模型中，DDO-02005 (free base) 显示出显著的抗房颤效果，并能有效对抗乌头碱所致的心律失常。
T64099	FXIa-IN-9
	FXIa-IN-9 (compound 3f) 是一种具有高选择性的FXIa抑制剂，通过与FXIa结合并形成氢键（human FXIaKi: 0.17 nM, rabbit FXIaKi: 0.5 nM），展现出显著的抗凝活性。该化合物在心房颤动、中风、心肌梗塞、深静脉血栓以及肺栓塞等血栓栓塞性疾病的研究中有潜在应用价值。

化合物

Dabigatran etexilate

Cat.No: T0389

Synonym: 达比加群酯,BIBR 1048

Target: Thrombin

Dabigatran Etexilate Mesylate

Cat.No: T5133

Synonym: 甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate

Target: Thrombin

Cat.No: T30520

Synonym: BMS394136,BMS 394136,BMS394136;UNII-M694U7167K

Target: Potassium Channel

Cat.No: T26689

Synonym: AVE 0118,AVE0118

Target: Potassium Channel

Cat.No: T30544

Synonym: BMS919373,BMS 919373

Target: Potassium Channel

Cat.No: T68038

Target: Potassium Channel

Cat.No: T28748

Synonym: RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009

Target: Adenosine Receptor

Dronedarone hydrochloride

Cat.No: T1073

Synonym: Dronedarone HCl,SR33589,决奈达隆盐酸盐,盐酸决奈达隆

Target: Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, Autophagy

Cat.No: T68730

Target: Potassium Channel

Cat.No: T13021

Synonym: RS-100302

Target: 5-HT Receptor

Cat.No: T61913

Target: EGFR

Cat.No: T6476

Synonym: UK 68789,UK-68798,Tikosyn,多非利特

Target: Potassium Channel

Cat.No: T6295

Synonym: BIBR 953,BIBR 953ZW,达比加群

Target: Thrombin

Sulcardine 2HCl

Cat.No: T83979

Synonym: Sulcardine 2HCl（343935-60-4 Free base）,HBI-3000 2HCl

Target: HER, Sodium Channel

Aprindine hydrochloride

Cat.No: T21373

Synonym: Fiboran,Amidonal,Aprinidine,Aprindin,Aprindine HCl,Aprindina,Fibocil

Cat.No: T30678

Synonym: C1resveratrol,C1 resveratrol

Vanoxerine free base

Cat.No: T68893

Cat.No: T30607

Synonym: ATI2042,ATI-2042,ATI 2042

AP 14145 hydrochloride

Cat.No: T37821

Cat.No: T62207

Cav 3.2 inhibitor 4

Cat.No: T79195

Target: Calcium Channel

Cat.No: T62283

Cat.No: T80039

Target: Sodium Channel

Cat.No: T21391

Synonym: Tambocor,Apocard,Flecainida,Flecainidum

AP14145 hydrochloride

Cat.No: T39963

Atecegatran metoxil

Cat.No: T30192

Synonym: Atecegatran fexenetil,AZD-0837,AZD 0837,AZD0837

Cat.No: T82936

Target: Sodium Channel

DDO-02005 free base

Cat.No: T61231

Cat.No: T64099

Cat. No.	Product Name	Target	Signaling Pathways
T41358	2-Hydroxybenzylamine	Others	Others
	2-Hydroxybenzylamine 是一种有效的 IsoLG 小分子清除剂，可将活性物质作为惰性加合物螯合。 2-Hydroxybenzylamine 可用于通过减少具有天然生物分子的 IsoLG 加合物来减少心房颤动消融后心房颤动和其他心房心律失常的早期复发。
T3S0081	Oxypeucedanin (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin	Potassium Channel	Membrane transporter/Ion channel
	Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物，分离自Angelica dahurica。它是选择性开放通道阻滞剂，可抑制hKv1.5通道电流，IC50值为 76 nM。它延长心脏动作电位持续时间，是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。
T7056	Dronedarone 决奈达隆,SR 33589	P450; Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Dronedarone (SR 33589) 是一种胺碘酮类似物，对治疗心房颤动可能有效。它是CYP3A4的底物和中度抑制剂。它是多种离子电流的有效阻滞剂，通过非竞争性结合到肾上腺素能受体显示出抗肾上腺素能的效果。

天然产物

2-Hydroxybenzylamine

Cat.No: T41358

Target: Others

Cat.No: T3S0081

Synonym: (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin

Target: Potassium Channel

Cat.No: T7056

Synonym: 决奈达隆,SR 33589

Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼