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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8318	BNC210 H-Ile-Trp-OH,IW-2143	AChR	Neuroscience
	BNC210 (IW-2143) 是一种α7 nAChR 负变构调节剂，在焦虑和抑郁动物模型中有活性。
T22994	ML 154	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	ML154 是NPSR 的有效拮抗剂。ML154 在焦虑、成瘾和食物障碍方面具有研究的潜力。
T7061	Duloxetine	Serotonin Transporter	Neuroscience
	Duloxetine 是一种 5 羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂，Ki=4.6 nM，可作用于广泛性焦虑症的研究。
T2200	Hydroxyzine dihydrochloride Hydroxyzine 2HCl,盐酸羟嗪	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) 是一种苯二氮卓抗组胺剂，是可口服的组胺 H1 受体和血清素拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它还可以作为止吐剂和镇静剂，有缓解焦虑和紧张的作用。
T2710	TCS 1102	OX Receptor	GPCR/G Protein; Neuroscience
	TCS 1102 是双食欲素受体拮抗剂，对 OX1和OX2受体的Ki 分别为3和 0.2 nM。
T1471	Duloxetine hydrochloride Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) 是一种 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI)，Ki=4.6 nM，可用于广泛性焦虑症的研究。
T28270	Osemozotan HCl Osemozotan hydrochloride,MN-305,MCI-242,MKC-242,MKC242,MCI242
	Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.
T22453	Venlafaxine Wy 45030,文拉法辛	Serotonin Transporter	Neuroscience
	Venlafaxine (Wy 45030) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。
T2132	Buspirone hydrochloride Buspirone HCl,盐酸丁螺环酮,Narol,Buspar	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Buspirone hydrochloride (Buspar) 是一种 5HT(1A) 受体激动剂，可用于研究广泛性焦虑症。
T68172	Zalospirone	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zalospirone 是一种5-HT1A 受体激动剂，可用于研究焦虑症和重度抑郁症。
T7136	AZD-6280	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	AZD-6280 是一种新型的亚型选择性 GABAAα2/3 受体阳性调节剂，用于治疗广泛性焦虑症。
T22442	Trazodone 曲唑酮,AF-1161	5-HT Receptor	GPCR/G Protein; Neuroscience
	Trazodone (AF-1161) 是一种 5-HT 2A/2C 受体拮抗剂，用作治疗主要焦虑症和抑郁症的抗抑郁药。
T26915	BTG-1640 ABIO-0801,ABIO-08-01,SP-1640
	BTG-1640 is used potentially for the treatment of anxiety and panic disorder.
T1885L	Siramesine Fumarate LU-28179,LU-28-179,LU 28 179
	Siramesine Fumarate, a sigma receptor agonist, is used potentially for the treatment of generalized anxiety disorder.
T68683	Sertraline Free Base
	Sertraline Free Base is a Selective Serotonin Reuptake Inhibitor (SSRI). It can treat depression, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), social anxiety disorder, and panic disorder.
T69063	Orvepitant
	Orvepitant is a potent and selective NK1 antagonist, which may be potentially useful for patients with major depressive disorder (MDD), anxiety and insomnia.
T68579	Fluvoxamine acid
	Fluvoxamine acid is a medication which functions as a selective serotonin reuptake inhibitor (SSRI) and σ1 receptor agonist. Fluvoxamine is used primarily for the treatment of obsessive-compulsive disorder (OCD), and is also used to treat major depressive disorder (MDD), and anxiety disorders such as panic disorder and post-traumatic stress disorder (PTSD).
T11113	Duloxetine D3 hydrochloride (S)-Duloxetine D3 hydrochloride,LY248686 D3 hydrochloride	Others	Others
	Duloxetine D3 hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) i
T60483	Fasedienol
	Fasedienol 是一种犁鼻器 (VON) 的神经化学刺激剂，可缓解焦虑和经前综合症。
T61376	Opipramol
	Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2].
T79056	Orexin receptor modulator-1
	Orexin receptormodulator-1 是一款针对食欲素受体的调节剂，主要应用于物质成瘾、惊恐障碍、焦虑、创伤后应激障碍 (PTSD)、疼痛、抑郁、季节性情感障碍、进食障碍及高血压的科研领域。
T60305	ZLc-002
	ZLc-002 是一种选择性的 nNOS-Capon 偶联小分子抑制剂。ZLc-002 抑制炎症和化疗引起的神经性疼痛。ZLc-002 可用于焦虑和炎症研究。

化合物

Cat.No: T8318

Synonym: H-Ile-Trp-OH,IW-2143

Target: AChR

Cat.No: T22994

Target: Neuropeptide Y Receptor

Cat.No: T7061

Target: Serotonin Transporter

Hydroxyzine dihydrochloride

Cat.No: T2200

Synonym: Hydroxyzine 2HCl,盐酸羟嗪

Target: Histamine Receptor

Cat.No: T2710

Target: OX Receptor

Duloxetine hydrochloride

Cat.No: T1471

Synonym: Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T28270

Synonym: Osemozotan hydrochloride,MN-305,MCI-242,MKC-242,MKC242,MCI242

Cat.No: T22453

Synonym: Wy 45030,文拉法辛

Target: Serotonin Transporter

Buspirone hydrochloride

Cat.No: T2132

Synonym: Buspirone HCl,盐酸丁螺环酮,Narol,Buspar

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T68172

Target: 5-HT Receptor

Cat.No: T7136

Target: GABA Receptor

Cat.No: T22442

Synonym: 曲唑酮,AF-1161

Target: 5-HT Receptor

Cat.No: T26915

Synonym: ABIO-0801,ABIO-08-01,SP-1640

Siramesine Fumarate

Cat.No: T1885L

Synonym: LU-28179,LU-28-179,LU 28 179

Sertraline Free Base

Cat.No: T68683

Cat.No: T69063

Fluvoxamine acid

Cat.No: T68579

Duloxetine D3 hydrochloride

Cat.No: T11113

Synonym: (S)-Duloxetine D3 hydrochloride,LY248686 D3 hydrochloride

Target: Others

Cat.No: T60483

Cat.No: T61376

Orexin receptor modulator-1

Cat.No: T79056

Cat.No: T60305

Cat. No.	Product Name	Target	Signaling Pathways
T20884	Hydroxyzine Hydroxyzine free base,羟嗪	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Hydroxyzine (Hydroxyzine free base) 是一种组胺 H1 受体拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它可作为止吐剂和镇静剂，缓解焦虑和紧张。

天然产物

Cat.No: T20884

Synonym: Hydroxyzine free base,羟嗪

Target: Histamine Receptor

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