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32

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T24178	Isatoribine Isatoribine free base,ANA 245,Immusine,ANA-245,Isatoribine,Isatoribine monohydrate,ANA245	HCV Protease; TLR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Isatoribine(ANA245) free base 是一种有效的 TLR7 受体激动剂，具有抗丙型肝炎病毒感染活性，可用于研究HCV感染。
T4121	Bicyclol SY801,双环醇	HBV; Autophagy	Autophagy; Microbiology/Virology
	Bicyclol (SY801) 是一种抗肝炎 HBV 和 HCV 药物。
T27586	IDX184 IDX-184,IDX 184	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	IDX184 是一种有效的，具有口服活性的靶向 HCV 聚合酶抑制剂和核苷聚合酶抑制剂。IDX184 有效抑制 HCV 聚合酶 (IC50=0.31 μM，Ki=52.3 nM)。 IDX184是一种肝脏靶向核苷酸前药，具有抗HCV活性，可抑制HCV NS5B聚合酶，可与聚乙二醇化干扰素-α2a 和利巴韦林联合用于初治慢性丙型肝炎。
T27499	GSK-A1	HCV Protease; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	GSK-A1 是 III 型磷脂酰肌醇 4-激酶 PI4KA 选择性抑制剂，pIC50为 8.5-9.8，抑制 PtdIns(4,5)P2 再合成，IC50约为 3 nM。GSK-A1有效降低 PtdIns(4)P 的水平，而对 PtdIns(4,5)P2 没影响。GSK-A1在抗丙型肝炎病毒方面有研究的潜力。
T12962	Sofosbuvir impurity G	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity G 是 Sofosbuvir 的非对映异构体，是 Sofosbuvir 的杂质。其中 Sofosbuvir 能够抑制 HCVRNA 的复制，具有抗丙型肝炎病毒作用。
T10067	2',5-Difluoro-2'-deoxycytidine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	2',5-Difluoro-2'-deoxycytidine has potent anti-HCV activity and toxicity to rRNA.
T12960	Sofosbuvir impurity E	Others	Others
	Sofosbuvir impurity E is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T13281	Valopicitabine NM283	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic HCV infection.
T62993	IMB-26
	IMB-26 是一种 HCV 抑制剂 (EC50: 2.1 μM)，显示出有效的抗 HCV 作用。
T14180	Alisporivir DEB-025,Debio-025	Others	Others
	Alisporivir (Debio-025) is a cyclophilin inhibitor molecule.It has potent anti-hepatitis C virus (HCV) activity.
T12957	Sofosbuvir impurity B	Others	Others
	Sofosbuvir impurity B is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity.
T12955	Sofosbuvir D6 PSI-7977 D6,GS-7977 D6	Others	Others
	Sofosbuvir D6 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
T12966	Sofosbuvir impurity K	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T10919	Cyclophilin inhibitor 1	Others	Others
	Cyclophilin inhibitor 1 is an effective and orally bioavailable cyclophilin A inhibitor with a Kd of 5 nM, showing potent anti-HCV activity, and an EC50 for HCV 2a of 98 nM.
T12969	Sofosbuvir impurity N	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12965	Sofosbuvir impurity J	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12964	Sofosbuvir impurity I	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity I is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12959	Sofosbuvir impurity D	Others	Others
	Sofosbuvir impurity D is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T12954	Sofosbuvir 13CD3 GS-7977 13CD3,PSI-7977 13CD3	Others	Others
	Sofosbuvir 13CD3 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity.
T12958	Sofosbuvir impurity C	Others	Others
	Sofosbuvir impurity C is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T12968	Sofosbuvir impurity M	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity M is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T11549	Helioxanthin 8-1 Helioxanthin analogue 8-1	Others	Others
	Helioxanthin 8-1, an analogue of helioxanthin, exhibits significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 μM.
TNU0180	7-Deazaguanosine
	Nucleoside Derivatives - 7-Deaza-purine nucleosides; Drugs and Inhibitors; Antiviral agent, anti-HCV
T64220	Cyclophilin inhibitor 3
	Cyclophilin inhibitor 3 (compound 7c) 是一种 cyclophilin A (CypA) 的有效抑制剂，表现出有效的抗 HCV 作用，其 EC50 值为 4.2 μM。
T74720	Mipomersen
	Mipomersen (ISIS 301012 free base) 是载脂蛋白 B(apoB)的反义寡核苷酸抑制剂。Mipomersen 具有抗HCV 的作用，可降低HCV 的感染性。Mipomersen 可用于纯合子家族性高胆固醇血症 (HoFH) 的研究。
T63396	HCV-IN-38
	HCV-IN-38 是选择性的、有效的、口服具有活力的丙型肝炎病毒 (HCV) 抑制剂，其EC50值为15 nM，SI 值为431。HCV-IN-38 具有良好的安全性及口服药代动力学，表现出较高的抗HCV 活性和较低的细胞毒性作用。
T12967	Sofosbuvir impurity L	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity L is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12963	Sofosbuvir impurity H	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is a diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T14493	Balapiravir R1626,Ro 4588161	Others	Others
	Balapiravir (R1626, Ro 4588161) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). IC50 Value: Target: HCV Balapiravir was discontinued for safety reasons in 28-36% of patients (m
T61871	DC-LC3in-D5
	DC-LC3in-D5 is a chemical compound that functions as an autophagy inhibitor by diminishing the process of LC3B lipidation. It forms a binding association with LC3B, disrupting the LC3B-LBP2 interaction with an IC50 of 200 nM. This compound, DC-LC3in-D5, exhibits potential for application in anti-HCV or combination cancer treatments by effectively inhibiting autophagy [1].
T36880	NHC-diphosphate
	NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1]. Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and ...
T36882	CAY10773
	CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen ...

化合物

Cat.No: T24178

Synonym: Isatoribine free base,ANA 245,Immusine,ANA-245,Isatoribine,Isatoribine monohydrate,ANA245

Target: HCV Protease, TLR

Cat.No: T4121

Synonym: SY801,双环醇

Target: HBV, Autophagy

Cat.No: T27586

Synonym: IDX-184,IDX 184

Target: HCV Protease

Cat.No: T27499

Target: HCV Protease, PI4K

Sofosbuvir impurity G

Cat.No: T12962

Target: HCV Protease

2',5-Difluoro-2'-deoxycytidine

Cat.No: T10067

Target: HCV Protease

Sofosbuvir impurity E

Cat.No: T12960

Target: Others

Cat.No: T13281

Synonym: NM283

Target: HCV Protease

Cat.No: T62993

Cat.No: T14180

Synonym: DEB-025,Debio-025

Target: Others

Sofosbuvir impurity B

Cat.No: T12957

Target: Others

Cat.No: T12955

Synonym: PSI-7977 D6,GS-7977 D6

Target: Others

Sofosbuvir impurity K

Cat.No: T12966

Target: HCV Protease

Cyclophilin inhibitor 1

Cat.No: T10919

Target: Others

Sofosbuvir impurity N

Cat.No: T12969

Target: HCV Protease

Sofosbuvir impurity J

Cat.No: T12965

Target: HCV Protease

Sofosbuvir impurity I

Cat.No: T12964

Target: HCV Protease

Sofosbuvir impurity D

Cat.No: T12959

Target: Others

Sofosbuvir 13CD3

Cat.No: T12954

Synonym: GS-7977 13CD3,PSI-7977 13CD3

Target: Others

Sofosbuvir impurity C

Cat.No: T12958

Target: Others

Sofosbuvir impurity M

Cat.No: T12968

Target: HCV Protease

Helioxanthin 8-1

Cat.No: T11549

Synonym: Helioxanthin analogue 8-1

Target: Others

7-Deazaguanosine

Cat.No: TNU0180

Cyclophilin inhibitor 3

Cat.No: T64220

Cat.No: T74720

Cat.No: T63396

Sofosbuvir impurity L

Cat.No: T12967

Target: HCV Protease

Sofosbuvir impurity H

Cat.No: T12963

Target: HCV Protease

Cat.No: T14493

Synonym: R1626,Ro 4588161

Target: Others

Cat.No: T61871

NHC-diphosphate

Cat.No: T36880

Cat.No: T36882

Cat. No.	Product Name	Target	Signaling Pathways
TN6732	Oenothein B	Apoptosis; HCV Protease; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Oenothein B 是一种聚（ADP-核糖）糖水解酶的特异性抑制剂。 Oenothein B 具有抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。
T7203	Oglufanide 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH	VEGFR; HCV Protease; Endogenous Metabolite	Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂，可抑制血管内皮生长因子，可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。
TN2089	Platycodin D3 桔梗皂苷D3,桔梗皂苷 D3	HCV Protease; NF-κB	Microbiology/Virology; NF-κB; Proteases/Proteasome
	Platycodin D3 是桔梗中有抗HCV 活性的一种三萜皂苷类天然产物。
TN6508	Trachelogenin (-)-Trachelogenin	Virus Protease; c-Myc; HCV Protease; Wnt/beta-catenin	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	Trachelogenin ((-)-Trachelogenin) 分离自Combretum fruticosum，是一种 HCV 进入抑制剂具有抗增殖作用，其机制与影响β-Catenin 信号通路中的 β-Catenin、c-Myc 和 GSK3 等关键蛋白的磷酸化有关，且呈浓度依赖性。Trachelogenin具有抗病毒、抗炎和镇痛活性，在 HCVcc 和 HCVpp 模型中的 IC50 分别为 0.325 和 0.259 μg/mL。
TN1138	γ-Fagarine γ-崖椒碱,gamma-Fagarine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug/ml, respectively. It has sister chromatid exchanges (SCEs)-inducing activity
TN3438	Arborinine	HCV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC50 values being 6.4 ± 0.7 ug/ml. Arborinine shows antifeedant activity against Spodoptera frugiperda. Arborinin shows

天然产物

Cat.No: TN6732

Target: Apoptosis, HCV Protease, Antibacterial, Antifungal

Cat.No: T7203

Synonym: 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH

Target: VEGFR, HCV Protease, Endogenous Metabolite

Cat.No: TN2089

Synonym: 桔梗皂苷D3,桔梗皂苷 D3

Target: HCV Protease, NF-κB

Cat.No: TN6508

Synonym: (-)-Trachelogenin

Target: Virus Protease, c-Myc, HCV Protease, Wnt/beta-catenin

Cat.No: TN1138

Synonym: γ-崖椒碱,gamma-Fagarine

Target: HCV Protease

Cat.No: TN3438

Target: HCV Protease, Antifection

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