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Cat. No. | Product Name | Target | Signaling Pathways |
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T23046 |
N-tert-butyl-α-Phenylnitrone
(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide,N-叔丁基-α-苯基硝酮 |
ROS; COX | Immunology/Inflammation; Neuroscience |
N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) 是基于硝酮的自由基清除剂,可形成一氧化氮自旋加合物。它可以穿透血脑屏障,抑制 COX2的催化活性,有 ROS 清除、抗炎、神经保护、抗衰老和抗糖尿病的作用。 | |||
T1564 |
Cisplatin
cis-Diaminodichloroplatinum,CDDP,顺铂 |
DNA Alkylator/Crosslinker; Ferroptosis; DNA/RNA Synthesis; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Cisplatin (CDDP) 是一种 DNA 交联剂。Cisplatin 具有抗肿瘤活性,能够通过在癌细胞中形成 DNA 加合物来抑制 DNA 合成。Cisplatin 还可激活铁死亡并诱导自噬。 | |||
T35366 |
4-Nitroquinoline 1-oxide
4-Nitroquinoline 1-oxide,4Nqo,NQO,4-NQO,4-Nitroquinoline-N-oxide,NQNO,4-硝基喹啉-N-氧化物 |
Others | Others |
4-Nitroquinoline 1-oxide (4-NQO) 是一种化学致癌物,可通过形成大量嘌呤加合物来诱导细菌、真菌和动物的突变。 | |||
T18967 |
Dansyl chloride
丹酰氯,丹磺酰氯,DNSCl |
Others | Others |
Dansyl chloride (DNSC-l) 是一种能够在脂族和芳族胺与伯氨基反应,并产生稳定蓝色或蓝绿色荧光磺酰胺加合物的试剂,广泛用于修饰氨基酸、蛋白质测序和氨基酸分析。 | |||
T21704 |
5-fluoro 203
5F-203,NSC-703786 |
Others | Others |
5-fluoro 203 (NSC-703786) 是一种细胞毒性分子。它可激活芳香烃受体(AhR) 信号传导,诱导 CYP1A1 的转录,从而形成 DNA 加合物以及细胞周期阻滞。它可以提高活性氧水平,并激活 ERK、p38以及JNK。 | |||
T36027 |
DEPMPO-biotin
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DEPMPO is a nitrone that is used to spin trap reactive O-, N-, S-, and C-centered radicals and allow their characterization when used in association with electron spin resonance. It is noted for the stability of adducts formed. DEPMPO can be used in vitro or in vivo, as it crosses lipid bilayer membranes and is a good trapping agent in biological systems. DEPMPO-biotin is a biotinylated form of DEPMPO which retains the outstanding persistency of its adducts. The biotin moiety offers an effective... | |||
T29689 |
AFB1-N7-guanine
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In epidemiological studies, Aflatoxin B1-N7-guanine serum albumin adducts have been established as biomarkers of dietary aflatoxin exposure. | |||
TNU1537 | O6-Methyldeoxy guanosine | ||
Nucleoside Derivatives - 6-Modified purine nucleosides; DNA adducts | |||
T36708 | Monohydroxy Melphalan (hydrochloride) | ||
Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan . Monohydroxy melphalan is formed by the hydrolysis of melphalan in aqueous solutions, including cell culture medium and human plasma. It increases the level of DNA adducts in ML-1 myeloblastic leukemia cells in a concentration-dependent manner and induces cytotoxicity with an IC50 value of 28.1 μg/ml. | |||
T36834 |
Abacavir Carboxylate
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Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues. | |||
T40706 |
Heliotrine N-oxide
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Heliotrine N-oxide is the pyrrolizidine alkaloid (PA) N-oxide counterpart of Heliotrine. It induces the generation of pyrrolic DNA adducts, potentially initiating PA-induced liver tumors in vivo. | |||
T19192 |
α-Hydroxytamoxifen
α-OHTAM,(E)-α-Hydroxy tamoxifen |
Others | Others |
α-Hydroxytamoxifen is a metabolite of tamoxifen. It reacts with DNA and causes the formation of DNA adducts. | |||
T16327 |
Nitracrine
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Others | Others |
Nitracrine is a 1-nitroacridine derivative and is an effective hypoxia-selective agent in vitro and antitumor drugs. Nitracrine suppresses RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine h | |||
T62582 |
WEHI-150
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WEHI-150是一种米托蒽醌类似物,作为DNA链间交联剂,具有12.5小时的半衰期。该化合物能够在CpG序列上形成共价加合物,对甲基化CpG位点表现出选择性。甲醛激活的WEHI-150能够诱导DNA链间交联,并表现出浓度依赖性的转录阻断作用。此外,WEHI-150还能在新的DNA序列中形成加合物,这不涉及与鸟嘌呤N-2的相互作用。 | |||
T32189 |
Iproplatin
JM-9,CHIP,Code name: JM9,JM 9 |
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Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione i | |||
T37612 |
IBTP (iodide)
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IBTP is a lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner. As a result, mitochondrial proteins that have changed thiol redox state following oxidative stress are selectively tagged with IBTP and can be separated by two-dimensional electrophoresis and isolated. IBTP-tagged proteins can also be evaluated by immunoblotting using an antibody directed against the triphenylphosphonium moiety of the IBTP molecule. IBTP has also been us... | |||
T35681 |
MeIQx
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MeIQx (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1It is activated by hydroxylation and subsequent O-acetylationviathe cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.3 | |||
T73469 |
SG2057
DRG16 |
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SG2057 (DRG16) 是一种含有戊二氧基键的 PBD 二聚体,该键选择性地结合DNA 小沟中的序列,形成 DNA 链间和链内交联加合物。SG2057 是一种高效抗肿瘤剂。 | |||
T82842 |
BODIPY FL EDA free base
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ODIPY FL EDA free base为绿色荧光胺类探针,能通过R-NH2与醛或酮反应形成可逆的席夫碱产物。使用如硼氢化钠或氰硼氢化钠等还原剂,ODIPY FL EDA free base可转化成稳定的胺衍生物,适用于检测修饰或未修饰脱氧核苷酸,以及评估DNA损伤和基因组DNA甲基化情况。 | |||
T36026 |
DEPMPO
5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide |
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DEPMPO is a phosphorylated derivative of the widely used DMPO spin trap. It has been reported to produce spin adducts with increased stability particularly for the adduct of superoxide. [1] [2] [3] DEPMPO displays a detectable spin adduct signal at a concentration as low as 1 mM, as compared to 5 mM for DMPO.[3] A significant advantage of using DEPMPO in trapping superoxide radical is that the decomposition of DEPMPO/O2 - does not produce the OH adduct, which can be a drawback when using DMPO.... | |||
T36709 |
N’-Nitrosonornicotine
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N’-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N’-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N’-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2 1.Hecht, S.... | |||
T71385 | Aroplatin | ||
Aroplatin is a synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. After displacement of the 2 long-chain aliphatic leaving groups (neodecanoic acid), platinum diaminocyclohexane (DACH) complexes become highly reactive and alkylate macromolecules, forming both inter- and intra-strand DNA crosslinks and inhibiting DNA synthesis, which results in tumor cell cytotox... | |||
T36745 |
cDPCP
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cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50values of 8.1 and 1.5 μM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when ad... | |||
T71401 | Oxaliplatin-d10 | ||
Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.... | |||
T36701 | Phosphoramide mustard (cyclohexanamine) | ||
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T41358 |
2-Hydroxybenzylamine
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Others | Others |
2-Hydroxybenzylamine 是一种有效的 IsoLG 小分子清除剂,可将活性物质作为惰性加合物螯合。 2-Hydroxybenzylamine 可用于通过减少具有天然生物分子的 IsoLG 加合物来减少心房颤动消融后心房颤动和其他心房心律失常的早期复发。 | |||
T3903 |
Angoroside C
安格洛甙C,安格洛苷C |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Angoroside C 是一种苯丙苷,从 Radix Scrophulariae 中提取到,有益于心室重构。 | |||
T16525 |
PhIP
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Others | Others |
PhIP 是来源于熟肉的一种杂环芳香胺(HAA),属于吡啶类杂环胺,是2B 类致癌物,具有雌激素活性。PhIP 可与 DNA 形成加合物,从而促进癌症发生。 | |||
T7031 |
Aristolochic acid B
马兜铃酸B,Aristolochic Acid II,马兜铃酸 B |
DNA | DNA Damage/DNA Repair |
Aristolochic acid B (Aristolochic Acid II) 是一种来自马兜铃科分类群的天然产物,是马兜铃酸的主要成分之一。 已知马兜铃酸是诱变剂和致癌物质。它在体内表现出比 Aristolochic acid I 更大的致癌风险。 |