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24

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7586	trifarotene CD5789,曲法罗汀	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Trifarotene (CD5789) 是一种有效的选择性 RARγ 激动剂，对 RARγ 的选择性是 RARα 和 RARβ 的 65 倍和 16 倍，EC50分别为7.7、500和125 nM。
T1093	Adapalene CD271,阿达帕林	Apoptosis; Retinoid Receptor; Autophagy	Apoptosis; Autophagy; Metabolism
	Adapalene (CD271) 是一种合成类视黄醇，局部应用于痤疮。它以非竞争性方式抑制 GOT1的酶活性，具有抗肿瘤活性。它是一种 RAR 激动剂，对 RARβ、RARγ、RARα的AC50值分别为 2.3 nM、9.3 nM 和 22 nM。
T1142	Clindamycin phosphate Clindamycin 2-phosphate,Clindamycin 2-dihydrogen phosphate,NSC 618653,U-28508,克林霉素磷酸酯	ribosome; Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Clindamycin phosphate (Clindamycin 2-dihydrogen phosphate) 是一种抗生素，抑制微生物的核糖体作用。可研究厌氧菌感染和原虫疾病。
T5002	Methyl Aminolevulinate Hydrochloride 5-Aminolevulinic acid methyl ester,Methyl δ-aminolevulinate hydrochloride,5-氨基酮戊酸甲酯盐酸盐,Methyl 5-aminolevulinate Hydrochloride,Aminolevulinic acid methyl ester Hydrochloride	Others	Others
	Methyl Aminolevulinate Hydrochloride (5-Aminolevulinic acid methyl ester) 是增敏剂，可用于光动力疗法。Methyl aminolevulinate 是一种前药，可代谢为原卟啉 IX。
T29022	TU-2100 Azeloyl diethyl salicylate,Azasal-2100,TU 2100,TU2100	Others	Others
	TU-2100 是一种含水杨酸乙酯的化合物，具有潜在抗痤疮作用，可用于研究痤疮。
T1466	Nadifloxacin OPC7251,那氟沙星	Antibacterial; Antibiotic	Microbiology/Virology
	Nadifloxacin (OPC7251) 是一种对粉刺有效的广谱氟喹诺酮类抗生素。
T3510	Olumacostat Glasaretil	Acetyl-CoA Carboxylase	Metabolism
	Olumacostat glasaretil 是乙酰辅酶A 羧化酶的有效抑制剂。
TP2316	Myristoyl Hexapeptide-23 Acetate	Others	Others
	Myristoyl Hexapeptide-23 Acetate 有抗粉刺作用。
T35903	N-acetyl Dapsone	Antibacterial; Parasite	Microbiology/Virology
	N-acetyl Dapsone 是一种抗炎和抗菌化合物，广泛用于治疗麻风病、疟疾、痤疮和各种免疫疾病。
T0339	Resorcinol monoacetate 乙醯間二酚(1,3-苯二醇单乙酸酯 ),Resorcin monoacetate	Others	Others
	Resorcinol monoacetate (Resorcin monoacetate) 是一种防腐剂，及消毒剂，是用于合成其他药品的化学中间体。有用于痤疮，脂溢性皮炎，湿疹，银屑病和其它皮肤病的研究潜力。
T24755	Salnacedin G-201,SCY,G-201,G201,SCY,G 201	Others	Others
	Salnacedin (G-201) 是一种小分子化合物，可用于治疗免疫系统疾病、皮肤和肌肉骨骼疾病，可用于研究寻常痤疮、皮炎和银屑病。
T21434	Sulfacetamide NSC 63871,磺胺醋酰,NSC-63871,Sebizon,Region,NSC63871,Sulphacetamide,Acetosulfamine	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Sulfacetamide (NSC-63871) 是一种抗生素，通过限制细菌生存所需的叶酸的存在来治疗睑缘炎或结膜炎，有潜力用于眼部感染的研究。
T77600	Methyl-4-oxoretinoate	Apoptosis	Apoptosis
	Methyl-4-oxoretinoate 是一种合成的类视黄醇化合物，具有抗癌化合物，可可以诱导癌细胞分化和凋亡。Methyl-4-oxoretinoate 可用于治疗痤疮、牛皮癣和其他皮肤病。Methyl-4-oxoretinoate 具有治疗各种眼部疾病（如年龄相关性黄斑变性）的潜力。
T25048	Algestone acetophenide Neolutin,苯甲孕酮	Others	Others
	Algestone acetophenide (Neolutin) 是用于发情同步的孕酮，已被评估为与庚酸雌二醇联合使用的注射避孕药。它在治疗上也用作局部抗炎药，并在治疗痤疮时局部应用。
T7370	Talarozole R115866,他拉罗唑	Others; P450; Retinoid Receptor; Autophagy	Autophagy; Metabolism; Others
	Talarozole (R115866) 是一种口服性全反式维甲酸代谢阻断剂，可抑制 CYP26A1 和 CYP26B1，IC50 分别为 5.4 和 0.46 nM。它用于治疗痤疮、牛皮癣和其他角化疾病。
T38683	SCD1 inhibitor-3 SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a	Dehydrogenase	Metabolism
	SCD1 inhibitor-3 (ML-270) 是一种高效、口服的化合物，可以抑制SCD1，且安全性极高。 SCD1 inhibitor-3 显示出在代谢疾病(包括肥胖、二型糖尿病和血脂异常，以及痤疮和癌症等各种皮肤病)方面的巨大研究潜力。
T1101	Minocycline hydrochloride Minocycline HCl,盐酸米诺环素,美满霉素	HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic	Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Minocycline hydrochloride (Minocycline HCl) 是四环素抗生素，具有出色的吸收和组织渗透性，可用于多种细菌感染以及痤疮的治疗。米诺环素可导致在开始治疗后 1 至 3 个月内发生的急性肝炎样综合征或通常在长期治疗后具有自身免疫特征的更隐匿的慢性肝炎。
T25831	Motretinide Ro-11-1430,Ro 11-1430,Tasmaderm,Ro11-1430
	Motretinide, an aromatic analog of retinoic acid, is an anti-acne preparation.
T21016	Cyproterone BAY 94-8367,Ciproterone,Androcur,SH 80881
	Cyproterone, an anti-androgen, is used in combination with estrogen for the therapy of hirsutism and severe acne in females and as a palliative in prostatic carcinoma.
T29167	XMP-629 XOMA629,XOMA 629,XOMA-629,XMP 629
	XMP-629, an endotoxin inhibitor, is used potentially for the treatment of impetigo and acne rosacea.
T21394	Sarecycline hydrochloride P005672,P-005672,WC-3035,WC 3035,Sarecycline HCl,WC3035,P 005672
	Sarecycline, a novel and tetracycline-derived antibiotic, is being developed for use as an oral once daily antibiotic treatment for patients suffering from moderate to severe acne vulgaris. Sarecycline has anti-inflammatory activity and the potential for
T39436	Omiganan
	Omiganan is a cationic antimicrobial peptide with activity against both gram-positive and gram-negative bacteria, as well as Candida spp. isolates. This compound, serving as an analogue of indolicidin, is utilized for research purposes related to alcohol nose and acne.
T38442	17,17-(Ethylenedioxy)androst-4-en-3-one
	17,17-(Ethylenedioxy)androst-4-en-3-one (4- androstene- 3, 17- dione- 17- cyclic ethylene ketal) is an effective ingredient in cosmetics, which can be used for acne and promote hair growth research. 17,17-(Ethylenedioxy)androst-4-en-3-one can inhibit the reductase activity and inhibit the bond of a receptor protein and 5α-DHT.
T75306	Clindamycin phosphate hydrochloride
	Clindamycin phosphate (Clindamycin 2-phosphate) hydrochloride 是一种广谱抑菌林可酰胺类抗生素 (antibiotic)。Clindamycin phosphate hydrochloride 是Clindamycin 的前体活性分子，在体外不具有抗菌活性，但在体内可通过磷酸酶酯水解迅速转化为具有活性的母体活性分子 Clindamycin。Clindamycin phosphate hydrochloride 可用于痤疮和细菌性阴道病的研究。

化合物

Cat.No: T7586

Synonym: CD5789,曲法罗汀

Target: Retinoid Receptor, Autophagy

Cat.No: T1093

Synonym: CD271,阿达帕林

Target: Apoptosis, Retinoid Receptor, Autophagy

Clindamycin phosphate

Cat.No: T1142

Synonym: Clindamycin 2-phosphate,Clindamycin 2-dihydrogen phosphate,NSC 618653,U-28508,克林霉素磷酸酯

Target: ribosome, Antibacterial, Antibiotic, Parasite

Methyl Aminolevulinate Hydrochloride

Cat.No: T5002

Synonym: 5-Aminolevulinic acid methyl ester,Methyl δ-aminolevulinate hydrochloride,5-氨基酮戊酸甲酯盐酸盐,Methyl 5-aminolevulinate Hydrochloride,Aminolevulinic acid methyl ester Hydrochloride

Target: Others

Cat.No: T29022

Synonym: Azeloyl diethyl salicylate,Azasal-2100,TU 2100,TU2100

Target: Others

Cat.No: T1466

Synonym: OPC7251,那氟沙星

Target: Antibacterial, Antibiotic

Olumacostat Glasaretil

Cat.No: T3510

Target: Acetyl-CoA Carboxylase

Myristoyl Hexapeptide-23 Acetate

Cat.No: TP2316

Target: Others

N-acetyl Dapsone

Cat.No: T35903

Target: Antibacterial, Parasite

Resorcinol monoacetate

Cat.No: T0339

Synonym: 乙醯間二酚(1,3-苯二醇单乙酸酯 ),Resorcin monoacetate

Target: Others

Cat.No: T24755

Synonym: G-201,SCY,G-201,G201,SCY,G 201

Target: Others

Cat.No: T21434

Synonym: NSC 63871,磺胺醋酰,NSC-63871,Sebizon,Region,NSC63871,Sulphacetamide,Acetosulfamine

Target: Others, Antibacterial, Antibiotic

Methyl-4-oxoretinoate

Cat.No: T77600

Target: Apoptosis

Algestone acetophenide

Cat.No: T25048

Synonym: Neolutin,苯甲孕酮

Target: Others

Cat.No: T7370

Synonym: R115866,他拉罗唑

Target: Others, P450, Retinoid Receptor, Autophagy

SCD1 inhibitor-3

Cat.No: T38683

Synonym: SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a

Target: Dehydrogenase

Minocycline hydrochloride

Cat.No: T1101

Synonym: Minocycline HCl,盐酸米诺环素,美满霉素

Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Cat.No: T25831

Synonym: Ro-11-1430,Ro 11-1430,Tasmaderm,Ro11-1430

Cat.No: T21016

Synonym: BAY 94-8367,Ciproterone,Androcur,SH 80881

Cat.No: T29167

Synonym: XOMA629,XOMA 629,XOMA-629,XMP 629

Sarecycline hydrochloride

Cat.No: T21394

Synonym: P005672,P-005672,WC-3035,WC 3035,Sarecycline HCl,WC3035,P 005672

Cat.No: T39436

17,17-(Ethylenedioxy)androst-4-en-3-one

Cat.No: T38442

Clindamycin phosphate hydrochloride

Cat.No: T75306

Cat. No.	Product Name	Target	Signaling Pathways
T1611	Isotretinoin 13-cis-Retinoic acid,异维A酸	Retinoid Receptor; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸，具有潜在的抗肿瘤活性。它结合并激活核视黄酸受体 (RAR)，活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物，用于治疗严重的痤疮和某些形式的皮肤、头颈癌。
T0978	Pantethine LBF disulfide,Pantosin,Pantetina,Bis-pantethine,泛硫乙胺(维生素B5),泛硫乙胺,Pantomin,D-Pantethine	Endogenous Metabolite	Metabolism
	D-Pantethine (Pantomin) 是泛酸的二聚体形式, 是生产辅酶 A 的中间体。D-Pantethine 能够作为膳食补充剂，用于改善血液胆固醇和研究痤疮。
TN1772	Isoastilbin	Anti-infection; Tyrosinase; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Isoastilbin 是Rhizoma Smilacis glabrae 和Astragalus membranaceus 中的二氢黄酮醇糖苷。它抑制酪氨酸酶活性，还抑制葡萄糖基转移酶，IC50值为 54.3 μg/mL。它具有神经保护、抗氧化、抗微生物和抗凋亡活性，可研究阿尔茨海默氏病。
T31766	Fenchone AI300736,AI3-00736,AI3 00736
	Fenchone is a Dapsone-Loaded Invasome for acne treatment.

天然产物

Cat.No: T1611

Synonym: 13-cis-Retinoic acid,异维A酸

Target: Retinoid Receptor, Endogenous Metabolite, Autophagy

Cat.No: T0978

Synonym: LBF disulfide,Pantosin,Pantetina,Bis-pantethine,泛硫乙胺(维生素B5),泛硫乙胺,Pantomin,D-Pantethine

Target: Endogenous Metabolite

Cat.No: TN1772

Target: Anti-infection, Tyrosinase, Antibacterial

Cat.No: T31766

Synonym: AI300736,AI3-00736,AI3 00736

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