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23
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8496 |
MAZ51
|
Apoptosis; VEGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
MAZ51 是一种 VEGFR-3酪氨酸激酶的选择性抑制剂。它抑制 VEGF-C 诱导的 VEGFR-3 激活,而没有阻断 VEGF-C 介导的 VEGFR2 刺激。它阻止增殖并诱导多种肿瘤细胞凋亡,具有抗肿瘤活性。 | |||
T9929 |
Ramucirumab
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Ramucirumab 是一种人 VEGFR-2 拮抗剂,具有抗实体瘤活性。它是人源化单克隆抗体,能够与 VEGFR-2 结合,阻碍 VEGFR 配体 VEGF-A,VEGF-C 和 VEGF-D 结合。 | |||
T72924 |
VEGFR-3-IN-1
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-3-IN-1 是一种新型有效且具有选择性的 VEGFR3 抑制剂,其 IC50 为 110.4 nM。VEGFR-3-IN-1 具有抗肿瘤活性,可使 VEGFR3 信号通路失活,可抑制 VEGF-C 诱导人真皮淋巴管内皮细胞 (HDLEC)、MDA-MB-231 和 MDA-MB-436 细胞的增殖和迁移,并且能有效抑制乳腺癌的生长。 | |||
T3708 |
BP-1-102
|
STAT | JAK/STAT signaling; Stem Cells |
BP-1-102 是可口服的转录因子Stat3小分子抑制剂,IC50值为 6.8 μM。 | |||
T28899 |
T-1840383
|
||
T-1840383 is an inhibitor of VEGF-induced VEGFR-2 phosphorylation and HGF-induced c-Met phosphorylation in vascular endothelial cells and cancer epithelial cells. | |||
T21387 |
Nafoxidine HCl(1845-11-0 Free base)
PNU-0011100,PNU0011100,CP5600,CP 5600,CP-5600,PNU 0011100,Nafoxidine HCl |
||
Nafoxidine is a partial estrogen antagonist. It inhibits angiogenesis in some tissues by blocking the effects of VEGF and FGF; paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces calcium signaling, oxidative stress, and p | |||
T71930 |
aPKC-I
|
||
aPKC-I is an inhibitor of atypical protein kinase C (aPKC ) which inhibits both PKCζ and PKCι with high specificity and prevents VEGF-induced endothelial permeability in cell culture and in vivo, thereby blocking ischemia-reperfusion (IR)-induced permeability. | |||
T80595 |
Conbercept
KH902 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Conbercept (KH902) 是一种针对 VEGFRA 的融合蛋白,由 FLT1 第二个 C-LIKE 结构域与 KDR 第三和第四个 C-LIKE 结构域结合而成,并与 IGHG1 Fc 片段融合。该化合物设计用于中和 VEGF家族因子,具有重要的生物医学应用。 | |||
T74422 | Sozinibercept | ||
Sozinibercept (OPT 302; VGX-300) 是VEGFR-3的可溶性形式,能有效抑制血管生成原因子VEGF-C/D 的活性,抑制血管生成和血管渗漏。Sozinibercept 对大鼠糖尿病视网膜水肿也有抑制作用。 | |||
T71204 |
Apatinib HC
Rivoceranib HCl,YN-968D1 HCl |
||
Apatinib, also known as Rivoceranib and YN-968D1, is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. The free-base form is also known as Rivoceranib. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SR... | |||
T71853 |
Enzastaurin HCl
|
||
Enzastaurin HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin HCl selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. | |||
T69354 |
Enzastaurin 2HCl
|
||
Enzastaurin 2HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin 2HCl selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. | |||
T37079 |
VEGFR2 Kinase Inhibitor II
|
||
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2's kinase activity (IC50 = 70 nM). It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases. V... | |||
T61604 |
PKC-IN-4
|
||
PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM. In vitro studies have demonstrated that PKC-IN-4 effectively suppresses NF-κB activity induced by TNF-α. Moreover, this compound effectively impedes the permeability of the retinal vasculature, induced by both VEGF and TNFα. [1] | |||
T27033 |
CKD-712
CKD 712,CKD712 |
||
CKD-712 is a nuclear factor NF-kappa B inhibitor. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by suppressing cyclin A, cyclin B and C | |||
T71180 | Oglufanide disodium | ||
Oglufanide disodium is t he disodium salt of a synthetic form of a naturally-occurring dipeptide consisting of L-glutamic acid and L-tryptophan with potential antiangiogenic and potential immunomodulating activities. Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections. Check for active clinical trials or closed clinical trials u... | |||
T73516 |
EVT801
|
||
EVT801 是一种口服有效、选择性的 VEGFR-3抑制剂 (IC50=11 nM),具有抗肿瘤作用。EVT801 不仅抑制VEGF-C 诱导的人内皮细胞增殖,还抑制肿瘤小鼠模型中的肿瘤 (淋巴) 血管生成。EVT801 能够减少肿瘤缺氧,减少免疫抑制细胞因子 (CCL4、CCL5) 和髓系衍生抑制细胞 (MDSC) 产生。EVT801 与免疫检查点疗法 (ICT) 组有协同作用,它提高 ICT 应答率,对癌小鼠模型的抑制效果更好。 | |||
T83741 |
S7 TFA
Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH |
||
S7是一种IL-6受体的肽类拮抗剂,能够浓度依赖性地抑制IL-6与IL-6受体的结合。在C-33 A宫颈癌细胞和RPMI-8226 B细胞淋巴细胞中,S7 (50 µM) 能抑制IL-6诱导的VEGF水平增加。在每两天给药一次,剂量为50 mg/kg的条件下,S7能减少IL-6过表达的C-33 A宫颈癌小鼠异种移植模型中的肿瘤体积。当S7与半胱氨酸结合,并连接到包裹多柔比星的脂质纳米粒子(LNPs)表面时,能增强LNPs对胶质瘤的靶向性,并在U251胶质母细胞瘤小鼠异种移植模型中提高生存率。 | |||
T36379 |
Halometasone
|
||
Halometasone is a synthetic corticosteroid.1,2Formulations containing halometasone have been used in the treatment of psoriasis vulgaris and eczematous dermatoses. 1.de la Brassine, M., Kint, A., Lachapelle, J.M., et al.Halomethasone (C 48.401-Ba) for the topical treatment of common dermatosesJ. Int. Med. Res.12(5)307-309(1984) 2.Zhu, J.-W., Wu, X.-J., Lu, Z.-F., et al.Role of VEGF receptors in normal and psoriatic human keratinocytes: Evidence from irradiation with different UV sourcesPLoS One8... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S0335 |
Soyasaponin Bb
Soyasaponin I,大豆皂苷Bb |
NF-κB; Caspase | Apoptosis; NF-κB; Proteases/Proteasome |
Soyasaponin Bb (Soyasaponin I) 是一种分离自菜豆科中的大豆皂苷,可用作醛糖还原酶差异抑制剂。 | |||
T3S2344 |
β,β-Dimethylacrylshikonin
β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin |
ERK; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; MAPK; Metabolism |
β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) 是一种萘醌衍生物,从 Arnebia nobilis 中提取得到。它利用 PI3K 通路诱导 eNOS、VEGF 和 HIF-1α 的表达,促进血管生成,具有抗肿瘤活性。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01007 |
VEGFC Protein, Human, Recombinant (His)
血管内皮生长因子,LMPH1D,VEGF-C,Flt4-L,vasc |
Human | HEK293 Cells |
VEGFC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.5 kDa and the accession number is P49767. | |||
TMPY-01008 |
VEGFD Protein, Human, Recombinant (His)
VEGFD,c-fos induced growth fa... |
Human | HEK293 Cells |
VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915. | |||
TMPK-01044 |
VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated
血管内皮生长因子,Flt4-L,VRP,VEGF-C,VEGF |
Human | HEK293 Cells |
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet enhancement of lymphatic growth after wounding is dependent on the release of VEGFC, but not VEGFD, a finding consistent with high expression of VEGFC in both platelets and avian thrombocytes. VEGFC Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mam... | |||
TMPK-01043 |
VEGFC Protein, Human, Recombinant (His & Avi)
Flt4-L,血管内皮生长因子,VEGFC,VRP,VEGF- |
Human | HEK293 Cells |
the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Genetic studies reveal that platelet enhancement of lymphatic growth after wounding is dependent on the release of VEGFC, but not VEGFD, a finding consistent with high expression of VEGFC in both platelets and avian thrombocytes. VEGFC Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells w... | |||
TMPY-03150 |
VEGFD Protein, Mouse, Recombinant (His)
VEGF-D,Vegfd,AI325264,c-fos indu<... |
Mouse | HEK293 Cells |
VEGFD Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14 kDa and the accession number is P97946. | |||
TMPY-02589 |
VEGFD Protein, Mouse, Recombinant (hFc)
c-fos induced growth factor (vas<... |
Mouse | HEK293 Cells |
VEGFD Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P97946. | |||
TMPK-00823 |
VEGF165 Protein, Human, Recombinant (His & Avi)
血管内皮生长因子,RP1-261G23.1,MVCD1,MGC70609,V... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4. | |||
TMPJ-00865 |
VEGF121 Protein, Human, Recombinant (His)
VEGFA,VEGF-A,Vascular permeabilit... |
Human | HEK293 Cells |
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel... | |||
TMPK-00445 |
VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi)
PCL,PCLFLT41,VEGFR3,FLT-4,LMPH1A,... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors.VEGF-R1, -R2 and -R3 were highly expressed in CRC cells and stromal vessels. VEGF-R1 strong positive staining correlated with shorter survival after CRC surgery. VEGFR3/FLT4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 87.4 k... | |||
TMPK-00825 |
VEGF121 Protein, Human, Recombinant (His & Avi)
VPF,VEGF,VEGFA,VEGFMGC70... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9. | |||
TMPK-00826 |
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子, |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9. | |||
TMPK-00446 |
VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated
PCL,FLT-41,LMPH1A,FLT-4,VEGFR3,PC... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF) and its receptors VEGF-R1, -R2 and -R3 play important roles in tumor angiogenesis and are associated with poor prognosis in several solid tumors.VEGF-R1, -R2 and -R3 were highly expressed in CRC cells and stromal vessels. VEGF-R1 strong positive staining correlated with shorter survival after CRC surgery. VEGFR3/FLT4 Protein, Human, Recombinant (aa 25-776, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted m... | |||
TMPK-00822 |
VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled
RP1-261G23.1,VEGFA,MGC70609,VEGF,... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4. | |||
TMPH-03240 |
Angiopoietin-2 Protein, Rat, Recombinant (His)
Angiopoietin-2,Angpt2,ANG-2 |
Rat | Baculovirus Insect Cells |
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Angiopoietin-2 Protein,... | |||
TMPH-00343 |
Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His)
Angiopoietin-1,ANG-1,ANGPT1 |
Canine | HEK293 Cells |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His) is expressed in HEK293 mammalian cells wi... | |||
TMPH-03239 |
Angiopoietin-1 Protein, Rat, Recombinant (His)
ANG-1,ANGPT1,Angiopoietin-1 |
Rat | HEK293 Cells |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis ... | |||
TMPH-00479 |
Angiopoietin-1 Protein, Canine, Recombinant (His)
ANG-1,ANGPT1,Angiopoietin-1 |
Canine | Baculovirus Insect Cells |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (His) is expressed in Baculovirus insect cells with C-6... | |||
TMPK-00978 |
ECSCR Protein, Human, Recombinant (hFc)
ECSM2,ECSCR,ARIA |
Human | HEK293 Cells |
Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC... | |||
TMPK-00988 |
ECSCR Protein, Mouse, Recombinant (hFc)
ECSCR,ARIA,ECSM2 |
Mouse | HEK293 Cells |
Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angioblasts and in axial vessels during angioblast migration and vasculogenesis. Morpholino-directed ecscr knockdown resulted in defective angioblast migration in the posterior lateral plate mesoderm, a process known to depend on vascular endothelial-derived growth factor (VEGF). ECSC... | |||
TMPJ-00802 |
THBS1 Protein, Human, Recombinant (His)
TSP,TSP1,Thrombospondin-1,THBS1 |
Human | HEK293 Cells |
Thrombospondin-1 (TSP-1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal Laminin G-like globular domain, an extended central region with one vWFC domain, 3 TSP type 1domains, 2 EGF-like domains, and 8 TSP type3 domains, and a globular TSP C-terminal domain. Distinct regions of TSP-1 have... | |||
TMPK-01450 |
HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
KRAS1,MHC,K-RAS4B,KRAS,CFC2,K-RAS... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01456 |
HLA-C*03:04&B2M&KRAS G12D (GADGVGKSAL) Tetramer Protein, Human, MHC (His & Avi)
KRAS2,NS,MHC,C-K-RAS,KRAS1,K-RAS2A,K-RAS2B... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. | |||
TMPK-01451 |
HLA-C 03:04&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein, Human, MHC (His & Avi)
NS3,K-RAS4A,K-Ras 2,NS,KRAS1,RASK2,MHC,KI-RAS,KRAS,... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |