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Search Results for " sphingosine-1-phosphate "

60

抑制剂 & 化合物

2

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Cat. No.	Product Name	Target	Signaling Pathways
T37955	Sphingosine-1-phosphate (d16:1) Sphingosine-1-phosphate (d16:1)
	C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells. C16 S1P was increased in postmortem primary open angle glaucoma trabecular meshwork samples.
T6923	Ozanimod 奥扎莫德,RPC-1063	S1P Receptor; LPL Receptor	GPCR/G Protein
	Ozanimod (RPC-1063) 是一种选择性S1P1和S1P5受体激动剂，在[35S]-GTPγS 结合实验中，EC50分别为 410 pM 和 11 nM。它可研究治疗克罗恩病、溃疡性结肠炎、多发性硬化症和复发性多发性硬化症的试验。
T83880	C18 Ceramide-1-phosphate (d18:1/18:0) ammonium Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate
	C18 Ceramide-1-phosphate (d18:1/18:0) 是一种在鼠皮肤中发现的长链ceramide-1-phosphate。它能在0.5至5 µM的浓度范围内促进分离的小鼠骨髓来源的多能间充质细胞和人脐静脉内皮细胞（HUVECs）的迁移。与胰腺癌干细胞相比，CFPAC-1胰管腺癌细胞中C18 Ceramide-1-phosphate (d18:1/18:0)的水平有所增加。在Langendorff分离的灌流小鼠心脏的离体缺血模型中，心肌中C18 ceramide-1-phosphate (d18:1/18:0)的水平有所增加。
T83910	S1PL-IN-31 Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
	S1PL-IN-31是一种鞘氨醇-1-磷酸(S1P)裂解酶的抑制剂(IC50 = 210 nM)，同时也是Smoothened(Smo)受体的对抗剂(IC50 = 440 nM)。在体内，S1PL-IN-31 (每天2 mg/kg)能够防止实验性自身免疫性脑炎(EAE)模型大鼠中，由髓鞘少突胶质细胞糖蛋白(MOG)肽段MOG29-152诱发的颈部及胸部淋巴细胞渗透和神经肌肉虚弱。该化合物降低了大鼠的淋巴细胞总数及CD4+ T细胞、CD8+ T细胞和B细胞的水平。S1PL-IN-31 (每天3及10 mg/kg剂量)在雄性和雌性大鼠心脏和淋巴结中增加了S1P水平，并且在雌性大鼠中降低了心率。
T27106	CYM50374
	CYM50374对Sphingosine-1-phosphate receptor 4（S1P4 ）具有抑制作用，IC50为 µM。
T27864	LX-2931 LX 3305,LX2931,LX-3305,ACB20034,LX 2931,LX3305	S1P Receptor	GPCR/G Protein
	LX-2931(LX-3305) 是一种鞘氨醇-1-磷酸裂解酶（S1P）抑制剂，可用于治疗类风湿性关节炎。
T10305	Amiselimod hydrochloride MT-1303 hydrochloride	S1P Receptor; LPL Receptor	GPCR/G Protein
	Amiselimod hydrochloride (MT-1303 hydrochloride) 是一种鞘氨醇 1-磷酸受体 1 (S1P1) 调节剂。
T12086	Mocravimod hydrochloride KRP-203	Others; LPL Receptor	GPCR/G Protein; Others
	Mocravimod hydrochloride (KRP-203) 是 1-磷酸鞘氨醇受体 1 型 (S1PR1) 的有效和口服活性激动剂。
T15031	CYM50260	Others; LPL Receptor	GPCR/G Protein; Others
	CYM50260 是有效的、强选择性的鞘氨醇-1-磷酸 4 受体 (S1P4-R) 激动剂 (EC50= 45 nM)，对 S1P1-R，S1P2-R，S1P3-R 和 S1P5-R 无活性。
T7360	GSK2018682	S1P Receptor; LPL Receptor	GPCR/G Protein
	GSK2018682 是 1-磷酸鞘氨醇受体S1P1和S1P5激动剂，pEC50值分别为 7.7 和 7.2，可用于多发性硬化的研究。
T28643	Ex26 S1P1-IN-Ex26	S1P Receptor	GPCR/G Protein
	Ex26 (S1P1-IN-Ex26) 是一种具有选择性和高效性的 sphingosine 1-phosphate receptor 1 (S1P1) 拮抗剂，可破坏 SR-B1-S1PR1相互作用，抑制 S1P-S1PR1 信号转导。Ex26 可用于实验性自身免疫性脑脊髓炎、动脉粥样硬化和胃癌。
TQ0227	Etrasimod APD334	S1P Receptor; LPL Receptor	GPCR/G Protein
	Etrasimod (APD334) 是一种特异性和口服的S1P1受体拮抗剂，在CHO 细胞中的IC50值为1.88 nM。
T9464	CYM50358	LPL Receptor	GPCR/G Protein
	CYM50358 是选择性的S1PR4拮抗剂，IC50值为 25 nM，可用于流感研究。
T63047	SLP9101555	S1P Receptor; LPL Receptor	GPCR/G Protein
	SLP9101555 是一种有效且具有选择性的鞘氨醇激酶 2（SphK2）抑制剂，Ki 为90 nM。SLP9101555对SphK2具有很高的亲和力，是 SphK1 的 200 倍。SLP9101555 显著降低细胞外 S1P 鞘氨醇 1- 磷酸（S1P）水平。
T3258	Ponesimod ACT-128800	S1P Receptor; LPL Receptor	GPCR/G Protein
	Ponesimod (ACT-128800) 是一种选择性 S1P1可口服激动剂，在放射性配体结合试验中的 IC50值为 6 nM。它可高效激活 S1P1介导的信号转导，EC50为5.7 nM。它可预防淋巴细胞介导的组织炎症，具有潜在的免疫调节活性。
T14924	Cenerimod ACT-334441	S1P Receptor	GPCR/G Protein
	Cenerimod (ACT-334441) 是一种具有口服活性、选择性和高效性的磷酸鞘氨醇 1 受体（S1P1）激动剂（EC50：1 nM）。Cenerimod 对多种 S1P 的亚型具有抑制作用，可用于研究鼠类实验性自身免疫性脑脊髓炎 (EAE)和鼠类硬皮病。
T22102	ML-178 CYM50179	Others	Others
	ML-178 是一种二氯苯，是鞘氨醇-1-磷酸受体4（S1PR4）的强效选择性激动剂，EC50 为 46 nM，在25 μM 的浓度下对其他 S1P 受体没有影响。
T10385	ASP-4058	S1P Receptor; LPL Receptor	GPCR/G Protein
	ASP-4058 是一种鞘氨醇磷酸受体 1 和 5 (S1P1 and S1P5) 的二代激动剂，具有选择性、安全性和口服活性。ASP-4058能改善小鼠实验性自身免疫性脑脊髓炎。
T2539	Fingolimod hydrochloride Fingolimod (FTY720) HCl,FTY720,盐酸芬戈莫德	TRP/TRPV Channel; S1P Receptor; PAK; LPL Receptor	Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel
	Fingolimod hydrochloride (FTY720) 是一种新型免疫调节剂，是一种 1-磷酸鞘氨醇(S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC50为 0.033 nM。它诱导 S1P1 的内化，从而抑制 S1P 活性。它被鞘氨醇激酶磷酸化，尤其是被 SK2 磷酸化，从而可与 S1PR1、3、4 和 5 结合
T15032	CYM50308	S1P Receptor; LPL Receptor	GPCR/G Protein
	CYM50308 是选择性和高亲和力的鞘氨醇-1-磷酸受体 4 激动剂，EC50为 56 nM。它对 S1P4-R 的选择性比 S1P5-R 高 37 倍。
T62552	Ozanimod hydrochloride
	Ozanimod (RPC-1063) hydrochloride 是一种鞘氨醇 1-磷酸 (S1P) 受体调节剂，能够高亲和力地选择性结合 S1P 受体亚型 1 (S1P1) 和 S1P5 (S1P5)。Ozanimod hydrochloride 能够调节 hS1P1 受体 (EC50: 1.03 nM) 和 hS1P5 受体 (EC50: 8.6 nM)。Ozanimod hydrochloride 能够用于研究复发性多发性硬化 (MS)。
T38294	4-Deoxypyridoxine hydrochloride	S1P Receptor	GPCR/G Protein
	4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解，与 S1P 一样，减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T13327	W146 W 146,W-146	Others	Others
	W146 is a selective sphingosine-1-phosphate receptor 1 (S1PR1) antagonist (EC50: 398 nM).
T31107	CS-0777 CS0777,CS 0777
	CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator).
T71564	GSK2018682 HCl
	GSK2018682 is a novel sphingosine-1-phosphate receptor 1 (s1p1) and 5 (s1p5) agonist.
T68678	VPC 24191
	VPC 24191 is a sphingosine 1-phosphate (S1P1/3) receptor agonist.
T10912	S1PR1-MO-1	Others	Others
	S1PR-MO-1 is a modulator of sphingosine-1-phosphate receptor and is used to study hyperproliferative inflammatory diseases.
T68448	XAX-162
	XAX-162 is an agonist of Sphingosine 1-phosphate receptor 2 (S1PR2)
T71392	(R)-FTY-720 Vinylphosphonate
	(R)-FTY-720 Vinylphosphonate is a sphingosine 1-phosphate type 1 (S1P1) receptor agonist and lacks anti-apoptotic activity.
T39097	Zectivimod
	Zectivimod, a sphingosine-1-phosphate receptor agonist, holds the potential for studying autoimmune diseases, chronic inflammatory diseases, and immunoregulation disorders.
T10387	ASP1126	Others	Others
	ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist (EC50s: 7.12 nM, 517 nM for hS1P1 and hS1P3).
T14930	Ceralifimod ONO-4641	Others	Others
	Ceralifimod (ONO-4641) is a potent agonist for sphingosine 1-phosphate receptors 1 and 5 (EC50s: 27.3, 334 pM for human S1P receptor 1 and 5).
T68698	VPC 23153
	VPC 23153 is a sphingosine 1-phosphate 4 receptor agonist. This hygroscopic phospholipid causes contraction of pulmonary artries in rats.
T37952	Sphinganine-1-phosphate (d17:0) Sphinganine-1-phosphate (d17:0)
	Sphinganine-1-phosphate (d17:0) is a sphingolipid analog of sphinganine-1-phosphate (d18:0) and sphingosine-1-phosphate (d18:1) that has a 17-carbon base. Sphinganine-1-phosphate (d17:0) levels are lower in surgical and cadaver trabecular meshwork samples isolated from patients with primary open angle glaucoma compared with control samples.
T28080	Mocravimod KRP 203 free base,KRP-203,KRP203
	Mocravimod is an agonist of sphingosine 1-phosphate receptor type 1. Mocravimod ameliorates atherosclerosis in LDL-R-/- mice. KRP-203 attenuates rat autoimmune myocarditis. KRP-203 combined with cyclosporine prolonged graft survival and abrogated transpla
T70613	SLP120701 HCl
	SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.
T36833	A6770
	A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50= <0.01 μM), an effect that is reduced in the presence of vitamin B6(EC50= <100 μM). 1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)
T41237	W146 TFA
	W146 TFA 是选择性 1-磷酸-鞘氨醇受体亚型 1 (S1PR1) 的拮抗剂，EC50值为 398 nM。
T78160	SLB1122168 formic	LPL Receptor	GPCR/G Protein
	SLB1122168 formic为一种高效的Spns2介导的S1P释放抑制剂，其半抑制浓度（IC50）为94 nM。
T70614	SLR080811 HCl
	SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.
T61406	RBM10-8
	RBM10-8不可逆地抑制人鞘氨醇-1-磷酸裂解酶（hS1PL），同时也作为酶底物发挥作用。
T28838	SPM-242 SPM 242
	SPM-242 is an orthosteric agonist of Sphingosine 1-phosphate (S1P) and a bitopic antagonist. S1P is a lysophospholipid signaling molecule that regulates important biological functions, including vascular development and lymphocyte trafficking, by activat
T71301	Opaganib HCl
	ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis a...
T35781	Sphinganine (d20:0) Sphinganine (d20:0)
	Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1-phosphate (d18:1) . In S. cerevisiae, the amount of sphinganine (d20:0) increases 10.8-fold in response to heat stress, indicating it is involved in heat stress adaptation. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well ...
T38000	Lysosphingomyelin (d18:1)
	Sphingomyelins are complex membrane lipids composed of phosphorylcholine, sphingosine, and an acylated group, such as a fatty acid. Lysosphingomyelin is a naturally-occurring lipid which is produced by the removal of the acylated group of sphingomyelin by a deacylase. Lysosphingomyelin may, in turn, serve as a substrate for autotaxin, which removes choline to produce sphingosine-1-phosphate. The receptors and signaling pathways that are activated by lyso-sphingosine are diverse and vary between ...
T41145	TASP 0277308
	TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECsin vitroand reverses or impairs the development of arthritis or mechano-allodynia.
T38716	SAR247799 SAR247799,S1P1 agonist 3
	SAR247799 (S1P1 agonist 3) is an orally-active, selective G-protein-biased agonist for the sphingosine-1 phosphate receptor-1 (S1P1). It demonstrates EC50 values ranging from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 holds promise as a valuable tool for investigating endothelial protection, particularly in the context of type-2 diabetes and metabolic syndrome[4].
T73360	RP101442
	RP101442 是 Ozanimod 的活性代谢物，是一种选择性强的 S1PR1激动剂，对 S1PR1和 S1PR5的 EC50分别为 2.6 nM 和 171 nM。
T70789	VPC03090
	VPC03090 is a Sphingosine-1-Phosphate Receptor Inhibitor. VPC03090 is an analog of FTY-720, acts as antagonist for S1PR1 and S1PR3. VPC03090-P, converted from VPC03090 through the phosphorylation by SK-2, causes a reduction in tumor growth in mice with mammary cancer, and its oral bioavailability is determined to be 30 hours.
T37548	azido-FTY720 azido-FTY720
	FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 recept...

化合物

Sphingosine-1-phosphate (d16:1)

Cat.No: T37955

Synonym: Sphingosine-1-phosphate (d16:1)

Cat.No: T6923

Synonym: 奥扎莫德,RPC-1063

Target: S1P Receptor, LPL Receptor

C18 Ceramide-1-phosphate (d18:1/18:0) ammonium

Cat.No: T83880

Synonym: Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate

Cat.No: T83910

Synonym: Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31

Cat.No: T27106

Cat.No: T27864

Synonym: LX 3305,LX2931,LX-3305,ACB20034,LX 2931,LX3305

Target: S1P Receptor

Amiselimod hydrochloride

Cat.No: T10305

Synonym: MT-1303 hydrochloride

Target: S1P Receptor, LPL Receptor

Mocravimod hydrochloride

Cat.No: T12086

Synonym: KRP-203

Target: Others, LPL Receptor

Cat.No: T15031

Target: Others, LPL Receptor

Cat.No: T7360

Target: S1P Receptor, LPL Receptor

Cat.No: T28643

Synonym: S1P1-IN-Ex26

Target: S1P Receptor

Cat.No: TQ0227

Synonym: APD334

Target: S1P Receptor, LPL Receptor

Cat.No: T9464

Target: LPL Receptor

Cat.No: T63047

Target: S1P Receptor, LPL Receptor

Cat.No: T3258

Synonym: ACT-128800

Target: S1P Receptor, LPL Receptor

Cat.No: T14924

Synonym: ACT-334441

Target: S1P Receptor

Cat.No: T22102

Synonym: CYM50179

Target: Others

Cat.No: T10385

Target: S1P Receptor, LPL Receptor

Fingolimod hydrochloride

Cat.No: T2539

Synonym: Fingolimod (FTY720) HCl,FTY720,盐酸芬戈莫德

Target: TRP/TRPV Channel, S1P Receptor, PAK, LPL Receptor

Cat.No: T15032

Target: S1P Receptor, LPL Receptor

Ozanimod hydrochloride

Cat.No: T62552

4-Deoxypyridoxine hydrochloride

Cat.No: T38294

Target: S1P Receptor

Cat.No: T13327

Synonym: W 146,W-146

Target: Others

Cat.No: T31107

Synonym: CS0777,CS 0777

Cat.No: T71564

Cat.No: T68678

Cat.No: T10912

Target: Others

Cat.No: T68448

(R)-FTY-720 Vinylphosphonate

Cat.No: T71392

Cat.No: T39097

Cat.No: T10387

Target: Others

Cat.No: T14930

Synonym: ONO-4641

Target: Others

Cat.No: T68698

Sphinganine-1-phosphate (d17:0)

Cat.No: T37952

Synonym: Sphinganine-1-phosphate (d17:0)

Cat.No: T28080

Synonym: KRP 203 free base,KRP-203,KRP203

Cat.No: T70613

Cat.No: T36833

Cat.No: T41237

SLB1122168 formic

Cat.No: T78160

Target: LPL Receptor

Cat.No: T70614

Cat.No: T61406

Cat.No: T28838

Synonym: SPM 242

Cat.No: T71301

Sphinganine (d20:0)

Cat.No: T35781

Synonym: Sphinganine (d20:0)

Lysosphingomyelin (d18:1)

Cat.No: T38000

Cat.No: T41145

Cat.No: T38716

Synonym: SAR247799,S1P1 agonist 3

Cat.No: T73360

Cat.No: T70789

Cat.No: T37548

Synonym: azido-FTY720

Cat. No.	Product Name	Target	Signaling Pathways
T21500	Sphingosine-1-phosphate S1P	Endogenous Metabolite; S1P Receptor; LPL Receptor	GPCR/G Protein; Metabolism
	Sphingosine-1-phosphate (S1P) 是 S1P1-5 受体 (S1P1-5 receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使，动员 Ca2+ 作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。
T7939	Fingolimod 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇,FTY-720A,FTY-720,芬戈莫德	S1P Receptor; PAK; LPL Receptor	Cytoskeletal Signaling; GPCR/G Protein
	Fingolimod (FTY-720A) 是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC50为 0.033 nM。它还是pak1激活剂和免疫抑制剂。

天然产物

Sphingosine-1-phosphate

Cat.No: T21500

Synonym: S1P

Target: Endogenous Metabolite, S1P Receptor, LPL Receptor

Cat.No: T7939

Synonym: 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇,FTY-720A,FTY-720,芬戈莫德

Target: S1P Receptor, PAK, LPL Receptor

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