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Search Results for " stat3-in-3 "

11

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13010	STAT3-IN-3	STAT	JAK/STAT signaling; Stem Cells
	STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
T13009	STAT3-IN-1	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	STAT3-IN-1 是一种选择性的、口服有效的 STAT3的强效抑制剂，可诱导肿瘤细胞凋亡，其在 HT29 和MDA-MB 231 细胞中的IC50值分别为1.82 μM 和2.14 μM。
T28865	STAT3-IN-B9 STAT3 IN B9,B9	STAT	JAK/STAT signaling; Stem Cells
	STAT3-IN-B9 (B9) 是异常 STAT3 激活的抑制剂，可抑制 MDA-MB-468、MDA-MB-231 和 DU145 等肿瘤细胞的增殖。
T79609	STAT3-IN-18	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	STAT3-IN-18 (compound SPP)，一种带紫檀芪衍生轴向配体的铂(IV)络合物，能抑制乳腺癌(BC)细胞的JAK2-STAT3通路，显示出抗增殖活性。它激活caspase-3和裂解聚ADP-核糖聚合酶，诱导apoptosis。此外，STAT3-IN-18可促进树突状细胞成熟与抗原呈递，体现了良好的体内安全性。
T82373	FPR2 agonist 3
	FPR2 agonist 3 能够抑制 LPS 刺激下的培养物中乳酸脱氢酶的释放，并减少促炎性因子IL-1β和IL-6的表达水平。此外，FPR2 agonist 3 还可以通过作用于 STAT3/SOCS3 信号通路来降低 STAT3 的磷酸化水平。
T70686	HJC-0123
	Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.
T79608	DPP	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	DPP，一种含紫檀芪衍生轴向配体的铂(IV)络合物，能够抑制乳腺癌(BC)细胞的JAK2-STAT3通路并显示出抗增殖特性。它通过激活caspase-3和裂解聚ADP-核糖聚合酶诱导细胞凋亡(apoptosis)，同时促进树突状细胞成熟及抗原呈现功能，并已证明体内具有安全性。
T36035	CAY10784
	CAY10784 is a STAT3 inhibitor (IC50= 0.74 μM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 μM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 μM for both). CAY10784 is also active againstH. pyloriandC. jejuni(MICs = 1.6 and 4.7 μM, respectively).2 1.Lü, Z., Li, X., Li, K., et al.Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway i...
T64672	Colivelin TFA
	Colivelin (sequence SALLRSIPAPAGASRLLLLTGEIDLP) is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative. It works as a neuroprotective peptide and activator of STAT3. Colivelin-induced neuroprotection has been confirmed to occur via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN. Co...
T68656	Brivudine monophosphate
	Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator...
T11449	Golotimod hydrochloride (229305-39-9 free base) Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride	STAT	JAK/STAT signaling; Stem Cells
	Golotimod (SCV 07) hydrochloride 是一种免疫调节肽，具抗菌活性，能显著提升抗结核疾病研究效果。该化合物通过刺激胸腺和脾细胞增殖、改善巨噬细胞功能，展现其生物调节能力。此外，Golotimod hydrochloride 通过抑制STAT3信号传导，有效调节接受放疗或与顺铂联用治疗动物模型中的口腔粘膜炎持续时间和严重程度。还显示出对研究复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 具有潜在应用价值。

化合物

Cat.No: T13010

Target: STAT

Cat.No: T13009

Target: Apoptosis, STAT

Cat.No: T28865

Synonym: STAT3 IN B9,B9

Target: STAT

Cat.No: T79609

Target: JAK

Cat.No: T82373

Cat.No: T70686

Cat.No: T79608

Target: JAK

Cat.No: T36035

Cat.No: T64672

Brivudine monophosphate

Cat.No: T68656

Golotimod hydrochloride (229305-39-9 free base)

Cat.No: T11449

Synonym: Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride

Target: STAT

Cat. No.	Product Name	Target	Signaling Pathways
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。
T3S1775	Tectochrysin NSC 80687,Techtochrysine,Techtochrysin,柚木柯因	NF-κB; STAT	JAK/STAT signaling; NF-κB; Stem Cells
	Tectochrysin (Techtochrysine) 是Alpinia oxyphylla 的主要黄酮类化合物之一，能够抑制NF-κB 活性。
T6S2246	Alisol B 23-acetate Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯	Others	Others
	Alisol B 23-acetate (Alisol B Acetate) 是三萜类化合物，能够激活法尼醇受体，诱导受损的肝脏再生。
T4S0145	Corylifol A Corylinin,补骨脂异黄酮A	hCE; STAT; UGT	JAK/STAT signaling; Metabolism; Stem Cells
	Corylifol A (Corylinin) 是补骨脂中的一种天然产物，可抑制IL-6 诱导的STAT3激活和磷酸化，IC50值为0.81 μM。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。
T6S1141	Ganoderic acid A 灵芝酸 A,灵芝酸A	Apoptosis; NF-κB; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism; NF-κB
	Ganoderic acid A 能够抑制 JAK-STAT3信号通路，也能抑制细胞增殖，存活率和 ROS。它对人骨肉瘤 HOS 和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。

天然产物

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

Cat.No: T3S1775

Synonym: NSC 80687,Techtochrysine,Techtochrysin,柚木柯因

Target: NF-κB, STAT

Alisol B 23-acetate

Cat.No: T6S2246

Synonym: Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯

Target: Others

Cat.No: T4S0145

Synonym: Corylinin,补骨脂异黄酮A

Target: hCE, STAT, UGT

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

Ganoderic acid A

Cat.No: T6S1141

Synonym: 灵芝酸 A,灵芝酸A

Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy

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