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Cat. No. | Product Name | Target | Signaling Pathways |
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T82763 |
CD33 splicing modulator 1 hydrochloride
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"CD33splicing modulator 1 (Compound 1) hydrochloride 是一种调节CD33/Siglec 3活性的化合物。CD33/Siglec 3 为髓系细胞表面受体,涉及小胶质细胞功能。该化合物通过提升细胞mRNA池中外显子2的剪接变异,展现在神经退行性疾病研究中的应用潜力,包括阿尔茨海默病。" | |||
T62612 | CD33 splicing modulator 1 | ||
CD33 splicing modulator 1 (Compound 1) 是一种 CD33 splicing modulator。CD33/Siglec 3 是一种已知可调节小胶质细胞活性的髓系细胞表面受体。CD33 splicing modulator 1 加强了细胞 mRNA 池中外显子 2 的跳跃。CD33 splicing modulator 1 具有潜力进行包括阿尔茨海默病在内的神经退行性疾病的研究。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04805 |
Siglec-3/CD33 Protein, Human, Recombinant
SIGLEC3,Siglec-3,CD3... |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 27.4 kDa and the accession number is AAH28152.1. | |||
TMPY-03805 |
Siglec-3/CD33 Protein, Human, Recombinant (His)
CD33 molecule,SIGLEC3, |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is AAH28152.1. | |||
TMPY-04952 |
Siglec-3/CD33 Protein, Human, Recombinant (His), Biotinylated
CD33 molecule,p67,SIGLEC3 |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is AAH28152.1. | |||
TMPY-02304 |
Siglec-3/CD33 Protein, Mouse, Recombinant (His)
gp67,CD33 molecule,Siglec-3 |
Mouse | HEK293 Cells |
Siglec-3/CD33 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is Q63994-1. | |||
TMPY-04808 |
Siglec-3/CD33 Protein, Mouse, Recombinant
gp67,CD33 molecule,Siglec-3 |
Mouse | HEK293 Cells |
Siglec-3/CD33 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.6 kDa and the accession number is Q63994-2. | |||
TMPY-05572 |
Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated
Siglec-3,p67,CD33 molecu... |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1. | |||
TMPY-03694 |
Siglec-3/CD33 Protein, Human, Recombinant (mFc)
p67,Siglec-3,CD33 molecu... |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 29.5 kDa and the accession number is AAH28152.1. | |||
TMPY-05381 |
Siglec-3/CD33 Protein, Human, Recombinant (hFc)
p67,CD33 molecule,SIGLEC3 |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.5 kDa and the accession number is AAH28152.1. | |||
TMPY-02263 |
Siglec-3/CD33 Protein, Mouse, Recombinant (hFc)
CD33 molecule,gp67,Siglec-3 |
Mouse | HEK293 Cells |
Siglec-3/CD33 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.6 kDa and the accession number is Q63994-1. | |||
TMPY-05571 |
Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated
CD33 molecule,Siglec-3,p... |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1. | |||
TMPK-01300 |
Siglec-3/CD33 Protein, Cynomolgus, Recombinant (His)
Siglec-3,CD33,Siglec... |
Cynomolgus | HEK293 Cells |
Siglec-3/CD33 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.83 kDa and the accession number is XP_005590138.1. | |||
TMPJ-00537 |
Siglec-3/CD33 Protein, Human, Recombinant (hFc & His)
Myeloid Cell Surface Antigen CD33,CD3<... |
Human | HEK293 Cells |
CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are c... | |||
TMPK-00844 |
Siglec-3/CD33 Protein, Human, Recombinant (His & Avi)
p67,CD33 molecule,FLJ00391,Si... |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1. | |||
TMPK-00843 |
Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), FITC-Labeled
CD33,CD33 molecule,gp67,... |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1. | |||
TMPK-00846 |
Siglec-3/CD33 Protein, Human, Recombinant (aa 18-259, hFc)
CD33,CD33 molecule,gp67,... |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant (aa 18-259, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.6 kDa and the accession number is P20138-1. | |||
TMPK-00845 |
Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated
Siglec3,p67,FLJ00391,Siglec |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1. | |||
TMPY-02409 |
Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His)
CD33 molecule |
Cynomolgus,Rhesus | HEK293 Cells |
Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.3 kDa and the accession number is EHH59833.1&EHH30318.1. | |||
TMPK-01295 |
Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi)
CD33 molecule-like 3,Siglec |
Cynomolgus | HEK293 Cells |
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mam... | |||
TMPK-00231 |
Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated
CD33 molecule-like 3,Siglec |
Mouse | HEK293 Cells |
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylate... | |||
TMPK-00217 |
Siglec-15 Protein, Human, Recombinant (His & Avi)
Siglec15,CD33 molecule-like 3... |
Human | HEK293 Cells |
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.. | |||
TMPK-01296 |
Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
CD33 molecule-like 3,CD3... |
Cynomolgus | HEK293 Cells |
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed... | |||
TMPJ-00217 |
Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD33L3,Siglec-15,Sialic ... |
Human | HEK293 Cells |
Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 58-75 KDa and the accession number is Q6ZMC9. | |||
TMPJ-00225 |
Siglec-15 Protein, Mouse, Recombinant (His)
Siglec-15,Sialic acid-binding Ig-like lectin 15,CD<... |
Mouse | HEK293 Cells |
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type I... | |||
TMPJ-00434 |
Siglec-15 Protein, Cynomolgus, Recombinant (His)
Siglec-15,CD33L3,Sialic ... |
Cynomolgus | HEK293 Cells |
Siglec-15 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is A0A2K5UY47. | |||
TMPY-05366 |
Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated
CD33 molecule |
Cynomolgus,Rhesus | HEK293 Cells |
Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.3 kDa and the accession number is XP_005590138.1. | |||
TMPY-03961 |
Siglec-6 Protein, Human, Recombinant (hFc)
sialic acid binding Ig like lectin 6,CD33L... |
Human | HEK293 Cells |
Siglec-6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 60.7 kDa and the accession number is O43699-3. | |||
TMPJ-01254 |
Siglec-F Protein, Mouse, Recombinant (His)
sialic acid binding Ig like lectin 8,SAF2,SIGLEC-8,... |
Mouse | HEK293 Cells |
Siglec 5 to 11 share a high degree of sequence similarity with CD33/Siglec-3 both in their extracellular and intracellular regions. They are collectively referred to as CD33-related Siglecs. One remarkable feature of the CD33-related Siglecs is their differential expression pattern within the hematopoietic system. This fact, together with the presence of two conserved immunoreceptor tyrosine-based inhibition motifs (ITIMs) in their cytoplasmic tails, suggests that CD33-related Siglecs are involv... | |||
TMPY-06986 |
FGF-8b Protein, Human, Recombinant
NEWENTRY,fibroblast growth factor 8 (androgen-induced),FGF-8... |
Human | E. coli |
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac... | |||
TMPY-00132 |
Mesothelin Protein, Human, Recombinant
MPF,SMRP,Mesothelin |
Human | HEK293 Cells |
Mesothelin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32.4 kDa and the accession number is Q13421-3. | |||
TMPY-04935 |
CD47 Protein, Human, Recombinant (aa 1-139, His)
MER6,CD47 molecule,IAP,OA3 |
Human | HEK293 Cells |
CD47 Protein, Human, Recombinant (aa 1-139, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q08722-3. | |||
TMPY-03763 |
Neuropilin-2 Protein, Human, Recombinant (hFc)
Neuropilin-2,NPN2,neuropilin 2,PRO2714,VEGF165R2,NP2 |
Human | HEK293 Cells |
Neuropilin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 120.7 kDa and the accession number is O60462-3. | |||
TMPY-01897 |
PRSS3 Protein, Human, Recombinant (His)
PRSS4,TRY4,TRY3,RP11-176F3.3,T9,M... |
Human | HEK293 Cells |
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ... | |||
TMPY-01020 |
Periostin/OSF-2 Protein, Human, Recombinant (His)
PN,OSF-2,OSF2,periostin,periostin, osteoblast specific facto... |
Human | HEK293 Cells |
Periostin/OSF-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is Q15063-3. | |||
TMPY-00892 |
Neuropilin-2 Protein, Human, Recombinant (His)
NP2,PRO2714,VEGF165R2,neuropilin 2,NPN2,Neuropilin-2 |
Human | HEK293 Cells |
Neuropilin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is O60462-3. | |||
TMPY-05191 |
CD47 Protein, Human, Recombinant, Biotinylated
CD47 molecule,MER6,OA3,IAP |
Human | HEK293 Cells |
CD47 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3. | |||
TMPY-04683 |
CD47 Protein, Human, Recombinant
MER6,CD47 molecule,OA3,IAP |
Human | HEK293 Cells |
CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3. | |||
TMPY-00072 |
GITR/TNFRSF18 Protein, Human, Recombinant (His)
AITR,GITR-D,tumor necrosis factor receptor superfamily, memb... |
Human | HEK293 Cells |
GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3. | |||
TMPY-01180 |
CD86 Protein, Human, Recombinant (His)
CD86 antigen,B70,B7.2,B7-2,CD28LG2,LAB72 |
Human | HEK293 Cells |
CD86 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P42081-3. | |||
TMPY-05748 |
CD45 Protein, Human, Recombinant (aa 26-577, His)
L-CA,T200,LCA,B220,protein tyrosine phosphatase, receptor ty... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3. | |||
TMPY-04142 |
RANK/TNFRSF11A Protein, Human, Recombinant (hFc)
OPTB7,OFE,OSTS,LOH18CR1,FEO,TRANCER,tumor necrosis factor re... |
Human | HEK293 Cells |
RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3. | |||
TMPJ-01099 |
IL-15RA Protein, Human, Recombinant (hFc, Human Cells)
interleukin-15 receptor subunit α,IL15RA,interleukin-15 rece... |
Human | HEK293 Cells |
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun... | |||
TMPY-04298 |
CDCP1 Protein, Human, Recombinant (His)
TRASK,CD318,CUB domain containing protein 1,SIMA1 |
Human | HEK293 Cells |
CDCP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.4 kDa and the accession number is Q9H5V8-3. | |||
TMPY-00357 |
HNT/NTM Protein, Human, Recombinant (His)
HNT,NTRI,IGLON2,neurotrimin |
Human | HEK293 Cells |
HNT/NTM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.3 kDa and the accession number is Q9P121-3. | |||
TMPY-00480 |
NCAM1 Protein, Human, Recombinant (His)
neural cell adhesion molecule 1,CD56,MSK39,NCAM |
Human | HEK293 Cells |
NCAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.1 kDa and the accession number is P13591-3. | |||
TMPK-00447 |
CD45 Protein, Human, Recombinant (aa 26-577, hFc)
CD45,CD45R,LCA,PTPRC,L-CA,T200,B220,GP180,LY5,EC 3.... |
Human | HEK293 Cells |
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (aa 26-577... | |||
TMPY-01268 |
SMYD3 Protein, Human, Recombinant (GST)
SET and MYND domain containing 3,ZMYND1,KMT3 |
Human | Baculovirus Insect Cells |
SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional reg... | |||
TMPY-03621 |
EphB2 Protein, Mouse, Recombinant (hFc)
Tyro5,Erk,Qek5,ETECK,Hek5,Drt,EPH receptor B2,Nuk,Prkm5,Sek<... |
Mouse | HEK293 Cells |
EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.6 kDa and the accession number is P54763-3. | |||
TMPJ-01288 |
KLF6 Protein, Human, Recombinant
CPBP,GC-Rich Sites-Binding Factor GBF,Suppressor of Tumorige... |
Human | E. coli |
Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. KLF6 expression is highest in the placenta followed by spleen, thymus, prostate, testis, small intestinem and colon. However, it is weakly expressed in the pancreas, lung, liver, heart, and skeletal muscle. KLF6 functions as a transcriptional activator and could play a role in B-cell growth and development. Defects in KLF6 will resul... | |||
TMPY-04386 |
EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)
PCBC,CAPB,Hek5,EK5,EPHT3,EPH receptor B2,Tyro5,DRT,... |
Human | Baculovirus Insect Cells |
EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.2 kDa and the accession number is P29323-3. | |||
TMPY-03149 |
CDCP1 Protein, Human, Recombinant (mFc)
TRASK,SIMA135,CD318,CUB domain containing ... |
Human | HEK293 Cells |
CDCP1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.4 kDa and the accession number is Q9H5V8-3. | |||
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