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Cat. No. | Product Name | ||
---|---|---|---|
L5200 | 抗代谢疾病化合物库 | 1544 compounds | |
1544 个代谢疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L4660 | 神经疾病库Plus | 1246 compounds | |
1246 种神经系统相关、结构新颖的化合物; | |||
L2620 | 神经退行性疾病化合物库 | 2154 compounds | |
2154 种与神经退行性疾病相关的化合物,可用于高通量和高内涵筛选; | |||
L9830 | 抗帕金森病化合物库 | 857 compounds | |
857 种帕金森病相关的化合物集合,可用于高通量和高内涵筛选; | |||
L9840 | 抗阿尔茨海默症化合物库 | 986 compounds | |
986 种阿尔茨海默症相关的化合物集合,可用于高通量和高内涵筛选; | |||
L5400 | 抗心血管疾病化合物库 | 1408 compounds | |
1408 种心血管疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3508 |
SEA0400
SEA 0400,2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺,SEA-0400 |
Calcium Channel; Na+/Ca2+ Exchanger | Membrane transporter/Ion channel; Metabolism |
SEA0400 是 Na+/Ca2+ 交换剂的选择性抑制剂,在培养的神经元、星形胶质细胞和小胶质细胞中,能够抑制 Na+-依赖性 Ca2+的吸收,IC50值为 5-33 nM。 | |||
T78312 |
Cifurtilimab
SEA-CD40 |
||
Cifurtilimab(SEA-CD40)是一种具有抗癌活性的人源化抗CD40 IgG1单克隆抗体。 | |||
T20812 |
Azamethiphos
甲基吡啶磷,唑啶磷 |
AChE | Neuroscience |
Azamethiphos 是有机磷杀虫剂和神经毒性物质,能够抑制乙酰胆碱酯酶的活性。 | |||
T69110 |
Aseanostatin P5
|
||
Aseanostatin P5 inhibits myeloperoxidase (MPO) release from human polymorphonuclear leukocytes. | |||
T80341 |
Seabream hepcidin
|
||
Seabream hepcidin是一种抗菌肽,具有针对细菌(V.anguillarum)、真菌(S.cerevisiae)以及病毒性出血性败血症病毒的活性。 | |||
T19437 |
MTSEA hydrobromide
|
Others | Others |
MTSEA hydrobromide is a sulfhydryl-reactive compound that modifies free cysteine residues to produce a positively charged side chain similar in size to lysine. | |||
T75368 |
MTSEA-Fluorescein
|
||
MTSEA-Fluorescein 是一种可用于离子通道研究的荧光探针。储存方式:避光。 | |||
T76252L |
WLSEAGPVVTVRALRGTGSW TFA
|
||
WLSEAGPVVTVTVRALGTGSW TFA 为心肌细胞特异性肽。该化合物通过表达外泌体,提高心肌细胞的特定摄取能力,降低心肌细胞凋亡率,并在体内心肌内注射后提升心脏潴留能力。 | |||
T77841 |
Duostatin 5
|
Others | Others |
Duostatin 5 (Duo-5)是一种海兔毒素类似物,常用于合成 ADC 化合物。 | |||
T7487L |
Speract TFA(76901-59-2(free base))
|
Others | Others |
Speract TFA(76901-59-2(free base)) 是一种海胆卵肽,可调节精子活力,也可刺激精子线粒体代谢。 | |||
T65687 |
CAPS
N-Cyclohexyl-3-aminopropanesulfonic acid |
Others | Others |
CAPS (N-Cyclohexyl-3-aminopropanesulfonic acid) 是一种表面活性剂,可作为化学发光增强剂,可用于开发深海原位分析仪。 | |||
TP1699L |
SEB Domain 144-153 acetate(210229-94-0 free base)
|
Others | Others |
SEB Domain 144-153 acetate(210229-94-0 free base) 是葡萄球菌肠毒素 B 结构域氨基酸残基 163-172。它已被证明可抑制多种葡萄球菌肠毒素、SEA、SEE 和 TSST-1 的转胞吞作用。 | |||
T34298 |
Retene
NSC 26317,NSC-26317,NSC26317 |
||
Retene (NSC-26317) 广泛存在于近代和古代沉积物中,可从冷杉林土壤、腐殖质煤、陆相石油烃源岩和深海沉积物中提取得到化合物。Retene 是松木酸在成岩作用过程中脱氢产生的。 | |||
T38374 |
2-hydroxy Myristic Acid
|
||
2-hydroxy Myristic acid is a hydroxy fatty acid that has been found in bovine, human, and horse milk, cow and buffalo cheeses, sea bass filet, seal oil, human vernix caseosa, and wool wax. It inhibits cleavage between the enterovirus capsid proteins VP4 and VP2, a process required for enterovirus infectivity, as well as Junin and Tacaribe viral replication (IC50s = 20.1 and 14.2 μM, respectively). 2-hydroxy Myristic acid was previously characterized as a weak inhibitor of peptide myristoylation ... | |||
T30099 |
Aplysistatin
|
||
Aplysistatin is a bromosesquiterpene derived from sea mollusks. | |||
T32595 |
Laurencin
NSC 122763,NSC122763,NSC-122763 |
||
Laurencin is a component of the sea hare, Aplysia dactylomela. | |||
TP2426 |
Cucumarioside C2
|
||
Cucumarioside C2 is a sea cucumber glycoside. | |||
T33884 |
Parkeol
|
||
Parkeol is the triterpene precursor of saponins in sea cucmbers. | |||
T33860 | Pacifenol | ||
Pacifenol is a sesquiterpene isolated from sea weeds and marine alga Laurencia claviformis. | |||
T34058 |
Phyllospadine
|
||
Phyllospadine is a natural flavonoidal alkaloid from the sea-grass Phyllosphadix iwatensis. | |||
T25091 |
Antho-riamide II
Tyr-arg-ile-NH2,Tyrosyl-arginyl-isoleucinamide |
||
Antho-riamide II is an inactive peptide isolated from sea anemone Anthopleura elegantissima. | |||
T32594 |
Laureatin
|
||
Laureatin is a component of the sea hare, Aplysia dactylomela. | |||
T31186 |
Dactylomelol
|
||
Dactylomelol is a new type of diterpene from sea hare. | |||
TP2442 |
Stichloroside C2
|
||
Stichloroside C2 is a triterpene saponin from the sea cucumber Stichopus chloronotus. | |||
T25092 |
Antho-rpamide II
Glu-asn-phe-his-leu-arg-pro-NH2 |
||
Antho-rpamide II is a biologically active neuropeptide isolated from the sea anemone Anthopleura elegantissima. | |||
T34289 |
Resact
|
||
Resact is an extracellular peptide from egg jelly of the sea urchin Arbacia punctulata. | |||
T32094 |
Holothurin B
|
||
Holothurin B, as a part of a group of toxins, is originally isolated from the sea cucumber Actinopyga agassizi. | |||
T25278 |
Cucumarioside A2-2
|
||
Cucumarioside A2-2 is a triterpene glycoside isolated from the Far-Eastern sea cucumber Cucumaria japonica, that exhibits antitumor activity. | |||
T23739 |
Antho-riamide I
|
||
Antho-Riamide I is an active peptide. It also inhibits the spontaneous contraction of sea anemone muscles. | |||
T23959 |
Dactylyne
|
||
Dactylyne is a new drug metabolism inhibitor of marine origin. It was isolated from the sea hare Aplysia dactylomela and characterized pharmacologically. | |||
T37798 |
Petromyzonol
|
||
Petromyzonol is a tetrahydroxy stearol which serves as the primary spawning pheromone in adult sea lamprey. It is produced in the bile of sea lamprey larvae from the bile acid precursor allocholic acid. While the adult sea lamprey is relatively insensitive to petromyzonol itself, the C-24 sulfate ester (petromyzonol sulfate) is a pheromone and a spawning chemoattractant which can be detected at very low concentrations by lamprey olfactory chemoreceptors. Petromyzonol, petromyzonol sulfate, and a... | |||
T11325 |
Frondoside A
|
Others | Others |
possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa, | |||
T25162 |
Bivittoside A
|
||
Bivittoside A 是一种非硫酸化的六苷类化合物,从波氏海参中提取得到,具有抗真菌活性和潜在抗肿瘤活性。 | |||
T25163 |
Bivittoside B
|
||
Bivittoside B 是一种非硫酸化的六苷类化合物,从波氏海参中提取得到,具有抗真菌活性和潜在抗肿瘤活性。 | |||
T33538 |
Mycobactin S
|
||
Mycobactin S is made from metabolic products of the acid-resistant form of Mycobacterium phlei, a tuberculosis bacillus derived originally from the cold-blooded sea turtle. Importantly, it is not based on cell wall fragments or killed bacteria. | |||
T7487 |
Speract
精子活化肽 |
Others; Mitochondrial Metabolism | Metabolism; Others |
Speract 是调节精子活力的海胆蛋肽,也能够刺激精子线粒体代谢。 | |||
TP1699 |
SEB Domain (144-153)
SEB Domain 144-153 |
||
SEB Domain (144-153) peptide is Staphylococcal Enterotoxin B domain amino acid residue 163-172. SEB Domain (144-153) has been shown to inhibit transcytosis of multiple staphylococcal enterotoxins, SEA, SEE, and TSST-1. | |||
T37632 |
TFM
|
||
TFM is a piscicide.1It is toxic to sea lamprey (P. marinus) with LC50values ranging from 1.97 to 2.11 and 2.05 to 2.21 mg/L for sac and swim-up fry, respectively, 1.6 to 2.45 mg/L for juveniles, and 1.6 to 1.63 mg/L for adults. It is also toxic to juvenile lake sturgeon (A. fulvescens) less than 100 mm in size but not to a variety of other fish species. TFM (50 μM) uncouples oxidative phosphorylation by 22 and 28% in isolated sea lamprey and rainbow trout (O. mykiss) liver, respectively.2Formula... | |||
T37489 |
11(R)-HEPE
|
||
11(R)-HEPE is produced by the oxidation of EPA by 11(R)-LO. This enzymatic activity and the resulting 11(R)-hydroxy acid have been isolated from the sea urchin S. purpuratus. | |||
TP2163 |
SEB Domain 144-153 TFA(210229-94-0 free base)
SEB Domain (144-153) (TFA) |
Others | Others |
SEB Domain 144-153 TFA is Staphylococcal Enterotoxin B domain amino acid residue 144-153. It inhibits transcytosis of multiple staphylococcal enterotoxins, SEE, SEA, and TSST-1. | |||
T83121 |
Anatumomab mafenatox
ABR-214936 |
||
Anatumomab mafenatox (ABR-214936)是一种73 KDa的重组蛋白,针对广泛表达于恶性肿瘤中的肿瘤相关抗原5T4。该分子构建于修饰后的SEA和小鼠Fab片段之间。Anatumomab mafenatox的主要副作用包括发烧、低血压、疼痛、恶心和嗜睡。 | |||
T80039 |
ATX-II
|
Sodium Channel | Membrane transporter/Ion channel |
ATX-II为特定Na+通道调节剂,源自海葵(Anemonia sulcata)毒液。该化合物会使细胞培养物对Na+Halothane、Caffeine及Ryanodine敏感,并可诱发肺静脉心律失常及心房颤动。 | |||
T37490 |
11(R)-HETE
|
||
11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris. The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results. | |||
T37803 | 8-bromo-Cyclic ADP-Ribose (sodium salt) | ||
Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, which in turn activate ryanodine receptors. 8-bromo-cADP-Ribose is a stable, cell-permeable analog that blocks calcium release evoked by cADP-ribose in sea urchin egg homogenates with an IC50 value of 1.7 μM. It is commonly used to investigate intracellular signaling through cADP-... | |||
T37263 |
14-methyl Pentadecanoic Acid methyl ester
|
||
14-methyl Pentadecanoic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluvialis microalgae. It is a major component of the vancomycin-induced biofilm produced by vancomycin-resistant S. aureus (VRSA). 14-methyl Pentadecanoic acid methyl ester has been used as a standard for the quantification of 14-methyl pentadecanoic acid in various foods by GC-MS. | |||
T35777 |
Nodularin
|
||
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory eff... | |||
T75924 |
APETx2 TFA
|
||
APETx2 TFA 是可来自Anthopleura elegantissima 的海葵肽,是选择性的、可逆的酸敏感的离子通道ASIC3 (acid-sensing ion channel)抑制剂,其 IC50值为 63 nM. APETx2 作用在ASIC3 通道外部。APETx2 TFA 能够逆转酸性诱导的炎症疼痛。 | |||
T82936 |
ATX-II TFA
|
Sodium Channel | Membrane transporter/Ion channel |
ATX-II TFA为源自海葵(Anemonia sulcata)毒素的特定Na+通道调节剂,能使细胞培养物对Na+、Halothane、Caffeine和Ryanodine敏感,并可诱发肺静脉心律失常和心房颤动。 | |||
T83801 |
ε-NAADP+ sodium
Etheno-NAADP,β-Nicotinic Acid-1,N6-Ethenoadenine dinucleotide phosphate,Nicotinic Acid adenine dinucleotide phosphate |
||
ε-NAADP+是钙动员诱导剂NAADP的荧光衍生物。在海胆卵细胞匀浆中诱导钙释放(EC50 = 5 µM)。ε-NAADP+在275 nm和410 nm分别显示激发/发射峰值,且在DMSO中的相对发射增加了三倍。 | |||
T75444 | Peniterphenyl A | ||
Peniterphenyl A,一种源于深海青霉属植物的天然产物,能够抑制HSV-1/2病毒的细胞内入侵。它可能通过与HSV-1/2病毒的糖蛋白D直接相互作用,干扰病毒的吸附和膜融合过程,进而有效阻断病毒感染。因此,Peniterphenyl A是抗HSV-1/2研究领域中一个极具潜力的先导化合物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8002 |
3-Hydroxycoumarin
|
Lipoxygenase | Metabolism |
3-hydroxycoumarin 是一种 15-LOX-1的有效氧化还原抑制剂,近期被证明能保护海胆生殖细胞免受紫外线 B 的损伤。 | |||
TN6388 |
Methyl epi-dihydrophaseate
|
||
Methyl epi-dihydrophaseate 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6388,CAS号为 57761-30-5。 | |||
T40458 |
3-Keto petromyzonol
|
||
3-Keto petromyzonol, a key constituent of Sea lamprey male sex pheromones, governs the synthesis and release of gonadotropin releasing hormone (GnRH). This in turn regulates the hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey. | |||
T34525 |
Sarcophine
Sarcophin,Sarcophin A |
||
Sarcophine is a natural cembranoid from the Red Sea soft coral Sarcophyton glaucum. | |||
T80012 |
Quellenin
|
||
Quellenin为一抗水霉化合物,可通过分离深海真菌Aspergillussp.YK-76获得。 | |||
T15721 |
Latrunculin A
LAT-A |
Others | Others |
Latrunculin A is a toxin isolated from the red sea sponge Latrunculia magnifica. Latrunculin A binds to actin monomers and it also inhibits polymerization of actin (Kds: 0.1, 0.4, 4.7 μM, and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin, and G-actin, re | |||
T75678 |
Tomentosin
|
Apoptosis | Apoptosis |
Tomentosin 是一种从里海旋覆花中提取出来倍半萜内酯,具有潜在的抗炎和抗癌活性,可促进胰腺癌细胞的凋亡并抑制增殖、迁移和侵袭。 | |||
T20636 |
Latrunculin B
LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644 |
Antifungal | Microbiology/Virology |
Latrunculin B 是一种 来自红海海绵的生物碱,是一种肌动蛋白聚合 (actin polymerization) 抑制剂,具有抗真菌和抗原生动物活性。Latrunculin B 调节肺静脉电生理特征并减轻牵张性心律失常的发生,可用于研究青少年青光眼。 | |||
T37451 |
Stachybotrysin B
|
||
Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 |1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).|2. Ma, X.-h., Zhen... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03537 |
Enterotoxin type A Protein, S. aureus, Recombinant (His)
Enterotoxin type A,SEA,entA |
Staphylococcus aureus | E. coli |
Enterotoxin type A Protein, S. aureus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is P0A0L2. | |||
TMPH-03538 |
Enterotoxin type A Protein, S. aureus, Recombinant (His & Myc)
Enterotoxin type A,SEA,entA |
Staphylococcus aureus | Baculovirus Insect Cells |
Enterotoxin type A Protein, S. aureus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 31.0 kDa and the accession number is P0A0L2. | |||
TMPH-03059 |
Newcastle disease virus (NDV) (strain Her/33) Hemagglutinin-neuraminidase Protein (His)
|
NDV | E. coli |
Mediates the viral entry into the host cell together with fusion/F protein. Attaches the virus to sialic acid-containing cell receptors and thereby initiates infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.; Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. Newcastle disease virus (NDV) (strain Her/... | |||
TMPJ-01203 |
HATL5 Protein, Human, Recombinant (His)
HATL5,Transmembrane Protease Serine 11B,Airway Trypsin-Like ... |
Human | HEK293 Cells |
Transmembrane Protease Serine 11B (TMPRSS11B) is a single-pass type II membrane protein member of the peptidase S1 family. TMPRSS11B contains one peptidase S1 domain and one SEA domain. TMPRSS11B is a serine protease that may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. |