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Retene

产品编号 T34298 CAS 483-65-8

别名: NSC 26317, NSC-26317, NSC26317

Retene (NSC-26317) 广泛存在于近代和古代沉积物中，可从冷杉林土壤、腐殖质煤、陆相石油烃源岩和深海沉积物中提取得到化合物。Retene 是松木酸在成岩作用过程中脱氢产生的。

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Retene, CAS 483-65-8

规格	价格/CNY	货期
1 mg	￥ 1,150	现货
5 mg	￥ 2,830	现货
10 mg	￥ 4,190	现货
25 mg	￥ 6,720	现货
50 mg	￥ 9,130	现货
100 mg	￥ 12,300	现货
500 mg	￥ 24,670	现货

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选择批次

纯度: 99.30%

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Retene (NSC-26317) is widely present in recent and ancient sediments, and compounds can be extracted from fir forest soils, humic coals, terrestrial petroleum hydrocarbon source rocks, and deep-sea sediments.Retene is produced by dehydrogenation of pine acids during petrogenesis.
靶点活性	Whitefish larvae:13.3 microg/L(LC50)
体外活性	In laboratory conditions whitefish larvae were pre-exposed to retene (10, 32 and 100 microg/l), with relevant controls, and irradiated in semi-static tests for 3 h once a day (2 consecutive days) with two UV-B doses (CIE-weighted 2.8 or 5.4 kJ per m(2) per day) or with visible light only. The photoinduced acute LC(50) for retene was 13.3 microg/L. Retene treated fish exhibited signs of behavioral irritation and hypoxia during and after the exposure to UV light. Severe skin damages were detected in larvae exposed simultaneously to retene and UV-B. The structural signs of sunburn could also be seen in UV-B and solvent controls (DMSO) with UV-B. Even at the lowest retene concentration, the number of mucous cells increased significantly in simultaneous chemical and UV-B treatment. We consider the tissue reaction as protective response against UV induced retene toxicity. Further, regarding liver parenchyma, fish exposed to retene with UV-B had lesions, revealing hepatotoxicity.[1]
体内活性	Retene (7-isopropyl-1-methylphenanthrene) is a naturally formed polycyclic aromatic hydrocarbon (PAH) that causes teratogenicity in fish larvae and induction of cytochrome P450 (CYP1A) enzymes. Retene occurs at high concentrations (< or =3,300 microg/g dry wt) in surface sediments contaminated by resin acids from pulp mill effluents. Industrially contaminated sediments collected near a bleached kraft pulp and paper mill discharging to Lake Saimaa, Finland, significantly induced trout liver CYP1A activity, indicating accumulation of arylhydrocarbon receptor (AhR)-active ligands. Induction of CYP1A in fish exposed to sediments spiked with retene or benzo[k]fluoranthene supported this conclusion.[2]

别名	NSC 26317, NSC-26317, NSC26317
分子量	234.34
分子式	C18H18
CAS No.	483-65-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 18.33 mg/mL (78.23 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.2673 mL	21.3365 mL	42.673 mL	106.6826 mL
	5 mM	0.8535 mL	4.2673 mL	8.5346 mL	21.3365 mL
	10 mM	0.4267 mL	2.1337 mL	4.2673 mL	10.6683 mL
	20 mM	0.2134 mL	1.0668 mL	2.1337 mL	5.3341 mL
	50 mM	0.0853 mL	0.4267 mL	0.8535 mL	2.1337 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Häkkinen J, et al. Histopathological responses of newly hatched larvae of whitefish (Coregonus lavaretus s.l.) to UV-B induced toxicity of retene. Aquat Toxicol. 2003;63(2):159-171. 2. Oikari A, et al. Bioavailability to juvenile rainbow trout (Oncorynchus mykiss) of retene and other mixed-function oxygenase-active compounds from sediments. Environ Toxicol Chem. 2002;21(1):121-128. 3. Maria VL, et al. Anguilla anguilla L. liver EROD induction and genotoxic responses after retene exposure. Ecotoxicol Environ Saf. 2005;61(2):230-238. 4. Geier MC, et al. Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol. 2018;41(18)30121-30122. 5. Sun H, et al. Direct determination of surfactant effects on the uptake of gaseous parent and alkylated PAHs by crop leaf surfaces. Ecotoxicol Environ Saf. 2018;154:206-213. 6. Bandowe BAM, et al. A 150-year record of polycyclic aromatic compound (PAC) deposition from high Andean Cajas National Park, southern Ecuador. Sci Total Environ. 2018;621:1652-1663. 7. De Oliveira Alves N, et al. Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells. Sci Rep. 2017;7(1):10937.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

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给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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